Notes

Rodents along with dysfunctional TGF-β signaling create modified digestive tract microbiome and intestinal tract most cancers resistance against 5FU.
In addition, the simulation showed that this strategy was suitable for timely sowing and therefore confirmed scholars and farmers views. Furthermore, this practice is relatively more effective compared to the others practices. These results show that association zaï + mulch could be considered as the best practice that can participate to a successful adaptation to reduce risk from climate change at the same time by reducing the vulnerability of farmers in Southwest of Niger for now and even for the future. © 2020 The Author(s).Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4-thiadiazol-2-yl)pyridine-3-[11C]-carboxamide), significant radioligand uptake was observed in the skull, where there was no known distribution of any aquaporin family proteins. Herein we confirmed via a newly developed method for bone-tissue immunohistology, a hitherto unrecognized distribution of AQP4, and not AQP1, in the skull. Other bony structures, by contrast, showed virtually no uptake of [11C]TGN-020, and likewise, do not express either AQP4 or AQP1. Immunohistological analysis demonstrated that the AQP4 expression in the skull is restricted to the diploë. Consequently, we suspect AQP4 plays a pivotal role in the formation and maintenance of yellow marrow and the diploë. However, elucidating the exact nature of that role will require further studies. © 2020 The Author(s).Background Human resources is the most prominent asset of an organization. Despite the constant effort to design optimal and effective systems for assessing employees, evidence shows that managers are not satisfied with the methods and systems to assess employees. Objectives Researchers wanted to assess the performance of nurses based on the 360-degree model and fuzzy multi-criteria decision-making technique (FMCDM) and selecting qualified nurses. Methods The present study is descriptive and conducted in 2016 in a hospital at Kashan University of Medical Sciences. This study conducted in three ‏stages. 1) Identification of criteria and sub-criteria for the performance assessment that classified into five groups (technical skills, human skills, and perceived skills; individual characteristics; and compliance with the organization's rules and regulations). 2) Weighing the criteria and sub-criteria based on the DEMATEL-ANP (DANP) method in a fuzzy environment. 3) Assessing the performance of nurses based on the 360-degree model, which includes supervisors, coworkers, self-assessment, and patients and their companions. In this stage, four groups used the VIKOR questionnaire to assess the performance. Results Among five criteria of assessment, "Human Skills" earned a top score, and among 21 sub-criteria, "Identify the strengths and weaknesses," "Suitable relationships with patients," and "Partnership with colleagues" earned the top score. In the 360-degree model, the supervisor's assessment score was 0.521, with the highest weight, and the self-assessment was 0.042 with the lowest weight. Finally, nurse 3 in children and infants ward earned the highest ranking. Conclusions The advantage of the proposed method is more realistic results than other methods because the criteria and sub-criteria are weighted, and the importance of each is determined. Hospitals can use the results of this study to assess the performance of medical groups. © 2020 The Author(s).Background To increase the number of hours available for cognitive rehabilitation, it may be an option to use the spouse or paid assistants to assist with computerized home training. However, the delegation of training responsibilities may affect the normal roles of the therapist, the spouse and the training assistants. Objective This article suggests a new model for understanding the impact of computerized home training on the therapeutic alliance between the therapist, the patient and training assistants. Aspects of this knowledge are relevant also for the development and use of computerized training systems in clinical settings. Method Qualitative Interpretative Phenomenological Analysis (IPA) of semi-structured interviews was used to analyse the experience gained during home-based computerized cognitive training. Results Home-based computerized training enforces the delegation of aspects of the therapeutic alliance established between the therapist and the patient. The perceived authority of assistants and computer training systems may differ from the authority established through the patient/therapist alliance. Information may be lost in transition impacting skills and expertise long-term. Conclusion Roles and responsibilities between the therapist, the assistants and the computerized training system need to be clearly defined. A Cognitive Training Alliance model is being proposed which takes into consideration the challenges of delegating training responsibility to computer systems and non-professional assistants. © 2020 The Author. Published by Elsevier Ltd.Obesity is one of the primary causes of type 2 diabetes mellitus (T2DM). To better understand how obesity impairs glucose-insulin homeostasis, we tracked fasting blood glucose and insulin levels and the key components of glucose-insulin homeostasis for 7 months in high fat diet (HFD; 45% fat) fed mice (n = 8). Every 2 weeks we measured body weight, fasting blood glucose and insulin levels, and estimated 5 key rate constants of glucose-insulin homeostasis using the methods established previously (Heliyon 3 e00310, 2017). Mice gained weight steadily, more than doubling their weights after 7 months (23.6 ± 0.5 to 52.3 ± 1.4 g). Fasting (basal) insulin levels were elevated (221.3 ± 16.7 to 1043.1 ± 90.5 pmol l-1) but fasting blood glucose levels unexpectedly returned to the baseline levels (152.8 ± 7.0 to 152.0 ± 7.2 mg/dl) despite significantly elevated levels (216.8 ± 44.9 mg/dl, average of 3 highest values for 8 mice) during the experimental period. After 7 months of HFD feeding, the rate constants for insulin secretion (k1), insulin-independent glucose uptake (k3), and insulin concentration where liver switches from glucose uptake to release (Ipi) were significantly elevated. Insulin-dependent glucose uptake (k2) and rate constant of liver glucose transfer (k4) were lowered but no statistical significance was reached. The novel and key finding of this study is the wide range of fluctuations of the rate constants during the course of obesity, reflecting the body's compensatory responses against metabolic alterations caused by obesity. © 2020 The Authors.Single Tube Nested PCR (ST-nPCR) is of value to clinical laboratories with limited settings for the detection of fastidious microorganisms. The detection sensitivity of ST-nPCR is dependent on ensuring minimal leftovers of outer primers during the second round of the reaction. In this work, we investigated various approaches to optimize the performance of outer primers, including decreasing outer primer concentrations; using antisense oligonucleotides to block outer primers; using chemically modified inner primers; and using Q5 Taq polymerase that lacks 5'-3' exonuclease and strand displacement capabilities. These solutions were tested on C. abortus and C. psittaci, which are both fastidious intracellular bacteria that are difficult to diagnose. The best obtained result was by using Q5 Taq polymerase. A detection limit with a range between 0.1 and 1 ag was achieved, which corresponds to a range between 0.2 and 2 copies of the plasmid positive control. This level of sensitivity is comparable or even better than the sensitivity achieved by TaqMan probe based real-time PCR assays. The assay was validated using 70 veterinary clinical samples from small ruminant abortions and 10% of these samples gave positive results. In conclusion, sensitivity of ST-nPCR to detect fastidious microorganisms can be improved by using Taq polymerases that lacks 5'-3' exonuclease. The proposed assay is affordable and applicable to a wide range of fastidious pathogens and can be suitable for laboratories with limited settings. © 2020 The Author(s).In this paper, a Wavelet transform-based approach for estimation of multipitch in music signal has been proposed. Among the Morlet Wavelet (MW), Mexican hat, and Shannon wavelet that belong to the widely used wavelets in different applications, the Morlet wavelet performs well for estimation of pitch in polyphonic music signals. This is why a method involving modification of the Morlet wavelet has been proposed for achieving better accuracy in estimation of multiple pitches in polyphonic music. Performance of the Modified Morlet Wavelet (MMW) based Multipitch Estimation (MPE) scheme has been compared with that of a method based on Fast Fourier Transform and another based on the original Morlet Wavelet, in terms of percentage Gross Pitch Error (GPE). Piano chord data base and Standard music IOWA data base have been used for performance evaluation of the proposed scheme. Simulation results show that percentage error in pitch (described by the fundamental frequency) is minimum for the proposed i.e. MMW-based method. © 2020 The Author(s).This paper shows the design of a radio-frequency transceiver coil for landmine detection in Colombia by nuclear quadrupole resonance (NQR). The radio-frequency transceiver coil is of great importance as it is responsible for exciting the target explosive and for picking up the weak NQR signal; however, little detail is found on the literature about its design. The strategy followed on this work consisted on constructing and experimentally comparing five different radio-frequency transceiver coils, whose dimensions were selected according to four design parameters noise rejection, magnetic flux density, coil sensitivity, and quality factor; taking into account the characteristics of landmines in Colombia, the second country most affected by anti-personnel mines in the world. The constructed coils were experimentally compared using a portable system and with three of them, the system was capable of detecting 200 g ammonium nitrate (the main substance used in Colombian landmines) up to 3 cm from the coil within 12 s, with a steady-state free precession pulse sequence. Conclusions from this work could help to guide RF coil design in other works that apply NQR for remote detection of substances in non-shielded environments and to direct future research about landmine detection in Colombia. Temsirolimus cost © 2020 Published by Elsevier Ltd.Introduction Primary hypertension can be masked and be responsible of a severe impact on the target bodies. The purpose of this study was to see if Phenobarbital at low dose is able to decrease the sympathetic hyperactivity assessed by cardiovascular autonomic reflexes in patients with masked hypertension. Materials and methods This prospective study was conducted on a total of 91 patients with masked hypertension (average age 52.1 ± 10.3 years old). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of Phenobarbital, included deep breathing, hand-grip, mental stress and orthostatic tests. Statistical analysis was done using the Student's t-test, Univariate and Multivariate logistic regression analysis; p is significant if less then 0.05. Results Cardiovascular autonomic reflexes responses before and after 3 months of Phenobarbital oral administration were as follows Vagal response (XDB) obtained on deep breathing test was of 32.6 ± 5.4% VS 30.
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