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Iatrogenic syringomyelia postcranial surgical treatment within kid patients: organized evaluate and also illustrative scenario.
We report herein the development of two pathways for the preparation of levo-praziquantel (R-PZQ), which involves three-/four-step processes of a mechanochemical (asymmetric) aza-Henry/acylation reaction, a hydrogenation reaction, (chiral resolution) and a solvent-free acylation-ring closing reaction. The key intermediate (R)-1-aminomethyl tetrahydroisoquinoline could be obtained either by chiral resolution with a rational reuse of the S-isomer or by mechanochemical enantioselective synthesis that refrained from using a bulky toxic solvent. The efficiency and scalability of both the developed routes were demonstrated and desired target product was obtained in a satisfactory yield with excellent enantiopurity (>99%), offering practical, concise and environmentally friendly alternatives to access R-PZQ.To detect coliform bacteria (CB) with simplicity and portability, a novel, single-tube quantitative rapid detection method was developed based on CB-specific enzymatic technology. This technology involved a simple multi-channel spectrometer which could detect 7 cfu mL-1 CB specifically, and the approach was applied to various food and water samples.Annona muricata (graviola) is a medicinal plant that can be used to alleviate chronic human diseases by providing antioxidants and inducing immunomodulation. In this study, we found that treatment of AML12 hepatocytes with steam (SGE) and ethanol (EGE) extracts of graviola leaf downregulated the expression of fatty acid (FA) oxidation genes, including ACOX1, CPT1, and PPARα, with no change in the expression of FA synthesis genes. However, whereas EGE inhibited the differentiation and lipid accumulation of 3T3-L1 adipocytes and downregulated FA synthesis genes, no similar changes were observed in response to treatment with SGE. In an in vivo experiment using mice fed a high-fat diet (HFD), body weight was reduced in response to treatment with EGE, which also dose-dependently alleviated liver hepatocyte ballooning induced by the consumption of a HFD. However, genes involved in FA oxidation and the secretion of very low density lipoprotein (VLDL) were downregulated. We also found that the size of adipocytes was reduced in response to EGE treatment, and that there was a downregulated expression of genes involved in adipogenesis and FA synthesis. Furthermore, we detected increases in the levels of cholesterol in the plasma, whereas ALT activity was reduced. Collectively, these results indicates that EGE inhibits lipid influx into the liver and adipogenesis in adipose tissues. These bioactive properties of EGE indicate its potential as a natural ingredient that can be used to prevent obesity.A novel protocol for Rh(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2'-bipyridine derivatives with sulfoxonium ylides is reported. This protocol provides a facile approach to synthesize structurally diverse acylmethylated 2,2'-bipyridine derivatives and acyl pyrido[2,3-a]indolizines with a broad range of functional group tolerance.Assessment of the sustainability of CO2 utilisation technologies should encompass economic, environmental and social aspects. Though guidelines for economic and environmental assessment of CO2 utilisation (CDU) have been presented, a methodology for social assessment of CDU has not. Nintedanib Herewith, social impact assessment for CDU is systematically investigated, a methodological framework derived and examples of application given. Both process and deployment scenarios are found to be key factors in the assessment and the sourcing of raw material is observed to be a hotspot for social impacts within the assessed CDU technologies. This framework contributes a new aspect to the development of holistic sustainability assessment methodologies for CDU by enabling a triple helix to be created between life cycle assessment (LCA), techno-economic assessment (TEA) and social impact assessment (SIA). Therefore, the triple helix approach will enable trade-offs between environmental, economic and social impacts to be explored, ultimately enhancing effective decision making for CDU development and deployment.N-Heterocyclic carbenes (NHCs) have recently emerged as viable alternatives to commonly used thiols to stabilize a variety of metal surfaces and nanoparticles. In this context, thanks to their biocompatibility and novel optical properties, NHC-stabilized gold nanoparticles (AuNPs) have been extensively studied. It has been shown that such materials exhibit improved stabilities in acidic and basic solutions, high temperatures, electrolyte solutions, cell culture media, and to some extent to nucleophilic thiols. Despite intense efforts, instability of NHC-functionalized AuNPs to thiols has been an ongoing challenge. In order to circumvent this problem, quantification of NHC desorption from nanoparticle surface by the invading thiols would constitute a necessary first step. To do this, we have first developed water-soluble azide decorated NHC-stabilized "clickable" AuNPs. Optically active perylene diimide (PDI)-tagged AuNP hybrids are then obtained by means of Cu-catalyzed alkyne-azide cycloaddition between these AuNPs and an alkyne-decorated PDI derivative. Investigation of photophysical properties of these AuNP/PDI hybrids revealed that the fluorescence of PDI molecules is effectively quenched by AuNPs in aqueous solution. The extent of NHC desorption from AuNP surface in presence of glutathione (4 mM), as a biologically relevant thiol, is then quantified by means of fluorescence emission restoration of PDI molecules upon detachment from AuNP surfaces. Our results demonstrate that while ∼20% of surface NHCs are displaced by glutathione within the first 24 h of their exposure to the thiol, ligand desorption reaches ∼45% after one week. We believe that these findings will provide more insight on true stability of NHC-stabilized materials.Transition-metal based carbon-heteroatom (C-X) bond formation has attracted the attention of synthetic chemists over the past few years because the resultant aryl/heteroaryl motifs are important substructures in many natural products, pharmaceuticals, etc. Several efficient protocols such as Buchwald-Hartwig amination, Ullmann coupling, Chan-Lam coupling and metal-free approaches have proved beneficial in C-X bond formation. Selective arylation of one hetero-centre over other centres without protection/deprotection thus allowing minimum synthetic manipulation has been achieved for several substrates using these protocols. Azoles are one such novel five-membered heterocyclic core with huge pharmaceutical applications. Though N-arylation on azole-bearing analogues has been extensively practised, selective N-arylation either on one N-centre or the exocyclic N-site of the azole ring in competition with other hetero-centres in the framework has been recently explored for azole-carrying systems. Thus, this review would focus on recent advances in chemo- and regio-selective N-arylation (either on one N-centre or the exocyclic N-site of the azole ring) on azole-containing frameworks.
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