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Epileptogenic zone (EZ) localization is a crucial step during diagnostic work up and therapeutic planning in medication refractory epilepsy. In this paper, we present the first deep learning approach to localize the EZ based on resting-state fMRI (rs-fMRI) data.
Our network, called DeepEZ, uses a cascade of graph convolutions that emphasize signal propagation along expected anatomical pathways. We also integrate domain-specific information, such as an asymmetry term on the predicted EZ and a learned subject-specific bias to mitigate environmental confounds.
We validate DeepEZ on rs-fMRI collected from 14 patients with focal epilepsy at the University of Wisconsin Madison. Using cross validation, we demonstrate that DeepEZ achieves consistently high EZ localization performance (Accuracy 0.88 ± 0.03; AUC 0.73 ± 0.03) that far outstripped any of the baseline methods. This performance is notable given the variability in EZ locations and scanner type across the cohort.
Our results highlight the promise of using DeepEZ as an accurate and noninvasive therapeutic planning tool for medication refractory epilepsy.
While prior work in EZ localization focused on identifying localized aberrant signatures, there is growing evidence that epileptic seizures affect inter-regional connectivity in the brain. DeepEZ allows clinicians to harness this information from noninvasive imaging that can easily be integrated into the existing clinical workflow.
While prior work in EZ localization focused on identifying localized aberrant signatures, there is growing evidence that epileptic seizures affect inter-regional connectivity in the brain. DeepEZ allows clinicians to harness this information from noninvasive imaging that can easily be integrated into the existing clinical workflow.MiRNAs are reported to be linked to the pathogenesis of human complex diseases. Disease-related miRNAs may serve as novel bio-marks and drug targets. This work focuses on designing a multi-relational Graph Convolutional Network model to predict miRNA-disease associations (HGCNMDA) from a Heterogeneous network. HGCNMDA introduces a gene layer to construct a miRNA-gene-disease heterogeneous network. We refine the features of nodes into initial and inductive features so that the direct and indirect associations between diseases and miRNA can be considered simultaneously. Then HGCNMDA learns feature embeddings for miRNAs and disease through a multi-relational graph convolutional network model that can assign appropriate weights to different types of edges in the heterogeneous network. Finally, the miRNA-disease associations were decoded by the inner product between miRNA and disease feature embeddings. We apply our model to predict human miRNA-disease associations. The HGCNMDA is superior to the other state-of-the-art models in identifying missing miRNA-disease associations and also performs well on recommending related miRNAs/diseases to new diseases/ miRNAs.This article proposes the Mediterranean matrix multiplication, a new, simple and practical randomized algorithm that samples angles between the rows and columns of two matrices with sizes m, n, and p to approximate matrix multiplication in O(k(mn+np+mp)) steps, where k is a constant only related to the precision desired. The number of instructions carried out is mainly bounded by bitwise operators, amenable to a simplified processing architecture and compressed matrix weights. Results show that the method is superior in size and number of operations to the standard approximation with signed matrices. Equally important, this article demonstrates a first application to machine learning inference by showing that weights of fully connected layers can be compressed between 30 × and 100 × with little to no loss in inference accuracy. The requirements for pure floating-point operations are also down as our algorithm relies mainly on simpler bitwise operators.Image super-resolution (SR) is a critical image preprocessing task for many applications. How to recover features as accurately as possible is the focus of SR algorithms. Most existing SR methods tend to guide the image reconstruction process with gradient maps, frequency perception modules, etc. and improve the quality of recovered images from the perspective of enhancing edges, but rarely optimize the neural network structure from the system level. In this article, we conduct an in-depth exploration for the inner nature of the SR network structure. In light of the consistency between thermal particles in the thermal field and pixels in the image domain, we propose a novel heat-transfer-inspired network (HTI-Net) for image SR reconstruction based on the theoretical basis of heat transfer. With the finite difference theory, we use a second-order mixed-difference equation to redesign the residual network (ResNet), which can fully integrate multiple information to achieve better feature reuse. In addition, according to the thermal conduction differential equation (TCDE) in the thermal field, the pixel value flow equation (PVFE) in the image domain is derived to mine deep potential feature information. The experimental results on multiple standard databases demonstrate that the proposed HTI-Net has superior edge detail reconstruction effect and parameter performance compared with the existing SR methods. The experimental results on the microscope chip image (MCI) database consisting of realistic low-resolution (LR) and high-resolution (HR) images show that the proposed HTI-Net for image SR reconstruction can improve the effectiveness of the hardware Trojan detection system.Forecast verification is a crucial task for assessing the predictive power of prognostic model forecasts and it is usually implemented by checking quality-based skill scores. In this article, we propose a novel approach to realize forecast verification focusing not just on the forecast quality but rather on its value. Specifically, we introduce a strategy for assessing the severity of forecast errors based on the evidence that, on the one hand, a false alarm just anticipating an occurring event is better than one in the middle of consecutive nonoccurring events, and that, on the other hand, a miss of an isolated event has a worse impact than a miss of a single event, which is part of several consecutive occurrences. Relying on this idea, we introduce a notion of value-weighted skill scores giving greater importance to the value of the prediction rather than to its quality. Then, we introduce an ensemble strategy to maximize quality-based and value-weighted skill scores independently of one another. We test it on the predictions provided by deep learning methods for binary classification in the case of four applications concerned with pollution, space weather, stock price, and IoT data stream forecasting. Our experimental studies show that using the ensemble strategy for maximizing the value-weighted skill scores generally improves both the value and quality of the forecast.In this article, we propose a multiscale cross-connected dehazing network with scene depth fusion. We focus on the correlation between a hazy image and the corresponding depth image. The model encodes and decodes the hazy image and the depth image separately and includes cross connections at the decoding end to directly generate a clean image in an end-to-end manner. Specifically, we first construct an input pyramid to obtain the receptive fields of the depth image and the hazy image at multiple levels. Then, we add the features of the corresponding dimensions in the input pyramid to the encoder. Finally, the two paths of the decoder are cross-connected. In addition, the proposed model uses wavelet pooling and residual channel attention modules (RCAMs) as components. A series of ablation experiments shows that the wavelet pooling and RCAMs effectively improve the performance of the model. We conducted extensive experiments on multiple dehazing datasets, and the results show that the model is superior to other advanced methods in terms of peak signal-to-noise ratio (PSNR), structural similarity (SSIM), and subjective visual effects. The source code and supplementary are available at https//github.com/CCECfgd/MSCDN-master.Vision-language navigation (VLN) is a challenging task, which guides an agent to navigate in a realistic environment by natural language instructions. Sequence-to-sequence modeling is one of the most prospective architectures for the task, which achieves the agent navigation goal by a sequence of moving actions. The line of work has led to the state-of-the-art performance. Recently, several studies showed that the beam-search decoding during the inference can result in promising performance, as it ranks multiple candidate trajectories by scoring each trajectory as a whole. However, the trajectory-level score might be seriously biased during ranking. The score is a simple averaging of individual unit scores of the target-sequence actions, and these unit scores could be incomparable among different trajectories since they are calculated by a local discriminant classifier. To address this problem, we propose a global normalization strategy to rescale the scores at the trajectory level. Concretely, we present two global score functions to rerank all candidates in the output beam, resulting in more comparable trajectory scores. In this way, the bias problem can be greatly alleviated. We conduct experiments on the benchmark room-to-room (R2R) dataset of VLN to verify our method, and the results show that the proposed global method is effective, providing significant performance than the corresponding baselines. Our final model can achieve competitive performance on the VLN leaderboard.This article investigates the finite-time synchronization (FTS) and H∞ synchronization for two types of coupled neural networks (CNNs), that is, the cases with multistate couplings and with multiderivative couplings. By designing appropriate state feedback controllers and parameter adjustment strategies, some FTS and finite-time H∞ synchronization criteria for CNNs with multistate couplings are derived. In addition, we further consider the FTS and finite-time H∞ synchronization problems for CNNs with multiderivative couplings by utilizing state feedback control approach and selecting suitable parameter adjustment schemes. Finally, two simulation examples are given to demonstrate the effectiveness of the proposed criteria.This brief investigates the robust optimal tracking control for a three Mecanum wheeled mobile robot (MWMR) with the external disturbance by the aid of online actor-critic synchronous learning algorithm. The Euler-Lagrange motion equation of MWMR subject to slipping is established by analyzing the structural characteristics of Mecanum wheels. Concatenating the tracking error with the desired trajectory, the tracking control problem is converted into a time-invariant optimal control problem of an augmented system. Then, an approximate optimal tracking controller is obtained by applying online actor-critic synchronous learning algorithm. With the help of Lyapunov-based analysis, the ultimately bounded tracking can be guaranteed. Finally, simulation results show the effectiveness of synchronous learning algorithm and approximate optimal tracking controller.
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