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The results of histological, micrometric and immunohistochemical studies performed on sectional material of 69 men corpses aged from 21 to 29 years are presented. Two groups were identified 42 deaths without drug addiction and 27 deaths from exposure to a toxic synthetic opioids drug, with the history their systematic use lasting from 16 months to 3 years. A comparative analysis of the morphological characteristics of cerebellar cortex tissues was carried out using staining with hematoxylin and eosin and according to the Nissl method (according to Snesarev). For immunohistochemical analysis of the samples, a panel of antibodies to the Vimentin protein was used. In each case, the distance between Purkinje cells was determined and the percentage of immunonegative Purkinje cells to Vimentin from their total number was calculated. In persons with a history of opioid dependence, signs of neurodegenerative changes in the cerebellar cortex were noted deformation of the shape of Purkinje cells, morphological transformation of nuclei from karyopyknosis to karyorrhexis, and the appearance of fuzzy cell boundaries. There was no statistically significant difference in the distance between the Purkinje cells and their number in the opioid-dependent group and in the conditionally healthy group. An increase in the number of Purkinje cells immunopositive to the Vimentin protein was found in the group of deaths with opioid dependence. The results of assessing the cytoarchitectonics of the cerebellar cortex using an immunohistochemical method for studying Purkinje cells positively stained with antibodies to Vimentin can be used as additional criteria for forensic medical determination of the opioid dependence presence in the deceased.The results of the study of the significance of axotomy in the postmortem diagnosis of diffuse axonal brain damage are presented. In the corpus callosum, two main types of changes in the processes of neurons were found damage to the processes without mechanical rupture and axotomy. The revealed polymorphism of damage to the processes of neurons indicates the heterogeneity and staging of pathological processes caused both by the trauma itself and by developing reactive post-traumatic changes. Severe damage to the processes is secondary and not earlier than 2 days after the injury lead to axotomy, the morphological manifestation of which is retraction balls with a diameter of 15.5±6.33 μm, detected by staining with hematoxylin and eosin. Research results indicate that axotomy should not be differentiated into primary and secondary.
Is to determine the features of the injuries formation in children-pedestrians in a collision with moving cars on the basis of studying the nature and localization of injuries on the body of the victims. It was analyzed the materials of the forensic medical examination of 140 children death cases (91 boys and 49 girls) caused by a collision of moving cars with pedestrian-children aged 6 to 17 years. It was found that the majority of children-pedestrians with a car injury develop concomitant craniocerebral trauma (CCT) (78%), concomitant trauma of the chest (CT) (46.4%) and abdomen (50.2%), spinal cord injury (SCI) (25.7%) and fractures of the limb bones (55%). TBI is quite often accompanied by fractures of the bones of the vault and base of the skull. For CT of the chest and organs of the chest cavity, unilateral fractures of the ribs and bruises of the lungs are typical. In the structure of the abdomen organs CT, damage to the parenchymal organs prevails. In SCI, damage to the structures of the cervical annilateral fractures of the ribs and bruises of the lungs are typical. In the structure of the abdomen organs CT, damage to the parenchymal organs prevails. In SCI, damage to the structures of the cervical and thoracic spinal column is more common, while separation of the spinal cord is quite common. This type of injury is characterized by the formation of femurs fractures, bones of the lower leg and upper limbs.The paper presents the results of a comparative epidemiological study of thermal injury and fatal hypothermia based on the results of consolidated reports of the Bureau of Forensic Medicine of the Moscow Department of Health for 2017-2019. It was analyzed the archival material for three calendar years. It was used a continuous retrospective research method with an assessment of the general aggregate of the death incidence from thermal injury and hypothermia in Moscow in 2017-2019 by means of nonparametric statistical methods. Deaths from thermal injury and hypothermia are the most often accidents. The incidence of this type of death is characterized by ups and downs depending on the season. selleck inhibitor May, January and December are the most dangerous for burns. A similar pattern, with the exception of May, was noted for hypothermia. link2 It was found that men aged 50-70 and women of 70-90 years old die most often. It was determined that most social characteristics (education, being married, etc.) alter the average age when deaths occur. The results obtained provide statistical justification for further more thorough study of thermal injury and hypothermia.The aim of the study was to investigate how Non- Pharmacological Techniques (NPT), in addition to standard pharmacological techniques, can help to manage and reduce the preoperative anxiety of children waiting for Day Surgery procedures (DS). Isola Serena activity started in 2008 to manage the preoperative time of children waiting for surgery in the playing room. The latter is run by a pedagogist. NPT includes use of games and toys, readings and drawings. A descriptive and comparative study was conducted on 50 children, aged 4 to 12 years, randomly assigned to Isola Serena group ISG and control group CG. All children received standard pharmacological techniques, while those of the ISG also received the NPT. The evaluation of the preoperative anxiety level (modified Yale Preoperative Anxiety Scale) and parent's coping style (Coping Inventory for Stressful Situation) compared the two groups. The ISG showed a significantly lower level of preoperative anxiety than the CG. Parents' coping style was not related to the preoperative anxiety. The activity performed in the Isola Serena Project resulted to be effective for the reduction of preoperative anxiety in children undergoing DS procedures.Fibrous Dysplasia (FD) is a non-malignant condition caused by post-zygotic, activating mutations of the GNAS gene that results in inhibition of the differentiation and proliferation of bone-forming stromal cells and leads to the replacement of normal bone and marrow by fibrous tissue and woven bone. The clinical behavior and progression of FD is variable. The management of this condition is difficult and in every case is strictly individualized. We report a case of frontal fibrous dysplasia in a 6month's old boy who underwent a successfully resection of the lesion with an excellent cosmetic effect.
When measuring thyroglobulin (Tg), simultaneous measurement of Tg autoantibodies (Ab) is recommended by clinical guidelines for follow-up of patients with differentiated thyroid cancers after thyroidectomy and radioactive iodine ablation. We aimed to investigate test utilization of Tg and Tg Ab assays in local clinics and hospitals in Korea.

We retrospectively reviewed data from the laboratory information system between November 6, 2017 and December 31, 2019.

During the study period, 10,551 Tg tests were performed on 2,592 Korean adults from 97 local clinics and hospitals. Among them, 3,924 (37.2%) test results lacked concurrent Tg Ab assays, while 6,627 test results had concurrently measured Tg Ab, and 528 (8.0%) showed positive Tg Ab results, which could interfere with measurement of Tg concentration.

The results of this study provide basic information regarding test utilization of Tg Ab assays to improve test utilization for accurate Tg measurement in Korean patients.
The results of this study provide basic information regarding test utilization of Tg Ab assays to improve test utilization for accurate Tg measurement in Korean patients.We report a 10-year-old female patient with der(X)t(X;3)(q21.1;q22.1), resulting in 3q duplication and Xq deletion. The main clinical feature was primary ovarian failure and there was no abnormal phenotype corresponding to 3q duplication syndrome. This might be explained by the XIST gene at the X-inactivation center on Xq13.2, which was not deleted in this case. The conventional karyotyping was preliminarily reported as 46,X,inv(X) (q13q26) due to the similar banding patterns of Xq13.2-q24 and 3q25.33-q29. This case highlights the value of using a chromosomal microarray as a clinical diagnostic test for individuals with developmental delay or congenital anomalies.
Mean platelet volume (MPV) is considered a marker of platelet function and is known to increase in immune thrombocytopenia (ITP). We aimed to investigate the predictive value of MPV for predicting the clinical course of ITP in children.

We retrospectively analyzed children aged < 18 years with ITP (n = 36) and healthy controls (n = 36) from June 2010 to November 2018. The subjects were stratified into (i) Healthy controls [group I, n = 36]; (ii) Newly diagnosed ITP (nITP) and persistent ITP (pITP) [group II, n = 24]; and (iii) Chronic ITP (cITP) [group III, n = 12]. Hematological indices including MPV were measured and compared between the three groups.

The median MPV values at diagnosis in group I, II, and III were 7.20, 8.15, and 8.65 fL, respectively (p = 0.0004). Cutoff value of MPV at diagnosis differentiating group I from group II + III was 7.6 fL, and group II from group III was 8.7 fL. MPV change (ΔMPV after three months minus MPV at diagnosis) in children with nITP and pITP (n = 22) was greater than in those with cITP (n = 6) (-2.18 fL vs. 0.66 fL, p = 0.0059).

This study revealed that group III had a higher MPV than group II at diagnosis. Therefore, an initial MPV value more than 8.7 fL may be used as a predictive factor for chronicity in children with ITP. The change in MPV over time as well as MPV at diagnosis, may be regarded as a prognostic marker to predict the course of ITP in children.
This study revealed that group III had a higher MPV than group II at diagnosis. Therefore, an initial MPV value more than 8.7 fL may be used as a predictive factor for chronicity in children with ITP. The change in MPV over time as well as MPV at diagnosis, may be regarded as a prognostic marker to predict the course of ITP in children.
Determining the prevalence of the human leukocyte antigen B27 (HLA-B27) in the general population in the Kingdom of Saudi Arabia.

This cross-sectional study was performed at King Abdulaziz University in the period May 23, 2019 - August 31, 2019 and included four hundred Saudi healthy blood donor subjects (200 male [50%]). We used blood samples in ethylenediaminetetraacetic acid (EDTA) tubes. The HLA-B27 alleles were detected by the Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) using the HLA-B27 Screen Real Time kit from BioDiagene S.R.L (Palermo, Italy). Data analysis was achieved by the statistical package for social science (IBM SPSS Inc., version 20).

Ten (2.5%) were positive for HLA-B27 (6 female [60.00%]). link3 HLA-B27 positivity in blood groups was 3% in O and B, 1.7% in A, nil in AB but almost equal in Rh+ve (2.5 %) and Rh-ve (2.4 %) blood groups, with no significant difference neither between male and female (p = 0.52), nor between blood groups (p = 0.77).

The prevalence of 2.5% for HLA-B27 in the general Saudi population was similar to that of Omair et al.
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