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In conclusion, we unravel a novel mechanism for explaining MSTO2P-involved osteosarcoma progression under hypoxia condition, which will facilitate development of potential diagnostic and therapeutical strategies for osteosarcoma.Limited studies focus on the effectiveness of regulatory actions on changes in sources and temporal trends of human health risks for trace elements in atmospheric particles less then 10 μm (PM10). To address this knowledge gap, PM10 samples were collected at three stations in the Great Lakes Basin over a thirty-year time span and analyzed for 19 representative elements. Temporal trends of trace elements in PM10 were derived using the Digital Filtration Technique and sources of these elements were determined using multiple statistical techniques, namely enrichment factor analysis, positive matrix factorization (PMF) and potential source contribution function (PSCF). Non-carcinogenic and carcinogenic risks by chronic exposure were assessed using US EPA reference concentrations and inhalation unit risk. Our results showed a strong relationship between element concentrations and local populations, which suggested that the emissions of trace elements were anthropogenically-related and was confirmed by the enrichrol strategies.
The effect of placing implants by using a fully guided protocol versus a partially guided protocol on the peri-implant soft and hard tissues is unclear. C-shaped guide holes are often used; however, their effect on drilling and peri-implant tissues has not been thoroughly investigated.

The purpose of this split-mouth clinical study was to clinically and radiographically evaluate peri-implant soft and hard tissues after implant placement by using fully guided versus partially guided surgical guides with cylindrical versus C-shaped guide holes.

Adopting an 80% power of the study in calculating sample size, a total of 48 implants were placed in the mandibular interforaminal area of 12 edentulous participants. Implants were randomly divided into 2 groups a fully guided group comprising 24 implants placed on 1 side by using a fully guided protocol and a partially guided group comprising 24 implants placed on the other side of the same participant by using a partially guided protocol. Each group was further sdrical or C-shaped.
The soft and hard tissues surrounding the implants placed by using fully guided surgical guides were clinically comparable with those placed by using partially guided surgical guides whether the guiding holes were cylindrical or C-shaped.
We aimed to establish diagnostic criteria for bleeding independently associated with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days after noncardiac surgery that is independently associated with mortality within 30 days of surgery, and to estimate the proportion of 30-day postoperative mortality potentially attributable to BIMS.

This was a prospective cohort study of participants ≥45 yr old having inpatient noncardiac surgery at 12 academic hospitals in eight countries between 2007 and 2011. Cox proportional hazards models evaluated the adjusted relationship between candidate diagnostic criteria for BIMS and all-cause mortality within 30 days of surgery.

Of 16 079 participants, 2.0% (315) died and 36.1% (5810) met predefined screening criteria for bleeding. Based on independent association with 30-day mortality, BIMS was identified as bleeding leading to a postoperative haemoglobin <70 g L
, transfusion of ≥1 unit of red blood cells, or that was judged to be the cause of death. Bleeding independently associated with mortality after noncardiac surgery occurred in 17.3% of patients (2782). Death occurred in 5.8% of patients with BIMS (161/2782), 1.3% (39/3028) who met bleeding screening criteria but not BIMS criteria, and 1.1% (115/10 269) without bleeding. BIMS was associated with mortality (adjusted hazard ratio 1.87; 95% confidence interval 1.42-2.47). We estimated the proportion of 30-day postoperative deaths potentially attributable to BIMS to be 20.1-31.9%.

Bleeding independently associated with mortality after noncardiac surgery (BIMS), defined as bleeding that leads to a postoperative haemoglobin <70 g L
, blood transfusion, or that is judged to be the cause of death, is common and may account for a quarter of deaths after noncardiac surgery.

NCT00512109.
NCT00512109.
Pseudomyxoma peritonei (PMP) arising from an intraductal papillary mucinous neoplasm of the pancreas (IPMN) is a rare condition. The diagnosis of IPMN as the origin of PMP is mainly inferred from the clinical course and the exclusion of PMP from other organs. The pathological diagnosis has not yet been established. To evaluate the usefulness of immunohistochemical staining for the diagnosis of the primary lesion of PMP as IPMN.

There are 2 cases of PMP arising from IPMN between March 2010 and December 2019 at National Center for Global Health and Medicine. A PubMed search that reported PMP arising from IPMN identified 16 additional cases. Diagnostic methods and clinicopathological features of 18 cases were compared.

Four cases including our two cases used immunohistochemical staining for the diagnosis of PMP arising from IPMN. The correspondence of the immunohistochemical staining between PMP and IPMN was shown in the three cases including previously reported two cases and one of our two cases to identify the primary lesion of PMP as IPMN. In addition, we revealed that the comparison of the immunostaining pattern of PMP with the representative immunostaining pattern of the candidate primary lesions is helpful for the diagnosis of the primary lesion of PMP.

Immunohistochemical staining is helpful to identify the primary lesion of PMP as IPMN.
Immunohistochemical staining is helpful to identify the primary lesion of PMP as IPMN.
With the rising prevalence of obesity, there is a plethora of literature discussing the relationship between obesity and acute pancreatitis (AP). Evidence has shown a possible correlation between visceral adipose tissue (VAT) and AP incidence and severity. This systematic review explores these associations.

Eligible articles were searched and retrieved using Medline and Embase databases. Clinical studies evaluating the impact of VAT as a risk factor for AP and the association of the severity of AP and VAT were included.

Eleven studies, with a total of 2529 individuals were reviewed. Nine studies showed a statistically significant association between VAT and the severity of AP. Only four studies found VAT to be a risk factor for acute pancreatitis. Two studies showed VAT to be associated with an increased risk of local complications and two studies showed a correlation between VAT and mortality.

This is the first systematic review conducted to study the association between VAT and AP. The existing bodyT may need to be incorporated into prognostic scores of AP to improve accuracy.In this contribution we seek to enrich the theoretical and methodological approaches of ethnobiology. The essay takes elements of Amerindian anthropology, classical ethnobiological studies and the freedoms provided by feminist philosophers to open up reflection. The central background of the essay is the method of "controlled equivocation" proposed by Viveiros de Castro (2004). We present a series of five ethnobiological equivocations ranging from the categorical equivocal, going through the subtle equivocal to the strictly ontological ones. The cases occurred in different territories of Argentina, including a case in an academic context. Through the fieldwork cases, we give an account of the origin of equivocations, the context for their emergence, which are the disciplinary nuances that cause them and even some academics' preconceptions. To inhabit the equivocation allows opening the possibilities of coexistence among people -and their respective worlds-, especially if these people are in different power positions. We propose the method of controlled equivocation as a theoretical-discursive tool, which permits us to rethink the current concepts of ethnobiology. Thus, we want to broaden the current definition of ethnobiology understood as a dialogue from different scientific points of view.
The current understanding of ventilator efficiency variables during ramp exercise testing in the normal Japanese population is insufficient, and the responses of tidal volume (VT) and minute ventilation (V̇E) to the ramp exercise test in the normal Japanese population are not known.

A total of 529 healthy Japanese subjects aged 20-78 years underwent cardiopulmonary exercise testing using a cycle ergometer with ramp protocols. VT and V̇E at rest, at anaerobic threshold, and at peak exercise were determined. The slope of V̇E versus carbon dioxide (V̇CO
) (V̇E vs. V̇CO
slope), minimum V̇E/V̇CO
, and oxygen uptake efficiency slope (OUES) were determined.

For males and females in their 20 s, peak VT (VTpeak) was 2192 ± 376 and 1509 ± 260 mL (p < 0.001), peak V̇E (V̇Epeak) was 80.6 ± 18.7 and 57.7 ± 13.9 L/min (sex differences p < 0.001), the V̇E vs. V̇CO
slope was 24.4 ± 3.2 and 25.7 ± 3.2 (p = 0.035), the minimum V̇E/V̇CO
was 24.2 ± 2.3 and 27.0 ± 2.8 (p < 0.001), and the OUES was 2452 ± 519 and 1991 ± 315 (p < 0.001), respectively. VTpeak and V̇Epeak decreased with age and increased with weight and height. The V̇E vs. V̇CO
slope and minimum V̇E/V̇CO
increased with age, while conversely, the OUES decreased with age.

We have established the normal range of VT and V̇E responses, the V̇E vs. V̇CO
slope, the minimum V̇E/V̇CO
, and the OUES for a healthy Japanese population. Some of these parameters were influenced by weight, height, sex, and age. These results provide useful reference values for interpreting the results of cardiopulmonary exercise testing in cardiac patients.
We have established the normal range of VT and V̇E responses, the V̇E vs. V̇CO2 slope, the minimum V̇E/V̇CO2, and the OUES for a healthy Japanese population. Some of these parameters were influenced by weight, height, sex, and age. These results provide useful reference values for interpreting the results of cardiopulmonary exercise testing in cardiac patients.To search for potent anti-ischemic stroke agents, a series of tetramethylpyrazine (TMP)/resveratrol (RES) hybrids 6a-t were designed and synthesized. These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, 6d, 6g-i, 6o and 6q were more active than TMP. The most active compound 6h exhibited more potent anti-platelet aggregation activity than TMP, RES, as well as positive control ticlopidine (Ticlid) and aspirin (ASP). Furthermore, 6h exerted strong antioxidative activity in a dose-dependent manner in rat pheochromocytoma PC12 cells which were treated with hydrogen peroxide (H2O2) or hydroxyl radical (·OH). Importantly, 6h significantly protected primary neuronal cells suffered from oxygen-glucose deprivation/reoxygenation (OGD/R) injury, comparable to an anti-ischemic drug edaravone (Eda). Together, our findings suggest that 6h may be a promising candidate warranting further investigation for the intervention of ischemic stroke.
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