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hormones and neurotransmitters bind to receptors on cell surface
activates adenylate cyclase
produced cyclic AMP
cAMP activates cAMP dependent kinase
kinase initiates cellular response
vasopressin
- v2 receptors on DCT AND CD
- increase cAMP
- increase and aquaporin
- increase kidney permeability
- water reabsorbed and concentrated urine
epinephrine
- increase cAMP
- act on same cells
- glycogen to glucose
histamine
- increase cAMP
- local mediator
- H2 receptors
- secretion of gastric acids
phospholipase system
phospholipase mobilising receptors
hormone binds to receptors
activate phospholipase c enzyme
second messenger DAG and IP3
activate cellular mechanism
release CA2+ from er
ca2+ mediate activities
ca2+ bind to prevent cell death
affinity is how strongly a drug binds to a receptor
intrisic efficacy ability of an agonist to inital a cellular esposne
categories of neurotrasnmitters
- biogenic amines
- amino acids
- neuropeptides
- purines
- gases
- lipids
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