Notes

Hydroxyurea remedy pertaining to sickle mobile anaemia.
Perceiving the shape of three-dimensional objects is essential for interacting with them in daily life. If objects are constructed from different materials, can the human visual system accurately estimate their three-dimensional shape? We varied the thickness, motion, opacity, and specularity of globally convex objects rendered in a photorealistic environment. These objects were presented under either dynamic or static viewing condition. Observers rated the overall convexity of these objects along the depth axis. Our results show that observers perceived solid transparent objects as flatter than the same objects rendered with opaque reflectance properties. Regional variation in local root-mean-square image contrast was shown to provide information that is predictive of perceived surface convexity.It is well known that the perceived duration for a given time period decreases with the reduction of the number of perceived events. We examined whether target detection failures in viewing Rapid Serial Visual Presentation (RSVP) sequence, caused by attentional blink, affect this reduction of perceived duration. In two experiments, trials consisted of displays of two series of RSVP sequences; in the first sequence (the comparison), two, one, or no numerals were presented as targets embedded within the string of letters, while in the second sequence (the standard), only alphabetic letters were presented. In each trial, participants judged whether the duration of the comparison is perceived as longer than that of the standard (Experiment 1), or whether the number of frames in the comparison is perceived as more than that in the standard (Experiment 2). Results showed that perceived duration was inflated with target detection, but not with the increment of presented frames although number of perceived frames was inflated with both target detection and increment of presented frames. These results suggest that perceived duration in viewing RSVP sequences is determined by the cognitive load necessary to accomplish target detection rather than by the number of perceived frames.This study examined the effect of character sample density on legibility. As the spatial frequency component important for character recognition is said to be 1 to 3 cycles/letter (cpl), six dots in each direction should be sufficient to represent a character; however, some studies have reported that high-density characters are more legible. Considering that these seemingly contradictory findings could be compatible, we analyzed the frequency component of the character stimulus with adjusted sample density and found that the component content of 1 to 3 cpl increased in the high-density character. In the following three psychophysical experiments, high sample density characters tended to have lower contrast thresholds, both for normal and low vision. Furthermore, the contrast threshold with characters of each sample density was predicted from the amplitude of the 1 to 3 cpl component. Thus, while increasing the sample density improves legibility, adding a high frequency is not important in itself. The findings suggest that enhancing the frequency components important for recognizing characters by adding the high-frequency component contributes to making characters more legible.Investigations of the "fat-face" illusion have unanimously agreed that the illusion is face-specific. Here, we offer several manipulations to highlight that the fat-face illusion is not restricted to the bottom image, isn't a property of internal features, facial contour/texture, and in general isn't even specific to faces. We propose the axis of horizontal asymmetry account to contextualize fat-face illusion as a geometry-led illusion.We describe a new illusory speed effect arising in visual events developed by Michotte (1946/1963) in studies of causal perception and, more specifically, within the so-called intentional reaction effect When an Object B is seen intentionally escaping from another Object A, its perceived speed is overestimated. In Experiment 1, we used two-alternative forced choice comparisons to estimate perceived speed scale values for a small square moving either alone or in different contexts known to elicit different impressions of animacy (Parovel et al., 2018). The results showed that B's speed was overestimated only in the condition in which it moved away from another approaching square moving in a nonrigid way, like a caterpillar. In Experiment 2, we psychophysically measured the magnitude of speed overestimation in that condition and tested whether it could be affected by further animacy cues related to the escaping object (the actual velocity of the square) and to the approaching square (its type of motion caterpillar or linear). Results confirmed that B's speed was overestimated up to 10% and that the degree of overestimation was affected by both experimental factors, being greater at higher speeds and when the chasing object moved in an animate fashion. This speed bias might be related to a higher sensitivity of the visual processes to threat-related events such as fighting and chasing, leading to evolutionary adaptive behaviours such as speedy flight from predators, but also empathy and emotion understanding.Sarcopenia is a progressive and generalised disorder of skeletal muscle strength, function and mass, that is most commonly associated with the normal ageing process. It is increasingly recognised that sarcopenia can also develop as a consequence of malabsorptive and inflammatory conditions, such as those seen by gastroenterologists and hepatologists. It affects 1%-30% of the general population, but is seen in approximately 40% of patients with gastrointestinal conditions including inflammatory bowel disease and cirrhosis. Within this group of patients, it is associated with increased complications and mortality. The pathogenesis of sarcopenia is multifactorial with several risk factors implicated in its development including undernutrition, physical inactivity and coexistent multimorbidity. The SARC-F questionnaire has been developed to screen for patients at risk of sarcopenia, however, this focuses on the functional consequences and will therefore not identify those patients who are early in the progression of sarcopenia. There are several different non-invasive techniques available to assess muscle quantity and quality including; grip strength, dual energy X-ray absorptiometry, CT which can be used together to diagnose sarcopenia. Assessment and correction of malnutrition, particularly protein intake, in those at risk of sarcopenia is important in preventing the development and progression of sarcopenia. There are no specific drugs that are available for the treatment of sarcopenia, however, resistance exercise programmes combined with nutritional interventions show promise. It is important that this common condition is screened for and recognised, with any contributing factors addressed to reduce the risk of its progression.
Peripheral cytopaenias and dyspoiesis are common in cirrhosis; however, the prevalence of dyspoiesis and its contribution in cirrhosis-related cytopaenias has not been studied. selleck kinase inhibitor We aimed to study the bone marrow (BM) dyspoiesis and its impact on peripheral blood cell counts and refractory anaemia in patients with cirrhosis.

We reviewed all the BM aspirates and biopsies of cirrhotic cases, done from 2011 to 2018 for clinical indications. Dyspoiesis was considered if >5% of the precursor cells of any of the three lineages showed dyspoietic changes. Primary haematological or non-haematological malignancies, chronic kidney disease, drug intake, acute and chronic hepatitis and granulomatous disease were excluded.

Of 608 these, 82 cases (13.5%) showed dyspoiesis in the BM precursors. There was no difference in age (p=0.16), gender (p=0.58) and spleen size (p=0.35) in cases with or without dyspoiesis. Majority of the cases had dyspoiesis in erythroid series (62, 75.6%) and megakaryocytes (15, 18.2%). Dyspoiesis was more prominent in alcoholics 44 cases (53.6%) and autoimmune diseases 13 cases (15.8%). Erythroid hyperplasia (47.7±14.4 vs 40±11.1; p<0.001) was more in cases with dyserythropoiesis, indicating ineffective erythropoiesis. Patients with dyspoiesis had lower haemoglobin (7.5±1.9 vs 9.3±2.2 g/dL, p<0.001). 54 (8.07%) had refractory anaemia with dyspoiesis present in 48 (88.8%) (p<0.01). Dyspoiesis was independently associated with refractory anaemia when adjusted for age, gender, aetiology and liver disease severity.

BM dyspoiesis, especially dyserythropoiesis, is associated with severe refractory anaemia in patients with cirrhosis and requires new therapeutic approaches.
BM dyspoiesis, especially dyserythropoiesis, is associated with severe refractory anaemia in patients with cirrhosis and requires new therapeutic approaches.
Fatigue is frequently reported in inflammatory bowel disease (IBD) and impacts on health-related quality of life (HRQoL). HRQoL has not been systematically reviewed in IBD fatigue.

To investigate what impact IBD fatigue has on HRQoL in adults with IBD.

Systematic searches (CINAHL, EMBASE, PsychINFO, Medline) were conducted on 25 September 2018, restricted to 'human', 'adult', 'primary research' and 'English language'. Search terms encompassed concepts of 'fatigue', 'IBD' and 'HRQoL'. A 5-year time limit (2013-2018) was set to include the most relevant publications. Publications were screened, data extracted and quality appraised by two authors. A narrative synthesis was conducted.

Eleven studies were included, presenting data from 2823 participants. Fatigue experiences were significantly related to three HRQoL areas symptom acceptance, psychosocial well-being and physical activity. Patients reporting high fatigue levels had low symptom acceptance. Psychosocial factors were strongly associated with both fatigue and HRQoL. Higher social support levels were associated with higher HRQoL. Physical activity was impaired by higher fatigue levels, lowering HRQoL, but it was also used as a means of reducing fatigue and improving HRQoL. Quality appraisal revealed methodological shortcomings in a number of studies. Notably, use of multiple measures, comparison without statistical adjustment and fatigue and HRQoL assessment using the same tool were some of the methodological shortcomings.

Psychosocial factors, symptom management and acceptance and physical activity levels have significant impact on HRQoL. Results support application of psychosocial or exercise interventions for fatigue management. Further exploration of HRQoL factors in IBD fatigue is required, using validated fatigue and HRQoL measures.

CRD42018110005.
CRD42018110005.
Gabapentin is recommended for the treatment of chronic refractory cough (CRC). This study aims to identify its therapeutic predictors in a prospective clinical study.

A total of 179 patients with CRC were treated with gabapentin. Prior to the therapy, all patients were assessed by Hull Airway Reflux Questionnaire (HARQ) and inhaled capsaicin challenge. When the treatment ended and cough resolution was confirmed, a stepwise logistic regression analysis was performed to identify the therapeutic predictors for gabapentin and to establish the prediction equation.

Gabapentin treatment achieved a therapeutic success rate of 66.48%. HARQ scores were significantly higher in responders than non-responders to gabapentin (29.79 ± 9.58
21.95 ± 7.83,
 = -3.685,
 <0.001), which were positively related to the therapeutic efficacy of gabapentin (
 = 0.433,
 <0.001). The optimal cutoff point of 21.50 in HARQ presented with a moderate ability to predict gabapentin efficacy, with a sensitivity of 84.60% and specificity of 63.
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