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We evaluated the impact of metal saturation of lactoferrin (with iron and manganese) on population numbers of pathogenic species relevant for neonatal sepsis that commonly originates from the gut due to bacterial translocation. Little attention has been paid to how metal ions bound to the protein affect its activity. Several reference and clinical strains as well as probiotic strains were incubated with different forms of lactoferrin metal-depleted (apolactoferrin), iron-saturated (hololactoferrin) and manganese-saturated lactoferrin. We also attempted to confirm the observed effects of lactoferrin forms in vivo using rat pups. The observed decrease in population numbers of Gram-negative rods could not be confirmed by quantitative plating-lactoferrin may regulate these populations diversely (e.g., by anti-biofilm activity) and contribute to the inhibition of inflammatory response. We did not see any effect of lactoferrin forms on staphylococci and bifidobacteria. However, we have noted a significant increase of population numbers of Lactobacillus strains upon incubation with manganese-saturated lactoferrin. These results were confirmed in vivo in a rat model. Metal saturation is an underestimated factor regulating lactoferrin activity. Some forms are more potent in the inhibition of pathogenic species while others, such as manganese-saturated lactoferrin, could contribute to the restoration of gut homeostasis.Fine recycled aggregates (FRA) (0/4 mm) are up to now not valorized on a high enough level because of characteristics like an elevated water absorption, higher fines content, and the presence of contaminations. Leftover gypsum residues from the construction site can cause internal sulfate attack when FRA are incorporated into new structures. Concern about this deteriorating reaction plays an important role in the rejection of FRA. In this study, samples of FRA from different recycling centers were characterized and incorporated into mortars. They were then subjected to swelling tests in order to evaluate the development of sulfate attack. Reference materials with different amounts of sulfates were used as a comparison. Results showed a variable sulfate content in industrial FRA, depending heavily on the source of the materials. In all but one case, the total amounts surpassed the acceptable sulfate contents specified in the European standard EN 206, meaning the FRA would be rejected for reuse in concrete. Nevertheless, swelling tests demonstrated that these contamination levels did not pose a risk for sulfate attack. These results indicated that the incorporation of FRA leads to acceptable mechanical performances and that the sulfate limit could be reviewed to be less strict.The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Here, we focused on the study of microRNAs that specifically target TMPRSS2. Through a bioinformatic approach, we identified miR-98-5p as a suitable candidate. Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, our findings indicate that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches.As an essential characteristic of air-coupled transducers, electrical impedance can provide valuable information for quality control during manufacturing of transducers. It is also found feasible to directly read the optimal operating frequency from the impedance plots when the resonance is independent of the others. However, the spurious resonance emerges when two neighboring resonances are closely spaced, resulting in distorted impedance and ambiguous optimal operating frequency. In this paper, the electrical impedance of air-coupled transducers with spurious resonance is modeled using the Butterworth-Van Dyke (BVD) equivalent circuit. Then model-based sensitivity analysis is performed to evaluate the mutual interference between adjacent resonances. Based on the analysis results, the prestress method is proposed to regulate and suppress the spurious resonance by adjusting the equivalent parameters of the BVD model. Experimental study was carried out on the response of the electrical impedance and the vibration velocity of the transducer with spurious resonance to pre-tightening force. The results show that the spurious resonance disappeared when the pre-tightening force was initially loaded. Moreover, the vibration velocity of two main resonance peaks increases about 45.6% and 33.9% as the pre-tightening torque increases to 0.25 N∙m. Hence it is validated that the proposed prestress method is efficient to suppress the spurious resonance and improve the transducers performance.A sexual cycle in Aspergillus fumigatus was first described in 2009 with isolates from Dublin, Ireland. However, the extent to which worldwide isolates can undergo sexual reproduction has remained unclear. In this study a global collection of 131 isolates was established with a near 11 ratio of mating types. All isolates were crossed to MAT1-1 or MAT1-2 Irish strains, and a subset of isolates from different continents were crossed together. Ninety seven percent of isolates were found to produce cleistothecia with at least one mating partner, showing that sexual fertility is not limited to the Irish population but is a characteristic of global A. fumigatus. However, large variation was seen in numbers of cleistothecia produced per cross, suggesting differences in the possibility for genetic exchange between strains in nature. check details The majority of crosses produced ascospores with >50% germination rates, but with wide variation evident. A high temperature heat shock was required to induce ascospore germination. Finally, a new set of highly fertile MAT1-1 and MAT1-2 supermater strains were identified and pyrimidine auxotrophs generated for community use. Results provide insights into the potential for the A. fumigatus sexual cycle to generate genetic variation and allow gene flow of medically important traits.
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