Notes

A manuscript Intraoperative Brain Mapping Incorporated Task-Presentation Podium.
COVID-19, an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout the world. China has achieved rapid containment of this highly infectious disease following the principles of early detection, early quarantine and early treatment with integrated traditional Chinese and Western medicine. The inclusion of traditional Chinese medicine (TCM) in the Chinese protocol is based on its successful historic experience in fighting against pestilence. Current findings have shown that the Chinese medicine can reduce the incidence of severe or critical events, improve clinical recovery and help alleviate symptoms such as cough or fever. To date there are over 133 ongoing registered clinical studies on TCM/integrated traditional Chinese and Western medicine. The three Chinese patent medicines (Lianhua Qingwen Keli/Jiaonang (Forsythiae and Honeysuckle Flower Pestilence-Clearing Granules/Capsules), Jinhua Qinggan Keli (Honeysuckle Flower Cold-Relieving Granules) and Xuebijing (Stasis-Resolving & Toxin-Removing) Injection were officially approved by the National Medical Products Administration to list COVID-19 as an additional indication. The pharmacological studies have suggested that Chinese medicine is effective for COVID-19 probably through its host-directed regulation and certain antiviral effects.This communication explores unique characteristics of obsessive-compulsive disorder (OCD) in the context of the current coronavirus pandemic. When do irrational fears of contamination as seen in OCD start to diverge from rational fears and behaviors? The current paper argues that the personal meaning attributed to viruses and germs, including their personification as entities that possess human-like characteristics, allows them to threaten and violate an individual's identity. Specifically, it suggests that fears of contamination become obsessional when the threat of viruses and germs becomes personal, not solely in terms of its objective outcomes, but in how these life forms are able to threaten the self as the result of a fear of inner corruption characterizing those with OCD. The person with OCD may act as if, or believe that they are acting upon reality when they fear contagion, but are in effect only acting upon an underlying fear of inner corruption that is confused with reality itself. The current paper concludes with some clinical recommendations on how to treat obsessional fears of contamination in the context of the current pandemic.An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and Doxycycline have been recommended or are being used to treat COVID-19 patients. In addition to these drugs, rationale and evidence have been presented to use chloroquine to treat COVID-19, arguably with certain precautions and criticism. In line with the proposed use of chloroquine, Nigella sativa (black seed) could be considered as a natural substitute that contains a number of bioactive components such as thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine. Further benefits to use N. sativa could be augmented by Zn supplement. Notably, Zn has been proven to improve innate and adaptive immunity in the course of any infection, be it by pathogenic virus or bacteria. The effectiveness of the Zn salt supplement could also be enhanced with N. sativa as its major bioactive component might work as ionophore to allow Zn2+ to enter pneumocytes - the target cell for SARSCoV-2. Given those benefits, this review paper describes how N. sativa in combination with Zn could be useful as a complement to COVID-19 treatment.A forgotten and valuable chapter in the history of tobacco concerns its role as a botanical medicine. For three hundred years following its importation into Europe, tobacco came to be considered a universal remedy highly prescribed by physicians. In the early history of tobacco, the literature on its medicinal benefits was voluminous. Nonetheless, bitter opposition to its use for non-medicinal purposes began to arise. There was little doubt of its medicinal efficacy at first, but with time, as the concepts and practice of medicine changed, the tide of medical opinion turned against it. Medical support for the therapeutic use of tobacco reached its nadir during the mid-nineteenth century, when it was dropped from most medical pharmacoepiae. Medical opinion on the health hazards of recreational smoking required another 100 years to arrive at the contemporary opinion that cigarette smoking is the single most important preventable environmental factor contributing to illness, disability and death in the U. S.Current urban, health and social challenges demand new multidisciplinary assessment systems for decision-making in the built environment from the perspective of the elderly, as an even more vulnerable population. This research contributes with a Multidimensional Assessment System of the Built Environment (MASBE) that provides an integral diagnosis on the perceived suitability of urban and housing environments for an ageing population, whose novel approach is structured and weighted through 35 multidisciplinary variables that are organised in seven dimensions design, accessibility, comfort, maintenance, security and health, use and control, and stimulus. The system is applied and tested in reference case studies from Spain and Mexico, in order to demonstrate its operation and replicability. The weighted and displayed results help to identify the weaknesses and strengths of each application scale, obtaining average values far from 7.50, as the ideal value for ageing in place, and certain dimensions below 5.00, discussing through a sensitivity analysis the main influencing factors, health risks and major demands of elderly residents before deciding action strategies. The key outcomes incorporate useful implications for policy-makers, promoters and construction firms by enabling assessment procedures to adapt urban and housing spaces for the elderly, thereby ensuring satisfactory proposals in the built environment.The socio-demographic factors have a substantial impact on the overall casualties caused by the Coronavirus (COVID-19). In this study, the global and local spatial association between the key socio-demographic variables and COVID-19 cases and deaths in the European regions were analyzed using the spatial regression models. A total of 31 European countries were selected for modelling and subsequent analysis. From the initial 28 socio-demographic variables, a total of 2 (for COVID-19 cases) and 3 (for COVID-19 deaths) key variables were filtered out for the regression modelling. The spatially explicit regression modelling and mapping were done using four spatial regression models such as Geographically Weighted Regression (GWR), Spatial Error Model (SEM), Spatial Lag Model (SLM), and Ordinary Least Square (OLS). Additionally, Partial Least Square (PLS) and Principal Component Regression (PCR) was performed to estimate the overall explanatory power of the regression models. For the COVID cases, the local R2 valuher controlling factors, such as environmental conditions, socio-ecological status, climatic extremity, etc. have not been considered. This could be the scope for future research.Courtyards have functioned as an effective passive architectural design strategy for various climate conditions, especially popular in hot-humid climates. Sustainable and delicate designs are necessary to create safe, healthy and comfortable courtyard environment. Most of the available literature focused on thermal comfort for courtyard, and the researches towards air pollution/disease control was rare. Further considering the severe impact of COVID-19 crisis, the current study aims to develop a numerical strategy to optimize physical environment in courtyard, including distributions of airborne pollutant, drought sensation and infection risk. Experimental data from literature was used to validate the numerical models. The evaluation indexes were adopted for the assessment of draft sensation, pollution exposure risk etc. The influences of geometric design parameters (i.e., courtyard width, height etc.) were investigated, and courtyard width (D) was the most sensitive parameter. If D increased from 5.8 m to 11.8 m, average air pollutant concentration decreased by 80 %, while drought sensation increased by 30 %. In static wind conditions, infection possibility (with R value up to 3 %) in courtyard was comparable to those in indoor environments during the COVID-19 period. This work will be of great importance for sustainable development of courtyards from the perspectives of airborne diseases control.Social distancing and ventilation were emphasized broadly to control the ongoing pandemic COVID-19 in confined spaces. Rationales behind these two strategies, however, were debated, especially regarding quantitative recommendations. The answers to "what is the safe distance" and "what is sufficient ventilation" are crucial to the upcoming reopening of businesses and schools, but rely on many medical, biological, and engineering factors. This study introduced two new indices into the popular while perfect-mixing-based Wells-Riley model for predicting airborne virus related infection probability - the underlying reasons for keeping adequate social distance and space ventilation. The distance index Pd can be obtained by theoretical analysis on droplet distribution and transmission from human respiration activities, and the ventilation index Ez represents the system-dependent air distribution efficiency in a space. The study indicated that 1.6-3.0 m (5.2-9.8 ft) is the safe social distance when considering aerosol transmission of exhaled large droplets from talking, while the distance can be up to 8.2 m (26 ft) if taking into account of all droplets under calm air environment. Because of unknown dose response to COVID-19, the model used one actual pandemic case to calibrate the infectious dose (quantum of infection), which was then verified by a number of other existing cases with short exposure time (hours). Projections using the validated model for a variety of scenarios including transportation vehicles and building spaces illustrated that (1) increasing social distance (e.g., halving occupancy density) can significantly reduce the infection rate (20-40 %) during the first 30 min even under current ventilation practices; (2) minimum ventilation or fresh air requirement should vary with distancing condition, exposure time, and effectiveness of air distribution systems.The COVID-19 pandemic elicited a global response to limit associated mortality, with social distancing and lockdowns being imposed. In India, human activities were restricted from late March 2020. This 'anthropogenic emissions switch-off' presented an opportunity to investigate impacts of COVID-19 mitigation measures on ambient air quality in five Indian cities (Chennai, Delhi, Hyderabad, Kolkata, and Mumbai), using in-situ measurements from 2015 to 2020. For each year, we isolated, analysed and compared fine particulate matter (PM2.5) concentration data from 25 March to 11 May, to elucidate the effects of the lockdown. Like other global cities, we observed substantial reductions in PM2.5 concentrations, from 19 to 43% (Chennai), 41-53% (Delhi), 26-54% (Hyderabad), 24-36% (Kolkata), and 10-39% (Mumbai). Generally, cities with larger traffic volumes showed greater reductions. Aerosol loading decreased by 29% (Chennai), 11% (Delhi), 4% (Kolkata), and 1% (Mumbai) against 2019 data. Health and related economic impact assessments indicated 630 prevented premature deaths during lockdown across all five cities, valued at 0.
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