Notes

Modulation involving Brain-Derived Neurotrophic Factor (BDNF) Signaling Path through Culinary arts Sage (Salvia officinalis T.).
ct with the jail's private correctional health care company in 2018-a strategy that can be replicated.
Correctional settings (prisons, jails, detention facilities) provide a unique opportunity to screen for sexually transmitted infections (STIs) among correctional populations with a high prevalence of infection. Immigrant detainees are a distinct and poorly described correctional population. The main objective of this study was to determine the feasibility of a national STI screening program for immigrant detainees.

We developed an opt-out STI testing program that included electronic health record integration, patient education, and staff member training. We piloted this program from June 22 through August 19, 2018, at 2 detention facilities with different operational requirements and detainee demographic characteristics. We assessed STI test positivity rates, treatment outcomes, estimated cost to conduct testing and counseling, and staff member perceptions of program value and challenges to implementation.

Of 1041 immigrant detainees approached for testing, 526 (50.5%) declined. Of 494 detainees who were tested, 42 (8.5%) tested positive for at least 1 STI; the percentage positivity rates were 6.7% (n = 33) for chlamydia, 0.8% (n = 4) for syphilis, 0.8% (n = 4) for gonorrhea, 0.6% (n = 3) for hepatitis B, and 0.2% (n = 1) for HIV. The estimated cost to detect any STI ranged from $500 to $961; the estimated cost to identify 1 person infected with HIV ranged from $22 497 to $43 244. Forty of 42 persons who tested positive began treatment before release from custody. 1-NM-PP1 Medical staff members had positive views of the program but had concerns about workload.

STIs are prevalent among immigrant detainees. A routine screening program is feasible if operational aspects are carefully considered and would provide counseling, education, and treatment for this vulnerable population.
STIs are prevalent among immigrant detainees. A routine screening program is feasible if operational aspects are carefully considered and would provide counseling, education, and treatment for this vulnerable population.
Federal funds have been spent to reduce the disproportionate effects of HIV/AIDS on racial/ethnic minority groups in the United States. We investigated the association between federal domestic HIV funding and age-adjusted HIV death rates by race/ethnicity in the United States during 1999-2017.

We analyzed HIV funding data from the Kaiser Family Foundation by federal fiscal year (FFY) and US age-adjusted death rates (AADRs) by race/ethnicity (Hispanic, non-Hispanic white, non-Hispanic black, and Asian/Pacific Islander and American Indian/Alaska Native [API+AI/AN]) from Centers for Disease Control and Prevention WONDER detailed mortality files. We fit joinpoint regression models to estimate the annual percentage change (APC), average APC, and changes in AADRs per billion US dollars in HIV funding, with 95% confidence intervals (CIs). For 19 data points, the number of joinpoints ranged from 0 to 4 on the basis of rules set by the program or by the user. A Monte Carlo permutation test indicated significant (
n-Hispanic black residents than for residents in other racial/ethnic groups. Increasing US HIV funding could be associated with decreasing future racial/ethnic disparities in the rate of HIV-related deaths.Policies facilitating integration of public health programs can improve the public health response, but the literature on approaches to integration across multiple system levels is limited. We describe the efforts of the Massachusetts Department of Public Health to integrate its HIV, viral hepatitis, sexually transmitted infection (STI), and tuberculosis response through policies that mandated contracted organizations to submit specimens for testing to the Massachusetts State Public Health Laboratory; co-test blood specimens for HIV, hepatitis C virus (HCV), and syphilis; integrate HIV, viral hepatitis, and STI disease surveillance and case management in a single data system; and implement an integrated infectious disease drug assistance program. From 2014 through 2018, the number of tests performed by the Massachusetts State Public Health Laboratory increased from 16 321 to 33 674 for HIV, from 11 054 to 33 670 for HCV, and from 19 169 to 30 830 for syphilis. Service contracts enabled rapid response to outbreaks of HIV, hepatitis A, and hepatitis B. Key challenges included lack of a billing infrastructure at the Massachusetts State Public Health Laboratory; the need to complete negotiations with insurers and to establish a retained revenue account to receive health insurance reimbursements for testing services; and time to train testing providers in phlebotomy for required testing. Investing in laboratory infrastructure; creating billing mechanisms to maximize health insurance reimbursement; proactively engaging providers, community members, and other stakeholders; and building capacity to transform practices are needed. Using multilevel policy approaches to integrate the public health response to HIV, STI, viral hepatitis, and tuberculosis is feasible and adaptable to other public health programs.
Agriculture is one of the most hazardous jobs in terms of occupational illness, especially musculoskeletal disorders (MSDs). This paper is a cross-sectional study designed to identify agricultural risk factors related to MSDs among older farmers.

A convenience sampling method was used to select 481 older farmers from the Nong Suea district in Pathum Thani province. A three-part questionnaire generated data that included demographics, work conditions, and environment, and self-reported MSDs. Multiple logistic regression analysis was used to identify the risk factors for MSDs.

The results indicated the prevalence of musculoskeletal symptoms in the past 7days and 12months were 87.9% and 88.9%, respectively. The three body parts with highest prevalence rates of MSDs were lower extremities (65.4%), lower back (42.6%), and shoulders (29.9%). Factors significantly associated with reporting MSDs during the past 12months (
<.05) were women (adjusted odds ratio=2.52 95% CI; 1.19-5.36), using agricultural tools (adjusted odds ratio=4.40 95% CI; 1.18-13.79), prolonged static postures (adjusted odds ratio=3.81 95% CI; 1.05-13.82), and lifting >10 kg (adjusted odds ratio=2.87 95% CI; 1.22-6.82).

Study results revealed older farmers had high prevalence of MSDs and various related risk factors. Occupational ergonomic issues for promoting safety awareness of agricultural risk factors among elderly farmers should be considered.
Study results revealed older farmers had high prevalence of MSDs and various related risk factors. Occupational ergonomic issues for promoting safety awareness of agricultural risk factors among elderly farmers should be considered.
Recent legal changes mean Canadian cannabis production has moved from an illegally grown crop to a potentially common one. However, little is known about the needs of long-time producers accustomed to operating outside a legal framework. In order to develop effective safety communication strategies, there is a need to better understand cannabis producers' perceptions of OHS regulations, OHS controls, and sources of OHS information.

The specific objectives of this study are to (1) Describe production tasks and identify potential hazards related to these tasks and (2) describe workers' current sources of OHS information. This study gathered two types of information facility and production information gathered from key informants during three facility walkthroughs, and health and safety perceptions gathered during face to face interviews with nine cannabis production workers. Interviews were thematically analyzed using interpretive description.

Cannabis production and related occupational health and safety issues occur within a larger context, and descriptions of contextual factors were interwoven with workers' responses which, on the whole, expressed positive views of occupational health and safety. Perceived barriers to OHS included cost, lack of specialized skills, and lack of worker consultation, while named sources of OHS information included courses, requests to OHS agencies, and the internet.

It is hoped that an enhanced understanding of Canadian cannabis producers can inform the development of effective occupational health and safety interventions to promote the health and productivity in this workforce.
It is hoped that an enhanced understanding of Canadian cannabis producers can inform the development of effective occupational health and safety interventions to promote the health and productivity in this workforce.
We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years.

Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2, stable knee OA that showed no progression; group 3, knee OA that had progressed over 6 years. Demographic hip and knee measurement factors were compared the three groups.

Women, age, body mass index (BMI), abductor angle of the hip, and mechanical-axis deviation were higher in group 2 than in group 1. BMI, the mechanical axis deviation were higher in group 3 than in group 1. Femoral offset was lower in group 3 than in groups 1 and 2. Men, age, condylar-hip angle, plateau-ankle angle were higher in group 2 than in group 1. Age, BMI were higher in group 3 than in groups 1. Condylar-hip and plateau-ankle angles were lower in group 3 than in group 2.

Strategies aimed at strengthening the muscles around the hip, changes in lifestyle should be implemented, especially in patients with changes in geometric indices of the hip and knee.
Strategies aimed at strengthening the muscles around the hip, changes in lifestyle should be implemented, especially in patients with changes in geometric indices of the hip and knee.Background Lentinan (LNT), an isolated traditional Chinese herbal component, has antitumor potential. In the current study, the intrinsic mechanism of LNT-induced immunity against bladder cancer was explored in a mouse model. Methods In the mouse model of bladder cancer, we used flow cytometry to detect the LNT caused population changes of T cells, macrophages, MDSC cells, and Treg cells. ELISA was used to evaluate cytokines expression in the supernatant of splenocytes. Results We found that the administration of LNT increased the proportions of CD3+CD4+ and CD3+CD8+ T cell subsets as well as CD11b+F480+ macrophages, whereas it diminished the subpopulations of CD4+CD25+Foxp3+ regulatory T cells (Tregs) and Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs). LNT also upregulated the expression of interferon (IFN)-γ and interleukin (IL)-12, accompanied by a significant reduction in IL-10 and tumor growth factor (TGF)-β (P  less then  .05). Our research further confirmed the synergy between LNT and gemcitabine (GEM) to activate immunity and inhibit the growth of bladder tumors in mouse model. Conclusions LNT induced macrophage activation, followed by the enhanced proliferation of CD4+ and CD8+ T cells, and the upregulated expression of IFN-γ and IL-2. Meanwhile, the proportions of MDSCs and Tregs were downregulated, leading to a reduced expression of the anti-inflammatory cytokines IL-10 and TGF-β. The synergy between LNT and GEM provides additional evidence supporting the application of this traditional Chinese herbal component for bladder cancer therapy.
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