Notes

Subsyndromal generalised anxiety: operationalisation and also epidemiology : a systematic novels review.
Major life transitions often co-occur with significant fluctuations in hormones that modulate the central nervous system. www.selleckchem.com/mTOR.html These hormones enact neuroplastic mechanisms that prepare an organism to respond to novel environmental conditions and/or previously unencountered cognitive, emotional, and/or behavioral demands. In this review, we will explore several examples of how hormones mediate neuroplastic changes in order to produce adaptive responses, particularly during transitions in life stages. First, we will explore hormonal influences on social recognition in both males and females as they transition to sexual maturity. Next, we will probe the role of hormones in mediating the transitions to motherhood and fatherhood, respectively. Finally, we will survey the long-term impact of reproductive experience on neuroplasticity in females, including potential protective effects and risk factors associated with reproductive experience in mid-life and beyond. Ultimately, a more complete understanding of how hormones influence neuroplasticity throughout the lifespan, beyond development, is necessary for understanding how individuals respond to life changes in adaptive ways.Pressurized vertical electro-osmotic dewatering (PVEOD) has been regarded as a feasible method to achieve sludge deep-dewatering, but the dewatering efficiency is still challenged by high electric resistance. This study employed cationic polyacrylamide (CPAM) as a skeleton builder to enhance electro-osmotic flow in PVEOD. The sludge dewatering efficiency and synergistic effect of CPAM and PVEOD were elucidated. The sludge morphology, surface property, extracellular polymeric substances (EPS) destruction and migration, spatial distributions of proteins and polysaccharides, and current changes were investigated. After the addition of optimal CPAM dose, the sludge formed a uniform and porous structure that provided water channels and enhanced electric transport, thus promoting EPS destruction. The sludge moisture content (MC) analysis indicated the more liberation of bound water due to EPS destruction. Besides, the re-flocculation of disintegrated sludge flocs improved the sludge filtration and thus dewaterability. Instantaneous energy consumption (Et,0.5) was optimized and two-step synergistic mechanism was thus proposed. These findings indicated that the combination of CPAM and PVEOD is a promising strategy to broaden the scope of industrial application of sludge deep-dewatering.Cadmium (Cd), a non-essential trace element, it's intrusion in groundwater has ubiquitous implications on the environment and human health. This review is an approach to comprehensively emphasize on i) chemistry and occurrence of Cd in groundwater and its concomitant response on human health ii) sustainable Cd remediation techniques, iii) and associated costs. Current study is depending on meta-analysis of Cd contaminations in groundwater and discusses its distributions around the globe. Literature review primarily comprises from the last three decades online electronic published database, which mainly includes i) research literatures, ii) government reports. On the basis of meta-data, it was concluded that Cd mobility depends on multiple factors such as pH, redox state, and ionic strength, dissolved organic (DOC) and inorganic carbon (DIC). A substantially high Cd concentration has been reported in Lagos, Nigeria (0.130 mg/L). In India, groundwater is continuing to be contaminated by Cd in the proximity of industrial, agricultural areas, high concentrations (>8.20 mg/L) were reported in Tamil Nadu and Maharashtra. Depending on chemical behavior and ionic radius cadmium disseminate into the food chain and ultimately cause health hazard that can be measured by various index-based assessment tools. Instead of chemical adsorbents, nanoparticles, phytoextraction, and bioremediation techniques can be very useful in the remediation and management of Cd polluted groundwater at a low-cost. For Cd pollution, the development of a comprehensive framework that links the hydro-geological, bio-geochemical processes to public health is important and need to be further studied.Hexavalent chromium [Cr(VI)] and its compounds have been associated with various respiratory diseases, while few studies have attempted to determine its adverse effect on lung function. To explore the potential early indicators of health surveillance for respiratory diseases induced by chromate exposure, a longitudinal cohort study including 515 workers with 918 measurements across 2010-2017 was conducted to investigate the impact of individual internal exposure on lung function. Inductively coupled plasma mass spectrometry (ICP-MS) and spirometry were used to measure whole blood chromium (blood Cr) and lung function respectively. In the linear mixed-effects analysis, each 1- unit increase in Ln- transformed blood Cr was significantly associated with estimated effect percentage decreases of 1.80 (0.35, 3.15) % in FEV1, 0.77 (0.10, 1.43) % in FEV1/FVC, 2.78 (0.55, 4.98) % in PEF, and 2.73 (0.59, 4.71) % in FEF25-75% after adjusting for related covariates. Exposure- response curve depicted the reduction of lung function with blood Cr increase, and the reference value of blood Cr was proposed as 6 μg/L considering the lung function as health outcome. Based on the repeated-measure analysis, compared with the low frequency group, subjects with high frequency of high exposure across 2010-2017 had an additional reduction of 5.65 (0, 11.3) % in FVC. Subjects with medium frequency showed more obvious declines of 9.48 (4.16, 14.87) % in FVC, 8.63 (3.49, 13.97) % in FEV1, 12.94 (3.34, 22.53) % in PEF and 10.97 (3.63, 18.30) % in MVV. These findings suggested that short- term high exposure to Cr associated with obstructive ventilatory impairment, and long- term exposure further led to restrictive ventilatory impairment.Land-use change can lead to profound changes in the storage of soil organic carbon (SOC) in the tropics. Soil microbial residues make up the majority of persistent SOC pools, yet the impact of land-use change on microbial residue C accumulation in the tropics is not well understood. Here, we investigated how the conversion of tropical primary montane rainforest to secondary forest and the conversions of secondary forest to Prunus salicina plantation and tea plantation, influence the accumulation of soil microbial residue C (indicated by amino sugars). Our results showed that the secondary forest had a higher SOC than that of the primary forest (+63%), while they had no difference in microbial residue C concentration, indicating a relatively slow microbial-derived C accrual during secondary succession. Moreover, the P. salicina plantation and tea plantation had lower SOC than the secondary forest (-53% and -57%, respectively). A decrease in fungal biomass (-51%) resulted in less fungal and total residue C concentrations in the tea plantation than in the secondary forest (-38% and -35%, respectively), indicating microbial-derived C loss following the forest conversion. The change in microbial residue C depended on litter standing crop rather than soil nutrient and root biomass. Litter standing crop affected microbial residue C concentration by regulating fungal biomass and hydrolytic enzyme activities. Taken together, our results highlight that litter-microbe interactions drive microbial residue C accumulation following forest conversions in the tropics.Arsenic (As) transformation by human gut microbiota has been evidenced to impact As toxicity and human health. However, little is known about the influence of gut microbiota on As bioavailability from incidental ingestion of soil. In this study, we assessed As relative bioavailability (RBA) using an in vivo mouse model and As bioaccessibility in the colon phase of in vitro assays. Strong in vivo-in vitro correlations (R2 = 0.70-0.92, P less then 0.05) were observed between soil As RBA (10.2%-57.7%) and colon bioaccessibility (4.8%-49.0%) in 13 As-contaminated soils. Upon in vitro incubation of human colon microbiota, we found a high degree of As transformation and 65.9% of generated As(III) was observed in soil residues. For in vivo mouse assay, DMA(V) accounted for 79.0% of cumulative urinary As excretion. Except for As(V), dominant As species including As(III), DMA(V) and As sulfides were also detected in mouse feces. Gut bacteria (families Rikenellaceae and Marinifilaceae) could be significantly correlated with As intake and excretion in mice (P less then 0.05). Our findings provide evidence that gut microbiota can affect transformation, bioavailability, and fate of the orally ingested soil As in human gastrointestinal tract.The minimization of Cd pollution in wheat is urgently needed in many parts of the world. Thus, the aims of the present study were to evaluate the feasibility of popular technologies (i.e., soil amendment and low-Cd wheat cultivar) at sites with different Cd risk levels (high and low) and to propose a risk-based strategy for safe grain production. At a high-Cd site, wheat variety JM22 yielded significantly lower grain Cd than SX828, regardless of soil amendment (biochar, sepiolite, and microbial agent YZ1). Neither biochar nor sepiolite amendment reduced grain Cd, DTPA-Cd, or bioconcentration factors, possibly due to low dosage. Metagenomic sequencing and quantitative PCR showed that YZ1 colonization had little effect on rhizospheric fungal community structure and could not be sustained through winter. At a low-Cd site, significantly lower grain Cd was observed in JM22, LX99, and JM262, which could be used as low-Cd cultivars in the study area. Interestingly, the grain Cd of JM22 was linearly correlated with soil Cd (R2 = 0.84), which allowed the inference of a soil Cd threshold of 1.55 mg·kg-1, below which JM22 alone was capable of producing safe grain. Cost-benefit analysis also indicated that the use of low-Cd cultivars is promising for pollution control. This study provides viable technical solutions for minimizing the grain Cd of wheat grown in northern China.Microplastics pose a serious threat to ecological processes and environmental health. To evaluate the toxic effects of the exposure of microplastics on submerged plants and biofilms, eel grass (Vallisneria natans) was exposed to different concentrations of microplastics (10-50 mg L-1). The changes in microbial community on leaf biofilms were also tested. The results showed that the ratio of variable fluorescence to maximum fluorescence was largely unchanged, but the contents of chlorophyll a and b increased by 56.5% and 23.0% respectively. Different concentrations of exposure to microplastics effectively induced antioxidant responses, such as increasing the activities of superoxide dismutase, peroxidase and catalase, as well as increasing the activity of glutathione S-transferase and the contents of glutathione and malondialdehyde. In addition, the leaf flesh cells of Vallisneria natans showed some degree of organelle damage when examined by transmission electron microscopy. Moreover, a high-throughput sequencing analysis showed that the abundances and structure of the microbial community on the leaf biofilms were altered by exposure to microplastics. These results demonstrated that environmentally relevant concentrations of microplastics could disrupt homeostasis, induce effective defense mechanisms of Vallisneria natans and alter the biofilms in aquatic ecosystems.
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