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Rational acting of throughout vitro difference associated with man monocytes into dendritic tissue unravels novel transcriptional regulating friendships.
The ecological environment in China's arid and semi-arid regions has been improving over the past few decades. Using the Mu Us Sandy Land (MUSL) as a case study, we examine the consequent climate feedbacks and the impacts of revegetation on regional climate by incorporating high-resolution remote-sensing vegetation data into the WRF-Noah model. From 2001 to 2010, although a small portion of the grassland was degraded in MUSL, vegetation overall improved, with green fraction and leaf area index increased and surface albedo decreased. The model simulation suggests a cooling of the near-surface temperature by 0.12-0.32 °C on average and up to >0.5 °C in summer, with a reduction in nighttime minimum of 0.15-0.46 °C and in daytime maximum of less then 0.13 °C. The cooling is accompanied by a slight increase in 2-m air humidity. The near-surface cooling and wetting are induced by revegetation-enhanced evapotranspiration, but they have insignificant effect on the local precipitation. The results of this study imply that while revegetation has positive effects on the ecological systems in MUSL, it bears the cost of an increase in evapotranspiration of 51 mm per summer, which may exacerbate the water shortages in the region.Identification of the key variables that influence spatial variation in stream water quality is crucial for designing sustainable water management strategies. In this study, we investigated the key variables that influence the spatial variability of stream of water quality, across multiple watersheds. This study uses water quality data collected over 19 years for 59 watersheds located in the Southeast Atlantic region of the United States, which includes the states of North Carolina, South Carolina, and Georgia. A conceptual modeling framework was developed to understand the linkage between the long-term mean water quality constituents (Total nitrogen, Total phosphorus, Turbidity, and pH) and the watershed characteristics (e.g., topography, land use/cover, soil type), streamflow data, and climatic variables (precipitation and temperature). The modeling results suggest that not only anthropogenic variables influence the mean water quality constituents, but other watershed characteristics, such as soil properties, have a significant impact. The natural watershed characteristics explain most of the spatial variability in the mean Turbidity and pH values in streams. The modeling results also suggest that once land use and soil properties are considered, watershed topography has a limited role to explain the variation in the mean water quality. Overall, the developed watershed models can be used to forecast stream water-quality responses to future land use, climate, soil, and land management changes within the study area.Air pollution exposure is recently reported to be one of the drivers of exacerbation in idiopathic pulmonary fibrosis (IPF). But there was a lack of direct evidence between pollution and lung fibrosis. Here, our data show effects of pollutant benzo[a]pyrene (BaP) and protein G-protein-coupled receptor family C group 5 type A (GPRC5A) on pulmonary fibrosis, which might help limit potential pollutant injury and disease progression. We cross-referenced epithelial differentially-expressed-genes (DEGs) from pollutant injury and published experimental fibrosis and IPF patients' data, top common-DEG (CO-DEG) GPRC5A was identified as a potential link between exposure-damage and fibrogenesis. The role of GPRC5A was evaluated under BaP exposure, in idiopathic interstitial pneumonia (IIP) tissue-array and via CRISPR/Cas9 knockout mice (Gprc5a-/-). BaP exposure enhanced bleomycin (BLM)-induced murine pulmonary fibrosis with increased Fibronectin and α-SMA expression in primary fibroblasts, thickened respiratory membrane osis of IIP patients and fibrogenesis in murine model; thus, GPRC5A could serve as a novel therapeutic target in pollutant injury and pulmonary fibrosis.Silicon (Si) addition to flooded rice paddy soil tends to decrease grain inorganic arsenic (iAs) and increase grain dimethylarsinic acid (DMA) concentrations, but the mechanism for the increase in plant-available DMA is unresolved. It has been suggested that Si displaces DMA from soil solids, rendering it plant-available; however, we hypothesize that Si desorbs primarily iAs from soil solids, which stimulates methylation to DMA. We added silicic acid to a contaminated paddy soil and a flooded upland soil that had been historically contaminated with lead arsenate in a batch incubation experiment, and measured changes in solid-phase As speciation, porewater As speciation, and As-methylating microbial (AsMM) abundance over time. We found that DMA was not detectable in soils prior to the start of the experiment nor throughout the experiment, so it comprised a trace amount of total soil As. Upon Si addition to paddy soil, total As increased in porewater following Si spike and this increase was mainly due to iAs desorption, and an order of magnitude less MMA and DMA was desorbed. The upland soil transitioned to reducing conditions throughout the experiment, but when they were achieved, iAs was desorbed first and this was followed by an increase of MMA and then DMA compared to control soils. Total microbial community abundance increased over the course of the experiments and arsM gene abundance increased from initial conditions, but did not differ between treatments. In the paddy soil, the ratio of arsM16S gene abundance decreased from the initial conditions, but it increased in the upland soil with historic As contamination. These results suggest that Si-induced desorption of DMA is small and likely does not explain the increases of plant-available DMA upon Si fertilization in prior work. Likely, Si-induced iAs desorption drives microorganisms to methylate iAs, but degree of methylation will differ between soils.The ingestion of microplastics by shellfish pose a potential health risk for human via seafood consumption. This study investigated and compared the contamination levels and potential human health risks of microplastics in the digestive system of commercial shellfish from North (Qingdao) and South (Xiamen) China. Microplastics were detected in 70%-100% of shellfish samples from Qingdao and 70%-90% of shellfish samples from Xiamen, with abundances ranging from 1.2 to 4.1 items/individual (or 0.8-4.4 items/g, wet weight of digestive system) in shellfish from Qingdao and 1.3-6.0 items/individual (or 2.1-4.0 items/g) in shellfish from Xiamen. The microplastic composition was dominated by rayon and tended to be fibrous in shape, and white, black, and transparent in color. Microplastics less then 500 μm were the dominant size range, in which the size range of 100-200 μm was the most abundant size. Features of microplastics in the water-dwelling shellfish were different from those of the sediment-dwelling shellfish, and the microplastic features in the shellfish correlated with the sampling region, shellfish length, total wet body weight, and wet weight of the digestive system. Risk assessment results revealed that the potential human health risk posed by microplastics from the digestive system of commercial shellfish was higher in Qingdao than Xiamen.Dredged sediment contains various contaminants that are released during the process of dewatering and subsequent utilization. In this study, two organic polymers-chitosan (CS) and cationic polyacrylamide (CPAM) both in samples of varying molecular weights (MWs)-were used as flocculants to improve dewatering and rheological behaviors of dredged sediment, and floc properties were characterized to unravel the mechanisms of flocculation treatment. Moreover, pollutant transfer and release in the flocculation-dewatering process was investigated. click here Compared to CPAM, CS had better performance in dredged sediment dewatering, and more compact flocs were produced after treatment. The flocculated sediment belonged to the type of yield dilatant fluid and showed good shear resistance. Three-dimensional excitation-emission matrix spectroscopy and PARAFAC showed that protein-like substances were removed after treatment. The MW of CS had insignificant effects on flocculation performance, whereas CPAM removal efficiency for protein-like substances was increased at higher MWs, which may be related to the adsorption bridging effect of CPAM polymer chains. There were significant correlations between the dewatering performance of sediments, MW distribution of organics and rheological properties. CS and CPAM treatments caused the transformation of Fe/Al-P into CaP, which could reduce phosphorus release and its ecological risk. The flocculants contributed to the formation of carbonate-bound forms of As, Cr, Pb, and Ni. Ecological risk assessment results of the geo-accumulation index showed that medium- and low-MW CS reduced risk of sediment contamination, whereas CPAM and high-MW CS increased the ecological risk. CS had a greater effect on the release of VOCs than CPAM, with an increased release of total VOCs at higher flocculant MWs. The study was helpful to understand the dewatering mechanism of dredged sediment and provided a new strategy for pollution release management in sediment dewatering.Lake Urmia, located in the North West of Iran, was once the most extensive permanent hypersaline lake in the world. Unsustainable water management in response to increasing demand together with climatic extremes have given rise to the lake's depletion during the last two decades. The Urmia Lake Restoration Program (ULRP) was established in 2013 and aims to restore the lake within a 10-year program. This study aims to monitor these restoration endeavours using spaceborne and ground-based observations. We analyzed the in-situ water level, the surface water extent, and the water volume of the lake. The water storage change of the Urmia Lake catchment is quantified using the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On satellite observations, which gives us a holistic view of hydrological components. Our analysis shows a positive trend of 14.5 cm/yr, 204 km2/yr, and 0.42 km3/yr in the time series of lake water level, lake water area, and water volume from 2015 to 2019 which indicates a short-lived stabilization of Lake Urmia. This has been achieved mainly due to an increase of 0.35 km3/yr in inflow from rivers to the lake, predominantly driven by anomalous precipitation events in 2016 and early 2019. However, the long-term trend from 2003 to 2019 still shows negative values of -22 cm/yr, -200 km2/yr, and -0.72 km3/yr for the water level, the surface area, and the water volume of the lake, respectively. The stabilization seems to be fragile however, since most of the increase in the water volume of the lake has spread over the large shallow southern region with high evaporation potential during hot seasons. Furthermore, due to the high correlation between the lake water level and precipitation, the recovery observed in 2016 and the first half of 2019 might not continue in case of a long drought period.The occurrence of Benzotriazole Ultraviolet Stabilizer-328 (BUV-328) in different environmental and biological matrices is of immediate environmental concern. In the present study, we evaluated the toxicity of BUV-328 in zebrafish liver tissues to understand the role of oxidative damage in hepatotoxicity. Adult zebrafish were exposed to 0.01, 0.1 and 1 mg/L of BUV-328. At the end of 14, 28 and 42 days, liver tissues were examined for the responses of antioxidant enzymes, gene expression and histopathological alterations. The results indicated that superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were elevated at concentrations of 0.1 and 1 mg/L on 14th and 28th day. Glutathione S-transferase (GST) activity and malondialdehyde (MDA) levels were elevated in all the treated groups. The transcriptional levels of genes encoding sod, cat, gpx and gst enzymes were increased at 14th day and then declined (except sod on 28th day). Moreover, transcription of cyp1a and hsp70 were up-regulated throughout the study period.
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