Notes

The function of host promiscuity in the attack process of any seaweed holobiont.
Residual fragments, when ≤4 mm, sometimes are included in the SFR definition. Most reports shown that these fragments may growth and cause complications and re-intervention when found in the follow-up of the patient that under went any endourological procedure. The majority of the publications found show that the residual fragment medical management is necessary to assure a lower recurrence rate. CONCLUSION Assuring a SFR can serve as a preventive method for recurrence, but not alone but in combination with medical therapy. Medical therapy is important in the follow-up and personalized for each patient. Drug therapy must be promoted if the patient continues to have the urolithiasis risk factors despite the dietary objectives have been reached.
Medical Expulsive Treatment (MET) for ureteral stones has been questioned for the last few years.

The main goal of our study is to define the indications of MET, the different drugs that are used and their effectiveness and to propose a follow-up strategy. Secondary objectives include the effectiveness of MET in some special subgroups such as pregnant women and children and to assess aspects of MET cost-effectiveness compared with other options for ureteral lithiasis treatment (ureterorenoscopy or extracorporeal shock wave lithotripsy).

We have reviewed the most relevant clinical trials and meta-analysis evaluating the impact of the different drugs available for MET. For the research we used some keywords like "medical expulsive treatment/therapy", "ureteral lithiasis", "urolithiasis", "effectiveness", "alpha-blockers" and "calcium-antagonists".MEDLINE database was used for there search (using the portal web Pubmed).

Highest quality studies currently availables how significant methodological limitatiois ≥ 5 mm and ≤ 10 mm, even though we have not found differences between the drugs that are available for MET.
Renoureteral colic (CRU) is the most common urological emergency, with a wide spectrum of severity that generates high morbidity and high health costs. However, there is no homogeneous scheme of pharmacological treatment in its acutephase.

The main objective of our work is to evaluate the effectiveness and safety profile of the different drugs used in the treatment of CCR and to propose a practical treatment scheme. The secondary objectives are to evaluate the role of fluid therapy in CRU and the treatment of CRU in pregnant women.MATERIAL AND METHODS We have carried out a literature search on PubMed using the MeSH terms "renalcolic", "treatment", "anti-inflammatory drugs", "antiemeticdrugs", "fluid therapy" and "pregnant". The most relevant clinical trials, meta-analyses and systematic reviews published from 1 January 2005 to 15 September 2020 in Spanish, English and French were reviewed.

In the different studies reviewed, non-steroidalanti-inflammatory drugs (NSAIDs) show better pain control, with lower rescue doses and fewer side effects than treatment with opioids. However, fluid therapy has failed to demonstrate an impact on the treatment of CRU.

The initial treatment for CRU is NSAIDs, reserving opioids for successive treatment lines. The control of vegetative cortex can be accomplished with Ondansetron as first choice.
The initial treatment for CRU is NSAIDs, reserving opioids for successive treatment lines. The control of vegetative cortex can be accomplished with Ondansetron as first choice.
Prevalence of urolithiasisis estimated between 5-15% with a clear trend to increasing in the industrialized countries. Stone recurrent patients show an increased risk of chronic renal disease which can potentially limit their life expectancy.

A review and summary of the different recommended treatment options to prevent urinary stone recurrence based on the type of calculi or urinary metabolic alterations in 24 h urine, according to recent guidelines and publications.

Dietetic and pharmacologic measures, when addressed depending on the type of stone and results of metabolic evaluation have shown a decrease up to 60% of the recurrent clinical events. The increase of prevalence worldwide and the potential risk of chronic kidney disease in these patients clearly justify the need of increasing physiopathologic knowledge leading urolithiasis formation in order to develop new and more effective drugs for its prevention.
Dietetic and pharmacologic measures, when addressed depending on the type of stone and results of metabolic evaluation have shown a decrease up to 60% of the recurrent clinical events. The increase of prevalence worldwide and the potential risk of chronic kidney disease in these patients clearly justify the need of increasing physiopathologic knowledge leading urolithiasis formation in order to develop new and more effective drugs for its prevention.Kidney stones is a prevalent condition with a rising incidence in the last few decades. Diseasere lapse is an especially important issue, that requires further investigations in order to prevent new episodes. Adequate work up must be suited to patients´ characteristics such as age and the presence of risk factors forrecurrence. An initial approach should focus on a thorough clinical history, with special attention to dietary habits, analysis of the stone composition when available, and basic blood and urine exams to guide further investigations. In this article, we aim to explain proper metabolic evaluation in kidney stone formers, explaining its indications, how to perform it and how to interpret it, in order to stablish an adequate treatment. Special attention will be given to hypercalciuria, yperoxaluria, hyperuricosuria, hypocitraturia, hypomagnesuria, hyperparathyroidism and the most frequent disturbances in urine analysis.Analysis of urinary stones is an essential step in establishing the diagnosis and treatment of the stone patient. In fact, the need for an exhaustive study of the stones increases as the relationships between the type of stone and the etiological factors that predispose to this disease become evident. The enumeration (qualitative or quantitative) of the major components that make up the kidney stone (calcium oxalate monohydrate, calcium oxalate dihydrate, uric acid, calcium phosphates, cystine), which is obtained by the most commonly used analytical method, infrared spectroscopy (IR), is no longer enough to guide the urologist on the etiology of the disease. Only a detailed structural analysis and macro and micro components can provide key information on the etiology of the stone, and therefore, on the possible causes that have led to its formation. This study should conclude with a report that is provided to the Urologist. Obtaining this report involves a detailed study, sample by sample, which involves the systematic handling of stereoscopic microscopy, IR spectroscopy and scanning electron microscopy (SEM) with energy dispersive X-raymicroanalysis (EDAX).Imaging in urolithiasis has a wide group of techniques, with different characteristics, limitations, and indications, which together allow the management of this prevalent pathology. Plain abdominal radiography and ultrasound are very accessible and in expensive techniques that combined present an acceptable sensitivity and specificity. They are widely used for monitoring the evolution of stone disease and for evaluation after treatments (surgery or SWL). Ultrasound is the primary radiological diagnostic tool in the pediatric population and in pregnant women. CT has prevailed over IVP in the anatomical assessment of the urinary tract and the description of the characteristics of the lithiasis, although it shows a greater exposure to ionizing radiation, so the use of low and ultra-low dose CT is spreading. In this article we also discuss other imaging techniques suchas Digital to mosynthesis, Fluoroscopy and DMSA Scintigraphy.
Kidney stone disease affects 1 in 10 persons at least once per life-time worldwide, in 2% the disease is recurrent. For the individual stone disease can be painful and lead even to chronic kidney disease, while the costs for the health system and economy can be very high. Thus, factors causing stone disease need to be identified in order to prevent or reduce the incidence of disease.

This review will discuss major risk factors contributing to stone disease with special emphasis on genetic and dietary risk factors.RESULTS Stone disease is multifactorial with a strong genetic component, gender-specific risks and prevalence, and a modifiable contribution of nutrition. The different factors contributing to the risk for developing stones are discussed.

Urolithiasis is a frequent disorder affecting almost 10% of the population with a high risk of recurrence. Treatment and prevention have to be tailored to the individual causes of disease and require an assessment of underlying predispositions and interacting modifiable environmental factors.
Urolithiasis is a frequent disorder affecting almost 10% of the population with a high risk of recurrence. Treatment and prevention have to be tailored to the individual causes of disease and require an assessment of underlying predispositions and interacting modifiable environmental factors.Urinary stones is a pathology whose incidence and prevalence are increasing in developed and underdeveloped countries. Overall, in the United States the prevalence has been increased from 3.2% in 1980 to 10.1% in 2014. In Spain, this increase has also been significant, from 5% in 2005 to 14.6% in 2016. In the rest of the world happens in a similar way, where an average increase is observed in the last 15-20 years of approximately 5-7%. The decade of life between 40-60 years is usually the highest incidence of stones. Regarding sex, in recent years there has been a growing in women, associated with a change in diet and obesity, and currently there are no differences between sex. It is a more frequent disease in the Western world,although there are countries in the Middle East such as Saudi Arabia where the prevalence is very high, around 20%. Respect the lithiasis composition, calcium oxalate continues to be the most frequent around 70-80%, with an increase in uric acid lithiasis in recent years and a decrease in infective lithiasis. In relation to the appearance of this pathology in children, it is rare in the first years of life, being more prevalent from 12-13 years of age and increasing in adolescence. It is usually more common in girls than in boys and in the Caucasian racecompared to African Americans. There are no differences in lithiasic composition with respect to adults, calcium oxalate being the most frequent composition, but with a prevalence of 50-60%. However, the causes and etiopathogenic factors in children are less studied and well known than in adults.Urolithiasis is a multifactorial and recurrent disease whose incidence is increasing, especially in women but also in the paediatric population. Differences can be found between different regions and between different ethnicities, often due to dietary and environmental factors, without forgetting the genetic influence on different types of stones. There are disease sthat require a high index of suspicion in order to reach a diagnosis, such as renal tubular acidosis (RTA), not only for the benefit of the patient but also for their family members in the case a genetic mutation. Calcium-based stones continue to be the most frequent, but with a progressive increase in uric stones...
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