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Recent state-of-the-art analysis techniques have revealed the high sensitivity of new generation perovskite photovoltaics to the organic/inorganic A-cation's chemical composition and atomic configuration. Various studies have focused on an extensive list of potential candidates to find the best A-cation with optimum stability and efficiency output. Regarding the perovskite band gap, different characteristics such as cation size, constituent elements, atomic configuration, possible bonding potential and induced lattice distortion, have been considered to screen plausible A-cations. However, there is not a comprehensive and comparative framework for developing predictive models because of the strong correlation between governing parameters. In this research, we develop an innovative approach, using first principle methods, to parametrize the role of A-cation on the regulation of the well-known ABX3 perovskites band gap in a quantitative and comparative form. Parameters are introduced concerning the A-cation impact on the shared electrons of the B-X bonds, whose s and p states control the whole band structure. The A-cation induced geometrical distortion on the BX3 network, including the subsequent bond length and bond angle, are designated as indirect parameters; and its impact on the electronic states of B-X bonding through long range electronic interactions, is attributed as the direct role. Dissociation of correlative parameters is achieved by comparing the electronic properties of the BX3 network including and excluding their A-cation, as well as swapping different A-cations on the corresponding equivalent BX3 scaffolds. The governing mechanisms behind the direct/indirect contribution of Cs, methylammonium (MA) and formamidinium (FA) cations, regarding their impact on electronic charge density distribution and bonding tendency via the introduced parametrization, are investigated and discussed.Drug-resistant infections pose a significant risk to global health as pathogenic bacteria become increasingly difficult to treat. The rapid selection of resistant strains through poor antibiotic stewardship has reduced the number of viable treatments and increased morbidity of infections, especially among the immunocompromised. To circumvent such challenges, new strategies are required to stay ahead of emerging resistance trends, yet research and funding for antibiotic development lags other classes of therapeutics. Though the use of metals in therapeutics has been around for centuries, recent strategies have devoted a great deal of effort into the pathways through which bacteria acquire and utilize iron, which is critical for the establishment of infection. To target iron uptake systems, siderophore-drug conjugates have been developed that hijack siderophore-based iron uptake for delivery of antibiotics. While this strategy has produced several potential leads, the use of siderophores in infection is diminished over time when bacteria adapt to utilize heme as an iron source, leading to a need for the development of porphyrin mimetics as therapeutics. The use of such strategies as well as the inclusion of gallium, a redox-inert iron mimic, are herein reviewed.BACKGROUND Eccrine porocarcinoma (EPC) was first described in 1963 as an epidermotropic eccrine carcinoma. Fifty years later, its etiology remains poorly understood. The infrequent nature of this disease merits further inquiry into its etiology, presentation, and standards of management. Furthermore, the propensity for metastasis, which may be as high as 31% on presentation, increases the importance of investigating this rare disease. CASE REPORT The patient was a 63-year-old mechanic who presented with the lesion as a chronic wound following a chemical exposure. The lesion involved the ulnar aspect of his right palm and had concern for extension to the underlying tendons. He underwent a wide excision extending from the wrist to the proximal interphalangeal joint, preserving the ulnar neurovascular bundle. The hand was reconstructed with an anterolateral thigh fascia perforator flap and a skin graft. He had an excellent functional and cosmetic recovery. Unfortunately, he developed metastases to the lymph nodes, necessitating an axillary lymphadenectomy followed by adjuvant chemoradiation using concurrent cisplatin and docetaxel with radiation for 6 weeks. Follow-up at 18 months found no recurrence. CONCLUSIONS Cases of EPC presenting in the fingers have been managed with amputation of the involved phalanges; however, in addition to obtaining complete excision with negative margins, surgeons who deal with tumors of the hand must also consider the goals of limb preservation, functional preservation, and functional reconstruction. Options for reconstruction following excision include primary closure, dermal regeneration templates, skin grafts, flaps, and free-tissue transfer, depending on what tissue types are needed.
As many countries fear and even experience the emergence of a second wave of COVID-19, reminding health care workers (HCWs) and other hospital employees of the critical role they play in preventing SARS-CoV-2 transmission is more important than ever. Building and strengthening the intrinsic motivation of HCWs to apply infection prevention and control (IPC) guidelines to avoid contaminating their colleagues, patients, friends, and relatives is a goal that must be energetically pursued. A high rate of nosocomial infections during the first COVID-19 wave was detected by IPC specialists and further cemented their belief in the need for an engaging intervention that could improve compliance with COVID-19 safe behaviors.
Our aim was to develop a serious game that would promote IPC practices with a specific focus on COVID-19 among HCWs and other hospital employees.
The first 3 stages of the SERES framework were used to develop this serious game. A brainswarming session between developers and IPC specialists waement systems.This paper is concerned with the problem of finite-time H∞ state estimation for genetic regulatory networks with randomly occurring uncertainties. The persistent dwell-time switching, as a more versatile class of switching signal, is considered in this paper. Besides, several random variables that obey the Bernoulli distribution are used to represent randomly occurring uncertainties. The overriding purpose of this paper is to design an estimator to ensure that the estimation error system is stochastically finite-time bounded and satisfies the H∞ performance. The sufficient conditions for the explicit form of the estimator gains can be obtained by the Lyapunov method. Finally, a numerical example is given to verify the correctness and feasibility of the proposed method.The firing rate of some biological neurons such as neocortical pyramidal neurons is consistent with fractional order derivative, and the fractional-order neuron models depict the firing rate of neurons more accurately than other integer order neuron models do. For this reason, first, the dynamical characteristics of fractional order Hindmarsh Rose (HR) neuron are investigated, here and then a two coupled neuronal system based on Hindmarsh Rose neuron is presented. The results show several differences in the dynamical cha.racteristics of integer order and fractional order Hindmarsh Rose neuron model. The integer order model shows only one type of firing characteristics when the parameter of the model remained the same. The fractional-order model depicts several dynamical behaviors even for the same parameters as the order of the fractional operator is varied with the same parameter values. The firing frequency increases as the order of the fractional operator decreases.Tree-based phylogenetic networks, which may be roughly defined as leaf-labeled networks built by adding arcs only between the original tree edges, have elegant properties for modeling evolutionary histories. We answer an open question of Francis, Semple, and Steel about the complexity of determining how far a phylogenetic network is from being tree-based, including non-binary phylogenetic networks. We show that finding a phylogenetic tree covering the maximum number of nodes in a phylogenetic network can be computed in polynomial time via an encoding into a minimum-cost flow problem.Among all the PTMs, the protein phosphorylation is pivotal for various pathological and physiological processes. About 30% of eukaryotic proteins undergo the phosphorylation modification, leading to various changes in conformation, function, stability, localization, and so forth. In eukaryotic proteins, phosphorylation occurs on serine (S), Threonine (T) and Tyrosine (Y) residues. Among these all, serine phosphorylation has its own importance as it is associated with various important biological processes, including energy metabolism, signal transduction pathways, cell cycling, and apoptosis. Thus, its identification is important, however, the in vitro, ex vivo and in vivo identification can be laborious, time-taking and costly. There is a dire need of an efficient and accurate computational model to help researchers and biologists identifying these sites, in an easy manner. Herein, we propose a novel predictor for identification of Phosphoserine sites (PhosS) in proteins, by integrating the Chou's Pseudo Amino Acid Composition (PseAAC) with deep features. We used well-known DNNs for both the tasks of learning a feature representation of peptide sequences and performing classifications. Among different DNNs, the best score is shown by Convolutional Neural Network-based model which renders CNN based prediction model the best for Phosphoserine prediction.This article is the second in a two-part series analyzing human arm and hand motion during a wide range of unstructured tasks. In this work, we track the hand of healthy individuals as they perform a variety of activities of daily living (ADLs) in three ways decoupled from hand orientation end-point locations of the hand trajectory, whole path trajectories of the hand, and straight-line paths generated using start and end points of the hand. These data are examined by a clustering procedure to reduce the wide range of hand use to a smaller representative set. Hand orientations are subsequently analyzed for the end-point location clustering results and subsets of orientations are identified in three reference frames global, torso, and forearm. Data driven methods that are used include dynamic time warping (DTW), DTW barycenter averaging (DBA), and agglomerative hierarchical clustering with Ward's linkage. Analysis of the end-point locations, path trajectory, and straight-line path trajectory identified 5, 5, and 7 ADL task categories, respectively, while hand orientation analysis identified up to 4 subsets of orientations for each task location, discretized and classified to the facets of a rhombicuboctahedron. Nevirapine price Together these provide insight into our hand usage in daily life and inform an implementation in prosthetic or robotic devices using sequential control.Current deep learning methods seldom consider the effects of small pedestrian ratios and considerable differences in the aspect ratio of input images, which results in low pedestrian detection performance. This study proposes the ratio-and-scale-aware YOLO (RSA-YOLO) method to solve the aforementioned problems. The following procedure is adopted in this method. First, ratio-aware mechanisms are introduced to dynamically adjust the input layer length and width hyperparameters of YOLOv3, thereby solving the problem of considerable differences in the aspect ratio. Second, intelligent splits are used to automatically and appropriately divide the original images into two local images. Ratio-aware YOLO (RA-YOLO) is iteratively performed on the two local images. Because the original and local images produce low- and high-resolution pedestrian detection information after RA-YOLO, respectively, this study proposes new scale-aware mechanisms in which multiresolution fusion is used to solve the problem of misdetection of remarkably small pedestrians in images.
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