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Gene-Microbiome Co-expression Networks within Cancer of the colon.
Particularly, MOF-808, with a rigid and tritopic benzenetricarboxylate linker, has the highest iodine adsorption capacity (2.18 g/g, 80 °C), as well as the largest pore volume after iodine elution. In contrast, UiO-67, with long linear ditopic linkers, exhibits the weakest stability and lowest adsorption capacity (0.53 g/g, 80 °C) because of its most serious collapse of pore structures. After incorporating with strong electron-donating imidazole/pyridine ligands, both the stability and adsorption capacity of MOF-808/NU-1000 decrease. DFT calculations verify that the N-heterocycle groups could enhance the affinity toward iodine by strong charge transfer. DFT calculations also suggest that the terminal -OH in MOF-808 has a strong affinity toward iodine (-54 kJ/mol I2) and water (-63 kJ/mol H2O) and a weak affinity toward NO2 (-27 kJ/mol NO2). With high adsorption capacity and excellent stability, MOF-808 shows great potential for the sustainable removal of radioiodine.AIMS To test for the possible antinociceptive effect of nifedipine in rodent models of acute and chronic neuropathic orofacial pain and the possible involvement of TRP- and NMDA-related processes in this effect. METHODS Acute nociceptive behavior was induced by administering formalin, cinnamaldehyde, glutamate, capsaicin, or acidified saline to the upper lip or hypertonic saline to the cornea of Swiss mice. Acute nociceptive behavior was also induced by formalin injected into the TMJ or mustard oil injected into the masseter muscle of Wistar rats. The chronic pain model involved infraorbital nerve transection (IONX) in Wistar rats to induce mechanical hypersensitivity, which was assessed with von Frey hair stimulation of the upper lip. The effects of pretreatment with nifedipine or vehicle (control) were tested on the nociceptive behaviors. Docking experiments were also performed. Statistical analysis included one-way ANOVA followed by Tukey post hoc test and two-way ANOVA followed by Bonferroni post hoc test (statistical significance P less then .05). RESULTS Nifedipine produced significant antinociceptive effects in all of the acute nociceptive behaviors except that induced by capsaicin. The antinociceptive effects were attenuated by NMDA, TRPA1, or TRPM3 receptor antagonists. The IONX animals developed facial mechanical hypersensitivity, which was significantly reduced by nifedipine. The docking experiments suggested that nifedipine may interact with TRPM3 and NMDA receptors. CONCLUSION The present study has provided novel findings in a variety of acute and chronic orofacial pain models showing that nifedipine, a selective inhibitor of L-type Ca2+ channels, can suppress orofacial nociceptive behavior through NMDA, TRPA1, and TRPM3 receptor systems.AIMS To conduct a systematic review of the available evidence regarding the clinical characteristics and treatment of Ernest syndrome. METHODS A systematic search was carried out in the EBSCOhost, Embase, MEDLINE, ScienceDirect, Scopus, Web of Science, and Trip databases. The free terms "stylomandibular ligament" and "Ernest syndrome" were used, and the Boolean operator "OR" was used for connection of the terms. The research protocol was registered in PROSPERO (CRD42018112914). The results of this study are presented according to the PRISMA statement, and risk of bias was assessed according to the Quality Assessment Tool for Quantitative Studies of the Effective Public Health Practice Project. RESULTS A total of 57 articles were found, 5 of which met the selection criteria and were included in this review. The selected articles represent a population of 81 patients with primarily unilateral pain in the periauricular and mandibular areas. Diagnosis was established according to clinical history, recognition of pain on palpation of the mandibular angle, and remission following infiltration with local anesthesia. Concerning the treatments applied, infiltration with corticosteroids was highly successful, as was partial resection of the stylomandibular ligament and part of the styloid process. Furthermore, in refractory cases, the application of radiofrequency thermoneurolysis was described. CONCLUSION The analyzed studies allow a better understanding of Ernest syndrome and the proposal of a tendinosis model for this condition. However, the evidence is scarce, and it is therefore necessary to carry out additional studies with better methodologic designs.AIMS To identify the clinical characteristics of patients with primary and secondary burning mouth syndrome (BMS), to assess the effectiveness of pharmacotherapy in treating BMS, and to determine the clinical variables that may predict significant relief of clinical symptoms. METHODS A retrospective chart review of patients who underwent clinical management for BMS in the Massachusetts General Hospital between January 2011 and December 2016 was carried out. Information regarding demographics, diagnostics, and therapeutic characteristics was extracted and analyzed. RESULTS Of 112 BMS patients, 77 had primary BMS. Patients with primary and secondary BMS had similar clinical characteristics except when it came to the presence of at least one symptom of sensory discrepancy, which was more prevalent in primary BMS. THZ531 Following pharmacologic intervention, 46.8% of the patients with primary BMS experienced significant relief in symptoms, and this therapy was associated with a lower level of pain, an onset of symptoms rimary BMS and secondary BMS, respectively.AIMS To study the effect of platelet-rich plasma (PRP) injections on pain reduction in patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS The authors performed a comprehensive search of the MEDLINE, PubMed, and Web of Science databases to retrieve RCTs published up to July 2018. Pain outcomes (visual analog scale scores) were extracted to assess the effect of PRP injections on TMJ OA. All data analyses were conducted using RevMan 5.3. RESULTS Six studies were included. According to the results of these trials, intra-articular injections of PRP were more effective than placebo for pain reduction (6 months postinjection mean difference [MD] -2.82, 95% CI -3.39 to -2.25, P less then .00001; 12 months postinjection MD -3.29; 95% CI -4.07 to -2.52, P less then .00001). Additionally, the comparison between PRP and hyaluronic acid injections showed a statistically significant difference in pain reduction in support of PRP (MD -0.81; 95% CI -1.22 to -0.40; P = .0001) at 12 months postinjection.
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