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PURPOSE The aim of this study is to describe the number and location of the nutrient foramina in human scapulae which can minimize blood loss during surgery. METHODS 30 cadaveric scapulae were macerated to denude the skeletal tissue. The nutrient foramina of 0.51 mm and larger were identified and labeled by adhering glass beads. CT scans of these scapulae were segmented resulting in a surface model of each scapula and the location of the labeled nutrient foramina. All scapulae were scaled to the same size projecting the nutrient foramina onto one representative scapular model. RESULTS Average number of nutrient foramina per scapula was 5.3 (0-10). The most common location was in the supraspinous fossa (29.7%). On the costal surface of the scapula, most nutrient foramina were found directly inferior to the suprascapular notch. On the posterior surface, the nutrient foramina were identified under the spine of the scapula in a somewhat similar fashion as those on the costal surface. Nutrient foramina were least present in the peri-glenoid area. CONCLUSION Ninety percent of scapulae have more than one nutrient foramen. They are located in specific areas, on both the posterior and costal surface.PURPOSE The subtalar joint (STJ) is complex in anatomy and function. LDN-212854 The purpose of this study is to classify the articular surface of the calcaneus in a sample Chinese population and discuss the relationship between its matching situation and the stability of STJ. METHODS 328 patients with 445 STJs were measured and classified using CT three-dimensional reconstruction. The calcaneal facets were classified according to the morphological characteristics. According to the number, shape, and fusion of the calcaneus and talus facets, the matching situation was determined. The parameters of measurement the Gissane's angle, the Böhler's angle, the long-axis sum and the short-axis sum, and the average total joint facet area. RESULTS The calcaneal surfaces in a sample Chinese population were classified into five types Type I (219, 49.2%), Type II (102, 22.9%), Type III (68, 15.3%), Type IV (47, 10.6%) and Type V (9, 2%). The total matching rate of STJ is 98%. In terms of Gissane's angle, there was a significant difference between Type II and Type IV (P  0.05). CONCLUSIONS According to Bunnins's classification, the type with separated facets predominated but the matching situation between STJ was not elaborated, which was closely linked to the stability of STJ and surgical strategy of calcaneus fracture. The calcaneus articular surfaces in a sample Chinese population were divided into five types. Type I was the most common type and Type V was the rarest. Type II have the highest stability, Type V may be the lowest stability and Type III was more prone to osteoarthritis. The STJ articular surfaces were basically matched, contributing to the coordinate movement of the STJ. The matching articular surfaces of STJ were more stable than the mismatching surfaces. To some extent that STJ facet number, shape, facet area, and matching situation are factors in STJ stability, and the anatomical variations of the STJ offer predictive value in determining the predisposition to STI.A long tortuous course of the abducens nerve (ABN) crossing a highly curved siphon of the internal carotid artery is of interest to neurosurgeons for cavernous sinus surgery. Although a "straight" intracavernous carotid artery in fetuses can change into an adult-like siphon in infants, there is no information on when or how the unique course of ABN is established. Histological observations of 18 near-term fetuses (12 specimens of frontal sections and 6 specimens of sagittal sections) demonstrated the following (I) the ABN consistently took a straight course crossing the lateral side of an almost straight intracavernous carotid artery; (II) the straight course was maintained when sympathetic nerves joined; (III) few parasellar veins of the developing cavernous sinus separated the ABN from the ophthalmic nerve; and (IV) immediately before the developing tendinous annulus for a common origin of extraocular recti, the ABN bent laterally to avoid a passage of the thick oculomotor nerve. Since the present observations strongly suggested morphologies at birth and in infants, major angulations of the ABN as well as the well-known course independent of the other nerves in the cavernous sinus seemed to be established during childhood. In the human body, the ABN might be a limited example showing a drastic postnatal change in course. Consequently, it might be important to know the unique course of ABN before performing endovascular interventions and skull base surgery for petroclival and cavernous sinus lesions without causing inadvertent neurovascular injuries to neonates or infants.INTRODUCTION Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naïve metastatic castration-resistant PC (mCRPC) treated with enzalutamide or abiraterone acetate plus prednisone (abiraterone). METHODS We performed a retrospective analysis on 3174 men (18 years or older) utilizing the Veterans Health Administration (VHA) database from 1 April 2014 to 31 March 2018. Men with mCRPC were included if they had at least one pharmacy claim for enzalutamide or abiraterone (first claim date = index date) following surgical or medical castration, had no chemotherapy treatment within 12 months prior to the index date, and had continuous VHA enrollment for at least 12 months pre- and post-index date. Men were followed until death, disenrollment, or end of study and were 11 propensity score matched (PSM). All-cause and PC-related resource use and costs per patient per month (PPPM) in the available for this article.INTRODUCTION Pharmacotherapy is a mainstay of treatment for lower limb chronic venous disease (CVD) and its complications. However, therapeutic agents with evidence-based efficacy for the treatment of CVD are limited. Sulodexide (registered as Vessel Due F in Russia) has confirmed therapeutic efficacy in patients with moderately severe or late-stage CVD, but real-world evidence of its use in Russian patients with initial manifestations of chronic venous insufficiency (CVI) remains scarce. METHODS Data concerning the use of sulodexide in Russian patients with CVD in routine clinical practice were collected and assessed within the framework of the ACVEDUCT program. This observational, prospective, non-controlled multicenter program included patients routinely prescribed sulodexide, as a solution for injections and/or soft capsules, by their physician in accordance with the registered Russian Federation instructions for use. RESULTS In total, 2263 patients took part in the program. The majority of patients were diagnosed as having CEAP class C3 (38.
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