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Took back: Medical Significance of Resistin Appearance in Osteoarthritis: A new Meta-Analysis.
Among them, the river area and transition area were more susceptible to silicon restriction in winter, whereas phosphorus restriction mainly occurred during the warm seasons from April to October. XAJR had a retention effect on nitrogen, phosphorus, and silicon, among which phosphorus was more easily retained by the reservoir. In addition, nitrogen underwent transformation processes between different forms inside the reservoir. In the reservoir, the different degrees of retention effect of nutrients also led to a significant increase in the ratio of silicon to phosphorus and nitrogen to phosphorus in the discharged water. This study confirmed that thermal stratification has important control over the contents and forms of nutrients in water. This finding provided an idea for the restoration of the fluxes and stoichiometric ratios of the nutrients in the downstream river using the reservoir's capacity for artificial regulation.Obsessive-Compulsive Disorder (OCD) most often emerges during adolescence, but we know little about the aberrant neural and cognitive developmental mechanisms that underlie its emergence during this critical developmental period. To move towards a computational psychiatry of juvenile OCD, we review studies on the computational, neuropsychological and neural alterations in juvenile OCD and link these findings to the adult OCD and cognitive neuroscience literature. We find consistent difficulties in tasks entailing complex decision making and set shifting, but limited evidence in other areas that are altered in adult OCD, such as habit and confidence formation. Based on these findings, we establish a neurocomputational framework that illustrates how cognition can go awry and lead to symptoms of juvenile OCD. We link these possible aberrant neural processes to neuroimaging findings in juvenile OCD and show that juvenile OCD is mainly characterised by disruptions of complex reasoning systems.Proteinopathies are key elements in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), with the nature and location of the proteinopathy characterizing much of the disease phenotype. Susceptibility of brain regions to pathology may partly be determined by intrinsic network structure and connectivity. It remains unknown, however, how these networks inform the disease cascade in the context of AD biomarkers, such as beta-amyloid (Aβ), in clinically-normal older adults.The default-mode network (DMN), a prominent intrinsic network, is heavily implicated in AD due to its spatial overlap with AD atrophy patterns and tau deposition. We investigated the influence of baseline Aβ positron emission tomography (PET) signal and intrinsic DMN connectivity on DMN-specific cortical thinning in 120 clinically-normal older adults from the Harvard Aging Brain Study (73 ± 6 years, 58% Female, CDR = 0). Participants underwent11C Pittsburgh Compound-B (PiB) PET, 18F flortaucipir (FTP) PET, and resting-state MRI scans at baselineand longitudinal MRI (3.6 ± 0.96 scans; 5.04 ± 0.8 years). Linear mixed models tested relationships between baseline PiB and DMN connectivity on cortical thinning in a composite of DMN regions. Lower DMN connectivity was associated with faster cortical thinning, but only in those with elevated baseline PiB-PET signal. This relationship was network specific, in that the frontoparietal control network did not account for the observed association. Additionally, the relationship was independent of inferior temporal lobe FTP-PET signal. Our findings provide evidence that compromised DMN connectivity, in the context of preclinical AD, foreshadows neurodegeneration in DMN regions.Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous expression of BGCs, a systemic understanding of how its genetic modifications affect the metabolism is lacking and limiting further development. We performed a comparative analysis of M1152 and its ancestor M145, connecting information from proteomics, transcriptomics, and cultivation data into a comprehensive picture of the metabolic differences between these strains. Instrumental to this comparison was the application of an improved consensus genome-scale metabolic model (GEM) of S. coelicolor. Although many metabolic patterns are retained in M1152, we find that this strain suffers from oxidative stress, possibly caused by increased oxidative metabolism. Furthermore, precursor availability is likely not limiting polyketide production, implying that other strategies could be beneficial for further development of S. coelicolor for heterologous production of novel compounds.Mitochondrial function relies on multiple quality control mechanisms, including the release of mitochondrial vesicles. To investigate the ultrastructure and prevalence of mitochondrial membranous protrusions (and, by extension, vesicles) in neurons, we surveyed mitochondria in rat and planarian brains using transmission electron microscopy (EM). We observed that mitochondrial protrusions mostly extend from the outer membrane. Leveraging available 3D EM datasets of the brain, we further analyzed mitochondrial protrusions in neurons of mouse and Drosophila brains, identifying high-resolution spatial views of these protrusions. To assess whether the abundance of mitochondrial protrusions and mitochondria-derived vesicles respond to cellular stress, we examined neurons expressing fluorescently tagged mitochondrial markers using confocal microscopy with Airyscan and found increased numbers of mitochondrial protrusions and vesicles with mild stress. Future studies using improved spatial resolution with added temporal information may further define the functional implications of mitochondrial protrusions and vesicles in neurons.Intestinal disequilibrium leads to inflammatory bowel disease (IBD), and chronic inflammation predisposes to oncogenesis. Antigen-presenting dendritic cells (DCs) and macrophages can tip the equilibrium toward tolerance or pathology. Here we show that delta-9-tetrahydrocannabinol (THC) attenuates colitis-associated colon cancer and colitis induced by anti-CD40. Working through cannabinoid receptor 2 (CB2), THC increases CD103 expression on DCs and macrophages and upregulates TGF-β1 to increase T regulatory cells (Tregs). THC-induced Tregs are necessary to remedy systemic IFNγ and TNFα caused by anti-CD40, but CB2-mediated suppression of APCs by THC quenches pathogenic release of IL-22 and IL-17A in the colon. By examining tissues from multiple sites, we confirmed that THC affects DCs, especially in mucosal barrier sites in the colon and lungs, to reduce DC CD86. Using models of colitis and systemic inflammation we show that THC, through CB2, is a potent suppressor of aberrant immune responses by provoking coordination between APCs and Tregs.
The study aim was to evaluate the associations among the presence of wisdom teeth (third molars, M3), periodontal disease, and serum C-reactive protein (CRP) in the US adult population, thus to generate population-based evidence to inform heart disease prevention and dental care.

We performed secondary data analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES), and included 3752 people aged 30 years and older who participated in the periodontal examination.

Descriptive analyses were performed to determine the prevalence of M3 presence, periodontal disease, and elevated CRP. Multivariate logistic regression modeling was used to determine the association between M3 presence, periodontal disease, and elevated CRP.

The prevalence of M3 presence, periodontal disease (probing periodontal pockets depth (PPD)≥ 4mm), and elevated serum C-reactive protein level (≥5mg/L) was 39%, 41%, and 19% respectively. M3 presence was highest among men, younger adults, Blacks and Hispanics compapresence alone is not associated with elevated CRP. Further research into cardiovascular health hazards related to the retention of wisdom teeth is needed, including examining possible relationships with other inflammatory factors.
In high-income countries, there is a positive relationship between neighborhood-level crime and cardiovascular risk factors (CRFs) in adolescence. A few studies that examined this association in low- and middle-income countries yielded inconsistent results. The aim of our study was to analyze the associations between homicide rates and prevalence rates of CRFs in adolescents living in Brazilian municipalities.

Cross-sectional ecologic study.

An ecologic study was conducted to evaluate associations between homicide rates and CRFs in 122 municipalities included in the Study of Cardiovascular Risk Factors in Adolescents (Portuguese acronym, ERICA). The following CRFs were evaluated adiposity (overweight/obese), sedentary behavior (screen time ≥3h per day), high waist circumference (between 10 and 16 years, percentile ≥90; 16-17 years, ≥90cm for men and ≥80cm for women), low high-density lipoproteins (HDL) levels (<45mg/dl), alcohol use (≥1 drink in the last 30 days) and hypertension (≥percentile 95th). ICA municipalities, although high prevalence rates of homicides and CRFs are important public health concerns, no significant associations were found between these variables.
In ERICA municipalities, although high prevalence rates of homicides and CRFs are important public health concerns, no significant associations were found between these variables.Driving under the influence (DUI) is illegal in the United States because a driver's mental and motor skills can be seriously impaired by alcohol or drugs. Consequently, DUI violators' involvement in severe crashes is high. Motivated by the spatial and temporal nature of traffic crashes, this study introduces an integrated spatio-temporal approach to analyzing highway safety data. Specifically, this study estimates Geographically and Temporally Weighted Regression (GTWR) models to understand the consequences of DUI in crashes. GTWR can theoretically outperform traditional regression methods by accounting for unobserved heterogeneity that may be related to the location and time of a crash. Using Southeast Michigan crash data, this study finds that DUI is associated with a 25% higher likelihood of injury in a crash. The association between injury severity and DUI varies significantly across space and time. From the spatial aspect, DUI crashes in rural or small-town areas are more likely to cause injuries than urban crashes. From the temporal aspect, different times are associated with varying relationships between injury severity and DUI. If focusing on DUI crashes in late nights and early mornings, on Fridays, the entire northeast part from Clinton Charter Township to Port Huron is associated with severer injuries than other regions including Detroit's urban area and its south. On Mondays, the DUI crashes in the northwest are also more likely to cause severe injuries. The methodology introduced in this study takes advantage of modern computational tools and localized crash/inventory data. This method offers researchers and practitioners an opportunity to understand highway safety outcomes in great spatial and temporal details and customize safety countermeasures for specific locations and times such as saturation patrols.
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