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Astrocyte-Derived Thrombospondin Triggers Cortical Synaptogenesis in the Sex-Specific Way.
Small deviations from cylindrical shapes evolve towards spheres or saddles depending on the initial condition, where dissipation rates decrease. Taken together the results and analysis provide novel and significant relations between shape evolution and viscous dissipation in deforming viscous membrane and surfaces.The first paper published as Finite-Time Thermodynamics is from 1977 [...].Polygenic adaptation in response to selection on quantitative traits has become an important topic in evolutionary biology. Here we review the recent literature on models of polygenic adaptation. In particular, we focus on a model that includes mutation and both directional and stabilizing selection on a highly polygenic trait in a population of finite size (thus experiencing random genetic drift). Assuming that a sudden environmental shift of the fitness optimum occurs while the population is in a stochastic equilibrium, we analyze the adaptation of the trait to the new optimum. When the shift is not too large relative to the equilibrium genetic variance and this variance is determined by loci with mostly small effects, the approach of the mean phenotype to the optimum can be approximated by a rapid exponential process (whose rate is proportional to the genetic variance). During this rapid phase the underlying changes to allele frequencies, however, may depend strongly on genetic drift. While trait-increasing alleles with intermediate equilibrium frequencies are dominated by selection and contribute positively to changes of the trait mean (i.e., are aligned with the direction of the optimum shift), alleles with low or high equilibrium frequencies show more of a random dynamics, which is expected when drift is dominating. A strong effect of drift is also predicted for population size bottlenecks. Our simulations show that the presence of a bottleneck results in a larger deviation of the population mean of the trait from the fitness optimum, which suggests that more loci experience the influence of drift.Machines usually employ a guess-and-check strategy to analyze data they take the data, make a guess, check the answer, adjust it with regard to the correct one if necessary, and try again on a new data set. An active learning environment guarantees better performance while training on less, but carefully chosen, data which reduces the costs of both annotating and analyzing large data sets. This issue becomes even more critical for deep learning applications. Human-like active learning integrates a variety of strategies and instructional models chosen by a teacher to contribute to learners' knowledge, while machine active learning strategies lack versatile tools for shifting the focus of instruction away from knowledge transmission to learners' knowledge construction. We approach this gap by considering an active learning environment in an educational setting. We propose a new strategy that measures the information capacity of data using the information function from the four-parameter logistic item response theory (4PL IRT). We compared the proposed strategy with the most common active learning strategies-Least Confidence and Entropy Sampling. The results of computational experiments showed that the Information Capacity strategy shares similar behavior but provides a more flexible framework for building transparent knowledge models in deep learning.Projects are rarely executed exactly as planned. Often, the actual duration of a project's activities differ from the planned duration, resulting in costs stemming from the inaccurate estimation of the activity's completion date. While monitoring a project at various inspection points is pricy, it can lead to a better estimation of the project completion time, hence saving costs. Nonetheless, identifying the optimal inspection points is a difficult task, as it requires evaluating a large number of the project's path options, even for small-scale projects. Puromycin nmr This paper proposes an analytical method for identifying the optimal project inspection points by using information theory measures. We search for monitoring (inspection) points that can maximize the information about the project's estimated duration or completion time. The proposed methodology is based on a simulation-optimization scheme using a Monte Carlo engine that simulates potential activities' durations. An exhaustive search is performed of all possible monitoring points to find those with the highest expected information gain on the project duration. The proposed algorithm's complexity is little affected by the number of activities, and the algorithm can address large projects with hundreds or thousands of activities. Numerical experimentation and an analysis of various parameters are presented.A complex network as an abstraction of a language system has attracted much attention during the last decade. Linguistic typological research using quantitative measures is a current research topic based on the complex network approach. This research aims at showing the node degree, betweenness, shortest path length, clustering coefficient, and nearest neighbourhoods' degree, as well as more complex measures such as the fractal dimension, the complexity of a given network, the Area Under Box-covering, and the Area Under the Robustness Curve. The literary works of Mexican writers were classify according to their genre. Precisely 87% of the full word co-occurrence networks were classified as a fractal. Also, empirical evidence is presented that supports the conjecture that lemmatisation of the original text is a renormalisation process of the networks that preserve their fractal property and reveal stylistic attributes by genre.This article focuses on using E-Bayesian estimation for the Weibull distribution based on adaptive type-I progressive hybrid censored competing risks (AT-I PHCS). The case of Weibull distribution for the underlying lifetimes is considered assuming a cumulative exposure model. The E-Bayesian estimation is discussed by considering three different prior distributions for the hyper-parameters. The E-Bayesian estimators as well as the corresponding E-mean square errors are obtained by using squared and LINEX loss functions. Some properties of the E-Bayesian estimators are also derived. A simulation study to compare the various estimators and real data application is applied to show the applicability of the different estimators are proposed.
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