Notes

BCR/ABL1-positive histiocytic sarcoma from the small intestine in a patient using long-term myeloid leukaemia.
Therefore, these complexes are a promising step towards modern, bioresponsive MRI contrast agents with a "human-friendly" metal.The astroglial network connected through gap junctions assembling from connexins physiologically balances the concentrations of ions and neurotransmitters around neurons. Astrocytic dysfunction has been associated with many neurological disorders including epilepsy. Dissociated gap junctions result in the increased activity of connexin hemichannels which triggers brain pathophysiological changes. Previous studies in patients and animal models of epilepsy indicate that the reduced gap junction coupling from assembled connexin hemichannels in the astrocytes may play an important role in epileptogenesis. This abnormal cell-to-cell communication is now emerging as an important feature of brain pathologies and being considered as a novel therapeutic target for controlling epileptogenesis. In particular, candidate drugs with ability of inhibition of connexin hemichannel activity and enhancement of gap junction formation in astrocytes should be explored to prevent epileptogenesis and control epilepsy.
The TLQP-21 peptide potentiates glucose-stimulated insulin secretion, hence we investigated its endogenous response to glucose.

Fasted mice received intraperitoneal glucose (3 g/kg), or saline (controls), and were sacrificed 30 and 120 min later (4 groups, n = 6/group). We investigated TLQP-21 in pancreas and plasma using immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and high performance liquid chromatography (HPLC), as well as TLQP-21 receptors (gC1q-R and C3a-R1) expression in pancreas by immunohistochemistry.

In pancreas, TLQP-immunoreactivity (TLQP-ir.) was shown in insulin-, glucagon- and somatostatin-containing cells. Upon glucose, TLQP-ir. decreased at 30 min (∼40 % vs. controls), while returning to basal values at 120 min. In all groups, C3a-R1 was localized in ∼50 % of TLQP labelled islet cells (mostly central), while gC1q-R was detected in ∼25 % of TLQP cells (mainly peripheral). HPLC fractions of control pancreas extracts, assessed by ELISA, confirmed the presence of a TLQP-21 compatible-form (∼2.5 kDa MW). In plasma, TLQP-ir. increased at 30 min (∼30 %), with highest concentrations at 120 min (both p<0.05 vs. controls), while HPLC fractions showed an increase in the TLQP-21 compatible form.

Upon hyperglycaemia, TLQP-21 would be released from islets, to enhance insulin secretion but we cannot exclude an autocrine activity which may regulate insulin storage/secretion.
Upon hyperglycaemia, TLQP-21 would be released from islets, to enhance insulin secretion but we cannot exclude an autocrine activity which may regulate insulin storage/secretion.Biometric recognition systems based on ultrasonic images have several advantages over other technologies, including the capability of capturing 3D images and detecting liveness. In this work, a recognition system based on hand geometry achieved through ultrasound images is proposed and experimentally evaluated. 3D images of human hand are acquired by performing parallel mechanical scans with a commercial ultrasound probe. Several 2D images are then extracted at increasing under-skin depths and, from each of them, up to 26 distances among key points of the hand are defined and computed to achieve a 2D template. A 3D template is then obtained by combining in several ways 2D templates of two or more images. A preliminary evaluation of the system is achieved by carrying out verification experiments on a home-made database. Results have shown a good recognition accuracy the Equal Error Rate was 1.15% when a single 2D image is used and improved to 0.98% by using the 3D template. The possibility to upgrade the proposed system to a multimodal system, by extracting from the same volume other features like palmprint and hand veins, as well as possible improvements are finally discussed.Mycoplasma bovis is a pathogenic bacterium in bovines that causes huge global economic losses. Numerous factors play important roles in M. bovis pathogenesis; however, the host immune response involved in M. bovis infection has not been fully elucidated. We aimed to determine the characteristics of the host immune response to Mycoplasma infection. We evaluated the responsiveness of bovine peripheral blood mononuclear cells (PBMCs) stimulated with M. bovis via microarray analysis. The transcriptional abundance of innate immune-related genes IL-36A, IL-27, IFN-γ, and IL-17 in PBMCs increased after M. bovis exposure. Upon M. bovis infection, there was increased expression of the lymphocyte activated genes basic leucine zipper transcription factor (BATF) and signaling lymphocytic activation molecule family members 1 and 7 (SLAMF 1 and SLAMF 7) in PBMCs compared with that in unstimulated cells. The study revealed that the transcriptional abundance of innate immunity genes in PBMCs increased during M. bovis infection. This induced the activation of PBMCs, giving rise to an immune response, which is followed by the development of the inflammatory response. The results from this study could be used as the basis for the development of novel vaccine candidates against M. bovis.Correction of the chemical composition effect for soil samples in gamma spectrometry is very important to perform at low emission energy ( less then 100 keV). This study presents an intensive Monte Carlo simulation using Geant4 code of CERN which investigates several items in this subject. First, it is confirmed that for soil samples, in presence of chemical composition effect, correction of the density effect at low energy is not sufficient to produce an accurate efficiency calibration of the detector. Chemical composition effect must also be corrected. Second, it was found that the slope of the linear fit to the decrease of the efficiency as a function of % of average chemical composition for a given emission energy is density independent. This is a new result which could be used to develop new efficiency correction methods against chemical composition effect. Finally, the usual method of correcting the efficiency using the simple ratio between the self absorption factor of the gamma ray inside the sample and inside the calibration standard, was found unable to correct the chemical composition effect for soil samples.Calcium metal soap and polyol (dipentaerythritol) additives are replacing or partially replacing organotin in poly(vinyl chloride) (PVC) heat stabilizers due to their low cost, nontoxicity and safety. Therefore, investigating the low-temperature thermal oxidative degradation of stabilized plasticized PVC from the source is essential for recycling. This work uses isothermal thermogravimetry to investigate the thermal degradation process and isothermal discoloration of PVC/calcium metal soap/dipentaerythritol/organotin soft products with excellent heat resistance at 453-503 K and under air atmosphere. The chemical kinetics method is used to fit a single equation model of mass loss and time during the thermal oxidation degradation of PVC, and the kinetic equation obtained is -ln(1 - α) = 3.83 × 103exp (-6834.4/T)t. When the temperature is 453-503 K, the calculation results are basically consistent with the experimental data and are independent of the heating rate and temperature changes. In addition, the isothermal discoloration of different PVC materials was tested under air atmosphere at 468 K. The results show that when the test material is PVC/calcium metal soap/dipentaerythritol/organotin, the heat aging time to become completely blackened is longer than that of the blank sample, which indicates a strong interaction occurs between Sn, Ca and dipentaerythritol complexes and PVC molecules, inhibiting the release of hydrogen chloride. At the same time, in order to recover PVC and prevent it from carbonization, if the temperature is set to 486 K, the thermal oxidation degradation time of PVC should be less than 130 min.By the end of 2015, approximately 6300 million tons (Mt) of plastic waste had been generated globally, but less than 10% of plastics was recycled. Since different types of plastics have various degrees of recyclability, consumer information about plastic product recyclability is paramount in order to increase the levels of plastic recycled. Against this context, the objective of this work is to define a plastic credit system to increase the amount of recyclable plastics. The plastic credit system assigns credit information to each plastic product and its corresponding company based on the percentage recyclability value of the plastic type and its composition. The methodology proposed is based on a unified and transparent credit system established by a double-chain system, which comprises a public blockchain CreditChain and a consortium blockchain M-InfoChain. The results show through the overall system performance analysis that the designed plastic credit system is capable of promoting a demand shift towards plastic products with higher plastic recyclability and achieving a lightweight operation for resource requirements and system maintenance.Palladium (Pd) is extremely expensive due to its scarcity and excellent catalytic performance. Thus, the recovery of Pd has become increasingly important. Herein, microbial extracellular polymeric substances (EPS) and magnetic nanocomposite EPS@Fe3O4 were applied to recover Pd catalysts from Pd(II) wastewater. Results indicated that Pd(II) was reduced to Pd (0), which was then adsorbed by EPS (101.21 mg/g) and EPS@Fe3O4 (126.30 mg/(g EPS)). LY 3200882 nmr After adsorbing Pd, EPS@Fe3O4 could be collected by magnetic separation. The recovered Pd showed excellent catalytic activity in the reduction of methylene blue (MB). The pseudo-second-order kinetic model and Redlich-Peterson model best fit the adsorption results. According to spectral analysis, Pd(II) was reduced to Pd (0) by chemical groups in EPS and EPS@Fe3O4, and the hydroxyl had a chelating effect on adsorbed Pd. Therefore, EPS@Fe3O4 is an efficient adsorbent for recovering Pd from Pd(II) wastewater.
Patients with liver cirrhosis and septic shock have a significantly higher risk of mortality and morbidity compared with non-cirrhotic patients. The peripheral blood lymphocyte-to-monocyte ratio (LMR) can determine the prognosis of cirrhotic patients. Our study aimed to investigate the usefulness of LMR as a predictive marker of mortality risk in cirrhotic patients with septic shock.

This single-center, retrospective case-control study included adult patients who visited the emergency department between January 1, 2018 and June 30, 2020 and diagnosed with liver cirrhosis and septic shock. They were divided into survivor and non-survivor groups according to their survival status at the 60-day follow-up. We used a Cox proportional hazards regression model to identify independent factors associated with mortality risk and tested the mortality discriminative ability of those factors using the area under a receiver operating characteristic curve.

A total of 93 patients were eligible for this study. Compared with the patients in the survivor group, those in the non-survivor group had significantly higher Child-Pugh (11±2 vs. 9±2, p<0.001) and MELD scores (29±6 vs. 22±8, p<0.001), higher serum international normalized ratio (1.7 vs.1.4, p=0.03), bilirubin (6.0 vs. 3.3mg/dL, p=0.02), lactate (5.4 vs. 2.7mmol/L, p<0.01), creatinine (2.2 vs. 1.6mg/dL, p=0.04), higher neutrophil-to-lymphocyte ratio (13.0 vs. 10.3, p=0.02), and lower LMR (1.1 vs. 2.3, p<0.01). The LMR (adjusted hazard ratio [aHR]=1.54, p=0.01) and lactate (aHR=1.03, p<0.01) were identified as independent predictive factors for mortality in the multivariate regression model. Furthermore, LMR (area under curve [AUC] 0.87) revealed a superior discrimination ability in mortality prediction compared with the Child-Pugh (AUC 0.72) and MELD (AUC 0.76) scores.

The LMR can be used to predict mortality risk in cirrhotic patients with septic shock.
The LMR can be used to predict mortality risk in cirrhotic patients with septic shock.
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