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However, only NSAIDs were identified to increase lithium levels independently. DISCUSSION Routine clinical practice needs to focus on drugs affecting renal blood flow and function, especially on NSAIDs as over-the-counter medication that may lead to an increase in lithium serum concentration. To prevent intoxications, clinicians should carefully monitor the comedications, and they should inform patients about possible intoxications due to NSAIDs. © Georg Thieme Verlag KG Stuttgart · New York.in German, FRAGESTELLUNG Hält die durch stationär-psychosomatische Behandlung erreichte klinische Besserung ein bzw. 2 Jahre nach der Entlassung an? Wie verändert sich die medizinische Inanspruchnahme nach der Entlassung verglichen mit dem Jahr vor der stationär-psychosomatischen Behandlung? METHODE Die einwilligende Stichprobe zum Entlasszeitpunkt (N=250) wird anhand von 6 klinischen, 2 ressourcenbezogenen und 11 versorgungsmedizinischen Variablen zu 6 Messzeitpunkten (Aufnahme, Entlassung und jeweils 6, 12, 18, 24 Monate nach Entlassung) untersucht. Die adhärente Teilstichprobe (n=86) und die nicht adhärente (n=164) Teilstichprobe werden anhand von 25 Variablen verglichen. Der Verlauf der Zielvariablen wird graphisch anhand von Box-Plots dargestellt. Bivariate Vergleiche werden mit Mann-Withney-, Wilcoxon- und t-Tests mit Bonferroni-Korrektur durchgeführt, Vergleiche aller Messzeitpunkte für die Zielvariablen unter statistischer Kontrolle mit ausgewählten Kovariaten anhand von multivariaten Random-Effects-Rs zeigte sich unter dem Einsatz multipler Imputation verringert. Die anhaltende klinische Besserung und die Verringerung der medizinischen Inanspruchnahme 2 Jahre nach der Entlassung sprechen für eine mittelfristige Effektivität der stationären psychosomatischen Behandlung. Strukturniveau der Persönlichkeitsorganisation und Neurotizismus sind die besten Prädiktoren für Ausmaß der psychischen Belastung über alle Messzeitpunkte hinweg.in English, German ZIELE In diesem Beitrag werden 3 Studien vorgestellt, in denen Patienten mit einer aktuellen oder vergangenen schweren körperlichen Erkrankung und ihre Partner in Hinblick auf dyadische Konkordanz sowie Geschlechts- und Rollenunterschiede in psychischer Belastung und Resilienz untersucht worden sind. METHODEN In Studie 1 wurden 55 Patienten und deren Partner im Mittel 4,5 Jahre nach einer schweren Sepsis untersucht. Studie 2 berücksichtigte 49 Lungenkrebspatienten, mehrheitlich im metastasierenden Tumorstadium, und ihre Partner. In Studie 3 wurden 69 Krebspatienten mit unterschiedlichen Tumorentitäten und Tumorstadien, die sich einer ambulanten homöopathischen Zusatzbehandlung unterzogen, und ihre Partner eingeschlossen. Zur Erfassung der psychischen Belastung wurde in allen Studien die Hospital Anxiety and Depression Scale (HADS) und zur Messung von Resilienz als Persönlichkeitsmerkmal die Kurzform der Resilienzskala RS-13 eingesetzt. Die jeweiligen Befunde wurden über die 3 Studien hinweg Belastung zwischen Patienten und deren Partnern sollten körperliche Erkrankungen grundsätzlich immer aus systemischer Perspektive betrachtet werden. Die psychische Belastung sowohl von Patienten als auch von deren Partnern bedarf einer besonderen Beachtung im psychosozialen Unterstützungsprozess, ebenso sollten partnerschaftliche Ressourcen in der Bewältigung der Erkrankung Berücksichtigung finden.BACKGROUND  Mandarin Chinese has a rich repertoire of high-frequency speech sounds. This may pose a remarkable challenge to hearing-impaired listeners who speak Mandarin Chinese because of their high-frequency sloping hearing loss. An adaptive nonlinear frequency compression (adaptive NLFC) algorithm has been implemented in contemporary hearing aids to alleviate the problem. PURPOSE  The present study examined the performance of speech perception and sound-quality rating in Mandarin-speaking hearing-impaired listeners using hearing aids fitted with adaptive NLFC (i.e., SoundRecover2 or SR2) at different parameter settings. RESEARCH DESIGN  Hearing-impaired listeners' phoneme detection thresholds, speech reception thresholds, and sound-quality ratings were collected with various SR2 settings. STUDY SAMPLE  The participants included 15 Mandarin-speaking adults aged 32 to 84 years old who had symmetric sloping severe-to-profound sensorineural hearing loss. INTERVENTION  The participants were fitted bilaterally w, New York, NY 10001, USA.BACKGROUND  Cortical auditory event-related potentials are a potentially useful clinical tool to objectively assess speech outcomes with rehabilitative devices. Whether hearing aids reliably encode the spectrotemporal characteristics of fricative stimuli in different phonological contexts and whether these differences result in distinct neural responses with and without hearing aid amplification remain unclear. PURPOSE  To determine whether the neural coding of the voiceless fricatives /s/ and /ʃ/ in the syllable-final context reliably differed without hearing aid amplification and whether hearing aid amplification altered neural coding of the fricative contrast. RESEARCH DESIGN  A repeated-measures, within subject design was used to compare the neural coding of a fricative contrast with and without hearing aid amplification. STUDY SAMPLE  Ten adult listeners with normal hearing participated in the study. DATA COLLECTION AND ANALYSIS  Cortical auditory event-related potentials were elicited to an /ɑs/-/ɑʃ/ vowel-fricative contrast in unaided and aided listening conditions. Neural responses to the speech contrast were recorded at 64-electrode sites. Peak latencies and amplitudes of the cortical response waveforms to the fricatives were analyzed using repeated-measures analysis of variance. RESULTS  The P2' component of the acoustic change complex significantly differed from the syllable-final fricative contrast with and without hearing aid amplification. Hearing aid amplification differentially altered the neural coding of the contrast across frontal, temporal, and parietal electrode regions. CONCLUSIONS  Hearing aid amplification altered the neural coding of syllable-final fricatives. However, the contrast remained acoustically distinct in the aided and unaided conditions, and cortical responses to the fricative significantly differed with and without the hearing aid. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Hyperacusis is a prevalent auditory disorder that causes significant distress and negatively affects quality of life for many patients. Patients with hyperacusis often have different complaints about the sounds and situations that they experience. Audiologists may have few patients with hyperacusis, and a limited understanding of the sounds and situations that are reported to be challenging by their patients. PURPOSE  To investigate the common complaints reported by hyperacusis patients. RESEARCH DESIGN  A qualitative study was conducted with 11 hyperacusis patients who participated in a group session. RESULTS  All 11 hyperacusis patients experienced negative reactions to specific sounds. In addition, many patients reported physical symptoms such as headaches, balance problems, dysosmia (strong smell problems), and light sensitivity. Sounds that induced discomfort were wide ranging and included low-frequency sounds, high-frequency sounds, wide-band noise, and sudden, high-intensity sounds. Most patients (9/11, 81.8%) reported negative reactions to music in loud rock concerts. Patients reported that stress/tension (90.9%) worsened their hyperacusis, while removing themselves from noise (90.9%) relieved their hyperacusis. CONCLUSION  Loudness is only one of the many factors related to the discomfort of patients with hyperacusis. Across patients, we observed that there were different complaints about the sounds and situations that produced difficulty due to hyperacusis. Physical symptoms following sound exposure were also reported by the patients, suggesting that hyperacusis is a complex disorder and requires intervention that often involves multiple members of the medical team. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Microphone location has been shown to influence speech recognition with a microphone placed at the entrance to the ear canal yielding higher levels of speech recognition than top-of-the-pinna placement. Although this work is currently influencing cochlear implant programming practices, prior studies were completed with previous-generation microphone and sound processor technology. Consequently, the applicability of prior studies to current clinical practice is unclear. PURPOSE  To investigate how microphone location (e.g., at the entrance to the ear canal, at the top of the pinna), speech-source location, and configuration (e.g., omnidirectional, directional) influence speech recognition for adult CI recipients with the latest in sound processor technology. RESEARCH DESIGN  Single-center prospective study using a within-subjects, repeated-measures design. STUDY SAMPLE  Eleven experienced adult Advanced Bionics cochlear implant recipients (five bilateral, six bimodal) using a Naída CI Q90 sound prostening environments. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Previous research has found that when the location of a talker was varied and an auditory prompt indicated the location of the talker, the addition of visual information produced a significant and large improvement in speech understanding for listeners with bilateral cochlear implants (CIs) but not with a unilateral CI. Presumably, the sound-source localization ability of the bilateral CI listeners allowed them to orient to the auditory prompt and benefit from visual information for the subsequent target sentence. PURPOSE  The goal of this project was to assess the robustness of previous research by using a different test environment, a different CI, different test material, and a different response measure. RESEARCH DESIGN  Nine listeners fit with bilateral CIs were tested in a simulation of a crowded restaurant. Auditory-visual (AV) sentence material was presented from loudspeakers and video monitors at 0, +90, and -90 degrees. Each trial started with the presentation of an auditory alerting phr is significantly underestimated in standard, auditory-only, single-speaker, test environments. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.BACKGROUND  Sensory gating is a measure used to evaluate inhibitory deficits underlying neurological disorders. However, the effects of hearing loss (HL), thought to decrease inhibition, remain unknown on gating function. PURPOSE  The goal of this study was to investigate gating performance in HL. RESEARCH DESIGN  This was a prospective, cross-sectional study with independent group comparison and correlational design. STUDY SAMPLE  Eleven adults (mean age/standard deviation = 47.546 ± 7.967 years) with normal hearing (NH) and 11 adults (mean age/standard deviation = 56.273 ± 13.871 years) with mild-moderate high-frequency HL. DATA COLLECTION AND ANALYSIS  Cortical auditory evoked potentials (CAEPs) were recorded in response to tonal pairs via high-density electroencephalography. The CAEP response to the second tone in the pair (S2) was compared with the response to the first tone in the pair (S1) within groups. Amplitude gating indices were compared between groups and correlated with auditory behavioral measures.
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