Notes

A clear case of ovarian serous cystadenofibroma together with scattered wounds in pelvic cavity, similar to cancerous disseminations.
Chemotrophic microorganisms gain energy for cellular functions by catalyzing oxidation-reduction (redox) reactions that are out of equilibrium. Calculations of the Gibbs energy ( ΔG r ) can identify whether a reaction is thermodynamically favourable and quantify the accompanying energy yield at the temperature, pressure and chemical composition in the system of interest. Based on carefully calculated values of ΔG r , we predict a novel microbial metabolism - sulfur comproportionation (3H2 S + SO 4 2 - + 2H+ ⇌ 4S0 + 4H2 O). We show that at elevated concentrations of sulfide and sulfate in acidic environments over a broad temperature range, this putative metabolism can be exergonic ( ΔG r less then 0), yielding ~30-50 kJ mol-1 . Selleckchem AMG510 We suggest that this may be sufficient energy to support a chemolithotrophic metabolism currently missing from the literature. Other versions of this metabolism, comproportionation to thiosulfate (H2 S + SO 4 2 - ⇌ S 2 O 3 2 - + H2 O) and to sulfite (H2 S + 3 SO 4 2 - ⇌ 4 SO 3 2 - + 2H+ ), are only moderately exergonic or endergonic even at ideal geochemical conditions. Natural and impacted environments, including sulfidic karst systems, shallow-sea hydrothermal vents, sites of acid mine drainage, and acid-sulfate crater lakes, may be ideal hunting grounds for finding microbial sulfur comproportionators. © 2020 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd.BACKGROUND Relative contraindications to adenosine use have included heart transplant and dipyridamole. We previously demonstrated the safety and efficacy of adenosine-induced atrioventricular (AV) block in healthy young heart transplant recipients while suspending dipyridamole therapy (dual antiplatelet agent). This prospective follow-up study evaluated the safety and efficacy of adenosine use in the same cohort of heart transplant recipients while on dipyridamole. METHODS Adenosine was incrementally dosed until AV block occurred (maximum 200 mcg/kg up to 12 mg). The primary outcome was clinically significant asystole (≥12 seconds). Secondary outcomes included maximal adenosine dose, AV block duration, dysrhythmias, and clinical symptoms. Outcomes were compared to the parent study. RESULTS Thirty of 39 eligible patients (5-24 years) were tested. No patient (0%, CI 0%-8%) experienced clinically significant asystole. AV block occurred in 29/30 patients (97%, CI 86%-100%). The median dose causing AV block was 50mcg/kg (vs 100 mcg/kg off dipyridamole; P = .011). Seventeen patients (57%, CI 39%-72%) required less adenosine to achieve AV block on dipyridamole; six (20%) required more. AV block occurred at doses ≥25 mcg/kg in all patients. In pairwise comparison to prior testing off dipyridamole, no significant change occurred in AV block duration, frequency of cardiac ectopy, or incidence of reported symptoms. No atrial fibrillation/flutter occurred. CONCLUSIONS AV block often occurs at twofold lower adenosine doses in healthy young heart transplant recipients taking oral dipyridamole, compared with previous testing of this cohort off dipyridamole. Results suggest that initial dosing of 25 mcg/kg (maximum 0.8 mg) with stepwise escalation poses low risk of prolonged asystole on dipyridamole. © 2020 Wiley Periodicals, Inc.It is of utmost importance to examine the consequences of healthcare teams' daily exposure to stress. This quantitative cross-sectional study examined the connection between exposure, secondary traumatization (stress deriving from helping suffering others), and personal growth. It compared the teams in maternity and neonatal wards with colleagues exposed to different levels of illness and death; and examined the contribution of social support and self-differentiation to personal growth. 149 Israeli physicians and nurses participated, comprising three groups (maternity and neonatal wards, exposed to suffering as well as to new life; high; and moderate-to-low exposure to illness and death). Data was collected through an online program (64.78% response rate). Whereas no group differences in secondary traumatization were found, personal growth was higher among individuals from maternity and neonatal wards. Moreover, the higher the social support and self-differentiation, the higher the personal growth. The findings highlight the necessity to design interventions to empower social support and investing in its development on both the organizational and personal level, especially for the maternity and neonatal wards' healthcare teams. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Fungal denitrification is claimed to produce non-negligible amounts of N2 O in soils, but few tested species have shown significant activity. We hypothesized that denitrifying fungi would be found among those with assimilatory nitrate reductase, and tested 20 such batch cultures for their respiratory metabolism, including two positive controls, Fusarium oxysporum and Fusarium lichenicola, throughout the transition from oxic to anoxic conditions in media supplemented with NO 2 - . Enzymatic reduction of NO 2 - (NIR) and NO (NOR) was assessed by correcting measured NO- and N2 O-kinetics for abiotic NO- and N2 O-production (sterile controls). Significant anaerobic respiration was only confirmed for the positive controls and for two of three Fusarium solani cultures. The NO kinetics in six cultures showed NIR but not NOR activity, observed through the accumulation of NO. Others had NOR but not NIR activity, thus reducing abiotically produced NO to N2 O. The presence of candidate genes (nirK and p450nor) was confirmed in the positive controls, but not in some of the NO or N2 O accumulating cultures. Based on our results, we conclude that only the Fusarium cultures were able to sustain anaerobic respiration and produced low amounts of N2 O as a response to an abiotic NO production from the medium. © 2020 Society for Applied Microbiology and John Wiley & Sons Ltd.N-C axially chiral compounds have emerged recently as appealing motifs for drug design. However, enantioselective synthesis of such molecules is still poorly developed and surprisingly no metal-catalyzed atroposelective N-arylation have been described. Herein we disclose an unprecedented Cu-catalyzed atroposelective N-C coupling, occurring at room temperature. Such mild reaction conditions, crucial parameter to warrant atropostability of the newly generated products may be reached thank to the use of hypervalent iodines as highly reactive coupling partner. A large panel of the N-C axially chiral compounds is hence afforded in very high enantioselectivities (up to > 99% ee) and good yields (up to 76%). Post-modifications of thus accessed atropisomeric compounds allows further expanding the diversity of these appealing compounds. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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