Notes

Complete opposite connection between miR-155 within the preliminary and later on stages regarding lipopolysaccharide (LPS)-induced inflammatory reaction.
A high-speed radiation imaging system based on an image converter of liquid scintillator filled capillary arrays has been developed, which is sensitive to x rays, gamma rays, and neutrons. This imaging system has advantages of both high spatial resolution and high sensitivity because increasing the thickness of the image converter only leads to little deterioration on imaging resolution. The capillary arrays have dimensions of 150 mm diameter and 50 mm thickness, with 100 µm diameter of each capillary. The fluorescence decay time of the filled liquid scintillator based on the mixture of p-xylene and 2,5-diphenyloxazole has been evaluated to be ∼3 ns with the single photon method under the gamma ray excitation. The spatial resolution has been experimentally evaluated to be about 1.15 and 0.6 mm, under excitation of x rays and neutrons, respectively. The imaging system has been applied for diagnosing the dynamic x-ray spot generated by the rod pinch. Two frames in single shot with 15 ns temporal resolution and 20 ns inter-frame separation time have been obtained, which show the spatiotemporal distribution of the electrons bombarding the tungsten rod, indicating the ability of this imaging system in diagnosing dynamic radiation objects. In addition, the technique of capillary arrays provides a promising path for applications of advanced liquid scintillators in the field of radiation imaging.The development of new facilities routinely challenges ion source designers to build and operate sources that can achieve ever higher beam intensities and energies. Electron cyclotron resonance ion sources have proven to be extremely capable in meeting these challenges through the production of intense beams of medium and high-charge state ions. As performance boundaries are pushed, source stability becomes an issue as does the technology required to meet the challenge. Multiple frequency heating, the simultaneous use of two or more plasma heating frequencies, is a powerful tool in meeting the simultaneous need of intensity and stability. Relatively straightforward to utilize, the technique has been employed at numerous facilities to increase beam current and achievable charge state while also stabilizing the plasma. Its application has expanded the operational boundaries of existing and next generation sources, demonstrating that these devices have not yet achieved their full operational potential. To better understand the underlying physics, the diagnostics used to probe the source operational boundaries and the plasma properties have become increasingly sophisticated. In concert with detailed modeling, they are beginning to provide insight into the heating mechanism and, with that, the prospect of future advances.Bdot probes and Rogowski coils are used in the measurement of transient magnetic fields and currents, respectively. They both share the mechanism of creating an induced electromotive force response via Faraday's law, which scales linearly with the pulsed magnetic field. High power capacitor direct current (DC) discharge systems release a single pulse of current that is both very high and very fast (≲1 ms). To capture these transient data and characterize these systems, high current tolerant and fast response time sensors are required. While these measuring devices have been well studied and utilized for almost 100 years, a comprehensive and detailed description of the custom design, calibration, and sensor fusion application of these tools for use in various pulsed DC capacitor value discharges is largely missing in the literature. Using robust analytical calculations, finite element analyses, and empirical methods, we have developed a sensor fusion protocol for current and magnetic field probes (with relative errors of ±13% and ±15%, respectively) for use in any geometry of high speed pulsed DC current calibrated capacitor discharge systems. This paper comprehensively outlines the design and sensor fusion methodologies that allow for the deployment of in-house built Bdot probes and Rogowski coils to a wide range of pulsed DC systems and demonstrates their use in a characteristic plasma environment.The success of high-pressure research relies on the inventive design of pressure-generating instruments and materials used for their construction. In this study, the anvils of conical frustum or disk shapes with flat or modified culet profiles (toroidal or beveled) were prepared by milling an Ia-type diamond plate made of a (100)-oriented single crystal using the focused ion beam. Raman spectroscopy and synchrotron x-ray diffraction were applied to evaluate the efficiency of the anvils for pressure multiplication in different modes of operation as single indenters forced against the primary anvil in diamond anvil cells (DACs) or as pairs of anvils forced together in double-stage DACs (dsDACs). All types of secondary anvils performed well up to about 250 GPa. The pressure multiplication factor of single indenters appeared to be insignificantly dependent on the shape of the anvils and their culets' profiles. The enhanced pressure multiplication factor found for pairs of toroidally shaped secondary anvils makes this design very promising for ultrahigh-pressure experiments in dsDACs.Piezoelectric pumps are applied in cooling systems of microelectronic devices because of their small size. However, cooling efficiency is limited by the low flow rate. A straight arm wheeled check valve made of silica gel was proposed, which can improve the flow rate of piezoelectric pumps, solve the influence of glue aging on the sealing ability of a wheeled check valve, and reduce the size of piezoelectric pumps. This paper discusses the influence of the valve arm number (N = 2, 3, and 4), the valve arm width (W = 1.0, 1.2, and 1.4 mm), and the valve thickness (T = 0.6, 0.8, and 1.0 mm) on the flow rate characteristics of piezoelectric pumps. When valve opening rises, the flow rate increases. The simulation results show that valves with 2 valve arm number, 0.6 mm valve thickness, and 1.0 mm valve arm width have maximum valve opening. The experimental results show that piezoelectric pumps with different valve parameters have different optimal frequencies. In addition, the maximum flow rate is 431.6 ml/min at 220 V and 70 Hz. This paper provides a reference for the application of piezoelectric pumps in cooling systems.We present a terahertz (THz) platform employing air plasma produced by an ultrashort two-color laser pulse as a broadband THz source and air biased coherent detection (ABCD) of the THz field. In contrast to previous studies, a simple peak detector connected to a micro-controller board acquires the ABCD-signal coming from the avalanche photodiode. Numerical simulations of the whole setup yield temporal and spectral profiles of the terahertz electric field in both source and detection area. The latter ones are in excellent agreement with our measurements, confirming THz electric fields with peak amplitude in the MV/cm range. We further illustrate the capabilities of the platform by performing THz spectroscopy of water vapor and a polystyrene reference sample.We present our results for using thin film lithium niobate devices for electric field sensing applications. Micro-ring modulator and Mach-Zehnder modulator-based electric field sensors are demonstrated. Micro-ring resonator sensors can be used for low frequency (up to several GHz) electric field sensing applications and achieve a high sensitivity of 80 mV/(m Hz1/2) with a very compact size of 300 μm, as limited by the intensity and phase noise of the used distributed feedback laser. A measurement bandwidth of 2.5 GHz is measured for these sensors and is limited by the detector bandwidth. Alternatively, Mach-Zehnder modulators allow for perfect phase matching between the radio frequency signals and optical signals, and they can be used for electric field sensing up to several THz. A sensitivity of 2.2 V/(m Hz1/2) was obtained using our Mach-Zehnder electric field sensor with an interaction length of 600 μm. The Mach-Zehnder sensor can sense electric fields with frequencies reaching 0.6 THz based on the calculated results.To date, there are three main hypotheses explaining why the human semicircular canals (HSCCs) cannot sense linear accelerations. To further study this issue, we designed a bionic ampulla (BA) instrumented with a symmetrical metal core polyvinylidene fluoride fiber as a bionic sensor, which imitates the structure and function of the human ampulla. The BA was confirmed to have a good sensing ability in experiments with a straight tube. Additionally, we designed a bionic semicircular canal model, a blocking model, and a square model. We compared the perception performance of these three models to test the "density hypothesis," the "closed loop hypothesis," and the "circular hypothesis." The outcomes of these experiments verified the "density hypothesis" and "circular hypothesis," but did not support the "closed loop hypothesis," shedding light on why the HSCC is sensitive to angular acceleration, but not to linear acceleration.Due to the shortage of the 3He gas and its rapidly increasing price, scintillator detectors, the advantages of which are high spatial resolution and capability of detection in real time, become widely used in many neutron instruments. find more In this work, a position-sensitive neutron detector consisting of a 6LiF/ZnS scintillation screen and a silicon photomultiplier array linked to a capacitive network to detect the positions of incident neutrons, is constructed and tested. To evaluate the detector performance, a series of neutron beam experiments with the detector prototype were performed in the BL20 at the China Spallation Neutron Source. The spatial resolution was measured, and the energy-selective neutron imaging and Bragg edge measurements of a 316L stainless steel sample were performed. A sub-millimeter spatial resolution could be obtained for the detector prototype under study. The detector with such a high spatial resolution is promising for applications in neutron scattering experimental installations, especially for neutron single-crystal diffractometers.We developed a novel contactless frequency-domain thermoreflectance approach to study thermal transport, which is particularly convenient when thermally anisotropic materials are considered. The method is based on a line-shaped heater geometry, produced with a holographic diffractive optical element, instead of using a spot heater as in conventional thermoreflectance. The heater geometry is similar to the one used in the 3-omega method, however, keeping all the technical advantages offered by non-contact methodologies. The present method is especially suitable to determine all the elements of the thermal conductivity tensor, which is experimentally achieved by simply rotating the sample with respect to the line-shaped optical heater. We provide the mathematical solution of the heat equation for the cases of anisotropic substrates, thin films, and multilayer systems. This methodology allows an accurate determination of the thermal conductivity and does not require complex modeling or intensive computational efforts to process the experimental data, i.e., the thermal conductivity is obtained through a simple linear fit ("slope method"), in a similar fashion to the 3-omega method. We demonstrate the potential of this approach by studying isotropic and anisotropic materials in a wide range of thermal conductivities. In particular, we have studied the following inorganic and organic systems (i) glass, Si, and Ge substrates (isotropic), (ii) β-Ga2O3 and a Kapton substrate (anisotropic), and (iii) a 285 nm thick SiO2 thin film deposited on a Si substrate. The accuracy in the determination of the thermal conductivity is estimated as ≈5%, whereas the temperature uncertainty is ΔT ≈ 3 mK.
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