Notes

Wearable plasmonic-metasurface sensor pertaining to non-invasive along with universal molecular fingerprint detection on biointerfaces.
Oxidation of methane at ambient conditions to useful oxygenates at a bilayer-coated electrode is demonstrated. The composition of the coating, a Mn porphyrin mediator layer on top of a N(OH)2/NiOOH one, allows a cascade of oxygen transfer events upon applying a potential. It is shown, using (spectro)electrochemical techniques, density functional theory computations and product analytical methods, that formate and methanol accompanied by CO2 suppression can be observed at a certain potential range. This can lead to further development of similar oxygen/electron transfer cascades for possible use in devices for energy conversion and fuel/product generation.The mechanism of Au(I)-catalyzed intermolecular annulation of 2-(1-alkynyl)-2-alken-1-one with N-allenamide was carefully elucidated using density functional theory (DFT). The reaction is initiated by the binding of the Au(I) catalyst with 2-(1-alkynyl)-2-alken-1-one rather than with N-allenamide. The key intermediate, a gold all-carbon 1,3-dipole species, is revealed to be more reactive than the gold allylic carbocation. The influence of ligands and substituents was rationally analyzed. We believe that our study will provide deeper mechanistic insights into the chemoselective reactions of alkynes with N-allenamide.Pentagonal compounds, as a new family of 2D materials, have recently been extensively studied in the fields of electrocatalysis, photovoltaics, and thermoelectrics. Encouraged by the successful synthesis of pentagonal PdSe2, the thermoelectric properties of low-cost pentagonal NiX2 (X = S, Se, and Te) monolayers are theoretically predicted with the help of first-principles calculations and the semiclassical Boltzmann transport theory. The high dynamic and thermal stabilities of pentagonal NiX2 (X = S, Se, and Te) monolayers are confirmed according to the phonon dispersion spectrums and ab initio molecular dynamics (AIMD) simulations. Indirect semiconductor features with wide bandgaps of 2.44, 2.31, and 1.88 eV at the Heyd-Scuseria-Ernzerhof (HSE06) level are discovered for pentagonal NiS2, NiSe2, and NiTe2 monolayers. Combining the Boltzmann transport equation and deformation potential theory, the Seebeck coefficient, power factor, and thermoelectric figure of merit (ZT) of NiX2 (X = S, Se, and Te) monolayers are evaluated from 300 to 600 K. The strongly anisotropic ZT values are discovered, which are attributed to the significant differences in electrical and thermal transport along the x and y directions. In addition, low lattice thermal conductivities are observed at 600 K for the pentagonal NiTe2 monolayer, accompanying higher ZT values of 1.81 and 1.58 along the x and y directions. The predicted thermoelectric properties indicate that the low-cost pentagonal NiSe2 and NiTe2 monolayers are potential anisotropic thermoelectric materials with high performance.It is of great significance to develop a dietary intervention strategy to prevent inflammatory bowel disease (IBD). A millet-rich diet can ameliorate IBD, but the active ingredients and mechanisms remain to be studied. Our results showed that the oral administration of foxtail millet protein hydrolysates (FMPH) reduced the disease activity index (DAI) score and improved the colon symptoms of dextran sulfate sodium (DSS)-induced colitis mice. FMPH reduced the serum LPS level, increased intestinal ZO-1 and occludin expression, inhibited NF-κB phosphorylation, and reduced the levels of TNF-α and IL-6. Further, FMPH inhibited Th17 cell differentiation, and inhibited inflammasome activation and IL-1β expression through the NLRP3/ASC/caspase-1 pathway. The results on Caco-2 cells confirmed the role of FMPH on tight junction and inflammasomes activation. A total of 2620 peptides were identified in FMPH by UPLC-MS/MS, of which 22 peptides were predicted as potential biopeptides, and the key sequences were LPF, ANP, PY, YW, and IPP. This study supports the effect of a diet rich in millet on the improvement of IBD and provides a scientific basis for the use of millet protein as a functional food to improve intestinal inflammation.The present study aims at developing a strategy to analyze bone samples in a rapid and facile mode. An efficient treatment method was found to be heating a material ratio of 0.5 g bone samples in 5 mL formic acid aqueous solution (10%, v/v) at 95 °C for at least 5.2 min, followed by a 50-fold dilution for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis. Principal component analysis (PCA) was used to analyze the obtained mass spectral datasets. Eight animal-sourced bones were analyzed as models. The extracts from these animal-sourced bones can be utilized to classify fish at species level with >90% accuracy. Domestic chicken and porcine bone samples were analyzed to verify whether this method can be applied for judicial authentication. The obtained results indicated that the developed strategy could differentiate samples by analyzing their bones via MALDI-TOF MS and PCA, holding a great potential for animal species monitoring including raw fish and meats and for judicial authentication.A novel, rapid and simple reverse-phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of three pesticides - mancozeb, azoxystrobin and difenoconazole by derivatization with ethyl iodide is presented. Analysis was performed on a C18 column (Agilent Eclipse plus, 150 mm × 4.6 mm; 5 μ) with the mobile phase consisting of acetonitrile + methanol (90 + 10 v/v) - water (0.1% v/v trifluoroacetic acid) (60  40, v/v) pumped isocratically at a flow rate of 1.0 mL min-1 and detection wavelength of 205 nm and 272 nm. The factors affecting the derivatization reaction and separation conditions were carefully evaluated and optimized. The method was linear over the concentration range of 3.50 mg L-1 to 31.48 mg L-1 for mancozeb, 0.32 mg L-1 to 2.85 mg L-1 for azoxystrobin and 0.32 mg L-1 to 2.89 mg L-1 for difenoconazole. The new method was successfully applied for the analysis of mancozeb, azoxystrobin and difenoconazole in the pesticide formulation with range recoveries of 99.46% to 100.76%, 99.07% to 101.09% and 98.59% to 101.59%, respectively. The present method is suitable and favorable for the simultaneous separation and analysis of tertiary mixture analytes on account of its sensitivity, rapidity and cost-effectiveness. In addition, it could have excellent application prospects for the simultaneous determination of all three pesticides in other formulated products.The growth of the bacterium E. coli was monitored by targeting the phospholipid constituents through desorption electrospray ionization and characterizing individual sets of isomers by recording the full 2D MS/MS data domain in a single scan of a modified quadrupole ion trap mass spectrometer. The experiments tested the applicability of the new instrumental capabilities which include sample interrogation at the molecular level for multiple components at speeds of less then 10 seconds/sample. The major lipids observed were phosphatidylethanolamines and phosphatidylglycerols and the growth experiment showed fatty acid chain modification from alkene to cyclopropyl groups over time. Notably, these novel MS scans were also performed using desorption electrospray ionization (DESI) to quickly sample complex mixtures without pre-separation. This demonstration experiment has implications for the value of ambient ionization mass spectrometry for monitoring biological systems on physiologically relevant timescales.Following the growth in visibility of Transgender and Gender Non-Confirming-identified people (TGNC) in popular culture and media, along with the increase in number of health clinics focusing on working with this population, and the development of a special interest in health professionals in TGNC-related issues, flourishing scientific literature and updated guidelines to help Mental Health Professionals (MHPs) work affirmatively with transgender individuals is pertinent. Despite the increased attention toward TGNC individuals, this population is still faced with political, economic, legal, and medical obstacles affecting their mental health and access to health care. Moreover, MHPs still report having limited training and experience in TGNC-affirmative care. This article aims at providing professionals with the most updated information and research findings to help them develop a more trans-affirmative practice. After defining key terms and providing a definition of TGNC-affirmative health care, this article will focus on summarizing the main documents that inform MHPs working with this population. This article offers research-based guidelines and discusses the major theoretical frameworks professionals are encouraged to incorporate in their work when developing TGNC-affirmative care. Additionally, this article will present the current debate around the diagnoses of Gender Dysphoria (DSM-V) and Gender Incongruence (ICD-11). The controversy between the Medical Model based on the Diagnosis of Gender Dysphoria and the emerging Informed Consent Model will be reviewed.Covid-19 is an infective respiratory illness caused by a novel virus, which might present different degrees of severity from mild or even asymptomatic carriers to severe pneumonia, requiring intubation and intensive care unit (ICU) management. SARS-CoV-2 may cause also central nervous system involvement, including psychiatric manifestations. Some cases of psychosis apparently covid-related have been reported since the start of the pandemic; we will briefly review some of them here, then we will report a case concerning a patient with emerging psychosis during the disease caused by the virus. Our case describes a man with no prior personal or familiar psychiatric history, who developed delusion and a post-traumatic stress symptoms (PTSS) which required hospitalization in a psychiatric unit. The patient was treated with antipsychotic medications and underwent a brief follow-up.
To explore the psychological status of patients with amputation injury and to evaluate the effects of psychological interventions based on magnetic resonance imaging (MRI) and X-ray characteristics.

Two hundred patients admitted from June 2016 to May 2019 were randomly assigned into control and observation groups (n=100). Routine care was performed for both groups, based on which observation group was given psychological interventions. Coping style, compliance to examinations, mental stress, degree of perceived control, degree of anxiety, degree of depression, incidence rate of adverse events, and satisfaction with nursing services were compared.

After interventions, the score of positive coping, score of compliance to examinations and Control Attitudes Scale-Revised (CAS-R) score were significantly higher, whereas the score of negative coping, Chinese perceived stress scale (CPSS) score, self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score were lower in observation group than those in control group. The score of positive coping, score of compliance to examinations and CAS-R score were significantly elevated, while the score of negative coping, CPSS score, SAS score and SDS score reduced in both groups (p<0.05). The satisfaction rate was significantly higher in observation group than that in control group (p<0.05). The incidence rate of these adverse events was significantly lower in observation group than that in control group (p<0.05).

Psychological interventions before MRI and X-ray examinations are conducive to adjustment of the mental state of patients receiving replantation of a severed limb, thus improving the compliance to examinations, completion rate and image quality.
Psychological interventions before MRI and X-ray examinations are conducive to adjustment of the mental state of patients receiving replantation of a severed limb, thus improving the compliance to examinations, completion rate and image quality.
Website: