Notes

The consequence associated with Plan-Do-Check-Act cycle medical treating gynecological surgical procedure: a deliberate evaluate as well as meta-analysis.
These results confirmed that random mutagenesis was an effective tool for improving enzyme properties and lay a foundation for practical applications of phthalate-degrading hydrolase in biotechnology and industrial fields.Ionic liquids (ILs) have been reported to be a potential water and soil pollutant, whose toxicity has gained much attention in recent years. In this work, silkworm larvae were used as a novel in vivo model to assess the biotoxicity of ILs, which were performed by three steps. The first step was to determine the susceptibility of different silkworm strains to ILs. Data showed that Jingsong×haoyue was the most susceptible one among three silkworm strains (Jingsong×haoyue, P50, and Yi16) for evaluating the biological effects of ILs. The second step was to compare the toxicity of ILs with different structures using the larvae of Jingsong×haoyue. It was found that three representative ILs, 1-octyl-3-methylimidazole chloride ([C8mim]Cl), N-octyl-3-methylpyridine chloride ([C8mpy]Cl), and 1-octyl-3-methylimidazole tetrafluoroborate ([C8mim]BF4), had significant toxic effects on the growth and development of the larvae with 24 h median lethal concentration (24 h-LC50) values of 112.3, 156.3, and 68.9 μg g-1, respectively, indicating that the types of anions and cations had impacts on the toxicity of ILs. The last step was targeted at investigating responses of the larvae to the exposure of ILs. It was observed that remarkable physiological and biochemical responses occurred in different tissues of the larvae. For example, activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) in different tissues increased significantly to form an active protective mechanism for alleviating the toxic effects of ILs. Additionally, an increase of malondialdehyde (MDA) contents was found in the larvae. The data suggested that ILs could induce lipid peroxidation and cellular damage, which may be the main reason for toxicity of ILs to the larvae. Therefore, silkworm larvae could be used as a susceptible and reliable in vivo model to evaluate the toxicity of ILs, and the results are helpful to reveal their toxic mechanism to insects.Non-trivial topology of proteins under shear suggests that even small structural changes in proteins result in dramatic variations in the mechanical properties and stability. In this study, we have analysed the elastic compliance of solvated bovine serum albumin (BSA) with NaCl,MgCl2, FeCl3 of concentration-ranging from 50 mM to 250 mM using Quartz crystal microbalance with dissipation. The compliance shows a reverse Hofmeister trend (Na + less then Mg 2+ less then Fe 3+) for high salt concentrations with a fine balance, between intra and intermolecular interactions for the cations. Radius of gyration of BSA with the electrolytes from small angle X-ray scattering (SAXS) is in agreement with this reverse Hofmeister trend. Depending on the valency and concentration of metal ion, the repulsive double layer screening provides sufficient energy to overcome the interactions between hydrophobic domains in the protein molecule resulting in protein assemblies. The long-range effect of high concentrations of divalent and trivalent ions in solution studied using UV-visible and fluorescence spectroscopy, zeta potential and circular dichroism, demonstrates spontaneous aggregated assemblies of BSA. These assemblies are dominated by the long-range distribution of the ions around the proteins, as described by Debye-Hückel theory, with the local salt structure near the protein surface playing a minor role.The understanding of the complex conformational landscape of amyloid aggregation and its modulation by relevant physicochemical and cellular factors is a prerequisite for elucidating some of the molecular basis of pathology in amyloid related diseases, and for developing and evaluating effective disease-specific therapeutics to reduce or eliminate the underlying sources of toxicity in these diseases. Interactions of proteins with solvating water have been long considered to be fundamental in mediating their function and folding; however, the relevance of water in the process of protein amyloid aggregation has been largely overlooked. Here, we provide a perspective on the role water plays in triggering primary amyloid nucleation of intrinsically disordered proteins (IDPs) based on recent experimental evidences. The initiation of amyloid aggregation likely results from the synergistic effect between both protein intermolecular interactions and the properties of the water hydration layer of the protein surface. ing on the particular microenvironment that the protein molecules encounter in the cell.Bottom ash contains unfavorable contaminants that could leach into the circulating water used for wet treatment, and its improper disposal of bottom ash could cause ecological pollution. This study was to discuss the partition of heavy metals and salts of bottom ash into circulating water and ash stockpile runoff in wet treatment plants in southern China. The leachability of bottom ash before and after the wet treatment was also investigated. The checked heavy metals Pb, Cu, and Ni and dissolved salts Cl- and SO42- show lower available fractions in leachate from the treated bottom ash than that in raw bottom ash. Circulating water is contaminated by target heavy metals, which the contents of Cu and Pb is higher than its limit for urban wastewater discharge. The circulating water owned the highest concentration of Cl- and SO42-, above10000 mg/L, and 1100 mg/L, which is far higher than the limits. The detected heavy metals, Cl- and SO42- in runoff also exceed the limits for urban wastewater discharge. Locations for bottom ash processing and storage sites should be selected to control and prevent any leaching and runoff impacts. Any runoff and circulation water should be discharged to the lined landfill's leachate collection system or suitable industrial wastewater treatment facilities.Co-pyrolysis of biomass and polyethylene(PE) wastes with different blending ratios were performed in a bench-scale fixed bed over Ni/char catalyst. The synergistic mechanism between coke depositions and gas products during co-pyrolysis was studied for better regulation of H2 production. The results showed that feedstock blending ratio played a decisive role in competitive growth of amorphous coke and multi-walled carbon nanotubes (CNTs) on the catalyst surface. For low PE ratio (≤50 wt%) a negative synergy on H2 yield was generated. It was ascribed to more oxygenates that were more inclined than hydrocarbons to be absorbed by porous char to form amorphous coke, which encapsulated Ni active sites and internal pore channel of catalyst, thus resulting in deactivation of catalyst. For higher PE content, Ni/char catalyst produced more than triple the amounts of H2 yield (42.28 mmol/gfeedstock) as compared to low PE ratio (11.3 mmol/gfeedstock). A maximum positive synergy on syngas quality was yielded at 75% PE. Despite the high yield (37.8 wt%) of deposited coke, more hydrocarbon gas from plastic pyrolysis condensed on catalyst and promoted CNTs growth via dehydrogenation and polymerization, simultaneously generating H2. The unique hollow tubular structure and tip-growth mode of CNTs exposed more Ni active sites and endowed catalyst with lower deactivation extent. The scission of more chain hydrocarbons was subsequently enhanced to interact with oxygenated compounds. Therefore, appropriate PE ratios (>50%) can exert a positive synergy on gaseous conversion by regulating coke nature during co-pyrolysis of biomass and plastics. Furthermore, coke structure rather than content seems to exert more significant effect.Co-treatment in municipal solid waste power plant has been deemed to one of the most suitable ways to handle sewage sludge. Economy of the co-treatment process is very concerned in the waste incineration plant. Thermal calculation of sewage sludge co-combustion was done. Four common sludge drying schemes was compared flue gas drying, steam drying, electric heating drying in the waste incineration plant and in situ electric heating drying in the sewage treatment plant. Sensitivity analysis was also performed. When the water content was 30-40% and the absolute-dry sludge ratio was 2-3%, the boiler efficiency was reduced by 0.56-1.12% compared with the case without mixing sludge, and the power generation decreased by 0.2568-0.3767 MW in steam drying scheme and by 0.0037-0.0094 MW in other schemes. Net present value (NPV) of flue gas drying was the highest among the four sludge drying schemes, which was more than 20 ¥ million, while the scheme of electric heating drying in the waste incineration plant had the lowest NPV, which can't recoup the initial investment. AZD4547 Sensitivity coefficient of flue gas drying was smallest among different schemes, showing that the risk of this program was the smallest. Absolute-dry sludge ratio and unit subsidy for sludge treatment were sensitive factors for NPV in flue gas scheme, which had a sensitivity coefficient of 1.123-1.171 and 1.232, respectively. Operating parameters optimization of co-combustion of sludge was done and ways to improve economic efficiency was discussed.Anaerobic digestion is a feasible and promising technique to deal with emerging waste activated sludge issues. In this work, the hydrodynamics and digestion performance of horizontal anaerobic systems equipped with double-bladed impeller and ribbon impeller were investigated. Simulation using computational fluid dynamics technique visually showcased the favorable mixing status implementing ribbon impeller. The mixing modes were considered as the major motivation for the difference of mixing efficiencies. Tracing experiment indicated that the minimum thorough mixing time with ribbon impeller was 20 min at a rotation speed of 50 rpm, whereas it was 360 min for the double-bladed impeller under similar conditions. The superior mixing performance of ribbon impeller resulted in better anaerobic digestion and energy efficiency outputs. The digester employing ribbon impeller obtained an ultimate biogas yield of 340.38 ± 15.91 mL/g VS (corresponding methane yield of 210.34 ± 7.55 mL/g VS) and produced a surplus energy of 16.23 ± 0.76 MJ/(m3·d). This study thus ascertained that ribbon impeller was proficient for high-solid anaerobic digestion and it will prominently benefit future system designs.
Viral encephalitis (VE) or bacterial meningoencephalitis (BME) in early childhood may cause brain injury and neurological sequelae, including epilepsy. Postencephalitic epilepsy (PEE) characterized by epileptic spasms (ES) is a rare but serious condition; there is an urgent need to develop new methods to evaluate the characteristics of these children and select appropriate treatments.

We conducted an observational study of 20 patients (11 males, 9 females) who experienced ES after VE or BME at the Chinese PLA General Hospital. Patients were followed up for over 12 months, and outcomes were analyzed.

The median ages at the onset of encephalitis and ES were 5.5 and 11.5 months, respectively. The median age at follow-up was 35.5 months. Sixteen (80 %) patients developed drug-resistant epilepsy (DRE), including all 12 patients with VE and 4 of 8 patients with BME. Epileptiform discharges were detected on electroencephalography, including 15 patients with hypsarrhythmia and 5 without. Fifteen of the patients were treated with a 14-day intravenous infusion of adrenocorticotropic hormone (ACTH) at a dose 2.
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