Notes

Connection of TP53 Change using Tissues Uniqueness as well as Affected person Upshot of IDH1-Mutant Glioma.
.. The clinical picture of acute poisoning, the features of its course, the data of radiological diagnostics and the effectiveness of pathogenetic approaches to intensive therapy are presented.The aim of this study was to determine the CK activity and its association with the length of hospital stay in acutely intoxicated patients with psychotropic and chemical substances. Rhabdomyolysis is defined as a creatine kinase (CK) > 250 U/L. We included adult patients ≥ 18 years of age, with rhabdomyolysis acutely intoxicated with psychotropic and chemical substances in the first 48 hours. We excluded patients with rhabdomyolysis in muscle trauma as a result of a traumatic accident, myocardial infarction, cerebral vascular infarction, cerebral hemorrhage, and chronic hepatic and renal disease. In all patients with rhabdomyolysis, the mean CK on the first, third and fifth day was consequently 5715.9±16088.8 U/L with a maximum value of 129077 U/L vs. 5548.5±9851.5 U/L with a maximum value of 63947U/L vs. 2970.42±7161.68 U/L with a maximum value of 53672 U/L. The comparison for the whole sample in the three measurement times, for p less then 0.05, showed a significant difference (Friedman Test N = 62; Chi-Square = 34.935; df = 2; p = 0.00001). For the whole sample of patients with rhabdomyolysis, as well as in the group of psychotropic intoxications, for p less then 0.05, the level of CK on the first day was confirmed as an independent predictor that significantly affected the variability of the length of hospitalization by 5.2% (R2 = 0.052) vs. 20% (R2=0.200). In rhabdomyolysis, as a result of acute intoxication with psychotropic and chemical substances it is important to examine the creatine kinase. Creatine kinase levels were higher in rhabdomyolysis in acutely intoxicated patients with psychoactive compared to chemical substances. In the group intoxicated with psychoactive substances creatine kinase as an independent predictor significantly affected the length of hospitalization.The aim of the work is to investigate the clinical symptoms of thrombotic complications (TC) and the tendency of patients to increased thromb-formation in patients with beta-thalassemia (β-T). Female patients with β-T aged 18-40 years were studied 130 beta-thalassemia major (β-TM), 95 patients beta-thalassemia intermediate (β-TI), 60 patients with beta-thalassemia minor (β-Tm). In patients with βT, the frequency of occurrence of TC was studied. In patients with βT who do not have TC and splenectomy, hemostasis parameters were studied; and also the risk factors were analyzed for the development of latent hypercoagulation. Conducted questionnaire included questions about the tendency to increased thrombosis (TIT), about various clinical signs, symptoms, extended medical history data. Clinical manifestations of TC (arterial and venous thrombosis, chronic venous insufficiency) were detected in 10.0±2.6% of patients with β-TM and 14.7±3.6% of patients with βTI; TC occurred more frequently in splenectomy patients con-splenectomized β-T patients.Vaccination has been the most powerful tool to fight the COVID-19 pandemic while the specific treatment options in clinical practice have been under review for approval and authorization by regulatory bodies. After registration of different vaccines, it is important to ensure a post-marketing surveillance to identify potential risks not observed in controlled trials. Authors report on the case of an 80-year-old male patient who developed severe leukocytoclastic vasculitis of skin and oral mucous membrane after receiving the second dose of COVID-19 mRNA vaccine. He was treated successfully with prednisolone. We also provide a literature review on other reported cases of COVID-19 vaccine induced vasculitis. This type of an adverse reaction seems to be rare. Fortunately, most cases were temporary and well controlled by corticosteroids. The majority of vaccine-associated vasculitis cases have been observed in association with BONT162b2 mRNA vaccine although other vaccines also may cause the event. The knowledge of this possible adverse event is important for early diagnosis and intervention.Objective - to establish the pathomorphological features of liver and lung tissue of patients with non-alcoholic steatohepatitis (NASH) and obesity depending on comorbidity with chronic obstructive pulmonary disease (COPD). The study used autopsy material of 13 cases of NASH and class I obesity (Group 1), 14 cases of NASH, class I obesity with comorbid COPD of stage II-III (Group 2). For comparison, we used the autopsy material of 12 patients with isolated COPD of stage II-III (Group 3), as well as 11 practically healthy individuals (PHI), whose death was caused by polytrauma or traumatic brain injury or sudden coronary death. The groups were randomized by age, sex, and class of obesity. The average age of patients was 59.3±3.21. In Group 2 there was a maximum percentage of hepatocytes in the state of steatosis (1.9 times more than in Group 1, p less then 0.05), 1.6 times more hepatocytes in the state of fatty necrosis compared with NASH, p less then 0.05), oncosis (2.1 times, p less then 0.05), as well as lipofuscinosis (3.1 times more than in case of NASH with obesity, p less then 0.05). The combined course of obesity, NASH and COPD contributed to a significant increase in the number of lipocytes in the lungs (29.6 times, p less then 0.05) compared with isolated COPD, as well as a probable increase in their diameter (1.8 times, p less then 0.05). In the comorbid course of NASH, obesity and COPD, more intense histological and histochemical changes were observed, indicating more significant dysmetabolic disorders and the role of COPD in the activity of the inflammatory process in the liver, namely a higher % of steatosis in hepatocytes. Accumulation of adipocytes was observed in the lungs in this combined pathology, which probably indicates the aggravating effect of NASH and obesity on the course of COPD.Aim - to assess the DNA damage of lymphocytes before and after the use of Metformin in obese individuals by two indicators the diameter and the number of DNA breaks in blood lymphocytes. The sample included 27 obese patients aged 18-61 years. Among the participants, persons with chronic decompensated diseases, with bad habits (smokers, drug users, alcohol) were excluded. In order to study the dynamics of blood lymphocyte DNA breaks, patients were prescribed Metformin (Acino) at a daily dose of 850 mg/day for 3 months. DNA damage analysis was performed by assessing foci of phosphorylated histone protein HAX (γ-H2AX) on blood lymphocytes (AKLIDES, Nuk Human Lymphocyte Complete, Medipan, Blankenfelde-Mahlow, Germany). With the appointment of Metformin, the diameter of the ruptures changed and amounted to 0.45±0.23 before treatment, and 0.44±0.27 after treatment, but no statistically significant differences were found. When evaluating the dynamics, a significant decrease in the indicator was revealed, and it amounted to 2.60% (p less then 0.0001; z=9.97). Before treatment, the value of the indicator "Mean number of ruptures per 1 cell" was 0.57±1.32, after the appointment of Metformin it decreased to 0.27±0.56, but the differences are insignificant and after treatment, there is a decrease in the indicator by 52.18% (p less then 0.0001; z=9.97). The use of metformin 850 mg/day for 3 months in obesity leads to a decrease in the diameter of cell ruptures and the average number of γ-H2AX foci per cell of serum lymphocyte DNA, which may affect the reduction in the risk of oncopathology. Further research is needed to determine the protective mechanisms of Metformin against genomic instability, especially in relation to DNA damage reactions and epigenetic changes.Determining the influence of body composition on stress resistance, endothelial function and wellness and as a function of daily physical activity level and gender is of great medical-preventive importance․ The aim of this study was to analyse the influence of body composition on the stress resistance, endothelial function and wellness in different physical activity groups. A cross-sectional study was conducted with 2000 participants (829 men and 1171 women) aged 10-90 years. The Multiscan BS_OXI instrument was applied to measure the integral indicators․ For the study, statistical analysis was performed using Primer of Biostatistics version 4.03 by Stanton A. Glantz. Data analysis showed (i) in the high physical activity group there was a significantly weak correlation between body composition and stress resistance in male (Rxy=0.24, p=0.000) and female (Rxy=0.28, p=0.0000) groups. In the case of low physical activity, a reliable weak correlation was registered only in the male group (ii) in the low physical should also focus on disease prevention.There is a paucity of data on the occurrence of fibromyalgia (FM) in chronic obstructive pulmonary disease (COPD). The objective of this study was to determine the frequency of fibromyalgia in a group of patients with COPD in Mosul, as well as characterization of the features of COPD patients with concomitant FM. Participants included seventy COPD-patients plus se-venty controls. The "2011 modification of the 2010 American College of Rheumatology's preliminary diagnostic criteria for fibromyalgia" was employed to make the diagnosis of FM. The demographic features and COPD data of the patients were documented. Pulmonary function tests and Chest-X-ray were evaluated for all patients. FM was present in 16 (22.9%) of 70 COPD patients, and only in 4 (5.7%) of the 70 controls, and the difference was significant. FM was found in 58.33% of female COPD patients compared to 15.52% of male COPD patients (p=0.004). There was no statistically significant difference in COPD patients with and without FM in respect to their age or BMI. SNX-5422 solubility dmso However, patients with FM tended to have a longer duration of COPD (8.06±2.69 vs. 4.78±2.13, P value less then 0.001), and higher scores on the Beck Depression Inventory (BDI) (20.7±9.200 vs. 14.8±7.900, P value=0.0139), and greater COPD severity (P less then 0.001). The frequency of FM in patients with COPD was higher than control. FM is more likely to occur in female patients. Patients with comorbid FM and COPD tended to report more depressive symptoms, have longer disease duration, and higher disease severity.Accumulating evidence showed that chronic inflammation is a risk factor for increased cardiovascular mortality in the population with Kidney Failure (KF) remaining on Kidney Replacement Therapy (KRT). The gut microbiome is altered in patients with Chronic Kidney Disease (CKD) and is one of the major sources of chronic inflammation. Uremic gut microbiome may have serious effects on patients' quality of life (QoL) and, especially, on their psychological, social, and economic prosperity. Factors that influence health-related quality of life (HRQOL) in patients with ESRD have received little attention. Aim - this study aimed to investigate changes of QOL in HD patients by the correction of intestinal microflora. The sample study consisted of 33 HD patients (age 18-75) from "The clinical center for development of nephrology". Data was collected through the completion of a specially designed questionnaire. For assessment of Qo was used the "Missoula VITAS Quality of life index. Fecal samples were analyzed before and after treatment with probiotics.
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