Notes

Chance notion, mindset, and use related to COVID-19: The cross-sectional research among 1085 Iranian health care employees.
Associated operative factors included abdominal surgery, blood transfusion, and prolonged operative time (P < 0.05 for all). Following adjustment for potential confounders, abdominal hysterectomy was associated with greater odds of VTE than laparoscopic or vaginal approaches (adjusted odds ratio [aOR] 1.81; 95% CI 1.48-2.21 and aOR 2.31; 95% CI 1.62-3.28, respectively). Greater odds of VTE were also observed with OR time >150 minutes (aOR 1.88; 95% CI 1.46-2.42), ASA class ≥III (aOR 1.53; 95% CI 1.05-2.26), and intra- and postoperative transfusion (aOR 2.65; 95% CI 1.78-3.95 and aOR 2.98; 95% CI 1.95-4.55, respectively).

The risk of VTE is low in women undergoing hysterectomy for non-malignant indications. Blood transfusion was associated with the highest risk of VTE.
The risk of VTE is low in women undergoing hysterectomy for non-malignant indications. Blood transfusion was associated with the highest risk of VTE.
To understand the risks associated with trisomy 21 in pregnancy in order to inform obstetrical care and improve outcomes.

A population-based retrospective cohort study was undertaken of all pregnancies involving a fetus with trisomy 21 in Nova Scotia, Canada, from 2000 to 2019. Cases were identified from the provincial laboratory genetics database, linked to the Nova Scotia Atlee Perinatal Database for pregnancy outcomes, and compared with the general obstetrical population.

A total of 350 pregnancies were identified, of which 23% were ongoing pregnancies in which trisomy 21 was diagnosed prenatally and 24% involved diagnoses made after delivery. Compared with the general obstetrical population, women with ongoing pregnancies affected by trisomy 21 were more likely to be older (mean age 34 vs. 29 y), multiparous (67% vs. 55%), and in a relationship (79% vs. 68%). Trisomy 21 was associated with a significantly increased risk of preterm birth (<37 weeks; 24.1% vs. 8.3%); small for gestational age (<10th percentile; 21.7% vs. 8.2%); cesarean delivery (31.5% vs. 27.1%); and combined perinatal/neonatal mortality (8.0% vs. 0.8%) (P < 0.001 for all).

Trisomy 21 is associated with significant adverse perinatal and neonatal risks. Population screening to identify trisomy 21 can be used to optimize perinatal outcomes with appropriate fetal surveillance in these pregnancies.
Trisomy 21 is associated with significant adverse perinatal and neonatal risks. Population screening to identify trisomy 21 can be used to optimize perinatal outcomes with appropriate fetal surveillance in these pregnancies.
This study of Canadian women estimates the prevalence of opioid and cannabis use during pregnancy and cannabis use during the breastfeeding period and explores the sociodemographic and mental health characteristics associated with use.

A total of 13000 women who gave birth between January and June 2018 were invited to participate in the Survey on Maternal Health by Statistics Canada; 7111 women participated for a response rate of 54.7%. Participants were asked about their mental health, supports during pregnancy, and substance use. Multivariable logistic regression was used to describe the relationship between sociodemographic and mental health characteristics and substance use during pregnancy and while breastfeeding.

The prevalence of self-reported opioid use during pregnancy was 1.4% (95% confidence interval [CI] 1.1%-1.8%). A higher proportion of women reported using cannabis during pregnancy and while breastfeeding, at 3.1% (95% CI 2.5%-3.6%) and 2.6% (95% CI 2.1%-3.1%), respectively. #link# Younger age, tal health characteristics are associated with the use of these substances, and public health interventions and policies should take into account these factors.
Apply Weiner's attribution-affect-action (AAA) model to the context of societal support for access to assisted reproductive technology (ART).

Five hundred and fifty-four Canadians were randomly assigned to 1 of 4 vignette conditions describing reproductively challenged women differentiated by the root cause of their need for ART. Following this, participants completed an online questionnaire measuring the components of the AAA model.

The overall expected relationships among the AAA framework variables were found. Participants were least willing to support access to ART for women perceived as relatively more responsible for their fertility issues and who elicited lower levels of sympathy, whereas participants were most willing to support access for women viewed as less responsible and who elicited more sympathy. Additionally, participants were most supportive of general access to ART and least supportive when asked to offer personal funds to assist the women with access.

These findings have potential implications for Canadian health care policy decisions on funding fertility treatments through the universal health care system. Further research on this issue, as well as the development and testing of interventions aimed at addressing beliefs around equitable and inclusive access to ART, are warranted.
These findings have potential implications for Canadian health care policy decisions on funding fertility treatments through the universal health care system. Further research on this issue, as well as the development and testing of interventions aimed at addressing beliefs around equitable and inclusive access to ART, are warranted.
Hepatocellular carcinoma (HCC) is one of the few cancers that can be diagnosed based on imaging findings alone. The factors associated with the decision to perform a biopsy and the clinical impact have not been previously studied.

We collected data of patients diagnosed with HCC between 2004 and 2015 from the National Cancer Database. We assessed associations between biopsy and survival with demographic and clinical factors.

We included 160,507 patients. The median age was 62 (40-90), 74.1% were male and 74.9% were white. Over the 12-year period, 47.7% (76,524/160,517) underwent a biopsy. Factors associated with a biopsy were black race, older age, presence of metastatic disease, larger tumor size, and treatment at a community cancer center. Factors associated with increased mortality were older age, higher comorbidity index, larger tumor size, presence of metastatic disease, higher AFP and elevated bilirubin. There was a significant decreased use of biopsy over successive years (2007-2015). After adjusting for prognostic factors, biopsy had no significant impact on survival HR 1.01 (95%CI 1.00-1.03. p=0.07).

A significant number of patients underwent a biopsy. Performing a biopsy did not have a significant impact on survival.
A significant number of patients underwent a biopsy. Performing a biopsy did not have a significant impact on survival.
The objective of the current study was to summarize and evaluate all published evidence regarding viscoelastic testing in the field of liver surgery.

A systematic search of the literature was performed using Medline/PubMed, Scopus, Cochrane Library Central, Google Scholar, and clinicaltrials.gov databases. The following keywords were used"Thromboelastography", "Thromboelastometry", "Viscoelastic tests OR testing", "Sonoclot Devices", "Point-of-care tests OR testing", "Coagulation OR Haemostasis OR Hemostasis", "Liver OR Hepatic Surgery", "Cirrhosis."

A total of 12 studies analyzing 348 patients who underwent viscoelastic testing of coagulation during liver surgery for benign or malignant diseases were included; 7 (58.3%) studies reported on the use of thromboelastography (TEG), and 5 (41.7%) reported on rotational thromboelastometry (ROTEM). Viscoelastic testing (TEG and ROTEM) identified normo-, hyper- and hypo-coagulable status in 77% (n=268/348), 18.4% (n=64/348), and 4.6% (n=16/348) of patients, respectively. In ML141 , conventional coagulation tests indicated normo-coagulability in 111 patients (34.2% out of 325) and hypo-coagulability in 214 (65.8% out of 325) patients following liver resection. No patient (0% out of 291) experienced postoperative hemorrhage, whereas 5.8% (n=17/291) experienced postoperative thromboembolic events.

Global viscoelastic testing may be a reasonable adjunct to conventional coagulation testing to provide a more robust assessment of the coagulation status of patients undergoing liver surgery.
Global viscoelastic testing may be a reasonable adjunct to conventional coagulation testing to provide a more robust assessment of the coagulation status of patients undergoing liver surgery.
The treatment of small intestinal overgrowth (SIBO) varies according to the center. The present study aimed to evaluate the efficacy of COLIGENTA, an association of colimycin and gentamycin, on SIBO symptomatology and breath test normalization PATIENTS AND METHODS In this prospective cross-sectional open study, 150 patients with functional bowel disorders and SIBO diagnosed by lactulose hydrogen breath test (LHBT) underwent COLIGENTA oral treatment. A new HLBT was performed 4 weeks after the first HLBT.

The patients were mainly female (74%), with a mean age of 47.4 ± 16.2 years and a body mass index of 26.2 ± 5.9 kg/m². After treatment, a decrease of expired hydrogen concentration (P<0.001) was found in the entire population. link2 Improvement of gastrointestinal symptoms was found in 129 patients (86%), while the breath test's normalization was found in 62 patients (42%). Logistic regression showed that normalization of bowel symptoms was not associated with demographics, clinical, or hydrogen breath concentration. In contrast, normalization of LHBT was associated with an increase of breath hydrogen concentration at time 100min during the first test (P = 0.003; OR=1.072; 95%CI= [1.023-1.123]).

The present study shows that 10-days of COLIGENTA treatment has a high SIBO clinical improvement rate and can be used as the first or second treatment line.
The present study shows that 10-days of COLIGENTA treatment has a high SIBO clinical improvement rate and can be used as the first or second treatment line.This study explored the photochemical activity of nitrogen-doped biochars (NCMs) by investigating their role in the degradation of sulfamethazine under simulated sunlight irradiation. NCMs with different doping amounts were prepared from corn straw and urea. Results showed that nitrogen doping can notably enhance the photodegradation of SMT rather than raw char. NCMs are of photochemical activity under visible light, which was confirmed by monochromatic light experiments. Quenching experiments, ESR, pH effect, and the influence of O2 were carried out to explore the involved oxidation mechanism in this system. Results showed that 1O2 was the main reactive oxygen species. 1O2 was produced from O2 by both energy transfer and electron transfer. DFT calculations showed that pyridinic N doping can decrease the energy of intersystem crossing and thus benefit the generation of 1O2 by triplet-triplet energy transfer. Results underscore the explicit importance of nitrogen element in photochemical reactivity of chars under simulated light irradiation even when the nitrogen content is low. link3 It is a meaningful reminder for us to pay more attention to the assessment of the fate and transport of contaminants in the soil where it is rich in NCMs as well as the potential use of NCMs for pollutants remediation, since visible light is very abundant near the earth's surface.
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