Notes

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42021155658.
CRD42021155658.
Neuropathic pain is a common disorder of the somatosensory system that affects 7%-10% of the general population. The disorder places a large social and economic burden on patients as well as healthcare services. However, not everyone with a relevant underlying aetiology develops corresponding pain. DOLORisk Dundee, a European Union-funded cohort, part of the multicentre DOLORisk consortium, was set up to increase current understanding of this variation in onset. In particular, the cohort will allow exploration of psychosocial, clinical and genetic predictors of neuropathic pain onset.

DOLORisk Dundee has been constructed by rephenotyping two pre-existing Scottish population cohorts for neuropathic pain using a standardised 'core' study protocol Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) (n=5236) consisting of predominantly type 2 diabetics from the Tayside region, and Generation Scotland Scottish Family Health Study (GSSFHS; n=20 221). Rephenotyping was conducted in two phases aiobank.
The cohort is being maintained by an access committee, through which collaborations are encouraged. Details of how to do this will be available on the study website (http//dolorisk.eu/). SAR 245509 Further follow-up surveys of the cohort are planned and funding applications are being prepared to this effect. This will be conducted in harmony with similar pain rephenotyping of UK Biobank.
Ambulatory care sensitive (ACS) conditions are those for which intensified primary care management could potentially prevent emergency admissions. This study aimed to quantify geographical variation in emergency admissions with ACS conditions in older adults and explore factors influencing variation.

Repeated cross-sectional study.

34 public hospitals in the Ireland.

Adults aged ≥65 years hospitalised for seven ACS conditions between 2012 and 2016 (chronic obstructive pulmonary disease, congestive heart failure (CHF), diabetes, angina, pyelonephritis/urinary tract infections (UTIs), dehydration and pneumonia).

Age and sex standardised emergency admission rates (SARs) per 1000 older adults.

Age and sex SARs were calculated for 21 geographical areas. Extremal quotients and systematic components of variance (SCV) quantified variation. Spatial regression analyses was conducted for SARs with unemployment, urban population proportion, hospital turnover, supply of general practitioners (GPs), and supply of hospital-based specialists as explanatory variables.

Over time, an increase in UTI/pyelonephritis SARs was seen while SARs for angina and CHF decreased. Geographic variation was moderate overall and high for dehydration and angina (SCV=11.7-50.0). For all conditions combined, multivariable analysis showed lower urban population (adjusted coefficient -2.2 (-3.4 to -0.9, p<0.01)), lower GP supply (adjusted coefficient -5.5 (-8.2 to -2.9, p<0.01)) and higher geriatrician supply (adjusted coefficient 3.7 (0.5 to 6.9, p=0.02)) were associated with higher SARs.

Future research should evaluate methods of preventing admissions for ACS conditions among older adults, including how resources are allocated at a local level.
Future research should evaluate methods of preventing admissions for ACS conditions among older adults, including how resources are allocated at a local level.
There is currently no defined method for assessing injury severity using population-based data, which limits our understanding of the burden of non-fatal injuries and community-based approaches for primary prevention of injuries. This study describes a systematic approach, Population-based Injury Severity Assessment (PISA) index, for assessing injury severity at the population level.

Based on the WHO International Classification of Functionality conceptual model on health and disability, eight indicators for assessing injury severity were defined. The eight indicators assessed anatomical, physiological, postinjury immobility, hospitalisation, surgical treatment, disability, duration of assisted living and days lost from work or school. Using a large population-based survey conducted in 2013 including 1.16 million individuals from seven subdistricts of rural Bangladesh, information on the eight indicators were derived for all non-fatal injury events, and these were summarised into a single injury severity level, and is relevant for improving the characterisation of the burden and epidemiology of injuries in non-health facility-based settings. Additional testing of the PISA index is needed to further establish its validity and reliability.
The PISA index provides a valid and systematic approach for assessing injury severity at the population level, and is relevant for improving the characterisation of the burden and epidemiology of injuries in non-health facility-based settings. Additional testing of the PISA index is needed to further establish its validity and reliability.
To investigate the long-term risk of developing hypertension and cardiovascular disease (CVD) among those women who suffered a postpartum haemorrhage (PPH) compared with those women who did not.

Population-based longitudinal open cohort study.

English primary care (The Health Improvement Network (THIN)) and secondary care (Hospital Episode Statistics (HES)) databases.

Women exposed to PPH during the study period matched for age and date of delivery, and unexposed.

We conducted an open cohort study using linked primary care THIN and HES Databases, from 1 January 1997 to 31 January 2018. A total of 42 327 women were included 14 109 of them exposed to PPH during the study period and 28 218 matched for age and date of delivery, and unexposed to PPH. HRs for cardiovascular outcomes among women who had and did not have PPH were estimated after controlling for covariates using multivariate Cox regression models.

Risk of hypertensive disease, ischaemic heart disease, heart failure, stroke or transient ischaemic attack.

During a median follow-up of over 4 years, there was no significant difference in the risk of hypertensive disease after adjustment for covariates (adjusted HR (aHR) 1.03 (95% CI 0.87 to 1.22); p=0.71). We also did not observe a statistically significant difference in the risk of composite CVD (ischaemic heart disease, heart failure, stroke or transient ischaemic attack) between the exposed and the unexposed cohort (aHR 0.86 (95% CI 0.52 to 1.43; p=0.57).

Over a median follow-up of 4 years, we did not observe an association between PPH and hypertension or CVD.
Over a median follow-up of 4 years, we did not observe an association between PPH and hypertension or CVD.
To assess the prevalence of hypertension, impaired fasting capillary glucose (IFCG) and coexistence of both as well as determinants of these conditions among rural adolescents.

A retrospective cross-sectional population-based study.

Three rural communities in southeast Nigeria.

A total of 401 adolescents (10 - 19 years) selected through a five-stage sampling technique completed the study. Sick adolescents, pregnant and nursing adolescent mothers were excluded.

Prevalence and determinants of hypertension, IFCG and comorbidity of both were assessed through weight, height, blood pressure, fasting capillary glucose measurements and statistical analysis.

Prehypertension (10.7%), hypertension alone (12.7%), IFCG alone (11.0%), diabetes (0.2%) and hypertension with IFCG (6.2%) were prevalent among the adolescents. The adolescents aged 15 - 19 years were less likely to be affected by hypertension alone (adjusted OR (AOR)=0.36, 95% CI 0.18 to 0.74, p<0.01). The likelihood of having hypertension alone waological characteristics that can become focus of interventions to curtail the emergence of cardiovascular events at an early age. Awareness creation through health and nutrition education is emphasised.
This study reported relatively low prevalence of hypertension alone, IFCG alone, hypertension with IFCG and epidemiological characteristics that can become focus of interventions to curtail the emergence of cardiovascular events at an early age. Awareness creation through health and nutrition education is emphasised.
There are multiple instruments for measuring multimorbidity. The main objective of this systematic review was to provide a list of instruments that are suitable for use in studies aiming to measure the association of a specific outcome with different levels of multimorbidity as the main independent variable in community-dwelling individuals. The secondary objective was to provide details of the requirements, strengths and limitations of these instruments, and the chosen outcomes.

We conducted the review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration number CRD42018105297). We searched MEDLINE, Embase and CINAHL electronic databases published in English and manually searched the
between 1 January 2010 and 23 October 2020 inclusive. Studies also had to select adult patients from primary care or general population and had at least one specified outcome variable. Two authors screened the titles, abstracts and full texts independently. Dtcome.
We listed the details of 33 instruments for measuring the level of multimorbidity as a resource for investigators interested in the measurement of multimorbidity for its association with or prediction of a specific outcome.
To improve our understanding of how television (TV) time is linked to cardiometabolic health among adults by systematically and critically evaluating the evidence that watching TV is associated with increased food consumption, lack of movement or negative affect or affects subsequent sleep.

Systematic review.

Web of Science and PubMed.

Studies that provided quantitative evidence on short-term associations of watching TV with dietary intake, characteristics of sitting, affect and sleep among samples of healthy adults (≥18 years old).

Study quality was assessed using the National Heart, Lung, and Blood Institute Quality Assessment Tools; studies deemed to be of low quality were excluded from the review. Due to heterogeneity of study designs and measurements, the findings were synthesised using narrative summary accompanied by custom plots.

We identified 31 studies that met the inclusion criteria. Most of the associations reported by the studies included in this review were weak or inconsistent. Thererstand how TV fits within everyday lives and relates to eating, sitting, affect and sleep to improve our understanding of how it might impact cardiometabolic health.
To evaluate the long-term (psychosomatic) health consequences of man-made earthquakes compared with a non-exposure control group. Exposure was hypothesised to have an increasingly negative impact on health outcomes over time.

Large-scale gas extraction in the Netherlands causing earthquakes and considerable damage.

A representative sample of inhabitants randomly selected from municipal population records; contacted 5 times during 21 months (T1 N=3934; T5 N=2150; mean age 56.54; 50% men; at T5, N=846 (39.3%) had no, 459 (21.3%) once and 736 (34.2%) repeated damages).

(Psychosomatic) health outcomes self-rated health and Mental Health Inventory (both validated; Short Form Health Survey); stress related health symptoms (shortened version of previously validated symptoms list). Independent variable exposure to the consequences of earthquakes assessed via physical (peak ground acceleration) and personal exposure (damage to housing none, once, repeated).

Exposure to induced earthquakes has negative health consequences especially for those whose homes were damaged repeatedly.
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