Notes

Climate-assisted endurance involving warm seafood vagrants throughout mild sea ecosystems.
007). Centesys was recognised to be more realistic in simulating cardiac anatomy on ultrasound (median 5 [IQR 4-5] versus 3.5 [IQR 3-4],
=0.002) than the agar-based model. There was greater satisfaction with Centesys (median 5 [IQR 5-6] versus 4 [IQR 3.75-4],
<0.001). see more All 20 participants achieved successful insertion of a pericardial drain into the simulated pericardial sac with Centesys.

Centesys achieved greater learner satisfaction as compared to the agar-based model, and was an effective tool for teaching ultrasound-guided pericardiocentesis and drain insertion.
Centesys achieved greater learner satisfaction as compared to the agar-based model, and was an effective tool for teaching ultrasound-guided pericardiocentesis and drain insertion.
To describe the maternal and fetal outcomes in systemic lupus erythematosus (SLE) pregnancies followed-up in a single tertiary referral centre.

We performed a retrospective cohort study of 75 SLE pregnancies who were followed up in Singapore General Hospital over a 16-year period from 2000 to 2016. link2 Adverse fetal and maternal outcomes including preterm delivery, miscarriages, fetal growth restriction, congenital heart block, neonatal lupus, pre-eclampsia and SLE flares were obtained from the medical records.

The mean age at conception was 32 years old (SD 3.8). The mean SLE disease duration was 5.9 years (SD 5.2). The majority (88%) had quiescent SLE disease activity at baseline. Most pregnancies resulted in a live birth (74.7%). The mean gestational age at birth was 37.4 weeks (SD 3.4). Adverse fetal outcomes occurred in 53.3%. Preterm delivery (33.9%), miscarriages (20%) and fetal growth restriction (17.3%) were the most frequent adverse fetal outcomes. There was 1 neonatal death and SLE flares occurred in a third (33%). In the subgroup of SLE pregnancies with antiphospholipid syndrome, there were higher SLE flare rates (40%) and adverse fetal outcomes occurred in 8 pregnancies (80%). There were no predictive factors identified for all adverse fetal and maternal outcomes. In the subgroup analysis of preterm delivery, anti-Ro (SS-A) antibody positivity and hydroxychloroquine treatment were associated with a lower risk of preterm delivery.

Although the majority had quiescent SLE disease activity at baseline, SLE pregnancies were associated with high rates of adverse fetal and maternal outcomes.
Although the majority had quiescent SLE disease activity at baseline, SLE pregnancies were associated with high rates of adverse fetal and maternal outcomes.
In this study, we described paediatric sports injuries seen in the paediatric emergency department of a large, tertiary paediatric hospital in Singapore and evaluated risk factors for severe sports injuries.

This is a retrospective review of a paediatric trauma surveillance registry from February 2012 to October 2017, including patient demographics, type of sports, circumstances, type of injuries, and clinical management in the hospital. Patients 5 to 17 years old with a sports-related injury were included. We performed logistic regression to identify predictors of severe sports injuries (defined by Injury Severity Score of ≥9), injuries requiring hospitalisation, trauma team activation, resuscitation, or those that resulted in death.

Among 10,951 patients analysed, the most common injuries sustained were fractures (4,819, 44.0%), sprains and contusions (3,334, 30.4%). For patients with severe injuries, the median length of hospital stay was 2 days (IQR 1-3 days), and time away from sports was 162 days (IQR 104-182 days). Predictors for severe injuries include transportation by emergency medical service (aOR 6.346, 95% CI 5.147-7.823), involvement in rugby (aOR 2.067, 95% CI 1.446-2.957), neurological injuries (aOR 4.585, 95% CI 2.393-4.365), dislocations (aOR 2.779, 95% CI 1.744-4.427), fractures (aOR 1.438, 95% CI 1.039-1.990), injuries to the head and neck (aOR 2.274, 95% CI 1.184-4.365), and injuries to the abdomen and pelvis (aOR 5.273, 95% CI 3.225-8.623).

Predictors for severe sports injuries identified may aid in risk stratification and resource allocation.
Predictors for severe sports injuries identified may aid in risk stratification and resource allocation.
Paediatric patients presenting to the general emergency departments (EDs) differ from those presenting to paediatric EDs. General EDs vary in preparedness to manage paediatric patients, which may affect delivery of emergency care with varying clinical outcomes. We aimed to elucidate the differences in utilisation patterns of paediatric and general EDs by paediatric patients.

This study was conducted in a public healthcare cluster in Singapore consisting of 4 hospitals. A retrospective review of the medical records of paediatric patients, defined as age younger than 16 years old, who attended the EDs from 1 January 2015 to 31 December 2018, was performed. Data were collected using a standardised form and analysed.

Of the 704,582 attendances, 686,546 (97.4%) were seen at the paediatric ED. General EDs saw greater number of paediatric patients in the emergent (P1) category (921 [5.1%] versus 14,829 [2.2%];
<0.01) and those with trauma-related presentations (6,669 [37.0%] vs 108,822 [15.9%];
<0.01). The mortality of paediatric patients was low overall but significantly higher in general EDs (39 [0.2%] vs 32 [0.005%];
<0.01). link3 Seizure, asthma/bronchitis/bronchiolitis, allergic reaction, cardiac arrest and burns were the top 5 diagnoses that accounted for 517 (56.1%) of all emergent (P1) cases seen at general EDs.

General EDs need to build their capabilities and enhance their preparedness according to the paediatric population they serve so that optimal paediatric emergency care can be delivered, especially for critically ill patients who are most in need of life-saving and timely treatment.
General EDs need to build their capabilities and enhance their preparedness according to the paediatric population they serve so that optimal paediatric emergency care can be delivered, especially for critically ill patients who are most in need of life-saving and timely treatment.
This study examined maternal, delivery and infant factors associated with cord thyroid-stimulating hormone (TSH) concentrations in an Asian population.

The Growing Up in Singapore Towards healthy Outcomes (GUSTO) study is a mother-offspring birth cohort from 2 major hospitals in Singapore. Cord serum TSH was measured using the Abbott ARCHITECT TSH Chemiluminescent Microparticle Immunoassay and the ADVIA Centaur TSH-3 Immunoassay. After excluding infants with a maternal history of thyroid disease, screening cord TSH results from 604 infants were available for multivariable regression analysis in relation to the factors of interest.

Babies born by vaginal delivery had significantly higher cord serum TSH concentrations than babies born by caesarean section. Cord serum TSH concentrations differed significantly by measurement method. There was no association of cord TSH concentrations with ethnicity, sex, birth weight, gestational age, maternal body mass index, gestational weight gain, gestational diabetes mellitus status and other maternal, delivery and infant factors studied.

Interpretation of cord serum TSH results may need to take into account mode of delivery and measurement method.
Interpretation of cord serum TSH results may need to take into account mode of delivery and measurement method.Lanthanide-doped nanoparticles (LNPs) are speedily colonizing several research fields, such as biological (multimodal) imaging, photodynamic therapy, volumetric encoding displays, and photovoltaics. Yet, the electronic transitions of lanthanide ions obey the Laporte rule, which dramatically hampers their light absorption capabilities. As a result, the brightness of these species is severely restricted. This intrinsic poor absorption capability is the fundamental obstacle for untapping the full potential of LNPs in several of the aforementioned fields. Among others, three of the most promising physicochemical approaches that have arisen during last two decades to face the challenges of increasing LNP absorption are plasmonic enhancement, organic-dye sensitization, and coupling with semiconductors. The fundamental basis, remarkable highlights, and comparative achievements of each of these pathways for absorption enhancement are critically discussed in this minireview, which also includes a detailed discussion of the exciting perspectives ahead.Machine learning techniques have been used to quantify the relationship between local structural features and variations in local dynamical activity in disordered glass-forming materials. To date these methods have been applied to an array of standard (Arrhenius and super-Arrhenius) glass formers, where work on "soft spots" indicates a connection between the linear vibrational response of a configuration and the energy barriers to non-linear deformations. Here we study the Voronoi model, which takes its inspiration from dense epithelial monolayers and which displays anomalous, sub-Arrhenius scaling of its dynamical relaxation time with decreasing temperature. Despite these differences, we find that the likelihood of rearrangements can nevertheless vary by several orders of magnitude within the model tissue and extract a local structural quantity, "softness," that accurately predicts the temperature dependence of the relaxation time. We use an information-theoretic measure to quantify the extent to which softness determines impending topological rearrangements; we find that softness captures nearly all of the information about rearrangements that is obtainable from structure, and that this information is large in the solid phase of the model and decreases rapidly as state variables are varied into the fluid phase.In comparison with the prevalent 2D material-supported single atom catalysts (SACs), the design and fabrication of SACs with single molecule substrates are still challenging. Here we introduce a new type of SAC in which a recently identified all-boron fullerene B40 is employed as the support and its catalytic performance toward the nitrogen reduction reaction (NRR) process is explored in theory. Taking advantage of the novel heptagonal ring substructure on the sphere and the electron-deficient nature of boron, the atomic metals are facile to reside on B40 to form atomically dispersed η7-B40M exohedral complexes. Among a series of candidates, originating from the proper metal-adsorbate interactions, the atomic tungsten-decorated B40W is screened out as the most feasible catalyst for the NRR with a low over-potential and high selectivity to passivate the competitive hydrogen evolution process.Two-dimensional (2D) materials have attracted great interest in the field of optoelectronics in recent years due to their atomically thin structure and various electronic properties. Based on the first-principles calculations combined with the non-equilibrium Green's function (NEGF) method, we predict a set of new 2D ternary materials, sodium copper chalcogenides (NaCuX, X = S, Se, and Te). These materials not only have direct band gaps ranging from 1.2 to 1.6 eV, but also possess relatively small carrier effective masses (0.1-0.2m0) at the band edges thus high carrier mobilities (103-104 cm2 V-1 s-1), which collectively imply that they are suitable for optical-electronic applications in the visible (even in the infrared) light region. Moreover, based on the high photo responsivity (Rph), e.g., up to 0.105 A W-1 for NaCuTe, we design a series of NaCuX monolayer based high performance optoelectronic junctions. These properties indicate that NaCuX monolayers are promising candidate materials for photodetectors and photovoltaic units.
Website: https://www.selleckchem.com/products/dnqx.html