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This article presents a new open source extension to the Emergency Events Database (EM-DAT) that allows researchers, for the first time, to explore and make use of subnational, geocoded data on major disasters triggered by natural hazards. The Geocoded Disasters (GDIS) dataset provides spatial geometry in the form of GIS polygons and centroid latitude and longitude coordinates for each administrative entity listed as a disaster location in the EM-DAT database. In total, GDIS contains spatial information on 39,953 locations for 9,924 unique disasters occurring worldwide between 1960 and 2018. The dataset facilitates connecting the EM-DAT database to other geographic data sources on the subnational level to enable rigorous empirical analyses of disaster determinants and impacts.High resolution simulations at 4.4 km and 1.5 km resolution have been performed for 12 historical tropical cyclones impacting Bangladesh. We use the European Centre for Medium-Range Weather Forecasting 5th generation Re-Analysis (ERA5) to provide a 9-member ensemble of initial and boundary conditions for the regional configuration of the Met Office Unified Model. The simulations are compared to the original ERA5 data and the International Best Track Archive for Climate Stewardship (IBTrACS) tropical cyclone database for wind speed, gust speed and mean sea-level pressure. The 4.4 km simulations show a typical increase in peak gust speed of 41 to 118 knots relative to ERA5, and a deepening of minimum mean sea-level pressure of up to -27 hPa, relative to ERA5 and IBTrACS data. The downscaled simulations compare more favourably with IBTrACS data than the ERA5 data suggesting tropical cyclone hazards in the ERA5 deterministic output may be underestimated. The dataset is freely available from https//doi.org/10.5281/zenodo.3600201 .Spin thermoelectrics, an emerging thermoelectric technology, offers energy harvesting from waste heat with potential advantages of scalability and energy conversion efficiency, thanks to orthogonal paths for heat and charge flow. However, magnetic insulators previously used for spin thermoelectrics pose challenges for scale-up due to high temperature processing and difficulty in large-area deposition. Here, we introduce a molecule-based magnetic film for spin thermoelectric applications because it entails versatile synthetic routes in addition to weak spin-lattice interaction and low thermal conductivity. Selleckchem STO-609 Thin films of CrII[CrIII(CN)6], Prussian blue analogue, electrochemically deposited on Cr electrodes at room temperature show effective spin thermoelectricity. Moreover, the ferromagnetic resonance studies exhibit an extremely low Gilbert damping constant ~(2.4 ± 0.67) × 10-4, indicating low loss of heat-generated magnons. The demonstrated STE applications of a new class of magnet will pave the way for versatile recycling of ubiquitous waste heat.Chronic obstructive pulmonary disease (COPD) and asthma impact on work productivity, but their population-based burden and clinical predictors are understudied. In this observational, real-life study, work absence of 14,383 asthma and/or COPD patients present in the MAJORICA cohort (Spain) was compared with the general population. Using multivariable regression, we studied the association of work absence with demographic and clinical characteristics. Patients with asthma and/or COPD had more work absence than the general population (15.2% vs 8.9%, p  less then  0.0001). Patients with asthma had more often periods of work absence compared to patients with COPD (16.0% vs 12.8%, p  less then  0.0001). The number of days absent were, however, less in asthma than in COPD (median 15 days [IQR 5-51] vs 39 days [IQR 13-134], p  less then  0.001). Patients with asthma-COPD overlap were in between (14.5% with absence; median 27 days [IQR 10-82]). Comorbid anxiety, allergic rhinitis, and sleep apnoea were independently associated with more work absence.Increases in adhesive and invasive commensal bacteria, such as Escherichia coli, and subsequent disruption of the epithelial barrier is implicated in the pathogenesis of inflammatory bowel disease (IBD). However, the protective systems against such barrier disruption are not fully understood. Here, we show that secretion of luminal glycoprotein 2 (GP2) from pancreatic acinar cells is induced in a TNF-dependent manner in mice with chemically induced colitis. Fecal GP2 concentration is also increased in Crohn's diease patients. Furthermore, pancreas-specific GP2-deficient colitis mice have more severe intestinal inflammation and a larger mucosal E. coli population than do intact mice, indicating that digestive-tract GP2 binds commensal E. coli, preventing epithelial attachment and penetration. Thus, the pancreas-intestinal barrier axis and pancreatic GP2 are important as a first line of defense against adhesive and invasive commensal bacteria during intestinal inflammation.Attributing the similarity between individuals to genetic and non-genetic factors is central to genetic analyses. In this paper we use the genomic relationship ([Formula see text]) among 417,060 individuals to investigate the phenotypic covariance between pairs of individuals for 32 traits across the spectrum of relatedness, from unrelated pairs through to identical twins. We find linear relationships between phenotypic covariance and [Formula see text] that agree with the SNP-based heritability ([Formula see text]) in unrelated pairs ([Formula see text]), and with pedigree-estimated heritability in close relatives ([Formula see text]). The covariance increases faster than [Formula see text] in distant relatives ([Formula see text]), and we attribute this to imperfect linkage disequilibrium between causal variants and the common variants used to construct [Formula see text]. We also examine the effect of assortative mating on heritability estimates from different experimental designs. We find that full-sib identity-by-descent regression estimates for height (0.66 s.e. 0.07) are consistent with estimates from close relatives (0.82 s.e. 0.04) after accounting for the effect of assortative mating.The Antarctic sea ice area expanded significantly during 1979-2015. This is at odds with state-of-the-art climate models, which typically simulate a receding Antarctic sea ice cover in response to increasing greenhouse forcing. Here, we investigate the hypothesis that this discrepancy between models and observations occurs due to simulation biases in the sea ice drift velocity. As a control we use the Community Earth System Model (CESM) Large Ensemble, which has 40 realizations of past and future climate change that all undergo Antarctic sea ice retreat during recent decades. We modify CESM to replace the simulated sea ice velocity field with a satellite-derived estimate of the observed sea ice motion, and we simulate 3 realizations of recent climate change. We find that the Antarctic sea ice expands in all 3 of these realizations, with the simulated spatial structure of the expansion bearing resemblance to observations. The results suggest that the reason CESM has failed to capture the observed Antarctic sea ice expansion is due to simulation biases in the sea ice drift velocity, implying that an improved representation of sea ice motion is crucial for more accurate sea ice projections.Broadband terahertz spectroscopy enables many promising applications in science and industry alike. However, the complexity of existing terahertz systems has as yet prevented the breakthrough of this technology. In particular, established terahertz time-domain spectroscopy (TDS) schemes rely on complex femtosecond lasers and optical delay lines. Here, we present a method for optoelectronic, frequency-modulated continuous-wave (FMCW) terahertz sensing, which is a powerful tool for broadband spectroscopy and industrial non-destructive testing. In our method, a frequency-swept optical beat signal generates the terahertz field, which is then coherently detected by photomixing, employing a time-delayed copy of the same beat signal. Consequently, the receiver current is inherently phase-modulated without additional modulator. Owing to this technique, our broadband terahertz spectrometer performs (200 Hz measurement rate, or 4 THz bandwidth and 117 dB peak dynamic range with averaging) comparably to state-of-the-art terahertz-TDS systems, yet with significantly reduced complexity. Thickness measurements of multilayer dielectric samples with layer-thicknesses down to 23 µm show its potential for real-world applications. Within only 0.2 s measurement time, an uncertainty of less than 2 % is achieved, the highest accuracy reported with continuous-wave terahertz spectroscopy. Hence, the optoelectronic FMCW approach paves the way towards broadband and compact terahertz spectrometers that combine fiber optics and photonic integration technologies.Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the nervous system. They have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. We report three structures of the Cys-loop 5-HT3A serotonin receptor (5HT3R) reconstituted into saposin-based lipid bilayer discs a symmetric and an asymmetric apo state, and an asymmetric agonist-bound state. In comparison to previously published 5HT3R conformations in detergent, the lipid bilayer stabilises the receptor in a more tightly packed, 'coupled' state, involving a cluster of highly conserved residues. In consequence, the agonist-bound receptor conformation adopts a wide-open pore capable of conducting sodium ions in unbiased molecular dynamics (MD) simulations. Taken together, we provide a structural basis for the modulation of 5HT3R by the membrane environment, and a model for asymmetric activation of the receptor.As countries in Europe implement strategies to control the COVID-19 pandemic, different options are chosen regarding schools. Through a stochastic age-structured transmission model calibrated to the observed epidemic in Île-de-France in the first wave, we explored scenarios of partial, progressive, or full school reopening. Given the uncertainty on children's role, we found that reopening schools after lockdown may increase COVID-19 cases, yet protocols exist to keep the epidemic controlled. Under a scenario with stable epidemic activity if schools were closed, reopening pre-schools and primary schools would lead to up to 76% [67, 84]% occupation of ICU beds if no other school level reopened, or if middle and high schools reopened later. Immediately reopening all school levels may overwhelm the ICU system. Priority should be given to pre- and primary schools allowing younger children to resume learning and development, whereas full attendance in middle and high schools is not recommended for stable or increasing epidemic activity. Large-scale test and trace is required to keep the epidemic under control. Ex-post assessment shows that progressive reopening of schools, limited attendance, and strong adoption of preventive measures contributed to a decreasing epidemic after lifting the first lockdown.
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