Notes
Notes - notes.io |
Recognized along with Unknown Transboundary Catching Ailments while Hybrid Threats.
9 patients. A lower phase angle did increase the odds of severe COVID-19. We believe that factors other than body composition play a more critical role in the development of severe COVID-19.
The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids and fermented red pepper paste (FRPP) supplementation on Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP).
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. All randomized clinical trials investigating the effect of capsinoids and FRPP supplementation on blood pressure including SBP and DBP were included.
Out of 335 citations, 7 trials that enrolled 363 subjects were included. Capsinoids and FRPP resulted in significant reduction in DBP (Weighted mean differences (WMD)-1.90mmHg; 95% CI,-3.72 to-0.09, P=0.04) but no significant change in SBP (WMD 0.55mmHg, 95% CI-1.45, 2.55, P=0.588). FRPP had a significant reduction in SBP. Greater effects on SBP were detected in trials, lasted ≥12 weeks, and sample size >50. Capsinoids with dosage ≤200 and FRPP with dosage of 11.9g significantly decreased DBP.
Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP.
Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP.
Ovarian cancer is a lethal disease with few modifiable risk factors. Circulating zinc and copper are potential biomarkers for ovarian cancer; however, evidence of their causal effects are scarce. This study aimed to examine the impact of circulating zinc and copper concentrations on ovarian cancer risk, using meta-analysis and Mendelian randomization (MR) approaches.
Twenty case-control studies, including 699 patients with ovarian cancer, 567 patients with benign ovarian lesions, and 1194 healthy controls, were selected for meta-analysis. With a Two-sample MR approach, genetic instruments of 21 single nucleotide polymorphisms (SNPs) associated with circulating zinc and 25 SNPs associated with circulating copper were created. Their genetic associations with ovarian cancer were extracted from a genome-wide association study of 25,509 ovarian cancer cases and 40,941 controls.
Ovarian cancer patients had significantly lower concentrations of circulating zinc than healthy controls (Standardized mean differences [SMD]=-1.01, 95% CI-1.38 to-0.64). selleck chemicals llc In contrast, circulating copper concentrations were significantly higher in ovarian cancer patients (SMD=1.46, 95% CI 0.82 to 2.09). In MR analysis, we only found increased circulating zinc concentration causally associated with a lower risk of ovarian cancer (odds ratio=0.968, 95% CI 0.941 to 0.995, per SD of ranked-inverse normalized concentration), especially in the high-grade serous subtype.
Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact.
Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact.
The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 μM vs 16.43 μM), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy.
Website: https://www.selleckchem.com/products/Deforolimus.html
9 patients. A lower phase angle did increase the odds of severe COVID-19. We believe that factors other than body composition play a more critical role in the development of severe COVID-19.
The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids and fermented red pepper paste (FRPP) supplementation on Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP).
Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. All randomized clinical trials investigating the effect of capsinoids and FRPP supplementation on blood pressure including SBP and DBP were included.
Out of 335 citations, 7 trials that enrolled 363 subjects were included. Capsinoids and FRPP resulted in significant reduction in DBP (Weighted mean differences (WMD)-1.90mmHg; 95% CI,-3.72 to-0.09, P=0.04) but no significant change in SBP (WMD 0.55mmHg, 95% CI-1.45, 2.55, P=0.588). FRPP had a significant reduction in SBP. Greater effects on SBP were detected in trials, lasted ≥12 weeks, and sample size >50. Capsinoids with dosage ≤200 and FRPP with dosage of 11.9g significantly decreased DBP.
Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP.
Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP.
Ovarian cancer is a lethal disease with few modifiable risk factors. Circulating zinc and copper are potential biomarkers for ovarian cancer; however, evidence of their causal effects are scarce. This study aimed to examine the impact of circulating zinc and copper concentrations on ovarian cancer risk, using meta-analysis and Mendelian randomization (MR) approaches.
Twenty case-control studies, including 699 patients with ovarian cancer, 567 patients with benign ovarian lesions, and 1194 healthy controls, were selected for meta-analysis. With a Two-sample MR approach, genetic instruments of 21 single nucleotide polymorphisms (SNPs) associated with circulating zinc and 25 SNPs associated with circulating copper were created. Their genetic associations with ovarian cancer were extracted from a genome-wide association study of 25,509 ovarian cancer cases and 40,941 controls.
Ovarian cancer patients had significantly lower concentrations of circulating zinc than healthy controls (Standardized mean differences [SMD]=-1.01, 95% CI-1.38 to-0.64). selleck chemicals llc In contrast, circulating copper concentrations were significantly higher in ovarian cancer patients (SMD=1.46, 95% CI 0.82 to 2.09). In MR analysis, we only found increased circulating zinc concentration causally associated with a lower risk of ovarian cancer (odds ratio=0.968, 95% CI 0.941 to 0.995, per SD of ranked-inverse normalized concentration), especially in the high-grade serous subtype.
Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact.
Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact.
The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
Three subject groups were included patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.
Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 μM vs 16.43 μM), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy.
Website: https://www.selleckchem.com/products/Deforolimus.html
|
|
Notes is a web-based application for online taking notes. You can take your notes and share with others people. If you like taking long notes, notes.io is designed for you. To date, over 8,000,000,000+ notes created and continuing...
With notes.io;
- * You can take a note from anywhere and any device with internet connection.
- * You can share the notes in social platforms (YouTube, Facebook, Twitter, instagram etc.).
- * You can quickly share your contents without website, blog and e-mail.
- * You don't need to create any Account to share a note. As you wish you can use quick, easy and best shortened notes with sms, websites, e-mail, or messaging services (WhatsApp, iMessage, Telegram, Signal).
- * Notes.io has fabulous infrastructure design for a short link and allows you to share the note as an easy and understandable link.
Fast: Notes.io is built for speed and performance. You can take a notes quickly and browse your archive.
Easy: Notes.io doesn’t require installation. Just write and share note!
Short: Notes.io’s url just 8 character. You’ll get shorten link of your note when you want to share. (Ex: notes.io/q )
Free: Notes.io works for 14 years and has been free since the day it was started.
You immediately create your first note and start sharing with the ones you wish. If you want to contact us, you can use the following communication channels;
Email: [email protected]
Twitter: http://twitter.com/notesio
Instagram: http://instagram.com/notes.io
Facebook: http://facebook.com/notesio
Regards;
Notes.io Team
