Notes

The enhanced proportional-derivative controller for your individual top extremity together with gravitational forces.
This study aims to investigate the relationship between work-related stress and sleep disorders in healthcare personnel working in emergency department and in other departments.

This cross-sectional study included 34 emergency department healthcare personnel (emergency group [EG]) and 35 healthcare personnel working in other departments (non-emergency group [NEG]) and was conducted between November 10, 2019 and March 1, 2020. Bestatin cell line All participants were administered the following questionnaires work-related strain inventory (WRSI), Epworth sleepiness scale (ESS), Berlin questionnaire, insomnia severity index (ISI), Pittsburgh sleep quality index (PSQI), Beck depression inventory (BDI), and Beck anxiety inventory (BAI).

While the mean WRSI score of EG was 39.53±7.77, the mean WRSI score of NEG was 30.06±7.26 (t=5.236, p<0.001). According to PSQI, 79.4% of EG and 57.1% of NEG were found to have poor sleep quality (X
=3.938, df=1,
=0.047). Median PSQI overall score was 12 (IQR 25th-75th percentiles 10-14) nts and that there was a significant relationship between sleep disorders and work-related stress.
Poor sleep quality and unhealthy sleep hygiene practices are often correlated and co-existing. However, there is no single validated tool to assess both sleep quality and sleep hygiene practices. Therefore, this study presents psychometric validation findings of an instrument developed to assess both sleep quality and sleep hygiene practices.

A sample (n=395, age = 21.9±4.2 years, body mass index = 20.86±3.22kg/m2, male = 328, female = 67) from Mizan-Tepi University, Ethiopia, completed this cross-sectional study involving the perceived stress scale 10 (PSS -10), the generalized anxiety disorder-7 scale (GAD-7), the Mizan sleep quality and sleep hygiene index (MiSQuaSHI), the Leeds sleep evaluation questionnaire-Mizan (LSEQ-M) and a socio-demographics tool.

No significant skewness, kurtosis, and ceiling/floor effect were seen in the MiSQuaSHI total score. The discriminative validity was favored by significant differences (8 item scores, MiSQuaSHI total and factor scores) in students with moderate-severe GAD than normal. The concurrent validity test found an area under the curve (AUC) of 0.81 (CI 0.76-0.85; p<.0001) with a sensitivity and specificity of 62% and 88%, respectively at the cut-off score of 7.5 with the LSEQ-M. The divergent validity was evidenced by correlations of MiSQuaSHI total score with both GAD -7 (r=0.24) and PSS -10 (r=0.20). The internal consistency was adequate (Cronbach's alpha=0.70). Exploratory factor analysis (EFA) results were inconsistent. However, confirmatory factor analysis (CFA) found that the 5-factor model had the best fit.

The findings support the validity of the MiSQuaSHI as a global measure of poor sleep quality associated with poor sleep hygiene.
The findings support the validity of the MiSQuaSHI as a global measure of poor sleep quality associated with poor sleep hygiene.
Sleep deprived people have difficulties to perform daily activities. Their performance depends on three basic cognitive processes attention, working memory, and executive functions.

The aim of this study was to identify which specific components of these cognitive processes are more susceptible to a 24-h sleep deprivation period.

Participants were 23 undergraduate students assigned to one of two groups a control group (n=11, age=18.73±1.62 years) and a sleep deprivation group (n=12, age=18.08±1.16 years). After sleeping freely, control group participants performed a continuous performance task to evaluate the components of attention, a phonological and a visuospatial tasks to record these components of working memory, and a Stroop-like task to assess cognitive inhibition and flexibility, two components of executive functions, at noon for 3 days. Whereas, the sleep deprivation group participants performed the same tasks at noon after sleeping freely for one night, after a 24-h sleep deprivation, and after one recovery night.

After the sleep deprivation, participants had a significant reduction in tonic alertness, selective and sustained attention, components of attention; and in cognitive inhibition, component of executive functions.

A 24-h sleep deprivation period reduces several specific components of the basic cognitive processes, which are crucial for performing many everyday activities, thus increasing the risk of errors and accidents.
A 24-h sleep deprivation period reduces several specific components of the basic cognitive processes, which are crucial for performing many everyday activities, thus increasing the risk of errors and accidents.
Sleep deprivation and insomnia have negative impacts on mental and physical health in adolescents. In order to examine the problems caused by insomnia, we need tools with acceptable validity and reliability for the target population. The aim of this study was to evaluate the psychometric properties of Insomnia Severity Index (ISI) in Iranian adolescent population.

The study was carried out as a descriptive-analytic normalization. Study group consisted of 701 adolescents aged 12 to 19, who were selected through cluster sampling. The participants completed ISI, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Inventory (PSQI), Adolescent sleep hygiene scale (ASHS) and global sleep assessment questionnaire (GSAQ). In addition, SPSS ver.22 and AMOSS ver.10 were used to analyze the data.

The reliability of the test was obtained equal to 0.77 based on Cronbach's alpha and a good reliability (0.84) was obtained through test/retest method. Exploratory and confirmatory factor analyses with seven items were computed. The models fitness indexes were suitable for the structural model (CFI=0.99%, NFI=0.98%, GFI=0.99%, TLI=0.98%, RMSEA=0.049%). Moreover, there was a direct and significant correlation between the ISI index and the total score of other indexes. As to gender-based reliability, Cronbach's alpha was 0.78 in female adolescents and 0.85 in male adolescents.

The results indicated that the Persian version of the insomnia severity index can be used as a reliable and valid tool for assessing the severity of insomnia in Persian-speaking adolescents.
The results indicated that the Persian version of the insomnia severity index can be used as a reliable and valid tool for assessing the severity of insomnia in Persian-speaking adolescents.
To identify the frequency of sleep complaints (SC) and associated menopausal symptoms in climacteric women, apparently healthy, residing in three different capital cities of the Colombian Caribbean.

Cross-sectional study which is part of the investigation project CAVIMEC [
]. Data were collected by interviewers, on a door-to-door visit. Healthy women residing in the Colombian Caribbean, 40-59 years old, were studied. Sociodemographic characteristics form and scales were applied Menopause Rating Scale, Jenkins Sleep Scale, Perceived Psychological Stress (perceived stress), Goldberg Anxiety and Depression Scale, SCOFF scale (eating disorders), and Loneliness Scale by Hughes. The women were divided into two groups with SC and without SC, according to the Jenkins scale result. Crude and adjusted logistic regressions were performed SC (dependent variable) with sociodemographic characteristics and the results of the scales used (independent variables).

Five hundred eighty-five women were studied. 16.5% with SC. No differences were observed in age, BMI, and high blood pressure. Proportionally more women with SC had depression, anxiety, perception of loneliness, severe menopausal symptoms, somatic, psychological, urogenital, and quality of life severe impairment (
<0.05). There were no differences in eating disorders and perceived stress. In the adjusted model, only depression was associated with SC, OR 9.81 [95% CI 1.29-74.3], p<0.05.

SC were identified in 16.5% of the climacteric women of the Colombian Caribbean. In an adjusted model, probable depression was the only factor associated with SC.
SC were identified in 16.5% of the climacteric women of the Colombian Caribbean. In an adjusted model, probable depression was the only factor associated with SC.[This corrects the article DOI 10.18632/oncotarget.3253.].Cancer is a global public health concern that is characterized by the uncontrolled growth of tumor cells. It is regarded as the subsequent cause of death after cardiovascular disease. The most common types of cancer include breast, colorectal, lung, and prostate. The risk factors attributed to the development of common types of cancer are tobacco smoking, excessive alcohol consumption, dietary factors, ultraviolet radiation (UV), and lack of physical activities. Two major cellular apoptotic pathways targeted in cancer therapies are intrinsic and extrinsic. These two pathways are regulated by different types of proteins, the multidomain pro-apoptotic proteins (Bak, Bax, and Bok), BH3-only pro-apoptotic proteins (Bid, Bim, Bad, Noxa, and Puma), and the anti-apoptotic proteins (Mcl-1, Bfl-1, Bcl-XL, Bcl-2, Bcl-w, and Bcl-B). Other significant molecules/factors that are known to execute cellular apoptotic pathways include bioactive compounds, and reactive oxygen species (ROS). Proteolytic caspases are known to play a vital role in the initiation of apoptotic activities in cancerous cells. Based on their functions, they are categorized into initiators and executioners. Nanotechnology has produced novel outcomes in modern medicine. The green synthesis of nanoparticles has demonstrated prospective improvements in cancer therapies in combination with the existing therapies including photodynamic therapy. This review aims at highlighting the association between pro-apoptotic and anti-apoptotic proteins, and their significance in cancer therapy.Patients with metastatic castration-resistant prostate cancer (mCRPC) have an average survival of only 13 months. Identification of novel predictive and actionable biomarkers in the homologous recombination repair (HRR) pathway in up to a quarter of patients with mCRPC has led to the approval of targeted therapies like poly-ADP ribose polymerase inhibitors (PARPi), with the potential to improve survival outcomes. The approval of PARPi has led to guideline bodies such as the National Comprehensive Cancer Network (NCCN) to actively recommend germline and or somatic HRR gene panel testing to identify patients who will benefit from PARPi. However, there are several challenges as genetic testing is still at an early stage especially in low- and middle-income countries, with cost and availability being major impediments. In addition, there are issues such as choice of optimal tissue for genetic testing, archival, storage, retrieval of tissue blocks, interpretation and classification of variants in the HRR pathway, and the need for pretest and post-test genetic counseling. This review provides insights into the HRR gene mutations prevalent in mCRPC and the challenges for a more widespread gene testing to identify actionable germline pathogenic variants and somatic mutations in the HRR pathway, and proposes a clinical algorithm to enhance the efficiency of the gene testing process.The aberrant expression of miRNAs is often correlated to tumor development. MiR-7-5p is a recently discovered downregulated miRNA in thyroid papillary carcinoma (PTC). The goal of this project was to characterize its functional role in thyroid tumorigenesis and to identify the targeted modulated pathways. MiR-7-5p overexpression following transfection in TPC1 and HT-ori3 cells decreased proliferation of the two thyroid cell lines. Analysis of global transcriptome modifications showed that miR-7-5p inhibits thyroid cell proliferation by modulating the MAPK and PI3K signaling pathways which are both necessary for normal thyroid proliferation and play central roles in PTC tumorigenesis. Several effectors of these pathways are indeed targets of miR-7-5p, among which EGFR and IRS2, two upstream activators. We confirmed the upregulation of IRS2 and EGFR in human PTC and showed the existence of a negative correlation between the decreased expression of miR-7-5p and the increased expression of IRS2 or EGFR. Our results thus support a tumor-suppressor activity of miR-7-5p.
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