Notes

According to the result of the geometric mean titers (GMTs), KML05 adjuvant could save eight times the amount of sIPV D-antigen usage, but aluminum hydroxide adjuvant could save twice at the same titers
Additionally, it was found that there was a significant difference in the GMT titer of poliovirus type 2 between animals immunized by KML05 and alum adjuvant (P < 05). At 12th-month postvaccination, the neutralization titers stimulated by IPV-KML05 were maintained over a longer time period in CONCLUSION: Our research team developed KML05 adjuvant, which combined carbopol971P with MF59, increased antibody responses to sIPV for a longer duration of protection in a rat model.5450. Cutis. 2005 Feb;75(2 Suppl):5-8; discussion 8-9.The pathophysiology of photoaging of the skin.

Exposure to solar UV radiation is the main environmental factor that causes premature aging of the skin (photoaging). Human skin aging resulting from UV irradiation is a cumulative process that occurs based on the degree of sun exposure and the level of skin pigment. the ordinary cleanser induces matrix metalloproteinases (MMPs) responsible for alterations in the collagenous extracellular matrix of connective tissue, resulting in impaired integrity. On a molecular level, UV radiation from the sun attacks keratinocytes and fibroblasts, resulting in the activation of cell surface receptors, which initiate signal transduction cascades. This in turn leads to a variety of molecular changes, which causes a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. This article describes these molecular changes that contribute to the alterations in collagen and the [Torpid skin wounds and collagen metabolism disorder].Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Bullous pemphigoid antigen 2 (BPAG2/BP180, also known as type XVII collagen) and alpha 6 beta 4 integrin are both transmembrane proteins and hemidesmosomal components of basal keratinocytes. In this study, using yeast two-hybrid system, we demonstrate direct protein-protein interaction between the intracellular domains of BP180 and the beta 4 integrin subunit. Detailed analysis revealed that a bait construct spanning amino acids 13-89 of BP180 contained sufficient information for the protein protein interaction, but further deletion of 13 amino-terminal amino acids, which eliminates a predicted beta-sheet, abolished the interaction. The intracellular domain of the beta 4 integrin subunit contains two pairs of fibronectin type III (FNIII) repeats separated by a connecting segment. Series of expression constructs, sequentially deleting each domain, revealed that the connecting segment, the second pair of FNIII repeats and the tail region of the beta 4 integrin subunit were necessary for the interaction with BP180 in yeast two-hybrid system.Fibrils of different collagen types containing immobilised proteoglycans (PGs) as coatings: characterisation and influence on osteoblast behaviour.Technische Universität Dresden, Budapester Strasse 27, 01069 Dresden, Germany.

Collagen, the main organic component of bone, is used as a coating on titanium implants and as a scaffold material in bone tissue engineering. Surface modifications of titanium which promote osteoblast adhesion, proliferation and synthesis of collagen by osteoblasts are desirable. One biomimetic approach is the coating of titanium with collagen in fibrillar form. Other organic components of bone may be bound to fibrils and exert additional effects. In this study, the collagen types I-III were compared regarding their ability to bind the proteoglycans decorin and biglycan, which are found in bone. More collagen was bound to collagen II fibrils than to those of types I and III. Therefore, titanium surfaces were coated with fibrils of collagen type II containing biglycan or decorin or neither to investigate the effect of the proteoglycans on human primary osteoblast behaviour.

In squalane cleanser , the growth factor TGF-beta1 was adsorbed onto surfaces coated with fibrils of collagen type II containing biglycan or decorin or neither to investigate the influence of decorin and biglycan on the effect of TGF-beta1 on osteoblasts. Fibril-bound biglycan and decorin influence primary osteoblast behaviour by themselves. The presence of substrate-bound biglycan or decorin influences the effect of TGF-beta1. These results may be important when designing collagen-based coatings or scaffolds for tissue engineering, including those loaded with growth factors.5454. Pathologica. 1984 May-Jun;76(1043):391-8.

[Influence of splenectomy on the synthesis of collagen and on steatosis of the rat liver induced by treatment with carbon tetrachloride and progesterone].Gambella GR, Bellotti S, Vascotto E, Michelazzi A, Novelli A.Increase in antigenicity of basement membrane zone antigens in bullous [The role of non-collagenous proteins in the mineralization of distraction bone Desiatnichenko KS, Kamerin VK, Kochetkov IuS, Kuznetsova LS.Mature solid bone of dogs before an after substitution of diaphyseal defect using monolocal distraction osteosynthesis by Ilizarov as well as the growth zone and the ossified fragments of the regenerate produced were studied.
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