Notes

By using a pond sediment document in order to infer the actual long-term good reputation for cyanobacteria along with the recent increase of your anatoxin generating Dolichospermum sp.
By comparing different algorithms, it can be seen that the video recommendation accuracy of the BP neural network algorithm based on swarm optimization (FEBP) is 15.8% higher than that of the traditional BP neural network algorithm. These intelligent algorithms are added into the image transmission system, in order to achieve the goal of improving the image transmission and recommendation effect.Motivation. Currently, the COVID-19 pandemic represents a critical issue all over the world. On May 11, 2020, at 05  41 GMT, approximately 0.28 million individuals had perished because of the COVID-19 pandemic, and the figure is continuously growing rapidly. Unfortunately, millions of people have died due to this pandemic. As a result, this issue forced governments and other corresponding organizations to take significant action, such as the lockdown and vaccinations. Furthermore, scientists have developed several vaccinations, and the World Health Organization (WHO) has urged governments and people to get vaccinated to eradicate this pandemic. Consequently, the findings of any scientific research into this phenomenon are highly interesting. Problem Statement. To enhance individual protection, it is now critical to analyze and compare the percentage of people fully vaccinated against COVID-19. It is constantly of interest in the field of big data science and other related disciplines to provide the best analysed statistical model can be used for statistics and generate new statistical distributions that can be used to compare and predict the process of people's willingness to vaccinate and take the vaccine to try to eliminate COVID-19.The aim of this experimental study was to analyze the impact of applying different configurations of the transpedicular fixation system on selected mechanical parameters of the thoracolumbar spine under conditions of its instability (after simulated fracture). Five study groups were tested physiological, with compression fracture of the vertebra, with two-segment fixation, with three-segment fixation, and with four-segment fixation. Each of the analyzed study groups was subjected to axial compression, flexion, and extension. Based on the conducted experimental tests, the mechanical parameters, i.e., stiffness coefficient and dissipation energy, were determined for all groups under consideration. The stiffness value of two-segment fixation is significantly lower than the physiological value (during flexion and extension). The use of long-segment fixation considered in two configurations (three- and four-segment fixation) may result in excessive stiffness of the system due to the high stiffness values achieved (approx. 25-30% higher than the physiological values in the case of compression and on average 60% higher in the case of flexion). The use of long-segment fixator design shows better results than short-segment fixation. Considering both biomechanical and clinical aspects, three-segment fixation seems to be a compromise solution as it saves the patient from more extensive stiffening of the spinal motion segments.
To detect the expression levels of miR-498 in the hepatoma cells and to clarify the biological roles of miR-498 in hepatoma by investigating CREB1, which is the target of miR-498. This study provides a new biomarker for the early diagnosis and targeted therapies for hepatoma.

The expression of miR-498 between hepatoma cells and hepatocytes was detected by qRT-PCR. miR-498 was overexpressed in hepatoma cells, and then, flow cytometry was used to analyze the cell apoptosis rate. Cell migration and invasion ability were evaluated by Transwell migration assay and Matrigel invasion assay. The downstream targets of miR-498 were searched in the biological database or related software, and the result can be verified by luciferase reporter assay. The knockdown of the downstream target using RNA interference detected its biological functions in hepatoma cells and was confirmed by cotransfection experiments.

miR-498 was downregulated in hepatoma cell lines compared with hepatocytes. The overexpression of miR-498 significantly promoted apoptosis. Luciferase reporter assays showed that miR-498 could target CREB1 3'UTR and CREB1 was one of the targets of miR-498. Knockdown of CREB1 also inhibited hepatoma cells' malignant potential and increased the apoptosis rate of hepatoma cells. CREB1 was able to alleviate the changes caused by miR-498 overexpression.

miR-498 is downregulated in hepatoma cell lines. Therefore, miR-498 can be one of the potential molecular markers for hepatoma diagnosis. miR-498 plays a role in tumor suppression through regulating CREB1.
miR-498 is downregulated in hepatoma cell lines. Therefore, miR-498 can be one of the potential molecular markers for hepatoma diagnosis. miR-498 plays a role in tumor suppression through regulating CREB1.
To explore the value of machine learning-based magnetic resonance imaging (MRI) liver acceleration volume acquisition (LAVA) dynamic enhanced scanning for diagnosing hilar lesions.

A total of 90 patients with hilar lesions and 130 patients without hilar lesions who underwent multiphase dynamic enhanced MRI LAVA were retrospectively selected as the study subjects. The 10-fold crossover method was used to establish the data set, 7/10 (154 cases) data were used to establish the training set, and 3/10 (66 cases) data were used to establish the validation set to verify the model. The region of interest was extracted from MRI images using radiomics, and the hilar lesion model was constructed based on a convolutional neural network.

There were significant differences in respiration and pulse frequency between patients with hilar lesions and without hilar lesions (
 <0.05). The subjective scores of the images in the first three phases of dynamic enhanced scanning in the training set were higher than those in the validation set (
< 0.05). There was no significant difference between the training and validation set in the last three phases of dynamic enhanced scanning.

Machine learn-based MRI LAVA dynamic enhanced scanning for diagnosing hilar lesions has high diagnostic efficiency and can be used as an auxiliary diagnostic method.
Machine learn-based MRI LAVA dynamic enhanced scanning for diagnosing hilar lesions has high diagnostic efficiency and can be used as an auxiliary diagnostic method.In the past few years, big data related to healthcare has become more important, due to the abundance of data, the increasing cost of healthcare, and the privacy of healthcare. Create, analyze, and process large and complex data that cannot be processed by traditional methods. The proposed method is based on classifying data into several classes using the data weight derived from the features extracted from the big data. Three important criteria were used to evaluate the study as well as to benchmark the current study with previous studies using a standard dataset.
To investigate the changes in vertebral function after minimally invasive surgery in patients with thoracolumbar spinal fractures and investigate the impact of percutaneous minimally invasive surgery on patients' quality of life by following up the patients in the long term.

A retrospective analysis was performed to select 80 patients with thoracolumbar spinal fractures treated in our hospital from April 2013 to October 2018, and the patients were divided into a study group and a control group according to the difference in their choice of procedure. The two groups were compared in terms of perioperative wound pain, serum creatine kinase (CK) activity, and C-reactive protein (CRP) levels, and the two groups were followed up for 2 years to compare the changes in anterior vertebral body height and Cobb's angle during the follow-up period and to compare the differences in quality of life between the two groups.

(1) The pain level of patients in the study group was significantly lower than that of the contrurgical outcomes and a significantly improved quality of life in patients at long-term follow-up.
Compared to traditional open surgery, minimally invasive percutaneous surgery for thoracolumbar fractures can significantly reduce perioperative pain and improve perioperative stress in patients, while achieving better surgical outcomes and a significantly improved quality of life in patients at long-term follow-up.
To synthesize the evidence regarding the effect and safety of drainage after the hip arthroplasty in randomized control trials.

Although the standard of hip replacement has matured in recent years, the need for postoperative drainage is still controversial which also is a clinical problem that needs to be addressed.

A systematic review and meta-analysis based on the Cochrane methods and Prisma guideline.
. A systematic search of the Cochrane Library, PubMed, EMBASE, CINAHL, Ovid, Wan Fang database, CNKI, and CBM database was carried out from January 1, 2000, to December, 2021.
. The quality of included randomized controlled trials was assessed individually by two reviewers independently using criteria recommended in the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0.

Nineteen randomized control trials involving 3354 participants were included in this analysis. From the above analysis, we can know that compared with nondrainage, there was a statistically significant difference in Vring down hematocrit reduction, decrease dressing uses, and shorten the hospital stay which promotes rapid recovery. This review provides a detailed theoretical reference for the proper clinical application of drains and improves the efficient use of resources.
The change of bacterial flora structure in colorectal cancer (CRC) patients after treatment is not clear. The aim of this study was to explore the change and function of intestinal microflora in CRC before and after treatment.

The 16S conserved region V3+V4 of intestinal flora obtained from CRC patients was sequenced and analyzed. Alpha and beta diversity indices were used to analyze the abundance and structure of gut flora. FAPROTAX, BugBase, and Tax4Fun software were used to analyze the species phenotypes and Kyoto Encyclopedia of Genes and Genomes Ontology (KO) function pathways.

Total abundance and structure of species in CRC patients were significantly increased compared with healthy people (control group) (
< 0.05), but there was no significant difference between CRC patients before and after treatment (
> 0.05). There was significant difference in relative abundance of bacteria at different levels (phylum, class, order, family, genus, and species) between the CRC group with after operatnificantly contrasted to healthy people, and surgery and chemotherapy were hard to reduce this phenomenon. Megamonas was involved in lipopolysaccharide biosynthesis and carcinogenesis in colorectal cancer. Surgery and drug treatment did not reduced lipopolysaccharide biosynthesis but increased the number of probiotic Akkermansia population and reduced the pathogenic bacteria Tyzzerella_4, participate in adipocytokine signaling pathway, and affect metabolism.
Lung cancer is a disease associated with high levels of morbidity and mortality, with approximately 2.1 million new cases every year. Anlotinib is a new small-molecule multitarget tyrosine kinase inhibitor independently developed in China that can inhibit the formation of tumor blood vessels and has a therapeutic effect on various cancers. However, the application of anlotinib in lung cancer needs further investigation.

We collected the progress notes of 43 patients with advanced lung cancer treated at the Oncology Department of Guangzhou Chest Hospital from March 2019 to March 2021. Additionally, we assessed the differences between drug combination therapy and single-drug therapy among patients treated with anlotinib.

Patients in both the anlotinib-combination and anlotinib-monotherapy groups experienced remission; however, the overall disease control rate in the anlotinib-combination group was higher than that in the anlotinib-monotherapy group. Reexamination via computed tomography showed that patients in the anlotinib-combination group had better recovery than those in the anlotinib-monotherapy group.
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