Notes

By employing synthetic biology approaches combined with a structure-guided design, we created a tunable array of whole-cell biosensors (WCBs)
The MopR genetic system that has the natural ability to sense and degrade phenol was adapted to detect phenol down to ∼1 ppb, making this sensor capable of directly detecting phenol in permissible limits in drinking water. Importantly, by using a single WCB design, we engineered mutations into the MopR gene that enabled generation of a battery of sensors for a wide array of pollutants. The engineered WCBs were able to sense inert compounds like benzene and xylene which lack active functional groups, without any loss in sensitivity. Synthesis of 6-butyl-n-hydroxynaphthimide trifluoromethanesulfonic acid and its Variants , this universal programmable biosensor platform can be used to create WCBs that can be deployed on field for rapid testing and screening of suitable drinking water sources.One-Pot Regiodirected Annulations for the Rapid Synthesis of π-Extended Eni Spa, Via Fauser 4, 28100 Novara, Italy.We demonstrate the broad applicability of the annulation protocol combining, in one pot, a direct arylation and cross aldol condensation for the straightforward synthesis at gram-scale of π-extended thiophene-based scaffolds.

The regiospecific direct arylation drives the subsequent cross-aldol condensation proceed under the same basic conditions, and the overall protocol has broad applicability in the synthesis of extended aromatics wherein the thiophene ring is annulated with furans, pyridines, indoles, benzothiophenes, and benzofurans. These scaffolds can be further elaborated into π-extended, highly fluorescent oligomers with a central deficient benzothiadiazole unit with up to nine aromatic rings through coupling reactions.Hydro/Deutero Deamination of Arylazo Sulfones under Metal- and Hydrodeaminated and monodeuterated aromatics were obtained via a visible-light driven reaction of arylazo sulfones. Deuteration occurs efficiently in deuterated media such as isopropanol-d8 or in THF-d8/water mixtures and exhibits a high tolerance to the nature and the position of the aromatic substituents.Lignin valorization meets synthetic biology.Bioengineering (Ministry of Education) School of Chemical Engineering and Lignin, an abundant renewable resource in nature, is a highly heterogeneous biopolymer consisting of phenylpropanoid units. It is essential for sustainable utilization of biomass to convert lignin to value-added products.

However, there are technical obstacles for lignin valorization due to intrinsic heterogeneity. The emerging of synthetic biology technologies brings new opportunities for lignin breakdown and utilization. In this review, we discussed the applications of synthetic biology on lignin conversion, especially the production of value-added products, such as aromatic chemicals, ring-cleaved chemicals from lignin-derived aromatics and bio-active substances. Synthetic biology will offer new potential strategies for lignin valorization by optimizing lignin degradation enzymes, building novel artificial converting pathways, and improving the chassis of model microorganisms.© 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, 6-butyl-n-hydroxynaphthimide trifluoromethanesulfonic acid as a Catalyst in Organic Transformations .[Development of the Direct Transformations of Aromatic C-H Bonds Using a Heterogeneous metal catalysts constitute a very important tool for the synthesis of functional materials and fine chemicals owing to their high efficiency, robustness, and facile recyclability.

Biaryls are privileged structural motifs in many natural products, chiral ligands, and catalysts. The oxidative biaryl coupling reaction is one of the most promising methods for biaryl synthesis in terms of atom and step economies. However, although oxidative biaryl coupling of naphthols has been studied thoroughly, the coupling of aryl amines providing biaryl amines like 2,2'-diamino-1,1'-binaphthyl (BINAM) and 2-amino-2'-hydroxy-1,1'-binaphthyl (NOBIN) derivatives remains elusive. Recently, we have found that aryl amines are efficiently dimerized with the use of a heterogeneous Rh/C catalyst under acidic conditions. This heterogeneously catalyzed method can be adapted to the highly selective cross-coupling reaction of aryl amines and the intramolecular biaryl coupling reaction. Furthermore, we developed an aerobic direct C-H oxidation of polycyclic aromatics catalyzed by a recyclable heterogeneous rhodium catalyst. These methodologies are advantageous compared with the existing reactions owing to the mild aerobic conditions employed and the facile recyclability of the heterogeneous catalysts used.

Anion-pi slides for transmembrane transport.The recognition and transport of anions is usually accomplished by hydrogen bonding, ion pairing, metal coordination, and anion-dipole interactions. Here, we elaborate on the concept to use anion-pi interactions for this purpose. 6-butyl-n-hydroxynaphthimide trifluoromethanesulfonic acid in Medicinal Chemistry to the popular cation-pi interactions, applications of the complementary pi-acidic surfaces do not exist. This is understandable because the inversion of the aromatic quadrupole moment to produce pi-acidity is a rare phenomenon. Here, we suggest that pi-acidic aromatics can be linked together to produce an unbendable scaffold with multiple binding sites for anions to move along across a lipid bilayer membrane. The alignment of multiple anion-pi sites is needed to introduce a cooperative multi-ion hopping mechanism.

Experimental support for the validity of the concept comes from preliminary results with oligonaphthalenediimide (O-NDI) rods.
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