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ents represent a distinctive subpopulation and are in need of further investigation to improve their survival outcomes.
Primary duct closure (PDC) after laparoscopic common bile duct exploration (LCBDE) has been widely applied for choledocholithiasis. However, there has been controversy over the placement of endoscopic nasobiliary drainage (ENBD) during operation. To date, few studies compare the clinical effect of PDC without and with ENBD. The aim of this study was to assess the safety and efficacy of PDC without ENBD for choledocholithiasis.
From January 2016 to December 2018, a total of 164 patients meeting the inclusion criteria were enrolled and divided into group A (undergone LCBDE + PDC without ENBD, 81 cases) and group B (undergone LCBDE + PDC with ENBD, 83 cases) in this study. The intraoperative conditions and postoperative complications were compared between the 2 groups.
In group A, the time of operation, postoperative first flatus, extubation, antibiotics, and discharge were shorter than in group B (
= -17.775,
= 0.000;
= -7.649,
= 0.000;
= -5.807,
= 0.000;
= -9.247,
= 0.000;
= -9.322,
= 0.000, respectively). Furthermore, intraoperative blood loss was less (
= -2.199,
= 0.029) and hospital costs were lower (
= -6.685,
= 0.000). However, there was no significant difference in postoperative complications between the 2 groups (
> 0.05).
In patients who meet the screening criteria, PDC without ENBD after LCBDE is safe and effective and worthy of clinical application.
In patients who meet the screening criteria, PDC without ENBD after LCBDE is safe and effective and worthy of clinical application.
Surveillance of gastric precancerous lesions (GPL) may reduce gastric cancer (GC)-related mortality, but some patients with GPL are lost to follow-up.
The aim of this study was to evaluate the feasibility and efficacy of a "phone-call" strategy in surveillance of the lost to follow-up patients.
Among all the patients diagnosed with GPL (atrophic gastritis, intestinal metaplasia, low-grade dysplasia) between 2000 and 2015, we identified those who should undergo surveillance endoscopy according to the current guidelines. They were contacted by telephone and invited to undergo endoscopy with gastric biopsies for histological analysis.
Among 535 patients with GPL, 134 were contacted. Sixty-two (46%) could not be joined, 36 did not have endoscopy for other reasons, and finally, 36 patients (22 males, median age 65 years) were included. After the median time interval of 57 months between 2 endoscopies, 18 patients showed stability, 11 regression, and 7 progression of GPL, including 1 patient who developed GC.
Despite several telephone calls, only one-third of the contacted patients could be brought to surveillance endoscopy. Most of the patients showed stability of GPL, but 1 progressed to GC and could be successfully treated.
Despite several telephone calls, only one-third of the contacted patients could be brought to surveillance endoscopy. Most of the patients showed stability of GPL, but 1 progressed to GC and could be successfully treated.
Cancer is one of the major causes of death worldwide and the third leading cause of death in Iran. One of the proteins that are considered having anticancer effects is the adiponectin hormone. Adiponectin leads to programmed cell death, prevents cell growth and proliferation, and increases the expression levels of
.
The aim of this study was to assay the expression of adiponectin receptors (
and
) genes in gastric cancer patients.
In this case-control study, 42 gastric cancer patients and 52 volunteers as healthy controls were enrolled. Total RNA was extracted. cDNA was synthesized by the reverse transcription method, and expression analysis was performed by real-time PCR. The serum level of adiponectin was also measured by ELISA.
The expression of both
and
was significantly higher than the control group (
= 0.02). Serum adiponectin was significantly lower in gastric cancer cases when compared with normal controls (
= 0.03).
We found that expression level of
and
is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Enitociclib mw Our study suggests that the expression of
and
, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.
We found that expression level of AdipoR1 and AdipoR2 is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Our study suggests that the expression of AdipoR1 and AdipoR2, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.2,2'6',2″-Terpyridine (tpy) is a versatile moiety used in the construction of small novel molecules or polymers. Extending or coupling tpy with π-conjugation structures can result in interesting optoelectronic properties. This mini-review summarizes the significant progress made over the past decades in the study of tpy-containing π-conjugated polymers and their application in light-emitting and photovoltaic materials. link2 When coordinated with metal ions, tpy exhibits immense potential for the synthesis of metallo-supramolecular or metallo-polymer materials. Therefore, tpy-based metallo-polymers are the primary focus of this study. Selected examples will be reviewed with a special emphasis on the properties of these functional systems, which can consequently help further their application in light-to-electricity or electricity-to-light conversion fields.Type II nodal line states have novel properties, such as direction-reliant chiral anomalies and high anisotropic negative magneto-resistance. These type II nodal line states have been widely investigated. Compared to nodal line materials, there are far fewer proposed nodal surface materials, and furthermore, a very recent challenge is to find a realistic material that co-exhibits both nodal line and nodal surface states. In this manuscript, we present the study of the electronic and topological states of pure zirconium within the density functional theory. We found that pure Zr is an interesting material that rarely exhibits both the type II nodal line state (in kz = 0 plane) and nodal surface state (in kz = π plane). The nontrivial topological states are explained based on the orbital-resolved band structures. Our study shows that pure Zr can serve as a new platform to investigate the interplay between the nodal line state and the nodal surface state.The formation of metal complexes with phytic acid is a complex process that depends strongly on the metal-to-ligand molar ratio, pH value and consequent protonation level of the phytate ligand as well as accompanying side reactions, in particular metal hydrolysis and precipitation of the formed coordination compounds. In the present work, the potentiometric titration technique was used in combination with a detailed analysis of the equivalent point dependencies for selected biologically relevant monovalent and divalent cations from the groups of alkaline earths and transition metals, namely Mg(II), Zn(II), Fe(II), Cu(I), and Cu(II) ions. The investigation of complex formation mechanism, the evaluation of the species formed, and the identification of other side reactions was based on the examination of three distinct equivalent points, which were detectable by alkalimetric titrations of phytic acid in the presence of selected metal ions. It has been demonstrated that alkaline earth metals interact with different binding site(s) than the transition metals, and experiments with both oxidation states of copper revealed similar complexing characteristics, which depend mainly on the ionic radius (and not on the ionic charge as initially expected). Quantitative data on phytate complexation, hydroxide formation and complex precipitation are presented herein for all metals studied, including Cu(I), which was investigated for the first time by means of alkalimetric titration.This review aims at offering an up-to-date comprehensive summary of carbon fibers (CFs)-based composites, with the emphasis on smart assembly and purpose-driven specific functionalization for their critical applications associated with flexible sensors. We first give a brief introduction to CFs as a versatile building block for preparation of mutil-fountional materials and the current status of research studies on CFs. This is followed by addressing some crucial methods of preparation of CFs. We then summarize multiple possibilities of functionalising CFs, an evaluation of some key applications of CFs in the areas of flexible biosensors was also carried out.The rise of CO2 in the atmosphere, which results in severe climate change and temperature increase, is known as the major reason for the greenhouse effect. Reducing CO2 to value-added products is an attractive solution to this severe problem, along with addressing the energy crisis, to which the catalysts being employed are of vital importance. Due to their high porosity and tunable compositions, metal-organic frameworks (MOFs) show great potential in energy conversion systems. By thermal or chemical treatment methods, the MOFs are easily turned into MOF-derived carbon nanomaterials. The much higher level of conductivity enables MOF-derived carbon nanomaterials to be employed in CO2 conversion processes. The present review, discusses the state of the art of MOF-derived carbon nanomaterials in CO2 electrochemical, photocatalytic, and thermal reduction applications. The corresponding reaction mechanisms and influence of various factors on catalyst performance are elaborated. link3 Finally, the deficiencies and recommendations are provided for future progress.The synergistic combination of visible-light-induced photoredox catalysis with hypervalent iodine(III) reagents (HIRs) represents a particularly important achievement in the field of hypervalent iodine chemistry, and numerous notable organic transformations were achieved in a mild and environmentally benign fashion. This account intends to summarize recent synthetic applications of HIRs in visible-light-induced photoredox catalysis, and they are organized in terms of the photochemical roles of HIRs played in reactions.Among hydrogen storage materials, hydrogen hydrates have received a particular attention over the last decades. The pure hydrogen hydrate is generated only at extremely high-pressure (few thousands of bars) and the formation conditions are known to be softened by co-including guest molecules such as tetrahydrofuran (THF). Since this discovery, there have been considerable efforts to optimize the storage capacities in hydrates through the variability of the formation condition, of the cage occupancy, of the chemical composition or of the hydrate structure (ranging from clathrate to semi-clathrate). In addition to this issue, the hydrogen insertion mechanism plays also a crucial role not only at a fundamental level, but also in view of potential applications. This paper aims at studying the molecular hydrogen diffusion in the THF hydrate by in-situ confocal Raman microspectroscopy and imaging, and at investigating the impact of strong acid onto this diffusive process. This study represents the first report to shed light on hydrogen diffusion in acidic THF-H2 hydrate.
Website: https://www.selleckchem.com/products/bay1251152.html
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