Notes

Adding Brand-new Therapies for Chronic Lymphocytic Leukemia.
Nine (90%) cases healed on medical management within 56.55 ± 26.74 days (range 9-120 d), although almost all required adjunctive procedures tissue adhesive application (n = 6) and/or tarsorrhaphy (n = 4). One case with a near total infiltrate had a mixed infection with Kocuria kristinae requiring therapeutic penetrating keratoplasty. One case developed endophthalmitis and phthisis after the corneal infiltrate resolved.

E. cloacae keratitis is a rare clinical entity seen more often in immunocompromised host conditions such as failed corneal transplants with concomitant topical steroids. Most cases healed with medical management.
E. cloacae keratitis is a rare clinical entity seen more often in immunocompromised host conditions such as failed corneal transplants with concomitant topical steroids. Most cases healed with medical management.Previous research indicates that quick, repetitive actions (pinches, taps, button presses) are executed with smaller force when followed by predictable and salient action effects (tones, light flashes). It has been suggested that successive actions become gradually softer until an optimum is reached, which presumably reflects a balance between the ability to maintain a high probability of action success, and the reduction of exerted force to conserve energy. In the present experiments, we investigated whether this action-effect-related motor adaptation appeared when the arrival of the action effect was unpredictable. Young adult participants produced evenly spaced pinches (Experiment 1) or taps (Experiment 2), which resulted in a tone in 50% of the trials. The presence of the tone effect varied randomly from trial to trial, leading to action sequences with various tone-elicitation patterns. We have found that pinches and taps preceded by sequences of tone-eliciting actions were softer than actions preceded by sequences of tone-absent trials. In the case of pinches, actions were also modulated on the fly, with the current action being softer and briefer when a tone was elicited. Our results demonstrate that action effects can modulate subsequent and ongoing actions even when the arrival of these effects is unpredictable. (PsycInfo Database Record (c) 2022 APA, all rights reserved).In multitasking research, a central question revolves around whether humans can process tasks in parallel. What "in parallel" refers to, however, differs between research perspectives and experimental approaches. From a task-level perspective, parallel processing can be conceived as to whether complete tasks are processed in an overlapping manner and how this impacts task performance. In contrast, a large body of literature solely focuses on the central stage of response-selection and whether it can run in parallel with other processing stages, an approach we refer to as the stage-level perspective. Importantly, although each perspective addresses related topics and highlights interindividual differences, they evolved through independent lines of research. In 2 experiments, we have taken a first step to investigate if individuals' tendencies for an overlapping versus serial processing mode on the task level are related to vulnerabilities for task interference on the stage level. Individual preferences for either task processing mode were assessed in the task switching with preview (TSWP) paradigm. Individuals' vulnerability for task interference was assessed with the backward crosstalk effect (BCE) in a classical dual task. Our results suggest that individuals who prefer overlapping relative to serial task processing at the task level are less vulnerable to task interference during response selection, indicated by a smaller BCE. This difference, however, only emerged in the second experiment with an increased sample size and with task-stimuli that facilitate a bottom-up separation of tasks in the dual-task. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The mind-wandering literature is long on results and short on theory. One notable exception is the Dynamic Framework, a theoretical framework that characterizes mind wandering as thoughts that are relatively unconstrained from deliberate and automatic sources, or "freely moving." Critically, this framework makes numerous testable predictions, including (a) a positive association between freely moving thought and ADHD, (b) negative associations between freely moving thought and depression, anxiety, and OCD, and (c) a positive association between freely moving thought and divergent thinking ability. In Study 1, to test these predictions, we measured participants' reports of freely moving thoughts during a cognitive task and assessed divergent thinking and various psychopathological symptoms. Results failed to support any of the Dynamic Framework's predictions. In Study 2, we assessed the predicted relations between freely moving thought and divergent-thinking performance by manipulating thought constraint during a creative-incubation interval that preceded a divergent-thinking task. Here, we found some evidence (albeit very weak) to support the Dynamic Framework's prediction. Finally, in Study 3, we examined the possibility that indexing freely moving thought during a divergent-thinking task would yield the predicted associations but failed to find support for these associations. These results, most of which are at odds with the predictions of the Dynamic Framework, suggest either the need to revise the framework and/or that current methods are inadequate to properly test these predictions. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The role of attention in visual awareness is a foundational issue for understanding consciousness, but remains highly controversial. Therefore, in two experiments, we investigated whether and how attention modulates visual awareness using a monocular cuing paradigm. Although observers are not aware of which eye received a cue, a monocular cue can attract eye-specific attention to a cued eye. In Experiment 1, we found that eye-specific attention enhanced subjective visual awareness (i.e., awareness reports) as well as objective task performance (i.e., orientation discrimination) of a Gabor target. Importantly, attention enhanced visual awareness only when a decision for orientation discrimination was correct, suggesting that the effect of attention on visual awareness is closely associated with perceptual evidence for orientation discrimination. In Experiment 2, we showed that the modulatory effect of attention on visual awareness was based on contrast gain, which amplified the effective contrast of an attended stimulus, and did not differ from that on orientation discrimination performance qualitatively and quantitatively. Our findings suggest that attention influences visual awareness by amplifying perceptual evidence on which visual awareness and objective performance are commonly based. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Detecting and learning structure in sounds is fundamental to human auditory perception. Evidence for auditory perceptual learning comes from previous studies where listeners were better at detecting repetitions of a short noise snippet embedded in longer, ongoing noise when the same snippet recurred across trials compared with when the snippet was novel in each trial. However, previous work has mainly used (a) temporally regular presentations of the repeating noise snippet and (b) highly predictable intertrial onset timings for the snippet sequences. As a result, it is unclear how these temporal features affect perceptual learning. In five online experiments, participants judged whether a repeating noise snippet was present, unaware that the snippet could be unique to that trial or used in multiple trials. In two experiments, temporal regularity was manipulated by jittering the timing of noise-snippet repetitions within a trial. In two subsequent experiments, temporal onset certainty was manipulated by varying the onset time of the entire snippet sequence across trials. We found that both temporal jittering and onset uncertainty reduced auditory perceptual learning. In addition, we observed that these reductions in perceptual learning were ameliorated when the same snippet occurred in both temporally manipulated and unmanipulated trials. Our study demonstrates the importance of temporal regularity and onset certainty for auditory perceptual learning. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Posttraumatic stress disorder (PTSD) and alcohol use (AU) are highly prevalent and comorbid among post-9/11 U.S. military veterans. Both issues are associated with working memory (WM) deficits, but have rarely been studied concurrently in cognitive studies of post-9/11 veterans. They also have been measured inconsistently, with variable outcomes, in prior veteran studies despite their relevance to new intervention paradigms involving WM.

The present study evaluated 52 post-9/11 veterans [predominantly male (94.2%); White (44.2%) or Black (36.5%); 50% being diagnosed with PTSD based on CAPS-5 results] with objectively verified valid neuropsychological test performance on measures of PTSD, AU, combat exposure, and verbal and visual WM.

PTSD was not associated with verbal or visual WM performances, whereas AU and combat exposure were significantly associated with poorer visual WM performances.

AU and prior combat exposure may influence visual WM performances in post-9/11 veterans, which is relevant to novel PTSD treatment paradigms. This sample was limited to mostly male and White or Black participants, and future studies should focus on sampling more heterogeneous groups of veterans with regard to sex and ethnicity. Improvements in specification/multimodal WM assessment are important for future research, as these may directly impact developing intervention efforts. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
AU and prior combat exposure may influence visual WM performances in post-9/11 veterans, which is relevant to novel PTSD treatment paradigms. This sample was limited to mostly male and White or Black participants, and future studies should focus on sampling more heterogeneous groups of veterans with regard to sex and ethnicity. Improvements in specification/multimodal WM assessment are important for future research, as these may directly impact developing intervention efforts. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Amazon's Mechanical Turk (MTurk) appears to be a reliable resource for studying clinical populations and accessing hard-to-reach populations. Recent research suggests that MTurk may also be a viable option for military recruitment.

The goal of the current study was to examine the utility of collecting clinical data on military samples recruited via MTurk.

Participants were 535 military veterans (

= 37.45; 71.8% men; 69.5% White) who completed measures assessing trauma and mental health.

Findings indicate that rates of military traumas and mental health diagnoses were higher than published comparisons; posttraumatic stress disorder (PTSD) and depression symptoms were found to be higher than values found in a nationally representative sample, lower than a treatment-seeking sample, and comparable to a MTurk-recruited military sample. Alcohol misuse was found to be higher than both nationally representative and treatment-seeking samples. Psychometric analyses indicated support for convergent validity of measures, and confirmatory factor analysis results demonstrated that empirically supported factor models of PTSD were replicated in the current sample; the hybrid model demonstrated the best fit.
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