Notes

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Ionizing radiation exposure from medical applications is increasing annually worldwide. It was estimated that 325 million dental procedures were performed in the United States. Radiation exposure from dental radiography consists of intraoral, panoramic, and 3D imaging cone-beam computed tomography (CBCT) imaging. Recent studies reported an association between dental imaging procedures and increased cancer probability of brain and thyroid. Previous studies showed that some dental imaging practices exposed patients and staff to unnecessary radiation doses due to incorrect image acquisition and insufficient radiation protection measures. This study aims to (i) measure the occupational and patients doses during dental procedures and (ii) assess the current imaging techniques and radiation protection practices. Two hundred fourteen patients were evaluated for periapical, bitewing, cephalometric, occlusal, and panoramic procedures. Organ equivalent doses were quantified for the breast, eye lens, and thyroid gland dnational diagnostic reference level (DRL). selleck chemicals llc Staff education and training in radiation protection aspects are highly recommended.
In May 2017, the Good Samaritan Drug Overdose Act (GSDOA) was enacted in Canada - amending the Controlled Drugs and Substances Act. For people present at an overdose, the GSDOA offers legal protection from simple drug possession as well as breach of charges related to simple possession including probation, pre-trial release, conditional sentences, and parole. It is unclear if the GSDOA has been fully implemented by police officers.

We conducted 22 key informant interviews with police officers across British Columbia, Canada. Convenience sampling was initially employed, followed by purposeful sampling to ensure diversity in jurisdictions and participant demographics (e.g. age, sex, policing experience). A thematic analysis was conducted RESULTS Our findings show that awareness and knowledge of the GSDOA vary among police officers. Many officers reported being unaware of the GSDOA or could not correctly define for whom and when the GSDOA applies. Information about the GSDOA was largely disseminated via emaiincluding the dissemination of information beyond email, is needed to improve officers' awareness and understanding of the GSDOA. Given officers' use of discretion when applying the GSDOA, greater legal reforms, such as de jure decriminalization, may be required to fully protect persons at an overdose from simple possession for controlled substances.Cadmium is a carcinogenic heavy metal that poses a severe threat to human beings. The underlying mechanism, however, remains elusive. N6-methyladenosine (m6A) is the most abundant post-transcriptional modification in mRNA that regulates RNA metabolism. Emerging evidence shows that m6A is involved in the pathogenesis of various cancers. In this study, human bronchial epithelial BEAS-2B cells were transformed by exposing to 2 μM of cadmium for 20 weeks to investigate the role of m6A in cadmium carcinogenesis. We found the level of m6A in mRNA was significantly decreased in cadmium-transformed BEAS-2B cells, and this change was regulated by m6A demethylase ALKBH5. ALKBH5 was significantly upregulated in the middle and late stages of cell transformation at week 8, 12, 16 and 20. Knockdown of ALKBH5 in cadmium-transformed cells alleviated cell proliferation, migration, invasion, and anchorage-independent growth, but co-transfection with ALKBH5 siRNA and PTEN siRNA restored the inhibitory effects of ALKBH5 knockdown on those transformation properties. ALKBH5 decreased the m6A level of PTEN mRNA, resulting in its instability and reduction of PTEN protein expression. These results indicate that ALKBH5-mediated demethylation m6A at PTEN mRNA is involved in cadmium-induced cell transformation. Our study provides a new perspective for the involvement of m6A modification in cadmium carcinogenesis.Veterinary antibiotics are widely used in animal agriculture. Owing to its good absorption in the gastrointestinal tract, strong tissue permeability, and long biological half-life, doxycycline (DOX) is widely used to treat bacterial infections; however, this use can pose an environmental risk. The adsorption/desorption and degradation of DOX in three agricultural soils were investigated. DOX rapidly adsorbed to the soils, with an adsorption equilibrium time of 12 h for the three soils. The Freundlich equation was used to fit the adsorption and desorption of DOX in soils. A high Freundlich affinity coefficient (KF) was obtained from Freundlich isotherms, indicating strong sorption of DOX to agricultural soils and weak mobility to aquatic environment. Soil organic matter, the clay ratio and the cation exchange capacity were significantly positively correlated with KF (P less then 0.05). The half-life (DT50) of DOX degradation in the soils ranged from 2.51 to 25.52 d. Soil microorganisms, soil moisture, temperature, the initial concentration, illumination and soil texture all significantly affected the degradation of DOX in soil (P less then 0.05). When 8% (w/w) manure was added, DOX degradation was significantly accelerated (P less then 0.05). Biotic and abiotic factors affected the degradation of DOX in soils. These results indicated that soil properties and environmental conditions greatly affected the fate and transport of DOX into agricultural soils.This study has investigated the effect of using the Uncaria tomentosa (UT) extract against immunotoxicity that induced by fipronil (FP) in male Wistar rats. link2 Twenty-eight, male Wistar rats were assigned randomly into four groups (7 rats each). Control group received distilled water. FP group received FP 9.7 mg/kg b. wt orally via gastric tube. UT group received 120 mg/kg b. wt. of UT extract orally. FP-UT group received both FP and UT (9.7 and 120 mg/kg b.wt, respectively) for 30 days. Hematological parameters, malondialdehyde (MDA), total antioxidant capacity (TAC), estradiol, histamine and immunoglobulin E (IGE) were assayed. Histopathological and electron microscopical examinations were performed to the lymphoid organs. Hematological parameters, were decreased in the FP group than the control group. There was a rise in MDA of FP group followed by a decrease in TAC content with histological and ultrastructure degenerative changes. UT extract treatment ameliorated the FP-induced perturbations for the former parameters. The results showed that FP treatment exerted an immunotoxic effect through acting as an endocrine disruptor and allergic, pro-inflammatory that was confirmed by histopathological and ultrastructure study of the lymphoid organs. Uncaria tomentosa extract could successfully modulate FP-induced immunotoxicity by diminishing all the studied parameters.Microcystin-LR (MC-LR) is widely distributed in the natural environment and causes hepatotoxicity. However, whether MC-LR promotes liver tumor progression remains controversial. krasV12 transgenic zebrafish were used as an inducible liver tumor model to evaluate the potential tumor-promoting effect of MC-LR. First, krasV12 transgenic larvae were exposed to 0, 0.1 and 1 mg/L MC-LR with 20 mg/L doxycycline (Dox) for 4 d. The gray values and histopathological examinations of the liver demonstrated that MC-LR aggravated liver tumor progression, which could be inhibited by the Protein arginine methyltransferase 5 (Prmt5) inhibitor compound 5 (CMP5). Second, 1-month-old juvenile transgenic zebrafish were exposed to 0, 20 mg/L Dox, 1 μg/L MC-LR, and 20 mg/L Dox with 0.1 or 1 μg/L MC-LR for 15 d to determine whether the exposure to environmental concentrations of MC-LR promoted hepatocellular carcinoma (HCC) progression. We found that environmental concentrations of MC-LR increased the hepatosomatic index (HSI) and gray value (intensity/area) and promoted HCC progression. The results indicate that environmental concentrations of MC-LR have the potential to promote liver tumor progression. Taken together, the present study demonstrates that MC-LR can promote tumor in krasV12 transgenic zebrafish and that the upregulation of prmt5 expression might contribute to MC-LR-mediated promotion of liver tumorigenesis.The study assessed the influence of pressmud (PM) application on soil available phosphorus (P) content, growth, yield, and arsenic (As) accumulation in wheat grains on a salt-affected soil receiving irrigation of As-contaminated water. Wheat seeds (cv. Faisalabad-2008) were sown in pots containing saline soil (EC 11.72 dS m-1; pH 8.07; SAR 31.3 mmol1/2 L-1/2) amended with PM (0, 2.5, 10 and 15 g kg-1) and irrigated with As-contaminated water (0, 25 and 100 µg L-1). The pot experiments had two sets, one was harvested after 30-days of germination while the other at crop maturity. link3 Pressmud application at 2.5, 10 and 15 g kg-1 improved biomass of 30-days old wheat seedlings by 44%, 86% and 90%, respectively compared to unamended soil. Irrigation with As-contaminated waters did not affect seedling biomass or grain yield of wheat. Plant height, fertile tillers, straw biomass and grain yield increased from 57-62 cm, 3-5 no. plant-1, 2.93-5.31 g plant-1 and 3.93-7.11 g plant-1, respectively by 15 g PM kg-1 soil. Moreover, PM application resulted in an 8-fold increase in soil available P content, which resulted in higher grain P uptake. Irrigation with water of 25 and 100 µg As L-1 increased soil available P by 7.6% and 11%, respectively, but its influence on the grain P concentration was non-significant. Pressmud application in combination with As-contaminated water increased accumulation of As in grains. By applying water of 25 and 100 µg L-1 As, accumulation of As in wheat grains increased from 3.12-42.4 and 49.58-91.85 µg kg-1, respectively compared with normal water. However, these concentrations of As in wheat grains were still below the permissible limit of 430 µg kg-1 prescribed for agronomic crops. In conclusion, PM is very effective in improving wheat productivity on salt-affected soils but it can aggravate As accumulation in wheat grains if applied in combination with As polluted water.
Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the western countries. We aimed to ascertain the relationship of urinary phthalates concentrations with presence of NAFLD among US adults.

A cross-sectional analysis of data from National Health and Nutrition Examination Survey (NHANES) during 2003-2016 was performed. NAFLD was predicted by Hepatic Steatosis Index (HSI) and US Fatty Liver Index (US FLI), respectively. The logistic regression models were conducted to evaluate associations of urinary phthalates with NAFLD by adjustment for other covariates.

Of the 4206 participants (mean age 47.99 years old; 50.06% men), risk of suspected NAFLD was increased in those with higher concentrations of urinary phthalates. The results of multivariate models suggested that urinary phthalate metabolites MEOHP (odds ratio [OR] = 1.56, 95% confidence interval [CI] = 1.08-2.24), MEHHP (OR = 1.55, 95% CI = 1.09-2.21), MECPP (OR = 1.44, 95% CI = 1.06-1.95) and the mixtures of nine phthalates (OR = 1.58, 95%CI = 1.18-2.11) were positively related to NAFLD defined by HSI; the similar significant associations were observed for MEHHP (OR = 1.98, 95% CI = 1.32-2.97) when NAFLD was determined based upon US FLI ≥30. In subgroup analyses, the positive associations of urinary phthalates concentrations with NAFLD risk remained robust both in males and females, whereas only in individuals aged <60 years.

Phthalates exposure was independently associated with NAFLD both in males and females, regardless of being defined using HSI or US FLI.
Phthalates exposure was independently associated with NAFLD both in males and females, regardless of being defined using HSI or US FLI.
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