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PEGylated interferon α can be used for ribavirin-resistant liver transplant patients with chronic hepatitis E. Further research in therapeutic options is essential considering the stormy course of hepatitis E infection during pregnancy and teratogenicity of all available options.
Hepatitis E virus is the most common cause of acute viral hepatitis worldwide. A combination of serology and nucleic acid amplification testing is the recommended strategy for suspected patients. Ribavirin therapy for a period of 3 months is the drug of choice for severe acute hepatitis, acute-on chronic liver failure, and chronic infections from hepatitis E virus in immunocompromised patients who are unresponsive to decreased immunosuppression. PEGylated interferon α can be used for ribavirin-resistant liver transplant patients with chronic hepatitis E. Further research in therapeutic options is essential considering the stormy course of hepatitis E infection during pregnancy and teratogenicity of all available options.
At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vector significantly decreased YF cases and reduced outbreaks to the tropical and subtropical forested regions of Africa and South America.
However, recent (2016) large outbreaks in Angola, Democratic Republic of Congo (DRC), and South-Eastern Brazil, where previously had been demarcated as low-risk regions, have highlighted the possibility of a rapidly changing epidemiology and the potential re-emergence of yellow fever virus (YFV). Furthermore, the first-ever importation of YFV into Asia has highlighted the potential fear of YFV emerging as a global threat.
In this review, we describe the changing epidemiology of YF outbreaks and highlight the use of public health policies, therapeutics, and vaccination as tools to help eliminate future YFV outbreaks.
In this review, we describe the changing epidemiology of YF outbreaks and highlight the use of public health policies, therapeutics, and vaccination as tools to help eliminate future YFV outbreaks.
There is a continuing debate regarding contact precaution (CP) usage for endemic multidrug-resistant organisms (MDROs). In this review, we examine current recommendations for CP and highlight differences in CP use between endemic and non-endemic MDROs.
The discontinuation of CP had no effect on the incidence of methicillin-resistant
and vancomycin-resistant
. The evidence regarding CP for extended-spectrum beta-lactamase producing Enterobacteriaceae is inconclusive, highlighting the need for more research to determine best infection control strategies. Carbapenem-resistant Enterobacteriaceae maintains a sporadic pattern in the USA, supporting current recommendations to use CP for colonized and infected patients. MDR
(MDR-AB) is extremely virulent and responsible for outbreaks in healthcare settings, emphasizing the need for CP use with MDR-AB infected patients.
(
) is often misdiagnosed; it is resistant to UV light and quaternary ammonium low-level disinfection. Because little is known about tach.The outbreak of SARS-CoV-2 coronavirus rapidly altered radiotherapy service delivery around the world.
The main objective of this study was to assess the impact of precautionary measures implemented in response to the COVID-19 pandemic on the performance of a radiation oncology departments and on mitigation the risk of COVID-19 contagion between and among patients and staff.
The study period was from March 15 until May 22, 2020. We evaluated total number of patients irradiated and those who initiated treatments, taking into account tumours localisations. We assessed the relationship of potential risk of contagion with patients' domiciles locations in regions with high number of COVID19 case.
The number of patients treated with radiotherapy during the study period decreased due to precautionary measures. After five weeks, the number of radiotherapy treatments began to increase. selleck Just over half of the radiotherapy patients (53.5%) treated at the GPCC reside in the city of Poznan or in one of the ten surrounff) revealing four staff members and none patient with a positive PCR result. Immunoglobulin testing was performed in 1132 individuals (patients and hospital staff). A total of 63 individuals were positive for antibodies.Immigration is increasingly politicised issues surrounding immigration are more salient and party immigration positions are becoming more polarised. Literature on this topic has overwhelmingly focused on Europe and the USA, while identifying radical right parties and particular social dynamics as the main drivers of politicisation. In this paper, we consider a case that exhibits growing politicisation, yet does not fit existing measures and explanation of this phenomenon Quebec, Canada. Considering party manifestos between 1991 and 2018, we ask how have Quebec major political parties treated immigration policy issues over time? We argue that Quebec's immigration partisan space is organised by a liberal-restrictive immigration policy continuum and a jurisdictional axis. Mapping provincial political parties' positions, we document a stable clustering towards liberal policy positions but a clear cleavage on the jurisdictional axis. We show that the emergence in 2012 of a highly moderate centre right party-the Coalition Avenir Québec-broke with these established positions and drove a politicisation of the issue. These results demonstrate the importance of considering alternative drivers to explain the politicisation of immigration, as well as of paying attention to the politics of immigration in contexts where pro-immigration discourses dominate.The article documents refugee experience in the first year of their settlement in a small city in Canada and then explores whether the size of the community matters in the settlement processes. This is based on an extensive study of Syrian refugee settlement experiences in one large Canadian city (Edmonton) and one small Canadian city (Lethbridge). The findings argue that contrary to existing scholarly literature, small municipalities such as Lethbridge were more creative, nimble, and efficient in settling Syrian newcomers. In small cities, however, lack of denominational and non-denominational organizations to complement government assistance, the onset of compassionate fatigue among the city dwellers, and limited retention of newcomers due to limited employment opportunity are real threats to the settlement process immediately after newcomers' arrival and in the long term. A more substantial role of municipal governments in the refugee resettlement process is recommended to offset the disproportionate burden settlement sector carries.
The current coronavirus disease 2019 (COVID-19) pandemic has strongly influenced many aspects of the medical care, including cancer surveillance.
We investigated how the COVID-19 pandemic influenced surveillance for hepatocellular carcinoma (HCC), focusing on patients with hepatitis C virus infection who were receiving surveillance for HCC after sustained virologic response (SVR) in Japan.
Patients who achieved SVR between 1995 and 2017 and continued receiving surveillance were compared by month in terms of the rate at which they kept their scheduled visits for HCC surveillance from July 2019 to May 2020.
The percentage of kept scheduled visits was above 97% before February 2020. By contrast, it declined sharply after March 2020 when COVID-19 became pandemic; the percentages were 75.5% in March, 63.0% in April, and 49.1% in May 2020 (July 2019-February 2020 vs. March-May 2020, p<0.0001). Similar declines were observed in patients with cirrhosis or advanced fibrosis and in those with a history of HCC. Whereas most patients who cancelled a scheduled visit before February 2020 did not reschedule it, the majority of patients with cancellations after March 2020 did want to reschedule.
The percentages of scheduled visits that were kept declined rapidly after COVID-19 became pandemic in Japan, where the spread of COVID-19 is relatively mild and the legal restriction of people's behavior and movement is absent. Instituting measures to follow-up with cancelled patients and resume surveillance will be necessary in the future.
The percentages of scheduled visits that were kept declined rapidly after COVID-19 became pandemic in Japan, where the spread of COVID-19 is relatively mild and the legal restriction of people's behavior and movement is absent. Instituting measures to follow-up with cancelled patients and resume surveillance will be necessary in the future.This paper revisits Jessop's governance of welfare framework, suggesting that in the post-financial crisis era of austerity we need to look again at its analytical dimensions. The paper reformulates Jessop's Schumpeterian Welfare Postnational Regime ideal-type framework through critique, and then applies its reformulated Galbrathian, Affluent Postnational Oligarchy ideal-type to the case of the English NHS to present a new political economy of health.Emerging perspectives of health as individualized and privatized capital seem promising to shed light on the construction of individual health in the face of the growing individualization of healthcare. This article reviews extant perspectives of health as capital, reflecting upon how a conceptualization of health capital might be conceived by two of the main contrasting traditions human capital theory affiliated with the Chicago School of Economics and Bourdieusian concepts of social field and capital. Arguing that a Bourdieusian perspective is potentially more fruitful to capture the importance of social and cultural dimensions in the construction of individual health, this article arrives at a conceptualization of health capital as the aggregate of the actual or potential resources possessed by a given agent that have the capacity to affect the position of agents in the social field of health. Drawing on Bourdieu's conceptualization of forms of capital, this article discusses the efficacy, the legitimation, and the positioning of health capital, uncovering its potential for understanding contemporary trends in health practices and health discourse.The COVID-19 pandemic brings to light many areas the field of counselling and psychotherapy may need to address in future research. We outline several issues stemming from or exacerbated by the pandemic and offer suggestions for future research to address the mental health needs of those impacted. Our suggestions focus on five domains (a) the health and well-being of helping professionals, (b) the infodemic, (c) discrimination and minority stress, (d) spiritual and existential dynamics in mental health and (e) couple and family stress and resilience. We aim to provide a multi-systemic perspective of mental health and well-being in the time of COVID-19, as well as encourage current and future studies to incorporate these suggestions to advance the health and well-being of our communities through evidence-based treatment approaches.The experiences and challenges of psychotherapists working remotely during the coronavirus pandemic were explored using a mixed-methods approach. An online survey completed by 335 psychotherapists produced both quantitative and qualitative data with the latter being subject to a reflexive thematic analysis. Large numbers of therapists were using video-link platforms and the telephone to conduct client sessions. A majority of therapists felt challenged by remote working, with reduced interpersonal cues, feelings of isolation and fatigue, and technical issues frequently cited concerns. At the same time, most therapists considered that remote working had been effective and that clients were comfortable with the process. Two-thirds of therapists indicated that remote working would now become core business for them. The great majority of therapists thought that remote working skills should be part of formal therapy trainings.
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