Notes

Mid-infrared ChG-on-MgF2 waveguide fuel sensor based on wave length modulation spectroscopy: publisher's be aware.
2% solely under the driving of gravity. Our strategy provides a generic way to convert cellulose-based materials into cellulose porous materials with excellent permeability, separation efficiency, antifouling, and reusability property for oil/water emulsions separation. This economical, environmentally friendly and functional cellulose sponge not only allows natural cotton resources to be used rationally with high value-added, but also effectively solves the problems of oily wastewater.Biosolids were applied as a fertilizer after drying, torrefaction (220, 320 °C), and pyrolysis (420, 520, 620 °C). Lettuce was grown on contrasting soils, and the transfer of pharmaceuticals to aboveground biomass was assessed. Of 42 compounds detected in dried biosolids, 10 were found in lettuce. read more Their potency for translocation to aerial parts was in the order ethenzamide > carbamazepine > mirtazapine~tramadol > N-desmethyltramadol~solifenacin > sertraline~trazodone~venlafaxine > propafenone. Application of dried biosolids resulted in the highest uptake of pharmaceuticals and the neutral soil further intensified the uptake due to prevalent neutral speciation of the ionizable basic molecules. Torrefaction reduced the total pharmaceutical content in biosolids by 92.2% and 99.5% at 220 and 320 °C, respectively. Torrefied biosolids significantly reduced the uptake of pharmaceuticals and led to the highest biomass on acidic soil but were phytotoxic on the neutral soil. Pyrolysed biosolids increased the biomass production of lettuce on both soils and blocked the uptake of pharmaceuticals. A minimum biosolids pyrolysis temperature of 420 °C should be ensured prior to soil application as it represents a good compromise between fertilization potential, pharmaceutical uptake, and homogeneity of plant response regardless of the soil characteristics.Accumulation of arsenite [As(III)] and dimethylarsinic acid (DMA) in rice grainsposes a threat to human health. Although silicon (Si) has been reported to reduce As uptake, the mechanisms involved are not fully understood. In this study, we first confirmed that the concurrent addition of Si and As in solution decreased As accumulation in rice. Then, the effect of Si previously deposited in shoots by the pretreatment of rice seedlings with Si for one week was investigated by using lsi2 mutant and its wild type. The uptake of both As(III) and DMA decreased in rice subjected concurrently to Si and As (III)/DMA in solution, without effects on OsLsi1 and OsLsi2 expression. This concurrent treatment also decreased total As concentration in the root cell walls and xylem sap, which might have restrained apoplastic transport of As to shoots. Silicon previously deposited in the shoots decreased root-to-shoot As(III) translocation and down-regulated OsLsi1, OsLsi2 and OsNRAMP1, but did not affect As concentration in the roots, and had no effect on DMA uptake and accumulation in shoots and roots either. This study sheds light on the role of silicon in solution and rice shoots in As(Ⅲ) and DMA uptake and transport by rice.Sludge-derived biochar (SDBC) has been regarded as persulfate (PS) activator during the remediation of organic contamination. However, the complexity of sludge composition makes it difficult to predict the activity of SDBC and the efficacy of PS. To improve the understanding of how the composition of sludge regulated activity of its parent SDBC towards PS activation, we used two SDBCs derived from different sludges with significantly different organic compositions and metals. Results indicated the higher content of organic and nitrogen content in sludge led to higher polymerization and condensation of carbon layer and more moieties in SDBC1, whereas more Fe species (e.g. Fe-O, Fe2+ and Fe3+) formed in SDBC2. According to the results of phenol (PN) degradation in SDBC/PS, the apparent rate constants (kobs) of SDBC2-700 (0.0037 min-1) was 2 folds higher than that of SDBC1-700 (0.0016 min-1), whereas the SDBC1-500 (6.0 ×10-4 min-1) exhibited higher kobs than that of SDBC2-500 (4.9 ×10-4 min-1). The difference of PS activation by different SDBCs mainly relied on generated reactive oxygen species (ROS). The persistent free radicals (PFRs) and Fe species acted as redox sites for generated ROS, which were depended on the organic compositions and involved metals in used sludges.
Immune checkpoint blockade (ICB) therapy shows limited efficacy in ovarian cancers due to the "cold" immune phenotype surrounding these tumors. Previous studies have shown that in ovarian cancer Wnt/β-catenin pathway activation contributes to this immune phenotype. Here, we evaluated the anti-tumor and immune-enhancing properties of the Wnt inhibitor, CGX-1321, used alone or in combination with either DKN-01 or anti-PD-1 therapy, in pre-clinical ovarian cancer models.

The parental ID8 murine ovarian cancer model harboring a knock-out of p53 (ID8p53
) and MISIIR-Tag spontaneous ovarian cancer models were used to test the effects of CGX-1321 alone or in combination therapies on tumor burden and immune cell landscape in the tumor microenvironment (TME). Flow cytometry and NanoString analyses were used to characterize the changes in tumor-intrinsic signaling and immune-related profiles in the TME of ovarian cancer in response to treatments.

CGX-1321 significantly reduced tumor burden and constrained tumor progression in the ID8p53
and MISIIR-Tag models. Furthermore, CGX-1321 increased infiltrating CD8+ T cells in the TME. Combining CGX-1321 with either DKN-01 or anti-PD-1 therapy also decreased tumor burden and increased CD8+ T cell infiltration in the omentum TME but did not do so to a greater extent that CGX-1321 monotherapy.

CGX-1321 significantly reduced tumor burden and enhanced CD8+ T cell levels in ovarian cancer, nevertheless the addition of DKN-01 or anti-PD-1 therapies did not enhance these effects of CGX-1321. Further investigation is needed to determine if CGX-1321+DKN-01 combination treatment sensitizes pre-clinical ovarian cancer to ICB therapy.
CGX-1321 significantly reduced tumor burden and enhanced CD8+ T cell levels in ovarian cancer, nevertheless the addition of DKN-01 or anti-PD-1 therapies did not enhance these effects of CGX-1321. Further investigation is needed to determine if CGX-1321 + DKN-01 combination treatment sensitizes pre-clinical ovarian cancer to ICB therapy.
Cytomegalovirus (CMV) is a common infection that establishes latency in healthy people. CMV has been associated with alterations of the immune compartment leading to improved responses, while inflammation has been shown to adversely impact outcomes. We investigated whether CMV serostatus predicts outcomes in ovarian cancer in the presence or absence of inflammation.

A total of 106 patients with serous ovarian cancer from 2006 to 2009 were analyzed. CMV and systemic inflammation was measured using CMV immunoglobulin G (IgG) and C-reactive protein (CRP), respectively, in serum collected prior to cytoreduction. Patients were stratified by CMV IgG (non-reactive, reactive/borderline) and CRP (≤10, >10mg/L) status. Overall survival (OS) and recurrence-free survival (RFS) were compared by group using log-rank tests and Cox proportional hazards regression models adjusting for age at surgery.

Of 106 eligible patients, 40 (37.7%) were CMV+/CRP+, 24 (22.6%) CMV+/CRP-, 19 (17.9%) CMV-/CRP+, and 23 (21.7%) CMV-/Ce absence of inflammation, may be protective.
The therapeutic role of pelvic and para-aortic lymphadenectomy in surgical staging of apparent early-stage epithelial ovarian cancer (eEOC) is still under debate. The aim of this study was to evaluate the potential therapeutic role of systematic lymphadenectomy in patients with eEOC.

Multi-center retrospective cohort study, comparing women with apparent eEOC who underwent comprehensive bilateral pelvic and para-aortic lymphadenectomy (defined as ≥20 lymph nodes) versus patients receiving no lymphadenectomy or lymph node sampling, from 05/1985 to 12/2016. Patients with bulky nodes at CT-scan and those without complete intra-peritoneal surgical staging were excluded. Only patients who received at least 3cycles of platinum-based adjuvant chemotherapy were included.

Out of 2559 patients with FIGO stage IA-IIIA1 ovarian cancer, 639 (25.0%) met inclusion criteria. 360 (56.3%) underwent comprehensive lymphadenectomy, 150 (23.5%) lymph node sampling and 129 (20.2%) no lymphadenectomy. Patients who underwent comrgical staging of eEOC improves DFS for the price of increasing post-operative complications and time to chemotherapy but does not affect OS. Better understanding of tumor biology may help to identify those patients in whom lymphadenectomy should still play a role.Decreasing the soil organic carbon (SOC) decomposition is critical to improve the quality of the soil and mitigate atmospheric CO2 emissions. To improve the ability to protect the SOC by optimizing tillage management, this study investigated the laboratory-based SOC mineralization (decomposition) and soil chemical properties under different tillage practices, including no tillage with straw mulch (NTS), rotary tillage with straw incorporated (RTS), moldboard plow tillage with straw incorporated (CTS) and moldboard plow tillage with straw removal (CT). Soil samples of six sampling dates from April 2017 to October 2018 were incubated at 25 °C and 70% water holding capacity for 60 d. Repeated Variance Analyses were conducted to compare the means of different treatments. The results showed that the average cumulative SOC mineralization (Cm) at the 0-5 cm soil depth was 7.09 g CO2 kg-1 soil under NTS, which was higher (P less then 0.05) than that of the other treatments. However, the C mineralizability at both the 0-5 and 5-10 cm soil depths were lower (P less then 0.05) under the NTS (0.16 and 0.15 g CO2 g-1 SOC) compared with the CTS and CT. Non-microbial CO2 emissions (CO2 emissions in sterilized soil) contributed to the lower C mineralizability under NTS, due to the lower mineralizability (0.041-0.089 g CO2 g-1 SOC) of sterilized soil under this treatment. Furthermore, some of the abiotic factors (e.g., C/N ratio and SOC content) significantly correlated with the Cm and C mineralizability. These factors might be critical for the ability to protect SOC under NTS. In summary, conservation tillage is an optimal management due to its protection on SOC, and part of this protection appeared to have been contributed by the soil abiotic factors, which were formed by long-term tillage management.Alum sludge, an Al-oxyhydroxide rich waste product from water treatment practices, has the potential to be valorized as a P adsorbent material. However, several challenges currently prevent its application as an adsorbent in industrial setting, i.e. a limited P adsorption capacity due to saturation by organic matter and a fine nature resulting in percolation problems in adsorption bed setups. In this study, granulation and subsequent calcination of alum sludge were proposed to overcome these issues and to improve the P adsorption properties of alum-based adsorbent (ABA) materials. The effect of calcination temperature on the physicochemical properties of granular material was examined using X-ray diffraction, mass-spectroscopy coupled thermogravimetric analysis, Fourier-transform infrared spectrometry and specific surface area analysis, combined with density and crushing strength measurements. The ABA material obtained at 550 °C showed superior P adsorption properties and, therefore, this material was selected for further P adsorption testing and characterization (scanning electron microscopy and sieving).
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