Notes

Multinational Study of Current Exercise from Photo for you to Treatment of Atherosclerotic Carotid Stenosis.
5%) and surgical excision (17.6%). The pooled complication rate across six studies was 21/261 (8.0%), with the most common complication being paraesthesia, reported in 14/261 (5.4%) patients.

There is a lack of high-quality research currently regarding the treatment of foot and ankle ganglia. Limited evidence suggests that there could potentially be associations between time to treatment, ganglion location and extent of surgical resection and recurrence rate. However, further research is required before any definitive conclusions can be drawn.
There is a lack of high-quality research currently regarding the treatment of foot and ankle ganglia. Limited evidence suggests that there could potentially be associations between time to treatment, ganglion location and extent of surgical resection and recurrence rate. However, further research is required before any definitive conclusions can be drawn.
The ratio of forced expiratory volume in 3 seconds to forced expiratory volume in 6 seconds (FEV3/FEV6) has been proposed as an index of peripheral airway disease, and could be decreased in patients at risk for COPD. However, the prevalence of FEV3/FEV6 decrease has never been assessed in patients attending a pneumology clinic. Here we set out to assess the prevalence of a decreased FEV3/FEV6 in smokers with symptoms of chronic bronchitis, and to test its predictive value for COPD diagnosis.

We performed a retrospective analysis of databased pulmonary function tests (PFTs) for smokers and ex-smokers aged >40 years old, with symptoms of chronic bronchitis and a normal FEV1/FVC ratio. Clinical data were retrieved from the hospital records. Patients presenting with clinical conditions liable to interfere with PFT results were excluded. For those included, we controlled for onset of an obstructive ventilatory defect 1 year later.

The dataset included 67 patients (median age 64 years [interquartile range e study is needed to determine whether decreased FEV3/FEV6 could be used to detect patients at risk for COPD.
Decreased FEV3/FEV6 suggestive of peripheral airway disease is highly prevalent in smokers with symptoms of chronic bronchitis and preserved pulmonary function. Altered FEV3/FEV6 is predictive of reduced FEV1/FVC ratio in the mid-term. A larger prospective study is needed to determine whether decreased FEV3/FEV6 could be used to detect patients at risk for COPD.The role of nitric oxide (NO) as a modulator of functional sympatholysis has been debated in the literature, but the preponderance of evidence suggests that the magnitude of NO-mediated dilation is restrained by sympathetic vasoconstriction. Therefore, we hypothesized that passive leg movement (PLM)-induced vasodilation, which is predominantly NO-mediated, would be attenuated by an exercise-induced increase in muscle sympathetic nerve activity (MSNA). To test this hypothesis, MSNA, leg blood flow (LBF), and mean arterial blood pressure (MAP) were measured and leg vascular conductance (LVC) calculated in 9 healthy subjects (30 ± 3 yr), during PLM with and without sympathoexcitation evoked by arm-cranking exercise (ACE), at 25, 50, and 75% of maximal capacity. During this incremental intensity ACE, MSNA increased significantly (26 ± 2, 34 ± 3, and 41 ± 5 bursts/100 HB, respectively). LVC during PLM fell markedly (~1.2 ml/min/mmHg) with each increase in ACE intensity, and there was a strong relationship (r = 0.92; p less then 0.05) between ∆MSNA and ∆Peak LVC induced by the three intensities of ACE. Thus, as anticipated, this study reveals that the, NO-mediated, PLM-induced vasodilation, is significantly and proportionally attenuated by exercise-induced MSNA. This finding highlights the dominant role of MSNA in regulating skeletal muscle vascular conductance.Light-sensitive small molecules can be applied to control cell signaling with enhanced spatiotemporal precision, and their accuracy in intact tissues like the brain can be further enhanced by tethering them to genetically encoded protein tags. Coined "photopharmacology," this approach can acutely manipulate neurotransmission through specific receptor pathways. However, it remains underutilized in neuroscience due to a lack of hardware to deliver fluids and light to rodent deep-brain structures during freely moving behavior. This review will cover the most recent advances in tethered photopharmacology in relation to the multifunctional neural implants that will aid their use in vivo. The merger of these fields will provide new methodologies for researchers to manipulate signaling pathways and neural circuits with previously unattainable resolution.
Although dysfunction of large-scale brain networks has been frequently demonstrated in patients with α-Synucleinopathy (α-Syn, i.e., Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy), a consistent pattern of dysfunction remains unclear. We aim to investigate network dysfunction in patients with α-Syn through a meta-analysis.

Whole-brain seed-based resting-state functional connectivity studies (published before September 1st, 2020 in English) comparing α-Syn patients with healthy controls (HC) were retrieved from electronic databases (PubMed, Web of Science, and EMBASE). Seeds from each study were categorized into networks by their location within a priori functional networks. Seed-based effect size mapping with Permutation of Subject Images analysis of between-group effects identified the network systems in which α-Syn was associated with hyperconnectivity (increased connectivity in α-Syn vs. HC) or hypoconnectivity (decreased connectivity in α-Syn vs. HC) within and between eacCouncil of Hong Kong (Grant No. RGC14116121).
This study was partially supported by the Research Grants Council of Hong Kong (Grant No. RGC14116121).Second-hand clothing consumption has grown in popularity in recent decades and has also attracted extensive worldwide efforts to investigate the dynamics behind consumers' purchase behaviours. However, research regarding this topic is scarce in China, which has also witnessed the rapid growth of the second-hand market in recent years. In this regard, this study analyzed the motivations and barriers to Chinese consumers' purchase of second-hand clothes as well as their perceived problems with this industry. Specifically, the study conducted a semi-structured online survey with 127 consumers of three second-hand clothing stores in China. Results show that the vast majority (96%) of the investigated consumers are young people born in the 1990s and 2000s, and they are neither significantly driven by economic nor environmental protection motivations. Instead, their purchase is primarily motivated by treasure-hunting fun. Moreover, past overseas shopping experiences are found to be a significant booster to second-hand clothing consumption. Concerns about poverty association and the sanitation conditions of second-hand clothing are the main purchase barriers for the investigated Chinese young consumers. As for the second-hand clothing market, "unregulated industry" (10.29%), "fake identification" (8.09%), and "sanitation concern" (5.88%) are the three most mentioned problems in China. This study provides second-hand retailors and managers with valuable insights into developing successful marketing tactics to attract customers and improve the second-hand industry's performance in China.Although numerous studies have been implemented on identifying the impact of acoustic waves on mineral beneficiation, its fundamental aspects remain unclear in the literature. The present work, for the first time, systematically investigates the role of ultrasound pre-treatment (UPT) in the carbonaceous copper-bearing shale flotation. To this end, conditioning was carried out at different powers of applied ultrasound. Non-treated and UPT shale flotation tests were performed in the presence of frother (MIBC) and collector (KEX). To analyse particle surface charge variation and collector adsorption properties after application of UPT, zeta potential and ultraviolet-visible spectroscopy measurements were implemented, respectively. The generation of sub-micron bubbles due to the acoustic cavitation was characterised by laser-based particle size measurements. Shale hydrophobicity was determined using the sessile drop and captive bubble techniques. The micro-flotation results showed that the mass recovery increased by 40% at 20 W of applied ultrasonic power. The positive effect of UPT on the copper-bearing shale flotation was related to i) generation of ultrafine bubbles due to the acoustic cavitation phenomenon and ii) the cleaning effect through transient bubble collapse. However, rigorous ultra-sonication diminished the recoverability of the sample owing to the less intensified number of ultrafine bubbles on the particle surfaces and formation of free H and OH radicals, which led to the oxidation of particle surfaces. These statements were correlated well with the observations of the zeta potential, particle size analysis and quantified ultrafine bubbles. Finally, we briefly highlighted fundamental knowledge gaps in flotation and ultrasound-related issues for future work.
Conjunctivitis is the inflammation of the conjunctiva. Although data on clinical efficacy and safety of various ayurvedic treatments in conjunctivitis is published, systematic review is not done. This systematic review and meta-analysis aims to evaluate the efficacy and safety of ayurvedic treatments in conjunctivitis.

A literature search of the Cochrane Library (Cochrane central register of controlled trials issue 6 of 12, June 2018), Pub Med, AYUSH research portal (Govt. of India), DHARA portal, Google scholar and online clinical trials registers was done. Randomized controlled trials (RCTs), quasi-randomized controlled trials (QRCTs), controlled clinical trials (CCTs) and multiple arms clinical trials were identified in which Ayurveda treatments with any dose, type, schedule, drug, dosage form, and advised Pathayapathya (lifestyle changes) were selected.

We identified 13 eligible RCTs, five CCTs and two multiple arms clinical trials which includes a total of 816 participants. Meta analysis of data from five trials showed that ayurvedic treatments benefitted more compared with non-ayurveda interventions in symptoms like itching (SMD=-0.98, 95% CI (-1.30,-0.65) p<0.00001, I
=38%), pain (SMD=-0.57, 95% CI (-0.87, -0.29, P=0.0001, I
=0%), ropy discharge (SMD=-1.02, 95% CI(-1.45, -0.59), P<0.00001, I
=0%), conjunctival congestion (SMD=-0.67, 95% CI (-0.91, -0.43), p<0.00001, I
=0%), foreign body sensation (SMD=-0.68, 95% CI(-1.06, -0.29), p=0.0006, I
=46%, Fig.8) and lid heaviness (SMD=-0.66, 95% CI(- 0.98, -0.33), p<0.0001, I
=0%).

Although some findings confirm the benefit of ayurveda as opposed to non ayurveda for the treatment of conjunctivitis, since the studies have high risk of bias and are of lower quality, the findings could not be generalized. There is a need for high quality studies in ayurveda in this regard.

CRD42019129436.
CRD42019129436.
Autism spectrum disorder (ASD) is a neurodevelopment disorder, marked by deficits in social communication and social interaction as well as by a restricted, repetitive patterns of behaviors, interests and activities. There is an increasing interest in the use of dance as part of rehabilitation for individuals with ASD. However, it is not clear how dance can influence on ASD symptoms. And few studies have measured and compared the outcomes of multiple studies. This study was aimed to provide a more comprehensive perspective of the efficacy of dance practice on ASD symptoms by conducting a systematic review with meta-analysis.

The electronic databases PubMed, EBSCO, MEDLINE, Cochrane and PsycINFO were searched for relevant studies reporting on the effects of dance on ASD symptoms. Only randomized controlled trials (RCTs) and non-randomized controlled studies were included in this review. Two review authors independently performed literature search, data extraction, and study quality assessment. Effect sizes for ASD symptoms were expressed as standardized mean differences (SMD) with 95% confidence intervals.
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