Notes

miR-124-3p Inhibits the Invasiveness and Metastasis regarding Hepatocarcinoma Cellular material by way of Targeting CRKL.
is one of the traditional medicinal plants used in Ethiopia for the treatment of wounds and other diseases. However, the plant has not been scientifically validated, and thus the present study evaluated the in vitro anti-oxidant and the in vivo wound healing activity of the crude extract and solvent fractions of
seeds in mice.

The crude extract was prepared by maceration using 80% methanol and formulated as 5% and 10% w/w ointments for topical application. The acute dermal toxicity was performed in female albino rats based on Organization for Economic Cooperation and Development (OECD) guideline number 434. Excision and incision wound healing models were used to evaluate the wound healing activities of crude extract and solvent fractions ointments in mice. Wound healing parameters such as wound area contraction and the period of epithelialization were determined in an excision model, whereas tensile strength was determined in an incision model. Moreover, the crude extract and solvent fractions were ev seeds of
possess potential wound healing and anti-oxidant effects, supporting the traditional use of the plant for wound management.
The present study demonstrated that the 80% methanol extract and solvent fractions of the seeds of B.carinata possess potential wound healing and anti-oxidant effects, supporting the traditional use of the plant for wound management.We are presenting a case report of a previously healthy 39-year-old man who was found to have acute inferior ST-elevation myocardial infarction (STEMI) and acute large right middle cerebral artery (MCA) ischemic stroke with hemorrhagic transformation. Transesophageal echocardiogram and chest CT angiogram revealed two thrombi; one attached to the wall of the ascending aorta just above the right coronary artery sinus, and one at the origin of the brachiocephalic trunk. The occlusion of the coronary artery and right MCA most likely could be because of embolization from these thrombi. Extensive workup looking for underlying etiology and risk factors for these concurrent vascular events in this young man revealed hyperhomocysteinemia along with unfavorable lipid profile, and family history of premature coronary artery disease which increased the suspicion of familial hypercholesterolemia. Besides, the presence of vitamin B12 and folate deficiencies. The elevated serum homocysteine is likely a major risk factor for thromboembolism in this patient. The patient received antithrombotics and vitamin supplementations and gradually improved without any worsening of the stroke's hemorrhagic transformation. We suggest that hyperhomocysteinemia needs to be considered in the differential etiology of vascular events in young people or those with no significant history of major vascular risk factors. Besides, vitamin supplementation could be a cost-effective, safe, and efficient way to decrease elevated serum homocysteine levels and prevent vascular complications. As well as this case report demonstrates that antithrombotics can safely be used after stroke's hemorrhagic transformation without neurological deterioration or aggravation of hemorrhagic transformation.
Despite the global maternal mortality ratio (MMR) fallen by nearly 44% from 1990 to 2015, however, maternal mortality remains a global problem. Reducing maternal morbidity and mortality is a global priority, which is particularly relevant for developing countries like Ethiopia. A good strategy for reducing maternal morbidity and mortality is increasing institutional delivery service utilization. This study aimed to assess the magnitude and associated factors of institutional delivery among reproductive-age women in southwest Ethiopia.

A community-based cross-sectional study was conducted among 526 women at Mizan-Aman town from January 1 to 30, 2019. The data were collected through face-to-face interviews, and a structured questionnaire was used to assess the prevalence and associated factors of institutional delivery among reproductive-age women who delivered in the past one year. The collected data were entered into the Epi Data manager and analyzed using SPSS version 21. Binary logistic regression was dtional delivery is an important segment of intervention that can be done through health extension workers. Besides, counseling mothers on the importance of institutional delivery by health professionals at each ANC follow-up visit plays paramount importance.
The utilization of institutional delivery service among mothers in the study area was good. But, more effort is needed to increase service utilization to 100%. The provision of the continuous house to house health education regarding institutional delivery is an important segment of intervention that can be done through health extension workers. Besides, counseling mothers on the importance of institutional delivery by health professionals at each ANC follow-up visit plays paramount importance.
Infertility is a global problem, with high prevalence in India. As a pronatalist society, infertility is particularly problematic in India, causing stigma, shame, and blame especially for women. Infertility consequences for women include discrimination, social exclusion, and abandonment, putting them at high risk for mental health distress. Furthermore, mental health is highly stigmatized and specialized care is largely unavailable. Despite the cultural importance of childbearing, research on infertility distress and resulting mental health sequelae is lacking, particularly among low-income women. The purpose of this study is to assess mental health, using validated scales, among Mumbai slum-dwelling women with a history of infertility.

We conducted a mixed-method, cross-sectional study. A focus group discussion with community health workers (n = 7) informed the development of a comprehensive survey. The survey consisted of validated scales whenever possible, in addition to questions pertaining to women's sociodemographic and reproductive history. After rigorous forward and back translation, the surveys were conducted as face-to-face structured interviews due to low literacy levels and the research naiveté of our respondents. Interviews were conducted by culturally, linguistically, gender-matched, trained research assistants.

Mumbai slum-dwelling women of reproductive age suffering from infertility (N = 74) participated. Most (85%) women and their husbands (66%) reported previous infertility testing. Participants had elevated mental health distress (anxiety and depression symptomology) largely explained by general health, length of marriage, and coping strategy employed.

Women facing the double stigma of mental health and infertility need innovative programs to address their challenges.
Women facing the double stigma of mental health and infertility need innovative programs to address their challenges.
Nearly, 350 million people in the world are currently living with depression. Depression happening in PLHIV leads to alteration of economic productivity, decrease of working abilities, social isolation, physical decline and difficulties in solving problems. This study investigates the burden of depression and associated factors on HIV/AIDS patients attending an ART clinic.

An institution-based cross-sectional study was implemented from April 1 to May 30, 2019 on a total of 417 HIV-positive patients. Systematic random sampling technique was used to access the study participants. Interviewer-administered structured questionnaire was used for data collection. Data were entered in to EpiData 3.1 and then were exported into Statistical Package for the Social Sciences (SPSS window version 20) for analysis.

Four hundred ten (410) respondents participated in the study with a response rate of 98.3%. The burden of depression was 50.5% in this study. Male (AOR=1.53; 95%CI 1.016-2.311), people living in urban (AOR=2.20; 95%CI 1.29-3.75), patients who had opportunistic infection (AOR=1.98; 95%CI 1.27-3.11), poor medication adherence (AOR=1.79; 95%CI 1.13-2.85) and high HIV-related perceived stigma (AOR=1.66; 95%CI 1.04- 2.67) were more likely depressed compared to their counterparts.

In this study, male sex, those patients living in urban areas, having opportunistic infections, poor medication adherence, and high HIV-related perceived stigma were significantly associated with depression. Hence, organizations working on HIV programs should address these factors to prevent and manage depression among HIV-positive patients.
In this study, male sex, those patients living in urban areas, having opportunistic infections, poor medication adherence, and high HIV-related perceived stigma were significantly associated with depression. Hence, organizations working on HIV programs should address these factors to prevent and manage depression among HIV-positive patients.
The objectives of this study were to describe and classify lingual arch form in dental students with normal occlusion and explore the possibility to provide a lingual arch form template for Nepalese population.

The occlusion and arch form of 220 undergraduate dental students were analyzed and thirty-three subjects (14 males, 19 females) fulfilling the inclusion criteria were selected for the study. Reference points were drawn on the lingual surfaces of the teeth of study model using an indelible marker. A transparent ruled grid was used to obtain x and y coordinate values of the reference point. Following distances were measured with a digital caliper inter-canine width, inter-molar width, inter-second molar width, canine depth, first molar depth, and second molar depth. Two-step cluster analysis was used to further classify the arch. The mean reference point values of each cluster were entered into the software (CurveExpert 1.4, Hymas developers). The curve finder tool of the software was used to obtain the curve which best described the arch forms.

Two-step cluster analysis identified two distinguished clusters of lingual arch forms. Tenth degree polynomial was chosen as the best possible fit for lingual arch forms by using Curvefinder tool of the software CurveExpert 1.4.

Two types of anatomical lingual arch forms derived from Nepalese dental students with normal occlusion have been described and templates for the same have been generated.
Two types of anatomical lingual arch forms derived from Nepalese dental students with normal occlusion have been described and templates for the same have been generated.[This corrects the article DOI 10.2147/CMAR.S258835.].
Increasing evidence has demonstrated that plasmacytoid dendritic cells (PDCs) in the tumor microenvironment (TME) play an important role in tumorigenesis and progression. PDC infiltration has been found in certain malignancies such as classic Hodgkin's lymphoma and chronic myelomonocytic leukemia. Our previous work reported that PDC infiltration could occur in acute myeloid leukemia (AML), but the clinical significance of PDC in AML has not been thoroughly investigated.

Here, we evaluated the clinical significance of PDC to AML transition in a leukemia microenvironment. The frequency of PDCs in 80 acute myelomonocytic leukemia (AML-M4) and 83 acute monocytic leukemia (AML-M5) patients was determined by flow cytometry.

We found 62 cases with PDC infiltration. These patients showed higher numbers of bone marrow blasts, higher mean Hb concentration, and required more cycles of chemotherapy before achieving complete remission (CR), but had lower white blood cell and platelet counts compared to patients without PDC infiltration.
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