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-onset sepsis in FICare in single family rooms was mediated by a reduced use of intravenous catheters and parenteral nutrition.This study investigated the dissimilarity in midlife adults' reports of support they and their spouse provide to their parents-in-law, gender differences in these dissimilarity patterns, and implications of this dissimilarity for marital quality. Middle-aged married participants (n = 164, mean age = 53.96 years) from Wave 2 of the Family Exchanges Study reported on the support they and their spouse provided to at least 1 living parent-in-law. Regression models examined associations of marital satisfaction with support for parents-in-law, evaluations of support for parents-in-law, and spousal dissimilarity in support. Gender differences in own and spousal support for parents-in-law revealed matrilineal focused support among married adults. Spousal dissimilarity in support was negatively associated with marital satisfaction for middle-aged adults. This pattern suggests the importance of a perceived balance in supporting one's spouse's parents for marital quality. © 2020 S. Karger AG, Basel.Molecular mechanisms underlying the development and progression of PanNET are still insufficiently understood. Efficacy of currently approved PanNET therapies is limited. While novel treatment options are being developed, patient stratification permitting more personalized treatment selection in PanNET is yet not feasible since no predictive markers are established. The lack of representative in vitro and in vivo models as well as the rarity and heterogeneity of PanNET are prevailing reasons for this. In this study, we describe an in vitro 3D human primary PanNET culture system as a novel preclinical model for more personalized therapy selection. We present a screening platform allowing multi-center sample collection and drug screening in 3D cultures of human primary PanNET cells. We demonstrate that primary cells isolated from PanNET patients and cultured in vitro form islet-like tumoroids. Islet-like tumoroids retain the neuroendocrine phenotype and are viable for at least two weeks in culture with high success rate (86%). Viability can be monitored continuously allowing for a per-well normalization. In a proof-of-concept study, islet-like tumoroids were screened with three clinically approved therapies for PanNET Sunitinib, everolimus and temozolomide. Islet-like tumoroids display varying in vitro response profiles to distinct therapeutic regimes. Treatment response of islet-like tumoroids (IC50) differs also between patient samples. We believe that the presented human PanNET screening platform is suitable for personalized drug testing in a larger patient cohort and a broader application will help in identifying novel markers predicting treatment response and in refining PanNET therapy. © 2020 S. Karger AG, Basel.OBJECTIVE A widely used chemical-mechanical method of gingival retraction can cause gingival tissue damage. The aim of this study was to test the influence of the chemical-mechanical gingival retraction procedures on the gingival bleeding index (GBI) and the salivary concentration of monocyte chemoattractant protein 1 (MCP-1) as an indicator of inflammatory changes in the gingiva. MATERIALS AND METHODS The effects of 2 different retraction agents (aluminum chloride and ferric sulfate) were compared, particularly their tissue damaging effect during tooth preparation. Therefore, GBI values and the salivary concentration of MCP-1 were assessed during the chemical-mechanical method of gingival retraction in a homogenous group of respondents. Selleckchem Cyclopamine The subjects (n = 60) were divided into 2 experimental groups (G1 and G2) regarding the need for tooth preparing and making artificial crowns. Each group was further divided into 2 subgroups (R1 and R2) according to the type of the gingival retraction agent used (aluminum chloride and ferric sulfate). RESULTS Compared to the values at the study start, a statistically significant increase in GBI and salivary MCP-1 (p less then 0.001) 1 day after gingival retraction agent application was observed in both experimental groups. After 72 h, the values were lower than in the second observation period but still statistically significantly higher compared to the study start (p less then 0.001), which indicated the reversibility of the tissue changes. CONCLUSION Higher values of the investigated parameters were observed in the group of subjects with prepared teeth, and clinical changes were more pronounced after the use of ferric sulfate. © 2020 The Author(s) Published by S. Karger AG, Basel.BACKGROUND To date, information on laser treatment of accidental tattoos is limited. OBJECTIVES This study analyzes the efficacy and safety of quality-switched ruby, quality-switched NdYAG and picosecond lasers in the treatment of accidental hyperpigmentation in a larger patient cohort. To date, there is limited information on laser therapy of accidental hyperpigmentation. METHODS We conducted a retrospective systematic single-center analysis on 70 patients, which presented with accidental hyperpigmentation at the Dermatology Department of the University Hospital of Zurich between 2008 and 2017. Patients with accidental tattoos due to road injuries, explosives or other traumas and iatrogenic measures were included. We analyzed the data including laser parameters such as wavelength, energy density, spot size and intervals between the sessions. Also, the number of sessions performed and the overall success were registered. RESULTS We treated 38 patients by quality-switched nano- and/or picosecond laser therapy and completed the treatment in 28 cases within a mean number of 3-5 laser sessions. No complications occurred. CONCLUSION We demonstrate the validity and safety of quality-switched and picosecond lasers in the treatment of accidental hyperpigmentation. Using a combination of different wavelengths and pulse lengths on the same lesion and gradually increasing the fluence in the course of the laser treatment is recommendable to increase efficacy. Selleckchem Cyclopamine We observed a tendency towards faster elimination of facial accidental tattoos and/or originating from road injuries compared to tattoos located on the extremities and those caused by explosions, piercings or iatrogenic measures or consisting of metal pigment particles. © 2020 S. Karger AG, Basel.
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