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Slowing chromophore synthesis of the neon necessary protein Venus discloses your molecular basis of a final corrosion phase.
In order to investigate the pollution characteristics of size-segregated particles and metal elements (MEs) after the Chinese Air Pollution Prevention Action Plan was released in 2013, an intensive field campaign was conducted in the suburban area of Chaoyang District, Beijing in winter 2016. The size distributions of particle mass concentrations were bimodal, with the first peak in the fine fraction (0.4-2.1 µm) and the second peak in the coarse fraction (3.3-5.8 µm). Moreover, the proportion of fine particles increased and the proportion of coarse particles decreased as the pollution level was more elevated. It was found that the composition of coarse particles is as important as that of fine particles when pollution of aerosol metals in the atmosphere in 2016 were compared to 2013. In addition, according to the size distribution characteristics, 23 MEs were divided into three groups (a) Fe, Co, Sr, Al, Ti, Ba, and U, which concentrated in coarse mode; (b) Zn, As, Cd, Tl, and Pb, which concentrated in fine mode; and (c) Na, K, Be, V, Cr, Mn, Ni, Cu, Mo, Ag, and Sn, showing bimodal distribution. Under clean air, slight pollution and moderate pollution conditions, most elements maintained their original size distributions, while under severe pollution, the unimodal distributions of most MEs became bimodal distributions. The factors analysis combined with size distributions indicated that Na, Zn, Mo, Ag, Cd, and Tl, showing the moderate to severe contamination on environment, were significantly influenced by diffuse regional emissions or anthropogenic source emissions (vehicle exhaust emissions and combustion process). The environmental risk assessment revealed that the heavy metal loading in the atmospheric particles collected had a high potential for ecological risk to the environment during sampling period because of the high contribution of Cd, Tl, Zn and Pb.It has been documented that arsenic has a potential risk to human health and identified as a risk factor for hearing impairment. However, there are few studies that confirm the ototoxic effect of arsenic, especially on the human auditory system. Therefore, the current study was conducted to investigate the correlation between auditory thresholds at different frequencies (0.25, 0.5, 1, 2, 4 and 8 kHz) and arsenic levels in drinking water samples. A total of 240 people, divided into two equal groups exposed and reference, were selected for the auditory tests. It should be noted that, at frequencies from 0.25 to 1 kHz, no hearing loss was observed in the both groups. Based on the results, no significant correlations (p > 0.05) were found between hearing thresholds and confounding variables including gender and BMI. However, smoking and age are known to be the main variables for hearing loss in univariate regression analysis. In the case of age, the hearing loss risk in the older participants was increased compared with the younger participants (4 kHz (OR =1.09; 95% CI 1.04, 1.13) and 8 kHz (OR =1.12; 95% CI 1.06, 1.18)). Smoking habits had significant associations with hearing loss risk at 4 kHz (OR = 3.48; 95% CI 1.47, 8.22) and 8 kHz (OR = 3.01; 95% CI 1.14, 7.95). The multivariate regression analysis showed that age, smoking status, and exposure to arsenic were significantly associated with increased risk of hearing loss. Moreover, no statistically significant correlation (p˃0.05) was observed between arsenic exposure and hearing loss in the logistic regression model compared to the reference group. These outcomes suggest that further investigation and cohort studies with a larger number of participants should be conducted to find an association between arsenic exposure and hearing loss in general population.Antibiotics are essential for treatments of bacterial infection and play important roles in the fields of aquaculture and animal husbandry. Antibiotics are accumulated in water and soil due to the excessive consumption and incomplete treatment of antibiotic wastewater. The accumulation of antibiotics in ecological systems leads to global environmental risks. The toxic effects of spiramycin (SPI), tigecycline (TGC), and amoxicillin (AMX) on Chlorella pyrenoidesa and Anabaena cylindrica were evaluated based on growth inhibition experiments, and determinations of ROS production and antioxidant enzyme activities (catalase, superoxide dismutase, and malondialdehyde). Half maximal effective concentrations (EC50) of TGC, SPI, and AMX for A. cylindrica were 62.52 μg/L, 38.40 μg/L, and 7.66 mg/L, respectively. Those were 6.20 mg/L, 4.58 mg/L, and > 2 g/L for C. pyrenoidesa, respectively. It was shown that A. BGT226 cylindrica was much more sensitive to these antibiotics than C. pyrenoidesa. In addition, EC50 values of SPI and TGC were lower than that of AMX. It was indicated that SPI and TGC had higher toxic than AMX to C. pyrenoidesa and A. cylindrica. The current study is helpful to evaluating possible ecological risks of TGC, SPI, and AMX by green microalgae and cyanobacteria.The chloroacetanilides are among the most commonly used herbicides worldwide, which contaminate aquatic environments and affect aquatic phototrophs. Their sub-lethal toxicity has been evaluated using freshwater algae; however, the modes of cellular toxicity and levels of toxicity to marine organisms are not fully understood. In the present study, we assessed the cellular and molecular effects of chloroacetanilides on marine phototrophs using the dinoflagellate Prorocentrum minimum and the herbicide metazachlor (MZC). The MZC treatment led to a considerable reduction in cell number and pigment, and the EC50 of MZC was calculated to be 0.647 mg/L. The photosynthetic parameters, Fv/Fm and chlorophyll fluorescence significantly decreased with MZC exposure time in a dose-dependent manner. In addition, MZC significantly induced photosynthesis genes, including PmpsbA, PmpsaA, and PmatpB, and the antioxidant PmGST, but not PmKatG. These findings were well matched to reactive oxygen species (ROS) production in MZC-treated cells. Interestingly, we observed inflated vacuoles, undivided chloroplasts, and breakdown of thylakoid membranes in MZC-treated cells. These results support the hypothesis that MZC severely damages chloroplasts, resulting in dysfunction of the dinoflagellate photosynthesis and possibly marine phototrophs in the environment.
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