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Coral reefs are impacted by a variety of anthropogenic stressors including inputs of chemical contaminants. Although data is currently limited, sunscreens containing ultraviolet (UV) filters have recently been suggested as an emerging class of chemical contaminants. To provide further data on the toxicity of the UV filter oxybenzone (benzophenone-3 or BP-3) to corals, we conducted three independent acute toxicity tests exposing the colonial stony coral Galaxea fascicularis to BP-3 (0.31 to 10 mg/L nominal concentrations). Assessments included daily analytical verification of the exposure concentrations, calculation of the lethal concentration to result in 50% mortality (LC50) and numerous biological endpoints to further investigate the potential impact to both the coral and symbiont. LC50s for the three tests were similar and averaged 6.53 ± 0.47 mg/L nominal concentration BP-3 (4.45 mg/L measured dissolved BP-3). BP-3 did not initiate coral bleaching or show a significant loss of symbionts from the coral tisarisons between studies.We all know that, nowadays, physics and philosophy are housed in separate departments on university campuses. They are distinct disciplines with their own journals and conferences, and in general they are practiced by different people, using different tools and methods. We also know that this was not always the case up until the early 17th century (at least), physics was a part of philosophy. So what happened? And what philosophical lessons should we take away? We argue that the split took place long after Newton's Principia (rather than before, as many standard accounts would have it), and offer a new account of the philosophical reasons that drove the separation. We argue that one particular problem, dating back to Descartes and persisting long into the 18th century, played a pivotal role. The failure to solve it, despite repeated efforts, precipitates a profound change in the relationship between physics and philosophy. The culprit is the problem of collisions. Innocuous though it may seem, this problem becomes the bellwether of deeper issues concerning the nature and properties of bodies in general. Selleck Linsitinib The failure to successfully address the problem led to a reconceptualization of the goals and subject-matter of physics, a change in the relationship between physics and mechanics, and a shift in who had authority over the most fundamental issues in physics.Despite the fact that Charles Darwin spent several months in Australia in the final year of his Beagle voyage that circumnavigated the globe, most studies that deal with Darwin's life or his discovery of evolution spend little time discussing his Australian period, if it is mentioned at all. His time there is largely deemed to have produced little of significance in comparison to his visits to other places such as the Galápagos Islands, which has long been mythologized as providing the key sources of observable data that ultimately led Darwin to develop his evolutionary speculations. In recent years, however, Darwin's period in Australia has received more attention, most notably a series of studies detailing the observations and connections Darwin made while in New South Wales, Tasmania, and King George Sound. While much of this literature has provided an important corrective to previous Darwin scholarship that had largely ignored Darwin's period in Australia, it has also worked to perpetuate a romantic and heroic view of scientific discovery by suggesting that Darwin's key "evolutionary revelation" was made not in the Galápagos Islands but in the Blue Mountains, a claim that has been recently made in print and online. This paper therefore examines the historical literature on Darwin Down Under, focussing in particular on this recent romantic turn that seeks to situate Australia as the key site of inspiration for Darwin's theory of evolution.The characteristic features of some of the methodological strategies adopted in scientific research in agroecology are discussed. They reflect that agroecology, as an approach to scientific research, is inextricably entangled with the other strands of agroecology (farming practice, social movement, political project); and that adopting agroecological strategies, and upholding the values of environmental sustainability, food sovereignty, social justice and democratic participation, mutually reinforce each other. After outlining the kinds of questions that agroecological research addresses so that it can produce knowledge that informs agroecological farming practices and the long term aspiration of agroecological movements to create an alternative agricultural/food system, and then making summary remarks about methodological strategies in general, three characteristic features of some agroecological strategies are introduced and discussed. The paper concludes with comments on the value of agroecological research.Public participation in scientific research has gained prominence in many scientific fields, but the theory of participatory research is still limited. In this paper, we suggest that the divergence of values and goals between academic researchers and public participants in research is key to analyzing the different forms this research takes. We examine two existing characterizations of participatory research one in terms of public participants' role in the research, the other in terms of the virtues of the research. In our view, each of these captures an important feature of participatory research but is, on its own, limited in what features it takes into account. We introduce an expanded conception of norms of collaboration that extends to both academic researchers and public participants. We suggest that satisfying these norms requires consideration of the two groups' possibly divergent values and goals, and that a broad characterization of participatory research that starts from participants' values and goals can motivate both public participants' role in the research and the virtues of the research. The resulting framework clarifies the similarities and differences among participatory projects and can help guide the responsible design of such projects.Obsessive-Compulsive Disorder (OCD) is a leading cause of disability world-wide (World Health Organization, 2008). Treatment of OCD is a specialized field whose aim is recovery from illness for as many patients as possible. The evidence-based psychotherapeutic treatment for OCD is specialized cognitive behavior therapy (CBT, NICE, 2005, Koran and Simpson, 2013). However, these treatments are not accessible to many sufferers around the world. Currently available guidelines for care are deemed to be essential but insufficient because of highly variable clinician knowledge and competencies specific to OCD. The phase two mandate of the 14 nation International OCD Accreditation Task Force (ATF) created by the Canadian Institute for Obsessive Compulsive Disorders is development of knowledge and competency standards for specialized treatments for OCD through the lifespan deemed by experts to be foundational to transformative change in this field. This paper presents knowledge and competency standards for specialized CBT for adult OCD developed to inform, advance, and offer a model for clinical practice and training for OCD. During upcoming ATF phases three and four criteria and processes for training in specialized treatments for OCD through the lifespan for certification (individuals) and accreditation (sites) will be developed based on the ATF standards.
Diagnosis and treatment of early-onset sepsis (EOS) of the newborn remains a controversial issue among providers due to the non-infectious symptomology which exists in the newborn period.
Pre/post interventional quality improvement project in a level III NICU to reduce antibiotic utilization and ancillary laboratory tests with the introduction of an evidence-based guideline for the evaluation of EOS in the NICU.
Primary outcome measures include mean number of empiric antibiotic treatment days and utilization rate (AUR), number of laboratory tests ordered, and incidence of unwarranted antibiotic therapy beyond the 48-h rule out period. Mean empiric antibiotic treatment days decreased from 2.94 to 1.58 days and overall antibiotic use decreased from 73.7% to 57.1%. Likewise, the mean AUR decreased from 212.5 to 147.6 days of therapy per 1000 patient days. There was an 86% decline in the number of ancillary tests and unwarranted antibiotic use beyond 48- h was reduced by 74%.
Guidelines for EOS of the newborn should include a thorough baseline evaluation of the drivers of antibiotic use to create an evidence-based foundation. Reducing unnecessary antibiotic use and EOS evaluations in a safe and effective manner have the potential to lower consumer and healthcare expenditures while improving the long-term health of the newborn in the NICU.
These findings emphasize the importance of implementing an evidence-based protocol for antibiotic stewardship in the NICU. With further research there is the potential to improve the healthcare of newborns while reducing expenditures in a safe, effective evaluation of EOS in the newborn population.
These findings emphasize the importance of implementing an evidence-based protocol for antibiotic stewardship in the NICU. With further research there is the potential to improve the healthcare of newborns while reducing expenditures in a safe, effective evaluation of EOS in the newborn population.Worker posture, task time and performance are often affected when one-handed manual dexterous tasks are performed in small overhead spaces under an obscured view. A common method used for supplementing visual feedback in these cases is a hand-held telescopic mirror, but that involves working with both arms extended overhead, and is often accompanied by awkward neck and shoulder postures. A video camera was considered as an alternative to using a mirror for visual feedback and reducing overhead reach. A mirror, a borescope and an omnidirectional camera were evaluated while laboratory participants performed three one-handed simulated manufacturing tasks in a small overhead enclosure. Videos were recorded for quantifying the time that postures were assumed while performing the tasks. The average time that both arms were above mid-shoulder height for the omnidirectional camera was more than 2.5 times less than for the mirror and borescope. The average proportion of neck strain time was 0.01% (or less) for both the omnidirectional camera and the borescope, compared to 83.68% for the mirror. No significant differences were observed in task completion times between the three modalities. Hence, an omnidirectional camera can provide visibility while reducing straining postures for manufacturing operations involving overhead work.In the workplace, overconfidence is generally considered undesirable as it may increase people's propensity to take risks. In many areas (e.g., aviation, shipping, nuclear control, and driving), risk-taking is detrimental to safety. We hypothesised that decision-makers would be overconfident and, due to group polarisation, decision-making pairs would be more overconfident than single decision-makers. As was predicted, when answering a 24-item general knowledge questionnaire (d = 0.94) and a task exploring how they might reorient themselves if lost (d = 1.93), participants (N = 63) were overconfident about their performance; importantly, participants in pairs (n = 32) were more overconfident on general knowledge (Hedges' g = 0.51) and lost procedures (Hedges' g = 0.52), than were participants who completed the tasks alone (n = 31). The findings imply that in some situations, single decision-makers may exhibit less overconfidence. The safety implications for a number of areas are discussed.
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