Notes

Distinct Steric Burden Assists Monoclinic Stage Creation toward High-Quality All-Inorganic Perovskites.
CHA
DS
-VASc Score is widely used to predict thromboembolic risk in patients with Atrial Fibrillation (AF). We sought to study if this score predicts outcomes in elderly patients with Non-ST segment Elevation Acute Coronary Syndromes (NSTEACS).

The multicenter LONGEVO-SCA prospective registry included 532 unselected patients with NSTEACS aged≥80years. Data to calculate CHA
DS
-VASc Score were available in 523 patients (98.3%). They were classified according to CHA
DS
-VASc Score group 1 (score≤4), and 2 (5-9). We studied outcomes in terms of mortality or readmission at 6months follow-up.

A total of 266 patients (51%) had a high CHA
DS
-VASc Score (group 2). They were more often women, with more cardiovascular risk factors, such as hypertension or diabetes mellitus, and history of previous stroke and cardiovascular disease and heart failure (all, P=.001). Geriatric syndromes (Barthel Index, Lawton Brody, cognitive impairment, and frailty) and Charlson Index were worse in this group (all, setting.
Variation in outcomes reported in maternity-related clinical trials and practice stifles data synthesis and contributes to ineffective or harmful treatments and interventions. Variation can be addressed using core outcome sets (COSs), minimum agreed sets of outcomes that should be measured and reported in all clinical trials in a specific area of health or health care. This scoping review identified studies that developed maternity-related COSs; evaluated the extent, scope, quality, and consistency of outcomes across similar COSs; and identified current gaps in evidence.

A multifaceted search of 2 COS registers (Core Outcome Measures in Effectiveness Trials, Core Outcomes in Women's and Newborn Health), the International Consortium for Health Outcomes Measurement website, electronic databases (MEDLINE, Embase, CINAHL), and hand search was conducted. Published, English-language studies describing maternal and neonatal COSs for any health condition and published from inception to January 2020 were included.ears, there is a need for improvement. This article presents an urgent need to minimize overlap in outcomes and standardize outcome measurement, case definitions, and timing of measurement between COSs.
Growth in COS development in the last 3 years signifies increasing commitment to address variation and improve data synthesis. Although the quality of the development process has improved in the last 3 years, there is a need for improvement. This article presents an urgent need to minimize overlap in outcomes and standardize outcome measurement, case definitions, and timing of measurement between COSs.
The willingness of interventional cardiologists to adopt innovation and implement changes in day-to-day practice has received limited study.

Online-based survey on learning and innovation 38 questions were distributed via email list to interventional cardiologists.

The survey was distributed to 8,110 e-mails and completed by 621 (7.7%, 91.8% men, 60% in the 35 to 54-year-old age group). Of the respondents who perform coronary interventions, 45% perform >100 cases of noncomplex percutaneous coronary interventions per year and of the respondents who perform structural interventions, 15% perform more than >100 transcatheter aortic valve replacements per year. Most respondents (86.7%) rate themselves as highly likely/likely to introduce recently approved equipment in everyday practice and 47.5% have tried a new coronary guidewire in the past 6 months. The most common reasons for reluctance to use new equipment were high cost (64%) and uncertainty about whether it provides additional benefits compared with existing equipment (48.5%). Radial access in STEMI cases is always used by 43.6% of the respondents and 55% always use radial access for coronary angiography. Of those who use femoral access, 32% always use ultrasound guidance and 91% have used a closure device in the last 6 months. Most respondents (80%) read journals to keep up with current practice and believe that the most effective way to learn is through attendance of workshops/short courses (77.5%). Most respondents (69%) are involved in research.

Interventional cardiologists who participated in the survey are highly likely to adopt innovation in daily clinical practice.
Interventional cardiologists who participated in the survey are highly likely to adopt innovation in daily clinical practice.The immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a cofactor-binding, redox-sensitive protein, which calls for monitoring of IDO1 activity in its native cellular environment. We developed a new, robust fluorescence-based assay amenable to high throughput, which detects kynurenine in cells. learn more Screening of a ca. link2 150 000-member compound library discovered unprecedented, potent IDO1 modulators with different mechanisms of action, including direct IDO1 inhibitors, regulators of IDO1 expression, and inhibitors of heme synthesis. Three IDO1-modulator chemotypes were identified that bind to apo-IDO1 and compete with the heme cofactor. Our new cell-based technology opens up novel opportunities for medicinal chemistry programs in immuno-oncology.Tricuspid valve endocarditis with recurrent septic pulmonary emboli is an indication for surgery. We present the case of a 36-year old man with tricuspid valve endocarditis and septic pulmonary emboli with percutaneous extraction of the vegetation. We discuss the nuances of such an approach and the need for more evidence in the management of these complex patients.
The functional constipation (FC) is a source of an expressive suffering in children, negatively affecting their emotional, social, and physical well-being. The objective of this study is to describe the clinical and behavioural characteristics of children/adolescents with FC.

A cross-sectional, observational, analytical study was conducted in public places by interviewing parents of children/adolescents about their child's bowel habits and psychological profile. Bowel symptoms were investigated using the Rome IV criteria. The Strengths and Difficulties Questionnaire (SDQ) was used to evaluate the emotional and behavioural problems.

Of 799 children/adolescents included, 424 (53.1%) were female. Mean age was 9.1 ± 2.7 years. FC prevalence was 20.4%. The most common symptoms in Rome IV criteria were 'painful or hard bowel movements' (n = 110; 67.5%; 95% confidence interval 60.0-74.3) and 'retentive posturing or excessive volitional stool retention' (n = 89; 54.6%; 95% confidence interval 46.9-62.1). Medianlising symptoms compared to non-constipated children.
The aim was to compare the perceived oral health and oral health behaviours of home-dwelling older people with and without domiciliary care.

Oral health is poor in long-term care, but less is known about perceived oral health of home-dwelling older people receiving domiciliary care.

Data from the Health 2000 and Health 2011 surveys (BRIF8901) were used. Interview participants were at least 70years old and living at home with or without domiciliary care (n=1298 in 2000 and n=1027 in 2011). Differences in perceived oral health (subjective oral health, pain, eating difficulties) and oral health behaviours (hygiene, use of services) were compared based on the use of domiciliary care and stratified by gender. Differences between groups were compared with the chi-square test.

In 2011, compared to non-clients, domiciliary care clients more often had poor subjective oral health (40.3% vs. 28.9%, P=.045). In both surveys, they also used oral health services less recently (2000, 76.4% vs. 60.9%; and 2011, 61.1% vs. 46.6%) and more often had difficulties chewing hard food (2000, 50.6% vs. 34%, P<.001; and 2011, 38.4% vs. 20.7%, P<.001) than non-clients. In 2000, clients had more difficulty eating dry food without drinking (39.5% vs. 21.6%, P<.001) and cleaning their teeth and mouth (14.3% vs. 1.1%, P<.001) than non-clients. Women clients in 2011 brushed their teeth less often than non-clients (43.5% vs. 23.7%, respectively, P=.001).

Domiciliary care clients havepoorer perceived oral health, and greater difficulties with eating and oral hygiene maintenance than non-clients.
Domiciliary care clients have poorer perceived oral health, and greater difficulties with eating and oral hygiene maintenance than non-clients.
Unhealthy alcohol consumption is a key concern for Aboriginal and Torres Strait Islander ('Indigenous') communities. It is important to identify and treat at-risk drinkers, to prevent harms to physical or social wellbeing. We aimed to test whether training and support for Aboriginal Community Controlled Health Service (ACCHS) staff would increase rates of alcohol screening and brief intervention.

Cluster randomized trial.

Australia. Cases/Intervention/Measurements Twenty-two ACCHSs that see at least 1000 clients per year and use Communicare as practice management software. The study included data on 70 419 clients, training, regular data feedback, collaborative support and funding for resources ($9000). Blinding was not used. link3 The comparator was waiting-list control (equal allocation). Alcohol Use Disorder Identification Test (AUDIT-C) screening and records of brief interventions were extracted from practice management software at 2-monthly intervals. Observations described the clinical actions taken forProviding Aboriginal Community Controlled Health Services with training and support can improve alcohol (AUDIT-C) screening rates.The present study describes the phytoremediation performance of water lettuce (Pistia stratiotes L.) for physicochemical pollutants elimination from paper mill effluent (PME). For this, pot (glass aquarium) experiments were conducted using 0% (BWW borewell water), 25%, 50%, 75%, and 100% treatments of PME under natural day/light regime. Results of the experiments showed that the highest removal of pH (10.75%), electrical conductivity (EC 63.82%), total dissolved solids (TDS 71.20%) biological oxygen demand (BOD 85.03%), chemical oxygen demand (COD 80.46%), total Kjeldahl's nitrogen (TKN 93.03%), phosphorus (P 85.56%), sodium (Na 91.89%), potassium (K 84.04%), calcium (Ca 84.75%), and magnesium (Mg 83.62%), most probable number (MPN 77.63%), and standard plate count (SPC 74.43%) was noted in 75% treatment of PME after treatment by P. stratiotes. PCA showed the best vector length for TKN, Na, and Ca. The maximum plant growth parameters including, total fresh biomass (81.30 ± 0.28 g), chlorophyll content (3.67 ± 0.05 mg g-1 f.wt), and relative growth rate (0.0051 gg-1 d-1 ) was also measured in 75% PME treatment after phytoremediation experiments. The findings of this study make useful insight into the biological management of PME through plant-based pollutant eradication while leftover biomass may be used as a feedstock for low-cost bioenergy production. PRACTITIONER POINTS Biological treatment of paper mill effluent using water lettuce is presented. Best reduction of physicochemical and microbiological pollutants was attained in 75% treatment. Maximum production of chlorophyll, plant biomass, and highest growth rate was also observed in 75% treatment.
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