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Characterization involving NAD+/NADP+-Specific Isocitrate Dehydrogenases Via Oleaginous Infection Mortierella alpina Involved in Lipid Piling up.
OBJECTIVE The present study aimed to identify and prioritize control measures of violence against Healthcare Workers (HWs) using the Fuzzy Analytical Hierarchy Process (FAHP) and Fuzzy Additive Ratio Assessment (F-ARAS). BACKGROUND Occupational violence is a pervasive problem in healthcare centers. Reducing violence against staff is one of the challenges for healthcare managers. METHOD At the first stage, the most common criteria and control options for violence against HWs were identified and extracted using a review of previous studies. At the next stage, criteria for selection of control measures were prioritized using the FAHP. Finally, control measures of workplace violence were prioritized using the F-ARAS method. RESULTS Results of the FAHP indicated that safety and efficiency were the most important criteria. Results of the F-ARAS also revealed that "increasing number of security personnel" and "training staff" were the best recommendations for controlling violence against HWs. CONCLUSION Based on expert's opinions, administrative measures are the optimal ways to control violence at health centers; therefore, it is suggested that violence control programs should be more focused on administrative measures. IMPLICATIONS FOR NURSING MANAGEMENT These results could assist nursing management to take best strategies for controlling occupational violence based on multi-criteria decision-making methods. This article is protected by copyright. All rights reserved.AIM To elicit intensive care unit (ICU) nurses' recommendations to prevent nursing errors. BACKGROUND Errors are usually induced by faulty systems, and managers play a key role in building a safe healthcare system. METHOD A qualitative research design was used. Semi-structured interviews with 112 Egyptian ICU nurses were conducted, and responses were analyzed using qualitative content analysis. RESULTS Responses from 108 nurses were analyzed. Six themes of recommendations were identified improvement and better organization of resources, policy modification, education and training, likeness minimization, use of technology, and work environment change. CONCLUSION Nurses' recommendations reflect the poor-resource context in developing countries. Several recommendations, however, are relatively cheap to implement strategies. IMPLICATIONS FOR NURSING MANAGEMENT All reported recommendations are organizational issues. Improvement and better organization of human and non-human resources is a priority issue to prevent or minimize nursing errors. Policy modification, education and training, and likeness minimization are relatively cheap, easy to implement strategies to tackle the occurrence of nursing errors in developing countries. Staff nurses should be actively involved in policy reform. Patient safety education should be supported by adopting modern technology and work environment reform. This article is protected by copyright. All rights reserved.The synthesis and full characterization of new air-stable Ag(I) and Cu(I) complexes bearing structurally bulky expanded-ring N-heterocyclic carbene (erNHC) ligands is presented. The condensation of protonated NHC salts with Ag2O afforded a collection of Ag(I) complexes, and their first use as ligand transfer reagents led to novel isostructural Cu(I) or Au(I) complexes. In situ deprotonation of the NHC salts in the presence of a copper(I) source, provides a library of new Cu(I) complexes. The solid state structures feature large N-CNHC-N angles (118-128°) and almost identical angles between the aryl groups on the nitrogen atoms and the plane of the N-C-N unit of the carbene (i.e. torsion angles close to 0°). Among the steric parameters, the percent buried volume (%Vbur) values span easily in the 50-57% range, and that one of (9-Dipp)CuBr complex (%Vbur = 57.5) overcomes to other known erNHC-metal complexes reported to date. Preliminary catalytic experiments in the copper-catalyzed coupling between N-tosylhydrazone and phenylacetylene, afforded 76-93% product at the 0.5-2.5 mol% catalyst loading, proving the stability of Cu(I) erNHC complexes at elevated temperatures (100°C). © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Article impact statement Insights from feminist political ecology can help conservationists incorporate gender equity more reflexively. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Preparation of recipient site plays a pivotal role in the outcome of vitiligo surgery. Common techniques of recipient site preparation in non-cultured epidermal cell suspension (NCES) include conventional manual dermabrasion (CMD) using Manekshaw's dermabrader, motorized dermabrasion and dermabrasion using carbon-dioxide laser. Reports of using ball tip electrode of radiofrequency in cutting/ coagulation mode and timed surgery (programmed diathermosurgery) for recipient site preparation also exist in literature. This article is protected by copyright. All rights reserved.The enzyme tyrosinase contains a reactive side-on peroxo dicopper(II) center as catalytically active species in C-H oxygenation reactions. The tyrosinase activity of the isomeric bis(µ-oxo) dicopper(III) form has been discussed controversially. We describe the synthesis and characterization of bis(µ-oxo) dicopper(III) species [Cu 2 (µ-O) 2 ( L1 ) 2 ](X) 2 ([ O1 ](X) 2 , X = PF 6 - , BF 4 - , OTf - , ClO 4 - ) via UV/Vis, Raman and XAS spectroscopy as well as cryo-UHR-ESI mass spectrometry, stabilized by the novel hybrid guanidine ligand 2-2-((dimethylamino)methyl)phenyl-1,1,3,3-tetramethylguanidine ( L1 ) . We highlight selective oxygenation of a plethora of phenolic substrates mediated by [ O1 ](PF 6 ) 2 , that results in mono- and bicyclic quinones and provides an attractive strategy on the route to design new phenazines . The selectivity is predictable using the Fukui function which is hereby introduced into tyrosinase model chemistry. Our bioinspired catalysis harnesses molecular dioxygen for organic transformations and achieves a substrate diversity which goes far beyond the enzyme's scope. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Animal welfare is increasingly important in our understanding of how human activity affects wildlife, but the conservation community is still grappling with meaningful terminology when communicating this aspect of their work. One example is the use of the terms 'humane' and 'inhumane'. These terms are used in scientific contexts but also have legal and social definitions. Without reference to a defined technical standard, describing an action or outcome as humane (or inhumane) constrains science communication because (i) the terms have variable definitions; (ii) they establish a binary (something is either humane or inhumane); and (iii) they imply underlying values reflecting a moral prescription. Invoking the term humane, and especially the strong antithesis inhumane, can infer a normative judgment of how animals ought to be treated (humane) or ought not to be treated (inhumane). The consequences of applying this terminology are not only academic. Publicizing certain practices as humane can create blurred lines around contentious animal welfare questions and, perhaps intentionally, defer scrutiny of actual welfare outcomes. Labeling other practices as inhumane can be used cynically to erode their public support. We suggest that, if this normative language is used in science, it should always be accompanied by a clear, contextual definition of what is meant by humane. Article impact statement The concept of conservation practices being either humane or inhumane is normative, misleading, and outdated. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.BACKGROUND Blood transfusion is a lifesaving intervention for millions of recipients worldwide every year. Storing blood makes this possible but also promotes a series of alterations to the metabolism of the stored erythrocyte. It is unclear whether the metabolic storage lesion is correlated with clinically relevant outcomes and whether strategies aimed at improving the metabolic quality of stored units, such as hypoxic storage, ultimately improve performance in the transfused recipient. STUDY DESIGN AND METHODS Twelve healthy donor volunteers were recruited in a two-arm cross-sectional study, in which each subject donated 2 units to be stored under standard (normoxic) or hypoxic conditions (Hemanext technology). End-of-storage measurements of hemolysis and autologous posttransfusion recovery (PTR) were correlated to metabolomics measurements at Days 0, 21, and 42. RESULTS Hypoxic red blood cells (RBCs) showed superior PTR and comparable hemolysis to donor-paired standard units. Hypoxic storage improved energy and redox metabolism (glycolysis and 2,3-diphosphoglycerate), improved glutathione and methionine homeostasis, decreased purine oxidation and membrane lipid remodeling (free fatty acid levels, unsaturation and hydroxylation, acyl-carnitines). Intra- and extracellular metabolites in these pathways (including some dietary purines) showed significant correlations with PTR and hemolysis, though the degree of correlation was influenced by sulfur dioxide (SO2 ) levels. CONCLUSION Hypoxic storage improves energy and redox metabolism of stored RBCs, which results in improved posttransfusion recoveries in healthy autologous recipients-a Food and Drug Administration gold standard of stored blood quality. In addition, we identified candidate metabolic predictors of PTR for RBCs stored under standard and hypoxic conditions. © 2020 AABB.Active targeting strategies are currently being extensively investigated in order to enhance the selectivity of photodynamic therapy. The aim of the present research is to evaluate if the external decoration of nanopolymeric carriers with targeting peptides could add more value to a photosensitizer formulation and increase antitumor therapeutic efficacy and selectivity. To this end, we assessed PLGA-PLA-PEG nanoparticles (NPs) covalently attached to a hydrophilic photosensitizer 5-[4-azidophenyl]-10,15,20-tri-(N-methyl-4-pyridinium)porphyrinato zinc (II) trichloride (ZnTriMPyP) and also to c(RGDfK) peptides, in order to target αv β3 integrin-expressing cells. In vitro phototoxicity investigations showed that the ZnTriMPyP-PLGA-PLA-PEG-c(RGDfK) nanosystem is effective at submicromolar concentrations, is devoid of dark toxicity, successfully targets αv β3 integrin expressing cells, and is 10-fold more potent than related nanosystems where the PS is occluded instead of covalently bound. This article is protected by copyright. All rights reserved.The search for new dyes to be used as photosensitizers in photodynamic therapy (PDT) is a field of great interest from both experimental and theoretical viewpoints. In this study, the main photophysical properties (excitation energies, singlet-triplet energy gap, and spin orbit coupling matrix elements) of some unsubstituted and iodine substituted phosphorus corrole complexes have been determined by using density functional theory and its time-dependent formulation. Results show that these compounds can be proposed as photosensitizers in PDT. selleck The heavy atom effects have been rationalized on the basis of El-Sayed rules. © 2020 Wiley Periodicals, Inc.
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