Notes

Exploring expression memorability: Just how do diverse term attributes make clear item free-recall probability?
Using natural products minimizes the side effects and morbidities associated with conventional therapies. The development of innovative treatments approaches would tremendously benefit the African and Indian populace and reduce the mortalities associated with OMCs in the developing world. Hence, we discuss herein, the potential benefits, opportunities and challenges of using bioactive compound libraries in the management of OMCs.Serologic testing for SARS-CoV-2 antibodies can be used to confirm diagnosis, estimate seroprevalence, screen convalescent plasma donors, and assess vaccine efficacy. Dried blood spot (DBS) samples have been used for serology testing of various diseases in resource-limited settings. We examined the use of DBS samples and capillary blood (fingerstick) plasma collected in Microtainer tubes for SARS-CoV-2 testing with the automated Abbott ARCHITECT™ SARS-CoV-2 IgG and IgM assays and use of venous whole blood with a prototype PANBIO™ rapid point-of-care lateral flow SARS-CoV-2 IgG assay. The ARCHITECT™ SARS-CoV-2 IgG assay was initially optimized for use with DBS, venous and capillary plasma, and venous whole blood collected from patients with symptoms and PCR-confirmed COVID-19 and negative asymptomatic controls. Linearity and reproducibility was confirmed with 3 contrived DBS samples, along with sample stability and signal recovery after 14 days. ARCHITECT™ SARS-CoV-2 IgG and IgM assay results showed high concordance between fingerstick DBS and venous DBS samples, and between fingerstick DBS and venous whole blood samples (n = 61). Fingerstick plasma collected in Microtainer tubes (n = 109) showed 100% concordant results (R2=0.997) with matched patient venous plasma on the ARCHITECT™ SARS-CoV-2 IgG assay. High concordance of assay results (92.9% positive, 100% negative) was also observed for the PANBIO™ SARS-CoV-2 IgG assay compared to the ARCHITECT™ SARS-CoV-2 IgG assay run with matched venous plasma (n = 61). Fingerstick DBS and plasma samples are easy and inexpensive to collect and, along with the use of rapid point-of-care testing platforms, will expand access to SARS-CoV-2 serology testing, particularly in resource-limited areas.
Considering the possibility of nasal self-sampling and the ease of use in performing SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs), self-testing is a feasible option.

The goal of this study was a head-to-head comparison of diagnostic accuracy of patient self-testing with professional testing using a SARS-CoV-2 Ag-RDT.

We performed a manufacturer-independent, prospective diagnostic accuracy study of nasal mid-turbinate self-sampling and self-testing with symptomatic adults using a WHO-listed SARS-CoV-2 Ag-RDT. Procedures were observed without intervention. For comparison, Ag-RDTs with nasopharyngeal sampling were professionally performed. Estimates of agreement, sensitivity, and specificity relative to RT-PCR on a combined oro-/nasopharyngeal sample were calculated. Feasibility was evaluated by observer and participant questionnaires.

Among 146 symptomatic adults, 40 (27.4%) were RT-PCR-positive for SARS-CoV-2. Sensitivity with self-testing was 82.5% (33/40; 95% CI 68.1-91.3), and 85.0%spread and frequent testing. Paired with the appropriate information of the public about the benefits and risks, self-testing may have significant impact on the pandemic.Since the SARS-CoV-2 pandemic onset, many routine medical activities have been put on hold and this has deeply affected the management of patients with chronic diseases such as obstructive sleep apnea. Untreated OSA is associated with increased mortality and difficulties in social functioning. A delay in initiating treatment may therefore have harmful consequences. Between February and April 2020, the so-called first wave of the pandemic, the overall activity of sleep centers in Europe was reduced by 80%. As the international infection control authorities released guidelines for SARS-CoV-2 outbreak control, many of the national sleep societies provided strategies for a gradual re-opening of sleep facilities. Most of these strategies were not evidences-based and, in a climate of general concern, worldwide it was strongly advised to post-pone any non-urgent sleep-related procedure. Despite the initial idea that the outbreak could be transient, after one year it is still ongoing and the price we are paying, not only includes deaths caused by COVID-19, but also deaths caused by missed or late diagnosis. As further delays in diagnosing and treating patients with sleep apnea are no more acceptable, a new arrangement of sleep facilities and resources, in order to operate safely and effectively, is now mandatory. In this article, we review most recent literature and guidelines in order to provide practical advice for a new arrangement of sleep laboratories and the care of patients with obstructive sleep apnea after one year from the onset of the COVID-19 pandemic.
The majority of research on sleep and cognition has focused on mean markers of sleep across multiple nights; however, variable sleep patterns have become increasingly common in the modern era. The purpose of this study was to examine whether objective intraindividual variability in sleep quantity and quality are related to verbal and visuospatial learning and memory functioning in young adults.

A total of 218 young adult college students were recruited from a university in the Eastern United States, among which 187 participants (70.6% female; mean age=20.5, SD=1.5) had complete actigraphy and cognitive performance data. Objective intraindividual means and variabilities of sleep quantity (total sleep time) and sleep quality (percent wake after sleep onset) were measured over a 1- to 2-week timeframe using wrist actigraphy. Verbal and visuospatial learning and memory were assessed using the International Shopping List and Groton Maze Learning tests of the Cogstate computerized test battery.

Greater intraindividual variability in actigraphy-derived sleep quality was associated with poorer visuospatial learning and memory performance after controlling for mean sleep quality and visuomotor attention and processing speed (ps<0.05). Actigraphic measures of sleep quantity were not related to any learning and memory measures.

In young adults, intraindividual variability in objective sleep quality was significantly related to visuospatial learning and memory, over and above mean sleep quality. Given these associations, future studies should aim to identify modifiable lifestyle and environmental factors contributing to variable sleep quality.
In young adults, intraindividual variability in objective sleep quality was significantly related to visuospatial learning and memory, over and above mean sleep quality. Given these associations, future studies should aim to identify modifiable lifestyle and environmental factors contributing to variable sleep quality.
Sleep difficulties have been reported in up to 85% of children with Attention Deficit hyperactivity disorder (ADHD). Children with ADHD exhibit commonly sensory modulation difficulties (SMD) and experience more significant functional difficulties. Sleep difficulties have also been associated with SMD. The aim of this study was to evaluate whether SMD are associated with sleep difficulties in children with ADHD.

We assessed sleep difficulties using the Children's Sleep Habits Questionnaire, and SMD using the Short Sensory Profile (SSP) questionnaire. A total of 25 children with ADHD and atypical sensory profiles, 13 children with ADHD and typical sensory profiles and 38 children used as controls (all children aged 8-11 years) were included.

Sleep difficulties were detected in 86.4% of children with ADHD and atypical SSPs, as compared to 30.8% of children with ADHD and typical SSPs, and 16.7% of controls. A multivariate logistic regression revealed that children with ADHD and atypical SSPs had significantly increased odds for sleep difficulties as compared to controls (OR=32.4; 95% CI 4.0-260.1, p=0.001), while children with ADHD and typical SSPs were indistinguishable from controls. Suspected confounders (gender, age, mother's education, and stimulant therapy) did not contribute to sleep difficulties.

In this pilot study, SMD were associated with sleep difficulties in children with ADHD.
In this pilot study, SMD were associated with sleep difficulties in children with ADHD.Objectification theory has provided a useful framework for the study of women's sexual outcomes. However, little research has been conducted on the role of self-objectification in predicting sexual satisfaction. We conducted a replication of Calogero and Thompson (2009a), which reported a direct relationship between self-surveillance and sexual satisfaction, and expanded upon their work. We tested four path analysis models Calogero and Thompson's reported and hypothesized models, and two previously untested models, all containing our variables of interest (media internalization, self-surveillance, body shame, sexual self-esteem, and sexual satisfaction). Each model was tested with the full sample (N = 349) and a restricted sample (N = 127) that met Calogero and Thompson's relationship status and sexual frequency inclusion criteria, and with and without BMI covaried. Both samples consisted of U.S. college women recruited in Fall 2019, with a mean age of M = 19.68 in the restricted sample. Results showed good fit for all tested models but failed to replicate the direct pathway between self-surveillance and sexual satisfaction. Instead, our models supported an indirect effect of self-surveillance on sexual satisfaction through body shame and sexual self-esteem. Findings support the role of sociocultural channels in influencing college women's body image and sexual experiences.Depression is a common mental health problem that is thought to develop through a combination of genetic, psychological, and environmental factors, including parental behaviours and parental mental health. The present study investigated the potential interaction between oxytocin receptor (OXTR) single nucleotide polymorphisms (SNPs) (rs53576, rs237880, rs237887, rs237889, rs237898, rs1042778, rs2268490, rs2268491, rs4686302, rs6770632, rs13316193) and parenting style in adolescence in relation to depressive symptoms among young adults. The sample consisted of 1,098 Caucasian participants (63.6% females) and their parents. The present study included data from the Survey of Adolescent Life Cohort study collected in 2012 at wave I (mage 14.4 years; DNA collection), 2015 at wave II (mage 17.36 years; Estimation of parenting style, depressive symptoms, and parental depression) and 2018 at wave III (mage 20.19 years; Depressive symptoms). Evidence for an interaction effect between OXTR SNP rs6770632 and negative parenting style on depressive symptoms among young adults was found with support for the diathesis-stress theory. The rs6770632 was associated with depressive symptoms at higher levels of negative parenting, with AA allele carriers reporting higher levels of depressive symptoms than CC and CA allele carriers. The present study provides preliminary knowledge about the potential moderation effects of perceived negative parenting on the effect of OXTR SNPs on depressive symptoms among young adults, independent of sex, previous reports of depressive symptoms, and parental depression.
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