Notes

Flu vaccination protection amongst crisis department workers is a member of perception of vaccine as well as unwanted effects, vaccination availability on location along with the COVID-19 pandemic.
Potential new techniques that target epigenetic processes and chromatin regulation provide opportunities for human cancer modeling and clinical applications of regenerative medicine.Background Dentin hypersensitivity (DH) is a condition characterized by short and sharp episodes of pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort in patients and reduce their quality of life. Recently, the novel zinc-containing desensitizer CAREDYNE Shield has been developed as a new type of desensitizer that acts by inducing chemical occlusion of dentinal tubules, and releasing zinc ion for root caries prevention. However, the clinical effectiveness of CAREDYNE Shield on DH remains unclear. Therefore, the aim of this study is to evaluate the effectiveness of CAREDYNE Shield on DH by comparing with that of another desensitizer, Nanoseal, commonly used in Japan. Methods/design This study protocol is a two-arm, parallel, pilot randomized controlled trial. Forty DH patients will be randomly allocated to two groups. Participants in the intervention group will be treated with CAREDYNE Shield, while those in the control group w020 (Hanke, Am Dent Assoc 271379-1393, 1940).Background The differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts (OBs) is a prerequisite for bone formation. However, little is known about the definitive surface markers for OBs during osteogenesis. Methods To study the surface markers on OBs, we generated and used monoclonal antibodies (MAbs) against surface molecules on transforming growth factor-β1 (TGF-β1)-treated cancer cells. The generated MAbs were further selected toward expression changes on hMSCs cultured with TGF-β1/bone morphogenetic protein-2 (BMP-2) or osteogenic differentiation medium (ODM) by flow cytometry. Immunoprecipitation and mass spectrometry were performed to identify target antigens of selected MAbs. Expression changes of the target antigens were evaluated in hMSCs, human periodontal ligament cells (hPDLCs), and human dental pulp cells (hDPCs) during osteogenic and adipogenic differentiation by quantitative polymerase chain reaction (qPCR) and flow cytometry. hMSCs were also sorted by the MAbs using magnetic-acd even in integrin αV-low hMSCs. Conclusion These findings suggest that integrin α3 and αV induction is a good indicator of OB differentiation. These findings also shed insight into the expression dynamics of integrins upon osteogenic differentiation of hMSCs and provide the reason why different integrin ligands are required for OB differentiation of hMSCs.Background Gravid females assess the conditions of oviposition sites to secure the growth and survival of their offspring. Conspecific-occupied sites may signal suitable oviposition sites but may also impose risk due to competition or cannibalism at high population density or heterogeneous larval stage structure, respectively. Chemicals in the habitat, including chemicals emitted from other organisms, serve as cues for females to assess habitat conditions. Here, we investigated the attraction and oviposition preference of the Old World cutaneous leishmaniasis vector, Phlebotomus papatasi, to young and old conspecific stages, including eggs and evaluated the effect of a semiochemical associated with eggs and neonate larvae. Methods Attraction and oviposition preference of Ph. papatasi to each of various life stages (eggs, first-, second-, third-, fourth-instar larvae, pupae and male and female adults) was investigated using cage and oviposition jar behavioral assays. Seliciclib Identification of organic chemical compoundmpetition. Findings also supported the predictions of our hump-shaped oviposition regulation (HSR) model, with attraction to conspecific eggs at low-medium densities and switching to repellence at high egg densities. This oviposition behavior is mediated by DA that was identified from surface extracts of both eggs and first-instar larvae. Isovaleric acid was also found in extracts of both stages.Background Physician-scientists are a vital segment of the healthcare workforce, but they may face significant challenges balancing and integrating clinical responsibilities, scientific research, and domestic responsibilities. This study investigates factors associated with burnout among highly successful early career physician-researchers in Japan. Method Among 1790 physician awardees of Grant-in-Aid for Young Scientists by the Japanese Ministry in 2014-2015, 490 participated in this cross-sectional survey in 2016 (usable response rate 23.8%). The primary outcome was psychological burnout, measured by the Copenhagen Burnout Inventory (i.e., personal burnout, work-related burnout, and patient-related burnout). "Workplace resources" in our study refers to the presence of career education in the workplace, promotion of gender equity, well-being consultation services on "career and work," "research," "harassment," and/or "mental health," as well as the presence of a role model in the workplace who has perceived ong physician-scientists aged older than 37 years (β = 6.25, p = 0.002) and those who had board certification (β = 9.01, p = 0.017), while these scores were lower among those had larger amounts of funding (β = - 5.01, p = 0.006) or a mentor (β = - 5.35, p = 0.006). Conclusions Workplace resources and mentorship appear to be associated with lower levels of psychological burnout for both men and women early career physician-scientists.Background Sit-to-stand and stand-to-sit transitions are frequent daily functional tasks indicative of muscle power and balance performance. Monitoring these postural transitions with inertial sensors provides an objective tool to assess mobility in both the laboratory and home environment. While the measurement depends on the sensor location, the clinical and everyday use requires high compliance and subject adherence. The objective of this study was to propose a sit-to-stand and stand-to-sit transition detection algorithm that works independently of the sensor location. Methods For a location-independent algorithm, the vertical acceleration of the lower back in the global frame was used to detect the postural transitions in daily activities. The detection performance of the algorithm was validated against video observations. To investigate the effect of the location on the kinematic parameters, these parameters were extracted during a five-time sit-to-stand test and were compared for different locations of the sensor on the trunk and lower back. Results The proposed detection method demonstrates high accuracy in different populations with a mean positive predictive value (and mean sensitivity) of 98% (95%) for healthy individuals and 89% (89%) for participants with diseases. Conclusions The sensor location around the waist did not affect the performance of the algorithm in detecting the sit-to-stand and stand-to-sit transitions. link2 However, regarding the accuracy of the kinematic parameters, the sensors located on the sternum and L5 vertebrae demonstrated the highest reliability.Purpose To analyze the efficacy of minimally invasive beating heart technique for mitral valve surgery in the cardiac patients with previous sternotomy and giant left ventricle. Methods Eighty cardiac patients with previous sternotomy and giant left ventricle according to the diagnostic criteria that left ventricular end diastolic diameter (LVEDD) was ≥70 mm, who underwent mitral valve surgery at our center from January 2006 to January 2019 were analyzed. We divided all patients into minimally invasive beating heart technique group (n = 30) and conventional median resternotomy arrested heart technique group (n = 50) according to the surgical methods. Preoperative, intraoperative, and postoperative variables were compared between two groups. Results Minimally invasive beating heart technique compared to the conventional median resternotomy arrested heart technique for mitral valve surgery in the cardiac patients with previous sternotomy and giant left ventricle had significant differences in operation time(P =benefit of minimally invasive beating heart technique compared to conventional median resternotomy arrested heart technique.Background SARS-CoV-2 infection presents a high transmission in the group of health professionals in Spain (12-15% infected). Currently there is no accepted chemoprophylaxis but hydroxychloroquine (HDQ) is known to inhibit the coronavirus in vitro. Our hypothesis is that oral administration of hydroxychloroquine to healthcare professionals can reduce the incidence and prevalence of infection as well as its severity in this group. Methods Design Prospective, single center, double blind, randomised, controlled trial (RCT). Participants Adult health-care professionals (18-65 years) working in areas of high exposure and high risk of transmission of SARS-COV-2 (COVID areas, Intensive Care Unit -ICUs-, Emergency, Anesthesia and all those performing aerosol-generating procedures) will be included. Exclusion criteria include previous infection with SARS CoV2 (positive SARS-CoV-2 PCR or IgG serology), pregnancy or lactation, any contraindication to hydroxychloroquine or evidence of unstable or clinically significant s 450 participants will need to be included (250 in each arm). Trial status The protocol approved by the health authorities in Spain (Spanish Agency for Medicines and Health Products "AEMPS") and the Ethics and Research Committee of Cantabria (CEIm Cantabria) corresponds to version 1.1 of April 2, 2020. link3 Currently, recruitment has not yet started, with the start scheduled for the second week of May 2020. Trial registration Eudra CT number 2020-001704-42 (Registered on 29 March 2020) FULL PROTOCOL The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2).Background Bullying is associated with negative health outcomes such as depression. Most studies target non-Latinxs, though they often experience higher rates of bullying and depression. This review examines the inclusion of Latinxs in studies of bullying and depression and factors unique to them. Methods Databases were searched for articles related to bullying and depression. Two reviewers found 957 publications and identified 17 for inclusion. Results All 17 studies demonstrated a relationship between bullying and depression. Nine examined variables unique to Latinxs. Conclusions Studies that included variables unique to Latinxs found a stronger relationship between bullying and depression. Inclusive measures and design are key to understanding and reducing the consequences of bullying in this population.Background According to the UK's Office for National Statistics, England and Wales reported a 2.9% increase in sexual aggression cases (3.4 million females and 631,000 males) between 2009 and 2019. In Scotland, sexual aggression cases increased by 66%, with 40% of these sexual violations being perpetrated on individuals under the age of 18 years, while incidents relating to sexual misconduct in Northern Ireland increased by 21.0%, with only 41.2% of those cases being prosecuted. Acts of sexual aggression can have physical, emotional and mental consequences which predispose young people to subsequent short- and long-term mental and social disorders and comorbidities. Such consequences include feelings of guilt, shame, anger, experiencing post-traumatic stress disorders, antisocial behaviour, alcohol and drug misuse and dependency, confusion surrounding sexuality and sexually transmitted illnesses including the human immuno-deficiency virus. However, despite the societal, health, economic and educational implications for young people in the UK and increasing statistics, few studies address this scourge.
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