Notes

Erdheim-Chester disease delivering being an intracardiac mass along with pericardial effusion validated by simply biopsy: an incident statement.
In this paper, a pulsed high voltage discharge (PHVD) reactor composed of a new type of high-voltage (HV) needle electrode and mesh grounding electrode was utilized to degrade 4-chlorophenol (4-CP). The effect of needle installation position on 4-CP degradation efficiency in solution systems with different conductivities was studied. It is verified that the recessed- and flush-tip structures could effectively overcome the main technical problem of protruded-tip HV electrode, which is that how to maintain stable discharge in the solution with high conductivity. When the conductivity of solution surpassed 116 μS cm-1, the recessed-tip and flush-tip electrodes possessed higher energy efficiency than that of the protruded-tip electrode. Within 40 min, the flush-tip electrode had the highest 4-CP removal rate (86.2%) in pure water, which could further increased to 95.8% via increasing immersion depth of net electrode. Comprehensively considering the experimental results of 4-CP removal rate, discharge characteristic and tail gas emission, it is indicated that the optimal installation positions were 0-F and 5-R. Meanwhile, the increase in immersion depth could reduce the generation of tail gas (e.g. O3 and NOX) obviously. The possible mechanism of 4-CP degradation via PHVD was proposed.The increasing needs for modelling of reactive transport phenomena in different areas of environmental modelling have led to the development of many numerical codes. However, many of them suffer from a lack of flexibility, which hinders the adaptation of the codes to new problems. Moreover, in many cases, changes can be done by a very reduced group of people, and often by a single person, the main developer. Implementation platforms based on multiphysics modelling removes these barriers, although until now within that programming environments has been only possible the coupling of geochemical codes to transport equations using operator splitting techniques. This paper presents the EE4MGM tool, a MS Excel worksheet, provided in supplementary material, for the edition and complete implementation of reactive transport models in COMSOL. The tool automatically generates the code needed to solve the desired reactive transport problem by selecting only which species make up the geochemical system. This way, the numerical model will be completely adapted to the idealisation to be applied, being able to choose easily and effortlessly from a wide range of different levels of conceptual complexity. The organization of data input and the equation libraries obtained for the implementation in the multiphysics COMSOL environment are first described. Afterwards, two examples, in one and two-dimensional domains, to check the utility of the tool are presented.Cationic textile dyes such as astrazon brilliant red (ABR), are frequently used in the textile industry and contaminait the water ecology. Photodegradation of such dyes in wastewater is considered as a promising method, while the existing approaches are usually involved complicated and costly materials as photocatalysts. Facial, effective and low-cost approaches for their decontamination are needed. What's more, the detailed decomposition path of ABR is not revealed. The present study shows that ABR could suffer effective self-photo-degradation under triethylamine treatment without a photocatalyst. Almost 100% of the dye degraded within 1 h under visible light irradiation. UV-vis, FTIR and UPLC-MS analysis conformed the degradation of ABR. Factors involved in the degradation system were investigated clearly. What's more, the accurate and detailed analysis of UV-vis, FTIR and UPLC-MS data combined with computational analysis revealed the decomposition process of ABR. Reactive oxygen species (ROS) was investigated from ROS trapping experiments and EPR measurements, which revealed that O2- was the critical ROS in the degradation process, while 1O2 and OH had slightly influence on the degradation progression.The coordinated utilization of nitrogen (N) and phosphorus (P) is vital for plants to maintain nutrient balance and achieve optimal growth. Previously, we revealed a mechanism by which nitrate induces genes for phosphate utilization; this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4, which in turn promotes cytoplasmic-nuclear shuttling of PHR2, the central transcription factor of phosphate signaling, and triggers the nitrate-induced phosphate response (NIPR) and N-P coordinated utilization in rice. In this study, we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1 (HINGE1, also known as RLI1), a MYB-transcription factor closely related to PHR2. RLI1/HINGE1, which is transcriptionally activated by PHR2 under nitrate induction, can directly activate the expression of phosphate starvation-induced genes. GSK269962A More importantly, RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus (SPX proteins), and consequently releases PHR2 to further enhance phosphate response. Therefore, RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade, thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient.Cell-to-cell and cell-to-environment communications are critical to the growth and development of plants. Cell surface-localized receptor-like kinases (RLKs) are mainly involved in sensing various extracellular signals to initiate their corresponding cellular responses. As important vegetative organs for higher plants to adapt to a terrestrial living situation, roots play a critical role for the survival of plants. It has been demonstrated that RLKs control many biological processes during root growth and development. In this review, we summarize several key regulatory processes during Arabidopsis root development in which RLKs play critical roles. We also put forward a number of relevant questions that are required to be explored in future studies.Crop domestication has fundamentally altered the course of human history, causing a shift from hunter-gatherer to agricultural societies and stimulating the rise of modern civilization. A greater understanding of crop domestication would provide a theoretical basis for how we could improve current crops and develop new crops to deal with environmental challenges in a sustainable manner. Here, we provide a comprehensive summary of the similarities and differences in the domestication processes of maize and rice, two major staple food crops that feed the world. We propose that maize and rice might have evolved distinct genetic solutions toward domestication. Maize and rice domestication appears to be associated with distinct regulatory and evolutionary mechanisms. Rice domestication tended to select de novo, loss-of-function, coding variation, while maize domestication more frequently favored standing, gain-of-function, regulatory variation. At the gene network level, distinct genetic paths were used to acquire convergent phenotypes in maize and rice domestication, during which different central genes were utilized, orthologous genes played different evolutionary roles, and unique genes or regulatory modules were acquired for establishing new traits. Finally, we discuss how the knowledge gained from past domestication processes, together with emerging technologies, could be exploited to improve modern crop breeding and domesticate new crops to meet increasing human demands.
The objective of this study was to determine if there has been an increase in the age of diagnosis of cervical cancer over time, specifically in the proportion of patients over 65 years old, given decreasing rates of hysterectomy.

A retrospective review of a single institution was conducted including cervical cancer patients seen between 1986 and 2016. Data included demographic variables including age of diagnosis, last cervical cancer screening, and cancer information. Cochran-Armitage test was used to assess temporal trends in the proportion of patients diagnosed over 65.

A total of 1,019 patients with cervical cancer were reviewed, of whom 116 were over the age of 65. The age of diagnosis increased by 0.2 years per calendar year, with an average age of diagnosis of 43.7 years old in 1986 versus 49.5 years old in 2016 (p<0.01). The proportion of patients diagnosed with cervical cancer over the age of 65 did not significantly differ over time (17.2 % in 1986 vs. 14.8 % in 2016, p=0.39). 19.0 % of women diagnosed with cervical cancer over the age of 65 developed cancer despite exiting screening appropriately.

In our cohort, the age of diagnosis of cervical cancer increased over time, however, there was no significant difference in the percentage of women diagnosed over the age of 65.
In our cohort, the age of diagnosis of cervical cancer increased over time, however, there was no significant difference in the percentage of women diagnosed over the age of 65.
Cardiotocography (CTG) has its limits in detecting fetal acidosis and intrapartum asphyxia. Our aim was to evaluate a CTG training programme based on fetal physiology in the Mediterranean perinatal network.

Professionals from 41 maternity units of the Mediterranean network were invited to participate in a CTG masterclass based on fetal physiology in March 2019 and October 2019. They were asked to react to three practical cases by a physiological approach before the training course (T0), one month after (T1) and six to seven months after (T2). The mean scores were compared by using a mixed model including lapse of time to evaluation, profession of participants and level of the maternity unit as fixed effects.

A total of 248 professionals from 32 maternity units finally participated in the organizational audit. By using a mixed model, we found a significant improvement of the mean score at T1 = 6.44/10 compared to T0 = 4.97/10 (p < 0.0001), and a significant improvement of the mean score obtained at T2 = 6.17/10 compared to T0 (p < 0.0001). T2 scores were not significantly different from T1 scores (p = 0.143).

A CTG training programme based on fetal physiology showed a significant improvement in the professionals' interpretation of CTG at short term and stable results at long term. Continuing medical education could help maintain and improve knowledge to ensure neonatal safety.
A CTG training programme based on fetal physiology showed a significant improvement in the professionals' interpretation of CTG at short term and stable results at long term. Continuing medical education could help maintain and improve knowledge to ensure neonatal safety.
Internal limiting membrane (ILM) flap techniques are used for the management of macular holes (MHs). Status of the flap after surgery often is uncertain. The current study evaluated the status of the ILM flap after MH surgery with superior wide-base ILM flap transposition (SWIFT).

Retrospective consecutive case series.

Eyes undergoing SWIFT for MH.

Data were collected on demographic characteristics, preoperative and postoperative visual acuity (VA), and MH status. OCT and indocyanine green (ICG) fluorescence were used to evaluate the MH and the ILM flap status.

Status of MH, ILM flap position, and ILM flap integrity.

Seventeen eyes of 17 patients with a mean age of 65.3 years and mean follow-up of 11.6 months were included in the study. Thirteen eyes had 1 or more high-risk characteristics. Four eyes (24%) were highly myopic, 6 eyes (35%) had chronic MH, and 3 eyes (18%) had a history of prior MH surgery and ILM removal. The mean MH basal diameter was 899.4 μm and the mean inner diameter was 516.1 μm.
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