Notes

Physiological responses and also molecular techniques in coronary heart involving sterling silver carp (Hypophthalmichthys molitrix) under hypoxia and reoxygenation.
Ultraviolet filters (UV-filters) are specific chemicals that absorb and reflect UVA and UVB radiation from the sun. They are regularly used in sunscreens and in other personal care products (PCPs), and in products like plastics, adhesives, toys, or furniture finishes. This work develops and validates a new method to determine concentrations of UV-filters (BP-1, BP-2, BP-3, BP-6, BP-8, 4-OH-BP, THB, AVB) in human nail samples. Nails are easily available and are considered to be suitable indicators of cumulative and continued exposure to harmful chemicals. The treatment of nail samples includes microwave assisted digestion/extraction (MAE) in a methanolic solution of o-phosphoric acid (0.05 mol L-1) followed by analyte determination using ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS/MS) in multiple reaction monitoring mode. The analytes were separated in less than 10 min. The digestion procedure was optimized using multivariate techniques. Matrix-matched calibration with a pig hoof matrix was used for validating the method. A study of accuracy with spiked blank samples was also conducted. The calculated detection limits varied between 0.2 and 1.5 ng g-1, and quantification limits between 1.0 and 5.0 ng g-1. The trueness of the method was an estimation of the recovery, which was between 90.2% and 112.2%; with an estimated precision (relative standard deviation, % RSD) lower than 12.3% for all UV-filters. Nail samples were obtained from 22 volunteers (male and female). The results showed that BP-1 and BP-3 mainly bioaccumulate in human nails.Metal organic framework (MOF) supported layered triple hydroxide (LTH) 2D/2D hybrid material was prepared by a simple hydrothermal method. The photophysical properties of the prepared samples were investigated through a set of analytical methods such as X-ray diffraction, Fourier-transform infrared spectroscopy, field emission scanning electron microscope, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy and mapping. The photocatalytic degradation activity of as prepared 2D/2D MOF-5/LTH hybrid sample was investigated against methylene blue (MB) dye under the UV-visible light irradiation. The degradation efficiency of the MOF-5/LTH hybrid sample was twice a time greater than that of pristine MOF-5, particularly degradation efficiency of the MOF-5, LTH and MOF-5/LTH hybrid samples are 43.3, 57.7 and 98.1% respectively. The Pseudo first order rate and the reusing investigation was further used to study the catalytic activity and stability of the as-synthesized 2D/2D photocatalyst. The observed improvement in the photocatalytic activity of the hybrid samples were owed to enhance visible light absorption, efficient separation and transportation of photoinduced electrons and holes.
Limited evidence is available for demonstrating effects of prenatal PM
and its components exposure on Apgar score and duration of labor.

We sought to investigate the associations between PM
constituents, Apgar score and duration of labor, and evaluated the potential mediating role of duration of labor.

This study included 5396 participants. The V4·CH.02 was applied to assessing exposure to PM
constituents. The associations between PM
constituents Apgar score and duration of labor were examined by multivariate linear regression. Mediation analysis was conducted to estimate the potential mediation effect of duration of labor.

Trimester-specific exposure to soil dust was significantly associated with 1-min Apgar score (1st trimester OR 1.03, 95% CI0.97, 1.10; 2nd trimester OR 1.07, 95% CI 1.01, 1.14; 3rd trimester OR 1.07, 95% CI 1.01, 1.13), duration of first stage of labor (1st trimester β 0.32, 95% CI 0.07, 0.58; 2nd trimester β 0.27, 95% CI 0.04, 0.51; 3rd trimester β 0.37, 95% CI 0.13, 0.61) and duration of second stage of labor (1st trimester β 0.04, 95% CI-0.00, 0.09; 2nd trimester β 0.05, 95% CI 0.01, 0.10; 3rd trimester β 0.05, 95% CI 0.00, 0.09). The duration of labor mediated the relationship between soil dust and 1-min Apgar score.

This study demonstrated that prenatal exposure to soil dust was significantly associated with the risk of abnormal 1-min Apgar score and extended stage of labor.
This study demonstrated that prenatal exposure to soil dust was significantly associated with the risk of abnormal 1-min Apgar score and extended stage of labor.In the present study, heterogeneous electro-Fenton (EF) process was applied to remove the sulfasalazine (SU) pharmaceutical from aqueous solutions. In the first part, 3D graphene loaded with Fe@Fe2O3 core-shell nanowires (Fe@Fe2O3/3D-GO) was used as a cathode electrode in the EF process. Graphene oxide (GO) was synthesized for the synthesis of 3D graphene nanocomposites using the improved Hummers' method and subsequently 3D graphene synthesized by the hydrothermal method using glycine. Finally, Fe@Fe2O3/3D-GO composite was synthesized and its properties were assessed by Scanning electron microscopy, Atomic force microscopy, Brunauer-Emmett-Teller, Fourier-transform infrared spectroscopy and X-ray diffraction methods. Then, the cathode electrode was prepared using the resulting composite and its performance was evaluated using Cyclic Voltammetry analysis. In the final part of this work, the Fe@Fe2O3/3D-GO electrode was used as the cathode electrode in the heterogeneous EF process to remove SU from aqueous solutions. The effect of operating parameters such as applied current (mA), initial pH of solution, initial pharmaceutical concentration (mg L-1) and process time (min) on pharmaceutical removal efficiency under heterogeneous EF process was investigated by response surface methodology. The results showed that the optimum values for applied current, pH, initial pharmaceutical concentration and electrolysis time were respectively 300 mA, 7, 30 mg L-1 and 100 min, resulting 99.60% of SU removal. Finally, the intermediates of SU degradation were determined by Gas chromatography-mass spectrometry analysis and the amount of mineralization was determined by total organic carbon analysis. About 5.2% drop in the SU removal efficiency was observed within 8 operational runs.Perfluorooctanoic acid (PFOA) is an artificial organic substance widely used for decades, which seriously threatens human health. This study aimed to identify human-relevant correlates between PFOA exposure and the male rodent reproductive system. We performed a systematic literature review of the relevant literature of PubMed, Cochrane Library databases, Web of Science and Embase from the establishment to April 2020. Studies included the effects of PFOA on the reproductive system of male rodents. The meta-analysis was performed on the basis of the following points level of testosterone and estradiol in serum, development of reproductive organs, pathological changes of reproduction organs and parameters of semen. A series of 16 studies was enrolled in this study. The standard mean difference (SMD) for PFOA-related reproductive toxicity was summarised as -0.39 (95% confidence interval [CI] 0.71, -0.07). The lower serum testosterone levels, decreased absolute testicular and epididymal weights, higher serum estradiol levels, elevated relative testicular and seminal vesicle weights and increased incidence of Leydig cell adenoma and percentage of abnormal sperm were observed in the exposed group compared with the control group. However, no statistical difference was found in the day of preputial separation of pups and percentage of motile sperm. In conclusion, PFOA exposure heightens the reproductive system damage in male rodents. However, many studies included in the review did not identify mechanisms by which PFOA induces changes to the male reproductive system, which is an area for additional study.Pesticides applied to agricultural land can enter aquatic ecosystems through runoff or leaching during precipitation events. In a lotic system, these events result in a pulse of exposure to biota living in these systems. The concentration of pesticide increases, peaks, and then gradually declines, and this pulsed exposure may occur multiple times over the course of a growing season. The dynamic nature of exposure to pesticides in the environment is not often mimicked in the laboratory testing of the toxicity of pesticides. The present study investigated the potential latent effects of a 24-h pulsed exposure of metolachlor, metribuzin, MCPA (2-methyl-4-chlorophenoxyacetic acid), MCPP (methylchlorophenoxypropionic acid or mecoprop), dicamba, and 2,4-D to the aquatic macrophyte Lemna minor followed by a 5-day recovery period. P110δ-IN-1 The relative sensitivity of L. minor to the herbicides were, in this decreasing order metolachlor > metribuzin >2,4-D > MCPA > MCPP > dicamba. This study also investigated the effects of short-term exposures of the diamide insecticides cyantraniliprole and chlorantraniliprole on the survival of the larvae of the parthenogenetic mayfly Neocloeon triangulifer. The median lethal concentrations (96-h LC50s) for cyantraniliprole and chlorantraniliprole were 8.60 and 2.92 μg/L, respectively.
Area postrema syndrome (APS) is recognized as a core feature in neuromyelitis optica (NMO) diagnosis. Isolated APS can occur at NMO onset and frequently results in a delay of diagnosis, along with devastating secondary neurologic deficits. To date, few studies have characterized APS-onset neuromyelitis optica spectrum disorder (APSO-NMOSD).

We aimed to describe the clinical and radiologic features of patients with APSO-NMOSD who are initially misdiagnosed in a cohort of patients from Zhengzhou, China.

We identified 15 patients who presented with APS as an initial manifestation, based on the 2015 international consensus diagnostic criteria for NMOSD, and reviewed their demographic, clinical, laboratory, and magnetic resonance imaging (MRI) data.

Fifteen patients (3 men, 12 women) aged 14-50years old were included in our study. All patients presented with APS that included intractable nausea, vomiting, or hiccups (INVH) as the initial manifestation; many experienced a delay in diagnosis. Serum AQP4 was positive in eleven patients and myelin oligodendrocyte glycoprotein (MOG) in one patient. All patients had a linear medullary lesion or a linear medulla-spinal lesion on sagittal MRI. An "inverted V sign" on axial medulla oblongata images, representing a lesion involving the area postrema, was noted in seven patients in this study.

APS can occur as a sole and initial manifestation of NMOSD, often leading to misdiagnosis in the early process of disease. Identifying patients with an "inverted V" sign and a linear medullary lesion upon MRI examination can help to quickly identify APS patients and avoid further diagnostic delays.
APS can occur as a sole and initial manifestation of NMOSD, often leading to misdiagnosis in the early process of disease. Identifying patients with an "inverted V" sign and a linear medullary lesion upon MRI examination can help to quickly identify APS patients and avoid further diagnostic delays.
To report predictive factors for therapeutic response to anti-VEGF in patients with neovascular age-related macular degeneration (nAMD) in daily clinical practice in our patient population.

Retrospective cohort study including 56 patients (69 eyes) with nAMD treated with anti-VEGF, followed for at least two years between February 2012 and April 2018. Patients received three intravitreal anti-VEGF (bevacizumab) injections (loading dose) and were monitored and treated according to a PRN regimen. We analysed whether a gain in visual acuity of 15 or more ETDRS letters at the final visit was associated with demographic characteristics, presence of systemic comorbidities, fundus lesions or measurable improvement on Cirrus optical coherence tomography (OCT) between the first and last visit.

After a mean follow-up of 15.5 months (4.7-27.8 interquartile range), central retinal thickness (CRT) (RR 1.004; IC 95% 1.001-1.007; P=0.011) and macular hemorrhage (RR 0.30; IC 95% 0.10-0.90, P=0.032) at baseline were found to be useful predictive factors for visual acuity improvement (≥15 letters) in patients treated for nAMD by anti-VEGF in a real world clinical setting.
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